(36 nodes) Regulation of filopodium assembly network (Drosophila ananassae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DanaGF22176	Uncharacterized protein. (1487 aa)
	DanaGF19209	Uncharacterized protein. (95 aa)
	DanaGF20763	Uncharacterized protein, isoform A. (422 aa)
	DanaGF19599	Uncharacterized protein. (2712 aa)
	DanaGF18788	Uncharacterized protein, isoform B. (476 aa)
	DanaGF14429	Uncharacterized protein, isoform C. (2050 aa)
	DanaGF20797	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (399 aa)
	DanaGF11157	Uncharacterized protein, isoform AU. (8872 aa)
	DanaGF23988	Uncharacterized protein. (2790 aa)
	DanaGF11290	Uncharacterized protein, isoform B. (211 aa)
	DanaGF12632	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (968 aa)
	DanaGF22825	Uncharacterized protein, isoform F. (533 aa)
	DanaGF15838	Uncharacterized protein, isoform D. (675 aa)
	DanaGF22322	Uncharacterized protein, isoform C. (1537 aa)
	DanaGF18619	Uncharacterized protein. (196 aa)
	DanaGF24582	Uncharacterized protein. (3942 aa)
	DanaGF10484	Uncharacterized protein; Belongs to the actin family. (418 aa)
	DanaGF10510	Uncharacterized protein. (400 aa)
	DanaGF10522	Uncharacterized protein; Belongs to the histidine acid phosphatase family. (467 aa)
	DanaGF10067	Uncharacterized protein. (192 aa)
	DanaGF11575	Uncharacterized protein, isoform A. (818 aa)
	DanaGF12040	Uncharacterized protein. (76 aa)
	DanaGF11927	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (286 aa)
	DanaGF15354	Uncharacterized protein, isoform A. (1089 aa)
	DanaGF14840	Uncharacterized protein. (2380 aa)
	DanaGF14290	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. (126 aa)
	DanaGF15618	Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (377 aa)
	DanaGF15693	Uncharacterized protein, isoform A. (390 aa)
	DanaGF20423	Uncharacterized protein, isoform A. (191 aa)
	DanaGF20451	Uncharacterized protein. (203 aa)
	DanaGF20461	Uncharacterized protein. (1189 aa)
	DanaGF21116	Uncharacterized protein. (355 aa)
	DanaGF20874	Protein kinase domain-containing protein. (1170 aa)
	DanaGF22994	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1291 aa)
	DanaGF20820	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (276 aa)
	DanaGF19486	PHB domain-containing protein; Belongs to the band 7/mec-2 family. Flotillin subfamily. (438 aa)

Your Current Organism:

Drosophila ananassae

NCBI taxonomy Id: 7217
Other names: D. ananassae, Drosophila annanassae

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DanaGF10067	DanaGF10484	B3M528	B3M425	Uncharacterized protein.	Uncharacterized protein; Belongs to the actin family.	0.570
DanaGF10067	DanaGF11290	B3M528	A0A0P8Y6D5	Uncharacterized protein.	Uncharacterized protein, isoform B.	0.723
DanaGF10067	DanaGF12040	B3M528	B3MCX6	Uncharacterized protein.	Uncharacterized protein.	0.641
DanaGF10067	DanaGF12632	B3M528	A0A0P8ZLZ9	Uncharacterized protein.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.754
DanaGF10067	DanaGF14290	B3M528	B3MMQ1	Uncharacterized protein.	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.	0.686
DanaGF10067	DanaGF15354	B3M528	B3MK23	Uncharacterized protein.	Uncharacterized protein, isoform A.	0.768
DanaGF10067	DanaGF15618	B3M528	B3MN25	Uncharacterized protein.	Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	0.544
DanaGF10067	DanaGF15838	B3M528	A0A0P9BQ73	Uncharacterized protein.	Uncharacterized protein, isoform D.	0.598
DanaGF10067	DanaGF18788	B3M528	A0A0N8P1Q6	Uncharacterized protein.	Uncharacterized protein, isoform B.	0.571
DanaGF10067	DanaGF20423	B3M528	B3MQD0	Uncharacterized protein.	Uncharacterized protein, isoform A.	0.592
DanaGF10067	DanaGF20797	B3M528	A0A0P8XKA5	Uncharacterized protein.	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	0.638
DanaGF10067	DanaGF20820	B3M528	B3MUA4	Uncharacterized protein.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.474
DanaGF10067	DanaGF20874	B3M528	B3MS41	Uncharacterized protein.	Protein kinase domain-containing protein.	0.553
DanaGF10067	DanaGF21116	B3M528	B3MQV2	Uncharacterized protein.	Uncharacterized protein.	0.961
DanaGF10067	DanaGF22176	B3M528	B3MYM9	Uncharacterized protein.	Uncharacterized protein.	0.603
DanaGF10067	DanaGF22994	B3M528	B3MSU9	Uncharacterized protein.	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family.	0.811
DanaGF10067	DanaGF23988	B3M528	A0A0P8XUU5	Uncharacterized protein.	Uncharacterized protein.	0.857
DanaGF10484	DanaGF10067	B3M425	B3M528	Uncharacterized protein; Belongs to the actin family.	Uncharacterized protein.	0.570
DanaGF10484	DanaGF11290	B3M425	A0A0P8Y6D5	Uncharacterized protein; Belongs to the actin family.	Uncharacterized protein, isoform B.	0.526
DanaGF10484	DanaGF11927	B3M425	B3MDV9	Uncharacterized protein; Belongs to the actin family.	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.707