43 items (Drosophila ananassae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DanaGF22418	Uncharacterized protein, isoform C. (3224 aa)
	DanaGF13942	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (375 aa)
	DanaGF11313	Protein kinase domain-containing protein. (714 aa)
	DanaGF18004	Uncharacterized protein; Belongs to the cyclin family. (570 aa)
	DanaGF17609	Uncharacterized protein, isoform A. (535 aa)
	DanaGF16815	F-box domain-containing protein. (561 aa)
	foxo	Forkhead box protein O; Transcription factor involved in the regulation of the insulin signaling pathway. Consistently activates both the downstream target Thord4EBP and the feedback control target InR. Involved in negative regulation of the cell cycle, modulating cell growth and proliferation. In response to cellular stresses, such as nutrient deprivation or increased levels of reactive oxygen species, foxo is activated and inhibits growth through the action of target genes such as Thor. Foxo activated in the adult fat body can regulate lifespan in adults; an insulin peptide itself m [...] (600 aa)
	DanaGF16690	Uncharacterized protein, isoform A; Belongs to the protein kinase superfamily. (314 aa)
	DanaGF16155	Uncharacterized protein. (602 aa)
	DanaGF18327	Uncharacterized protein, isoform A; Belongs to the PI3/PI4-kinase family. (1099 aa)
	DanaGF18893	Mitogen-activated protein kinase. (366 aa)
	DanaGF18894	Mitogen-activated protein kinase. (365 aa)
	DanaGF17088	Methyltransf_25 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (379 aa)
	DanaGF24522	Uncharacterized protein. (354 aa)
	DanaGF10050	Uncharacterized protein. (575 aa)
	SAK	Serine/threonine-protein kinase PLK4; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the mother centriole cylinder, using mother centriole as a platform, leading to the recruitment of centriole biogenesis proteins such as sas-6. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Centrosome amplification following overexpression can initiate tumorigenesis, highlighting [...] (770 aa)
	DanaGF24802	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (109 aa)
	DanaGF23641	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (506 aa)
	DanaGF24126	Uncharacterized protein, isoform A. (208 aa)
	DanaGF12821	Receptor protein-tyrosine kinase. (1439 aa)
	DanaGF11971	Uncharacterized protein. (647 aa)
	DanaGF11970	Uncharacterized protein. (639 aa)
	DanaGF12951	AMPKBI domain-containing protein. (330 aa)
	DanaGF13446	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (217 aa)
	DanaGF11326	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (514 aa)
	DanaGF12703	Ribosomal_L7Ae domain-containing protein. (169 aa)
	DanaGF12221	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (627 aa)
	DanaGF14950	WH1 domain-containing protein. (534 aa)
	DanaGF15039	Fork-head domain-containing protein. (470 aa)
	DanaGF15540	Catalase domain-containing protein. (506 aa)
	DanaGF14259	Uncharacterized protein. (1587 aa)
	DanaGF14126	Mitogen-activated protein kinase. (376 aa)
	DanaGF14124	Uncharacterized protein, isoform A. (512 aa)
	DanaGF21013	Non-specific serine/threonine protein kinase. (581 aa)
	DanaGF20979	Mothers against decapentaplegic homolog. (471 aa)
	DanaGF20824	Uncharacterized protein. (121 aa)
	DanaGF22974	Mothers against decapentaplegic homolog. (770 aa)
	DanaGF23293	Uncharacterized protein, isoform B; Belongs to the protein kinase superfamily. (441 aa)
	DanaGF23138	Uncharacterized protein. (122 aa)
	DanaGF23057	Mitogen-activated protein kinase. (365 aa)
	DanaGF19514	Uncharacterized protein; Belongs to the peptidase C19 family. (1144 aa)
	DanaGF22213	Uncharacterized protein. (727 aa)
	Dsor1	Downstream of raf1, isoform A; Belongs to the protein kinase superfamily. (396 aa)

Your Current Organism:

Drosophila ananassae

NCBI taxonomy Id: 7217
Other names: D. ananassae, Drosophila annanassae

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DanaGF10050	DanaGF11326	B3M4S1	B3MEJ1	Uncharacterized protein.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.983
DanaGF10050	DanaGF14124	B3M4S1	B3MPP1	Uncharacterized protein.	Uncharacterized protein, isoform A.	0.479
DanaGF10050	DanaGF16690	B3M4S1	B3LZV9	Uncharacterized protein.	Uncharacterized protein, isoform A; Belongs to the protein kinase superfamily.	0.882
DanaGF10050	DanaGF16815	B3M4S1	B3LY05	Uncharacterized protein.	F-box domain-containing protein.	0.470
DanaGF10050	DanaGF18004	B3M4S1	B3LV01	Uncharacterized protein.	Uncharacterized protein; Belongs to the cyclin family.	0.971
DanaGF10050	DanaGF19514	B3M4S1	B3MXT1	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase C19 family.	0.510
DanaGF10050	DanaGF23293	B3M4S1	B3MT53	Uncharacterized protein.	Uncharacterized protein, isoform B; Belongs to the protein kinase superfamily.	0.623
DanaGF10050	SAK	B3M4S1	B3M6I4	Uncharacterized protein.	Serine/threonine-protein kinase PLK4; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the mother centriole cylinder, using mother centriole as a platform, leading to the recruitment of centriole biogenesis proteins such as sas-6. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Centrosome amplification following overexpression can initiate tumorigenesis, highlighting [...]	0.977
DanaGF11313	DanaGF12821	A0A0P8Y173	B3MC66	Protein kinase domain-containing protein.	Receptor protein-tyrosine kinase.	0.416
DanaGF11313	DanaGF14124	A0A0P8Y173	B3MPP1	Protein kinase domain-containing protein.	Uncharacterized protein, isoform A.	0.965
DanaGF11313	DanaGF16155	A0A0P8Y173	B3LZY7	Protein kinase domain-containing protein.	Uncharacterized protein.	0.992
DanaGF11313	DanaGF18894	A0A0P8Y173	B3M0L5	Protein kinase domain-containing protein.	Mitogen-activated protein kinase.	0.413
DanaGF11313	DanaGF19514	A0A0P8Y173	B3MXT1	Protein kinase domain-containing protein.	Uncharacterized protein; Belongs to the peptidase C19 family.	0.417
DanaGF11313	Dsor1	A0A0P8Y173	B3MZP8	Protein kinase domain-containing protein.	Downstream of raf1, isoform A; Belongs to the protein kinase superfamily.	0.529
DanaGF11313	foxo	A0A0P8Y173	B3LYS5	Protein kinase domain-containing protein.	Forkhead box protein O; Transcription factor involved in the regulation of the insulin signaling pathway. Consistently activates both the downstream target Thord4EBP and the feedback control target InR. Involved in negative regulation of the cell cycle, modulating cell growth and proliferation. In response to cellular stresses, such as nutrient deprivation or increased levels of reactive oxygen species, foxo is activated and inhibits growth through the action of target genes such as Thor. Foxo activated in the adult fat body can regulate lifespan in adults; an insulin peptide itself m [...]	0.951
DanaGF11326	DanaGF10050	B3MEJ1	B3M4S1	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Uncharacterized protein.	0.983
DanaGF11326	DanaGF16690	B3MEJ1	B3LZV9	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Uncharacterized protein, isoform A; Belongs to the protein kinase superfamily.	0.947
DanaGF11326	DanaGF18004	B3MEJ1	B3LV01	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Uncharacterized protein; Belongs to the cyclin family.	0.976
DanaGF11326	DanaGF18893	B3MEJ1	B3M0L4	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Mitogen-activated protein kinase.	0.407
DanaGF11326	DanaGF23057	B3MEJ1	B3MV57	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Mitogen-activated protein kinase.	0.407