(27 nodes) Negative regulation of JNK cascade network (Drosophila ananassae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DanaGF23353	Uncharacterized protein, isoform B. (375 aa)
	DanaGF14574	Uncharacterized protein, isoform B. (757 aa)
	DanaGF10060	Uncharacterized protein, isoform B. (572 aa)
	DanaGF22303	Uncharacterized protein, isoform D. (222 aa)
	DanaGF22237	Uncharacterized protein, isoform C. (1095 aa)
	DanaGF16939	JmjC domain-containing protein. (439 aa)
	DanaGF17460	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. (456 aa)
	DanaGF16102	LIM domain-containing protein. (348 aa)
	DanaGF23912	Uncharacterized protein, isoform A. (930 aa)
	DanaGF24443	Uncharacterized protein, isoform A. (618 aa)
	Urm1	Ubiquitin-related modifier 1 homolog; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as Jafrac1, Ciao1, Eip71CD and GILT1. The thiocarboxylated form serves as substrate [...] (101 aa)
	DanaGF10661	Uncharacterized protein, isoform A. (444 aa)
	DanaGF10184	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (482 aa)
	DanaGF10220	Ubiquitin carboxyl-terminal hydrolase. (826 aa)
	DanaGF10914	Uncharacterized protein. (934 aa)
	DanaGF11927	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (286 aa)
	DanaGF14357	Uncharacterized protein, isoform A. (998 aa)
	DanaGF20412	Uncharacterized protein. (374 aa)
	DanaGF21176	Uncharacterized protein, isoform B; Belongs to the SKP1 family. (163 aa)
	DanaGF23258	N-acetyltransferase domain-containing protein. (199 aa)
	DanaGF20820	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (276 aa)
	DanaGF20766	Uncharacterized protein. (763 aa)
	DanaGF20651	Uncharacterized protein. (698 aa)
	DanaGF21702	Uncharacterized protein. (283 aa)
	DanaGF19359	Uncharacterized protein. (1899 aa)
	DanaGF19539	Serine/threonine-protein phosphatase. (303 aa)
	DanaGF21923	Uncharacterized protein. (5255 aa)

Your Current Organism:

Drosophila ananassae

NCBI taxonomy Id: 7217
Other names: D. ananassae, Drosophila annanassae

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DanaGF10060	DanaGF23353	A0A0P8XTZ8	A0A0N8NYZ8	Uncharacterized protein, isoform B.	Uncharacterized protein, isoform B.	0.554
DanaGF10914	DanaGF19539	B3MA06	B3MXY0	Uncharacterized protein.	Serine/threonine-protein phosphatase.	0.994
DanaGF11927	DanaGF20820	B3MDV9	B3MUA4	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.998
DanaGF14574	DanaGF23912	A0A0P8XF23	B3M4I5	Uncharacterized protein, isoform B.	Uncharacterized protein, isoform A.	0.968
DanaGF16102	DanaGF21702	B3M0N2	B3MV41	LIM domain-containing protein.	Uncharacterized protein.	0.999
DanaGF19539	DanaGF10914	B3MXY0	B3MA06	Serine/threonine-protein phosphatase.	Uncharacterized protein.	0.994
DanaGF20651	DanaGF21176	B3MUI0	B3MQX8	Uncharacterized protein.	Uncharacterized protein, isoform B; Belongs to the SKP1 family.	0.921
DanaGF20820	DanaGF11927	B3MUA4	B3MDV9	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.998
DanaGF21176	DanaGF20651	B3MQX8	B3MUI0	Uncharacterized protein, isoform B; Belongs to the SKP1 family.	Uncharacterized protein.	0.921
DanaGF21702	DanaGF16102	B3MV41	B3M0N2	Uncharacterized protein.	LIM domain-containing protein.	0.999
DanaGF23353	DanaGF10060	A0A0N8NYZ8	A0A0P8XTZ8	Uncharacterized protein, isoform B.	Uncharacterized protein, isoform B.	0.554
DanaGF23912	DanaGF14574	B3M4I5	A0A0P8XF23	Uncharacterized protein, isoform A.	Uncharacterized protein, isoform B.	0.968