(82 nodes) Regulation of neuron differentiation network (Drosophila ananassae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DanaGF16118	Uncharacterized protein, isoform F. (4059 aa)
	DanaGF19599	Uncharacterized protein. (2712 aa)
	DanaGF20739	Uncharacterized protein. (2233 aa)
	DanaGF20618	Paired domain-containing protein. (470 aa)
	DanaGF19146	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1234 aa)
	DanaGF21819	Uncharacterized protein. (329 aa)
	DanaGF22213	Uncharacterized protein. (727 aa)
	DanaGF22531	Uncharacterized protein. (672 aa)
	DanaGF22649	Homeobox domain-containing protein. (562 aa)
	DanaGF20690	Uncharacterized protein. (1321 aa)
	DanaGF22992	Uncharacterized protein. (357 aa)
	DanaGF21460	Uncharacterized protein. (803 aa)
	DanaGF20860	Protein kinase domain-containing protein. (972 aa)
	DanaGF20993	Uncharacterized protein, isoform B. (667 aa)
	DanaGF21253	Non-specific serine/threonine protein kinase. (623 aa)
	DanaGF21164	Uncharacterized protein. (1104 aa)
	DanaGF14126	Mitogen-activated protein kinase. (376 aa)
	DanaGF14745	Mcm10 domain-containing protein. (775 aa)
	DanaGF14256	SEC7 domain-containing protein. (1656 aa)
	DanaGF15083	Uncharacterized protein. (716 aa)
	DanaGF14431	CBFD_NFYB_HMF domain-containing protein. (150 aa)
	DanaGF14515	Uncharacterized protein, isoform D. (1577 aa)
	DanaGF19706	Uncharacterized protein. (662 aa)
	DanaGF15305	Uncharacterized protein. (747 aa)
	DanaGF13818	Uncharacterized protein, isoform A. (850 aa)
	DanaGF12652	Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (639 aa)
	DanaGF12650	Uncharacterized protein. (342 aa)
	DanaGF13641	CULLIN_2 domain-containing protein; Belongs to the cullin family. (775 aa)
	DanaGF11361	DUF3677 domain-containing protein. (2053 aa)
	DanaGF13459	Uncharacterized protein, isoform A; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1708 aa)
	DanaGF11414	Uncharacterized protein. (998 aa)
	DanaGF12887	HMG box domain-containing protein. (709 aa)
	DanaGF11569	Uncharacterized protein. (662 aa)
	DanaGF23441	Uncharacterized protein, isoform A; Belongs to the small GTPase superfamily. Arf family. (182 aa)
	DanaGF25181	Uncharacterized protein. (1821 aa)
	DanaGF24683	Uncharacterized protein. (1182 aa)
	Rpd3	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (525 aa)
	DanaGF24724	Tyrosine-protein kinase. (554 aa)
	DanaGF10268	Uncharacterized protein. (591 aa)
	DanaGF24954	Uncharacterized protein, isoform B. (184 aa)
	DanaGF24423	Uncharacterized protein. (481 aa)
	DanaGF23925	PID domain-containing protein. (2257 aa)
	DanaGF25271	Uncharacterized protein. (523 aa)
	DanaGF23936	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (322 aa)
	DanaGF23937	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (328 aa)
	DanaGF23990	Uncharacterized protein, isoform A; Belongs to the peptidase C19 family. (1554 aa)
	DanaGF17014	Uncharacterized protein; Belongs to the DOCK family. (2170 aa)
	DanaGF18514	Uncharacterized protein. (614 aa)
	DanaGF16518	Uncharacterized protein. (1006 aa)
	DanaGF18433	Uncharacterized protein, isoform A. (648 aa)
	DanaGF18432	Uncharacterized protein, isoform A. (759 aa)
	Ras85D	Ras-like protein 1; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays a role in eye development by regulating cell growth, survival of postmitotic ommatidial cells and differentiation of photoreceptor cells. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis. (189 aa)
	DanaGF18327	Uncharacterized protein, isoform A; Belongs to the PI3/PI4-kinase family. (1099 aa)
	DanaGF17776	Zn-C2H2_12 domain-containing protein. (361 aa)
	DanaGF17365	Uncharacterized protein. (994 aa)
	DanaGF18131	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
	DanaGF18652	Uncharacterized protein. (803 aa)
	DanaGF17520	Uncharacterized protein, isoform A. (487 aa)
	DanaGF16415	Homeobox domain-containing protein. (472 aa)
	DanaGF16418	Uncharacterized protein, isoform C. (1251 aa)
	DanaGF16997	Ncstrn_small domain-containing protein. (693 aa)
	DanaGF16416	Uncharacterized protein, isoform B. (399 aa)
	DanaGF21177	Uncharacterized protein, isoform F. (2350 aa)
	DanaGF27086	Uncharacterized protein. (198 aa)
	DanaGF22186	Uncharacterized protein, isoform B. (141 aa)
	DanaGF27656	Uncharacterized protein. (89 aa)
	DanaGF23761	Uncharacterized protein, isoform D. (1259 aa)
	DanaGF16746	Uncharacterized protein. (1505 aa)
	DanaGF18012	Uncharacterized protein, isoform C. (735 aa)
	DanaGF24711	Uncharacterized protein, isoform H. (4663 aa)
	DanaGF18271	Uncharacterized protein, isoform B. (502 aa)
	DanaGF17811	Uncharacterized protein, isoform B. (2121 aa)
	DanaGF11179	Uncharacterized protein, isoform B. (652 aa)
	DanaGF26852	Non-specific serine/threonine protein kinase. (903 aa)
	DanaGF22273	Dynein light chain. (89 aa)
	DanaGF14504	Uncharacterized protein, isoform B. (876 aa)
	DanaGF16857	Uncharacterized protein, isoform B. (1868 aa)
	DanaGF13942	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (375 aa)
	DanaGF11039	Uncharacterized protein, isoform C. (1638 aa)
	Fas2	Fasciclin 2, isoform C. (883 aa)
	DanaGF23353	Uncharacterized protein, isoform B. (375 aa)
	DanaGF22979	Uncharacterized protein, isoform B. (838 aa)

Your Current Organism:

Drosophila ananassae

NCBI taxonomy Id: 7217
Other names: D. ananassae, Drosophila annanassae

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DanaGF10268	DanaGF13942	B3M831	A0A0N8P175	Uncharacterized protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.733
DanaGF10268	DanaGF21460	B3M831	B3MSF7	Uncharacterized protein.	Uncharacterized protein.	0.428
DanaGF10268	DanaGF22213	B3M831	B3MYV0	Uncharacterized protein.	Uncharacterized protein.	0.912
DanaGF11039	DanaGF13459	A0A0N8P0J6	B3MDK2	Uncharacterized protein, isoform C.	Uncharacterized protein, isoform A; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.423
DanaGF11039	DanaGF15083	A0A0N8P0J6	B3MM74	Uncharacterized protein, isoform C.	Uncharacterized protein.	0.437
DanaGF11039	DanaGF17014	A0A0N8P0J6	B3M338	Uncharacterized protein, isoform C.	Uncharacterized protein; Belongs to the DOCK family.	0.405
DanaGF11039	DanaGF18327	A0A0N8P0J6	B3M0A8	Uncharacterized protein, isoform C.	Uncharacterized protein, isoform A; Belongs to the PI3/PI4-kinase family.	0.630
DanaGF11039	DanaGF19146	A0A0N8P0J6	B3N0S7	Uncharacterized protein, isoform C.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.529
DanaGF11039	DanaGF21253	A0A0N8P0J6	B3MRC1	Uncharacterized protein, isoform C.	Non-specific serine/threonine protein kinase.	0.526
DanaGF11039	DanaGF21460	A0A0N8P0J6	B3MSF7	Uncharacterized protein, isoform C.	Uncharacterized protein.	0.588
DanaGF11039	DanaGF22213	A0A0N8P0J6	B3MYV0	Uncharacterized protein, isoform C.	Uncharacterized protein.	0.987
DanaGF11039	DanaGF24724	A0A0N8P0J6	B3M9I4	Uncharacterized protein, isoform C.	Tyrosine-protein kinase.	0.459
DanaGF11039	DanaGF24954	A0A0N8P0J6	B3M791	Uncharacterized protein, isoform C.	Uncharacterized protein, isoform B.	0.504
DanaGF11039	DanaGF25181	A0A0N8P0J6	B3MAV9	Uncharacterized protein, isoform C.	Uncharacterized protein.	0.406
DanaGF11039	Fas2	A0A0N8P0J6	A0A0N8NZU1	Uncharacterized protein, isoform C.	Fasciclin 2, isoform C.	0.413
DanaGF11039	Ras85D	A0A0N8P0J6	B3M185	Uncharacterized protein, isoform C.	Ras-like protein 1; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays a role in eye development by regulating cell growth, survival of postmitotic ommatidial cells and differentiation of photoreceptor cells. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis.	0.963
DanaGF11361	DanaGF11414	B3MDY1	B3MDA4	DUF3677 domain-containing protein.	Uncharacterized protein.	0.992
DanaGF11361	DanaGF17365	B3MDY1	B3LXB0	DUF3677 domain-containing protein.	Uncharacterized protein.	0.999
DanaGF11361	DanaGF21164	B3MDY1	B3MQV7	DUF3677 domain-containing protein.	Uncharacterized protein.	0.999
DanaGF11414	DanaGF11361	B3MDA4	B3MDY1	Uncharacterized protein.	DUF3677 domain-containing protein.	0.992