(81 nodes) Photoreceptor cell fate commitment network (Drosophila ananassae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DanaGF26751	TGF_BETA_2 domain-containing protein. (564 aa)
	DanaGF22418	Uncharacterized protein, isoform C. (3224 aa)
	DanaGF11096	Uncharacterized protein, isoform E. (970 aa)
	DanaGF25012	Uncharacterized protein, isoform B. (990 aa)
	DanaGF13942	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (375 aa)
	DanaGF16857	Uncharacterized protein, isoform B. (1868 aa)
	DanaGF20585	Uncharacterized protein, isoform B. (629 aa)
	DanaGF20577	Mothers against decapentaplegic homolog. (581 aa)
	DanaGF14574	Uncharacterized protein, isoform B. (757 aa)
	DanaGF11678	Uncharacterized protein, isoform H. (1301 aa)
	DanaGF15881	Uncharacterized protein, isoform B. (1058 aa)
	DanaGF22979	Uncharacterized protein, isoform B. (838 aa)
	DanaGF16442	Uncharacterized protein, isoform AB. (3324 aa)
	DanaGF12019	Uncharacterized protein, isoform D; Belongs to the 14-3-3 family. (248 aa)
	DanaGF22303	Uncharacterized protein, isoform D. (222 aa)
	DanaGF18012	Uncharacterized protein, isoform C. (735 aa)
	DanaGF19273	Uncharacterized protein, isoform B; Belongs to the peptidase S8 family. (1638 aa)
	DanaGF20147	TGF_BETA_2 domain-containing protein. (738 aa)
	DanaGF17520	Uncharacterized protein, isoform A. (487 aa)
	DanaGF17542	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (521 aa)
	DanaGF18117	Uncharacterized protein. (687 aa)
	Kibra	Protein kibra; Regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. Kibra acts synergistically along with Ex and Mer to regulate the Hippo signalin [...] (1271 aa)
	DanaGF17607	Uncharacterized protein. (692 aa)
	DanaGF16791	G_PROTEIN_RECEP_F3_4 domain-containing protein. (892 aa)
	DanaGF17697	Uncharacterized protein, isoform A. (634 aa)
	DanaGF18269	Uncharacterized protein. (608 aa)
	DanaGF16716	Uncharacterized protein. (543 aa)
	DanaGF17706	Uncharacterized protein. (952 aa)
	DanaGF17240	Uncharacterized protein. (729 aa)
	DanaGF18335	BHLH domain-containing protein. (293 aa)
	Ras85D	Ras-like protein 1; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays a role in eye development by regulating cell growth, survival of postmitotic ommatidial cells and differentiation of photoreceptor cells. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis. (189 aa)
	DanaGF17014	Uncharacterized protein; Belongs to the DOCK family. (2170 aa)
	DanaGF18562	Homeobox domain-containing protein. (334 aa)
	DanaGF18570	P/Homo B domain-containing protein; Belongs to the peptidase S8 family. (659 aa)
	DanaGF24601	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (623 aa)
	DanaGF23937	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (328 aa)
	DanaGF23936	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (322 aa)
	DanaGF24399	Uncharacterized protein. (856 aa)
	DanaGF24954	Uncharacterized protein, isoform B. (184 aa)
	DanaGF24235	Uncharacterized protein, isoform A. (862 aa)
	rho	Rhomboid, isoform A; Belongs to the peptidase S54 family. (365 aa)
	DanaGF24760	Rhomboid domain-containing protein; Belongs to the peptidase S54 family. (317 aa)
	DanaGF10395	BHLH domain-containing protein. (196 aa)
	DanaGF13338	Uncharacterized protein. (1324 aa)
	DanaGF12821	Receptor protein-tyrosine kinase. (1439 aa)
	DanaGF11350	Uncharacterized protein. (417 aa)
	DanaGF12511	TGF_BETA_2 domain-containing protein. (454 aa)
	DanaGF11787	Uncharacterized protein. (1556 aa)
	DanaGF12602	Uncharacterized protein. (441 aa)
	DanaGF11180	Uncharacterized protein. (211 aa)
	DanaGF13179	Uncharacterized protein. (654 aa)
	DanaGF12221	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (627 aa)
	DanaGF11102	C2H2-type domain-containing protein. (331 aa)
	DanaGF15305	Uncharacterized protein. (747 aa)
	DanaGF15397	Uncharacterized protein. (1251 aa)
	DanaGF14515	Uncharacterized protein, isoform D. (1577 aa)
	DanaGF14981	Uncharacterized protein, isoform A. (593 aa)
	DanaGF14886	C2H2-type domain-containing protein. (541 aa)
	DanaGF15519	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (562 aa)
	DanaGF15014	Uncharacterized protein, isoform A. (548 aa)
	DanaGF14872	Uncharacterized protein, isoform A. (1162 aa)
	DanaGF14259	Uncharacterized protein. (1587 aa)
	DanaGF15158	XPG_I_2 domain-containing protein. (847 aa)
	DanaGF15679	Rhomboid domain-containing protein. (260 aa)
	DanaGF20371	Protein kinase domain-containing protein. (177 aa)
	DanaGF20397	Uncharacterized protein. (2561 aa)
	DanaGF20269	FERM domain-containing protein. (635 aa)
	DanaGF20482	Uncharacterized protein, isoform A. (1037 aa)
	DanaGF20979	Mothers against decapentaplegic homolog. (471 aa)
	DanaGF21460	Uncharacterized protein. (803 aa)
	DanaGF23311	Uncharacterized protein. (1087 aa)
	DanaGF23073	Uncharacterized protein, isoform A; Belongs to the 14-3-3 family. (263 aa)
	DanaGF23044	Metalloendopeptidase. (1069 aa)
	DanaGF21096	Uncharacterized protein. (595 aa)
	DanaGF21831	Serine/threonine-protein phosphatase. (309 aa)
	DanaGF22649	Homeobox domain-containing protein. (562 aa)
	DanaGF22416	Uncharacterized protein, isoform A. (131 aa)
	DanaGF22818	Uncharacterized protein. (900 aa)
	DanaGF22213	Uncharacterized protein. (727 aa)
	Dsor1	Downstream of raf1, isoform A; Belongs to the protein kinase superfamily. (396 aa)
	DanaGF25100	Uncharacterized protein. (442 aa)

Your Current Organism:

Drosophila ananassae

NCBI taxonomy Id: 7217
Other names: D. ananassae, Drosophila annanassae

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DanaGF10395	DanaGF18012	B3MAE9	A0A0P8YE47	BHLH domain-containing protein.	Uncharacterized protein, isoform C.	0.906
DanaGF10395	DanaGF18335	B3MAE9	B3M0C5	BHLH domain-containing protein.	BHLH domain-containing protein.	0.600
DanaGF10395	DanaGF20585	B3MAE9	A0A0P8XDR4	BHLH domain-containing protein.	Uncharacterized protein, isoform B.	0.483
DanaGF11180	DanaGF12821	B3MGZ3	B3MC66	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.994
DanaGF11180	DanaGF13942	B3MGZ3	A0A0N8P175	Uncharacterized protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.411
DanaGF11180	DanaGF14259	B3MGZ3	B3MN28	Uncharacterized protein.	Uncharacterized protein.	0.998
DanaGF11180	DanaGF15397	B3MGZ3	B3MKG1	Uncharacterized protein.	Uncharacterized protein.	0.610
DanaGF11180	DanaGF17706	B3MGZ3	B3LZH5	Uncharacterized protein.	Uncharacterized protein.	0.616
DanaGF11180	DanaGF20371	B3MGZ3	B3MQ37	Uncharacterized protein.	Protein kinase domain-containing protein.	0.745
DanaGF11180	DanaGF20397	B3MGZ3	B3MQ86	Uncharacterized protein.	Uncharacterized protein.	0.925
DanaGF11180	DanaGF21460	B3MGZ3	B3MSF7	Uncharacterized protein.	Uncharacterized protein.	0.990
DanaGF11180	DanaGF21831	B3MGZ3	B3MV12	Uncharacterized protein.	Serine/threonine-protein phosphatase.	0.587
DanaGF11180	DanaGF22213	B3MGZ3	B3MYV0	Uncharacterized protein.	Uncharacterized protein.	0.695
DanaGF11180	DanaGF22303	B3MGZ3	A0A0P8Y8F7	Uncharacterized protein.	Uncharacterized protein, isoform D.	0.724
DanaGF11180	DanaGF24235	B3MGZ3	B3M7Y8	Uncharacterized protein.	Uncharacterized protein, isoform A.	0.992
DanaGF11180	DanaGF24399	B3MGZ3	B3M5I4	Uncharacterized protein.	Uncharacterized protein.	0.990
DanaGF11180	DanaGF24954	B3MGZ3	B3M791	Uncharacterized protein.	Uncharacterized protein, isoform B.	0.710
DanaGF11180	DanaGF25100	B3MGZ3	B3N297	Uncharacterized protein.	Uncharacterized protein.	0.990
DanaGF11180	Dsor1	B3MGZ3	B3MZP8	Uncharacterized protein.	Downstream of raf1, isoform A; Belongs to the protein kinase superfamily.	0.728
DanaGF11180	Kibra	B3MGZ3	B3LWS4	Uncharacterized protein.	Protein kibra; Regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. Kibra acts synergistically along with Ex and Mer to regulate the Hippo signalin [...]	0.550