(70 nodes) Regulation of stress-activated protein kinase signaling cascade network (Drosophila ananassae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DanaGF10821	Uncharacterized protein. (65 aa)
	DanaGF10220	Ubiquitin carboxyl-terminal hydrolase. (826 aa)
	DanaGF10184	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (482 aa)
	DanaGF10661	Uncharacterized protein, isoform A. (444 aa)
	Urm1	Ubiquitin-related modifier 1 homolog; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as Jafrac1, Ciao1, Eip71CD and GILT1. The thiocarboxylated form serves as substrate [...] (101 aa)
	DanaGF10633	Uncharacterized protein, isoform A. (1219 aa)
	DanaGF24433	Uncharacterized protein, isoform A. (497 aa)
	DanaGF24443	Uncharacterized protein, isoform A. (618 aa)
	DanaGF10067	Uncharacterized protein. (192 aa)
	DanaGF23912	Uncharacterized protein, isoform A. (930 aa)
	DanaGF25236	Battenin. (422 aa)
	DanaGF10466	UBIQUITIN_CONJUGAT_2 domain-containing protein. (145 aa)
	DanaGF17866	Uncharacterized protein, isoform A. (1573 aa)
	DanaGF16070	Uncharacterized protein, isoform D. (2064 aa)
	DanaGF16102	LIM domain-containing protein. (348 aa)
	DanaGF17710	Uncharacterized protein, isoform A. (1169 aa)
	DanaGF16724	Uncharacterized protein. (491 aa)
	DanaGF18796	Uncharacterized protein, isoform A. (822 aa)
	DanaGF17624	Protein kinase domain-containing protein. (1357 aa)
	DanaGF17609	Uncharacterized protein, isoform A. (535 aa)
	DanaGF18695	BRO1 domain-containing protein. (836 aa)
	DanaGF18082	Uncharacterized protein, isoform A. (1314 aa)
	DanaGF17460	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. (456 aa)
	DanaGF16939	JmjC domain-containing protein. (439 aa)
	DanaGF27571	Uncharacterized protein. (339 aa)
	DanaGF22237	Uncharacterized protein, isoform C. (1095 aa)
	DanaGF16263	Uncharacterized protein, isoform D; Belongs to the DOCK family. (1990 aa)
	DanaGF27507	Helicase C-terminal domain-containing protein. (609 aa)
	DanaGF22303	Uncharacterized protein, isoform D. (222 aa)
	DanaGF15056	Uncharacterized protein, isoform B. (240 aa)
	DanaGF10060	Uncharacterized protein, isoform B. (572 aa)
	DanaGF14324	Uncharacterized protein, isoform B. (378 aa)
	DanaGF15271	Receptor protein-tyrosine kinase. (1183 aa)
	DanaGF14574	Uncharacterized protein, isoform B. (757 aa)
	DanaGF23353	Uncharacterized protein, isoform B. (375 aa)
	DanaGF20730	CG6036-PA. (366 aa)
	DanaGF15984	Protein kinase domain-containing protein. (732 aa)
	DanaGF19567	Uncharacterized protein, isoform A. (473 aa)
	DanaGF19053	Uncharacterized protein, isoform B; Belongs to the PDGF/VEGF growth factor family. (328 aa)
	DanaGF19231	Uncharacterized protein, isoform A; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
	DanaGF23415	Uncharacterized protein. (278 aa)
	DanaGF21923	Uncharacterized protein. (5255 aa)
	DanaGF19539	Serine/threonine-protein phosphatase. (303 aa)
	DanaGF19359	Uncharacterized protein. (1899 aa)
	DanaGF20561	Uncharacterized protein, isoform A. (177 aa)
	DanaGF21563	ELMO domain-containing protein. (723 aa)
	DanaGF21702	Uncharacterized protein. (283 aa)
	DanaGF20651	Uncharacterized protein. (698 aa)
	DanaGF20766	Uncharacterized protein. (763 aa)
	DanaGF20820	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (276 aa)
	DanaGF21137	Uncharacterized protein. (488 aa)
	DanaGF23258	N-acetyltransferase domain-containing protein. (199 aa)
	DanaGF21465	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (360 aa)
	DanaGF20974	Uncharacterized protein. (476 aa)
	DanaGF21176	Uncharacterized protein, isoform B; Belongs to the SKP1 family. (163 aa)
	DanaGF20423	Uncharacterized protein, isoform A. (191 aa)
	DanaGF20412	Uncharacterized protein. (374 aa)
	DanaGF14119	Uncharacterized protein, isoform A. (642 aa)
	DanaGF15270	Receptor protein-tyrosine kinase. (1578 aa)
	DanaGF14357	Uncharacterized protein, isoform A. (998 aa)
	DanaGF11645	Uncharacterized protein. (843 aa)
	DanaGF12707	Uncharacterized protein, isoform A. (734 aa)
	Atg9	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (851 aa)
	DanaGF11827	Uncharacterized protein, isoform A. (210 aa)
	DanaGF12469	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	DanaGF11927	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (286 aa)
	DanaGF11964	Uncharacterized protein. (638 aa)
	DanaGF11445	Uncharacterized protein. (122 aa)
	DanaGF11577	Uncharacterized protein. (1255 aa)
	DanaGF10914	Uncharacterized protein. (934 aa)

Your Current Organism:

Drosophila ananassae

NCBI taxonomy Id: 7217
Other names: D. ananassae, Drosophila annanassae

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Atg9	DanaGF20974	B3MFM7	B3MRL9	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	Uncharacterized protein.	0.861
DanaGF10060	DanaGF23353	A0A0P8XTZ8	A0A0N8NYZ8	Uncharacterized protein, isoform B.	Uncharacterized protein, isoform B.	0.554
DanaGF10067	DanaGF10633	B3M528	B3M5P9	Uncharacterized protein.	Uncharacterized protein, isoform A.	0.425
DanaGF10067	DanaGF11645	B3M528	B3MIH5	Uncharacterized protein.	Uncharacterized protein.	0.401
DanaGF10067	DanaGF15984	B3M528	B3N113	Uncharacterized protein.	Protein kinase domain-containing protein.	0.484
DanaGF10067	DanaGF16263	B3M528	A0A0P9A1P7	Uncharacterized protein.	Uncharacterized protein, isoform D; Belongs to the DOCK family.	0.906
DanaGF10067	DanaGF16724	B3M528	B3LZ87	Uncharacterized protein.	Uncharacterized protein.	0.605
DanaGF10067	DanaGF20423	B3M528	B3MQD0	Uncharacterized protein.	Uncharacterized protein, isoform A.	0.592
DanaGF10067	DanaGF20820	B3M528	B3MUA4	Uncharacterized protein.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.474
DanaGF10067	DanaGF21563	B3M528	B3MVH5	Uncharacterized protein.	ELMO domain-containing protein.	0.744
DanaGF10067	DanaGF23415	B3M528	B3MZ90	Uncharacterized protein.	Uncharacterized protein.	0.557
DanaGF10184	DanaGF10466	B3M6T5	B3M3Q9	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.752
DanaGF10184	DanaGF15984	B3M6T5	B3N113	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	Protein kinase domain-containing protein.	0.545
DanaGF10184	DanaGF19231	B3M6T5	B3MZT3	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	Uncharacterized protein, isoform A; Belongs to the ubiquitin-conjugating enzyme family.	0.940
DanaGF10220	DanaGF14119	B3M7D9	B3MPQ3	Ubiquitin carboxyl-terminal hydrolase.	Uncharacterized protein, isoform A.	0.502
DanaGF10466	DanaGF10184	B3M3Q9	B3M6T5	UBIQUITIN_CONJUGAT_2 domain-containing protein.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	0.752
DanaGF10466	DanaGF10661	B3M3Q9	B3M632	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Uncharacterized protein, isoform A.	0.493
DanaGF10466	DanaGF14119	B3M3Q9	B3MPQ3	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Uncharacterized protein, isoform A.	0.593
DanaGF10466	DanaGF15984	B3M3Q9	B3N113	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Protein kinase domain-containing protein.	0.955
DanaGF10466	DanaGF18082	B3M3Q9	B3LW35	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Uncharacterized protein, isoform A.	0.401