(53 nodes) Negative regulation of smoothened signaling pathway network (Drosophila ananassae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DanaGF22237	Uncharacterized protein, isoform C. (1095 aa)
	DanaGF24284	Uncharacterized protein, isoform C. (377 aa)
	DanaGF19572	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (264 aa)
	DanaGF13077	Uncharacterized protein, isoform D. (518 aa)
	DanaGF26637	SAC domain-containing protein. (1220 aa)
	DanaGF24453	Uncharacterized protein, isoform B. (1063 aa)
	DanaGF24326	Uncharacterized protein, isoform F. (1982 aa)
	DanaGF14531	Uncharacterized protein, isoform D; Belongs to the cullin family. (966 aa)
	DanaGF19339	Uncharacterized protein, isoform C. (672 aa)
	DanaGF22186	Uncharacterized protein, isoform B. (141 aa)
	DanaGF13879	Uncharacterized protein, isoform C; Belongs to the protein kinase superfamily. (351 aa)
	DanaGF11135	Uncharacterized protein, isoform B; Belongs to the AAA ATPase family. (827 aa)
	DanaGF17501	Arrestin_C domain-containing protein. (485 aa)
	DanaGF18131	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
	DanaGF17579	CPSF_A domain-containing protein. (1140 aa)
	DanaGF18796	Uncharacterized protein, isoform A. (822 aa)
	DanaGF17266	Uncharacterized protein, isoform A. (657 aa)
	DanaGF17785	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (722 aa)
	DanaGF17874	Suppressor of fused homolog. (476 aa)
	DanaGF16526	Uncharacterized protein. (1150 aa)
	DanaGF18514	Uncharacterized protein. (614 aa)
	DanaGF24568	Uncharacterized protein. (317 aa)
	DanaGF10539	Uncharacterized protein, isoform D. (990 aa)
	DanaGF24443	Uncharacterized protein, isoform A. (618 aa)
	DanaGF23715	WD_REPEATS_REGION domain-containing protein. (346 aa)
	DanaGF10836	Uncharacterized protein. (168 aa)
	DanaGF23553	Uncharacterized protein, isoform A. (488 aa)
	Rpd3	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (525 aa)
	DanaGF24700	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (183 aa)
	DanaGF12372	SSD domain-containing protein. (1290 aa)
	DanaGF13641	CULLIN_2 domain-containing protein; Belongs to the cullin family. (775 aa)
	DanaGF11213	CULLIN_2 domain-containing protein; Belongs to the cullin family. (821 aa)
	DanaGF13717	E2_bind domain-containing protein. (450 aa)
	DanaGF12234	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1234 aa)
	DanaGF11657	Uncharacterized protein. (1047 aa)
	DanaGF11094	ULP_PROTEASE domain-containing protein. (529 aa)
	DanaGF11046	Uncharacterized protein. (269 aa)
	DanaGF14597	Uncharacterized protein. (963 aa)
	DanaGF15221	Uncharacterized protein, isoform A. (666 aa)
	DanaGF14648	Ubiquitin-like domain-containing protein. (81 aa)
	DanaGF20505	WD_REPEATS_REGION domain-containing protein. (340 aa)
	DanaGF20304	Uncharacterized protein, isoform A. (174 aa)
	DanaGF21042	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (302 aa)
	DanaGF21383	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (337 aa)
	DanaGF23293	Uncharacterized protein, isoform B; Belongs to the protein kinase superfamily. (441 aa)
	DanaGF21892	Uncharacterized protein, isoform B; Belongs to the protein kinase superfamily. (353 aa)
	DanaGF21831	Serine/threonine-protein phosphatase. (309 aa)
	DanaGF22837	WD_REPEATS_REGION domain-containing protein. (318 aa)
	DanaGF22541	Uncharacterized protein, isoform C. (822 aa)
	DanaGF19488	Serine/threonine-protein phosphatase. (307 aa)
	DanaGF16000	ULP_PROTEASE domain-containing protein. (1044 aa)
	DanaGF13888	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded. (763 aa)
	DanaGF20754	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)

Your Current Organism:

Drosophila ananassae

NCBI taxonomy Id: 7217
Other names: D. ananassae, Drosophila annanassae

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DanaGF10539	DanaGF11657	B3M4J8	B3MIF7	Uncharacterized protein, isoform D.	Uncharacterized protein.	0.920
DanaGF10539	DanaGF12372	B3M4J8	B3MFV3	Uncharacterized protein, isoform D.	SSD domain-containing protein.	0.755
DanaGF10539	DanaGF13888	B3M4J8	B3N197	Uncharacterized protein, isoform D.	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.	0.416
DanaGF10539	DanaGF14597	B3M4J8	B3MJD3	Uncharacterized protein, isoform D.	Uncharacterized protein.	0.941
DanaGF10539	DanaGF14648	B3M4J8	B3MPE2	Uncharacterized protein, isoform D.	Ubiquitin-like domain-containing protein.	0.486
DanaGF10539	DanaGF17501	B3M4J8	B3LVE2	Uncharacterized protein, isoform D.	Arrestin_C domain-containing protein.	0.458
DanaGF10539	DanaGF18131	B3M4J8	B3LWS2	Uncharacterized protein, isoform D.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.596
DanaGF10539	DanaGF18514	B3M4J8	B3M2V7	Uncharacterized protein, isoform D.	Uncharacterized protein.	0.406
DanaGF11046	DanaGF18514	B3MJ67	B3M2V7	Uncharacterized protein.	Uncharacterized protein.	0.618
DanaGF11135	DanaGF13641	A0A0P9C0U8	B3MGA3	Uncharacterized protein, isoform B; Belongs to the AAA ATPase family.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.606
DanaGF11135	DanaGF14531	A0A0P9C0U8	A0A0P8ZFA9	Uncharacterized protein, isoform B; Belongs to the AAA ATPase family.	Uncharacterized protein, isoform D; Belongs to the cullin family.	0.694
DanaGF11135	DanaGF17266	A0A0P9C0U8	B3LZ22	Uncharacterized protein, isoform B; Belongs to the AAA ATPase family.	Uncharacterized protein, isoform A.	0.997
DanaGF11135	DanaGF22186	A0A0P9C0U8	A0A0P9A6R4	Uncharacterized protein, isoform B; Belongs to the AAA ATPase family.	Uncharacterized protein, isoform B.	0.405
DanaGF11135	DanaGF24568	A0A0P9C0U8	B3M3W9	Uncharacterized protein, isoform B; Belongs to the AAA ATPase family.	Uncharacterized protein.	0.975
DanaGF11213	DanaGF13641	B3MGE3	B3MGA3	CULLIN_2 domain-containing protein; Belongs to the cullin family.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.526
DanaGF11213	DanaGF13717	B3MGE3	B3MHF3	CULLIN_2 domain-containing protein; Belongs to the cullin family.	E2_bind domain-containing protein.	0.802
DanaGF11213	DanaGF14531	B3MGE3	A0A0P8ZFA9	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Uncharacterized protein, isoform D; Belongs to the cullin family.	0.518
DanaGF11213	DanaGF14648	B3MGE3	B3MPE2	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Ubiquitin-like domain-containing protein.	0.958
DanaGF11213	DanaGF17579	B3MGE3	B3LX39	CULLIN_2 domain-containing protein; Belongs to the cullin family.	CPSF_A domain-containing protein.	0.999
DanaGF11213	DanaGF18131	B3MGE3	B3LWS2	CULLIN_2 domain-containing protein; Belongs to the cullin family.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.405