32 items (Drosophila ananassae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DanaGF23314	Uncharacterized protein, isoform B; Belongs to the protein kinase superfamily. (379 aa)
	DanaGF22254	Uncharacterized protein, isoform B; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1684 aa)
	DanaGF23607	Uncharacterized protein, isoform B. (1324 aa)
	DanaGF26483	Raptor_N domain-containing protein. (1459 aa)
	DanaGF16437	Fork-head domain-containing protein. (652 aa)
	DanaGF16781	Uncharacterized protein, isoform A. (267 aa)
	foxo	Forkhead box protein O; Transcription factor involved in the regulation of the insulin signaling pathway. Consistently activates both the downstream target Thord4EBP and the feedback control target InR. Involved in negative regulation of the cell cycle, modulating cell growth and proliferation. In response to cellular stresses, such as nutrient deprivation or increased levels of reactive oxygen species, foxo is activated and inhibits growth through the action of target genes such as Thor. Foxo activated in the adult fat body can regulate lifespan in adults; an insulin peptide itself m [...] (600 aa)
	DanaGF16155	Uncharacterized protein. (602 aa)
	DanaGF18327	Uncharacterized protein, isoform A; Belongs to the PI3/PI4-kinase family. (1099 aa)
	DanaGF18385	Uncharacterized protein; Belongs to the heat shock protein 70 family. (644 aa)
	DanaGF18384	Uncharacterized protein; Belongs to the heat shock protein 70 family. (644 aa)
	DanaGF17965	Uncharacterized protein; Belongs to the heat shock protein 70 family. (643 aa)
	DanaGF10442	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (489 aa)
	Sod1	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (153 aa)
	DanaGF10187	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1751 aa)
	DanaGF24856	Uncharacterized protein, isoform A; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1163 aa)
	DanaGF23641	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (506 aa)
	Rpd3	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (525 aa)
	DanaGF24052	Uncharacterized protein, isoform A; Belongs to the heat shock protein 70 family. (638 aa)
	DanaGF12951	AMPKBI domain-containing protein. (330 aa)
	DanaGF13446	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (217 aa)
	DanaGF12396	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (210 aa)
	DanaGF11829	Uncharacterized protein, isoform A; Belongs to the small heat shock protein (HSP20) family. (187 aa)
	DanaGF15486	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1177 aa)
	DanaGF15540	Catalase domain-containing protein. (506 aa)
	DanaGF14216	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2470 aa)
	DanaGF15239	Uncharacterized protein. (117 aa)
	DanaGF21013	Non-specific serine/threonine protein kinase. (581 aa)
	DanaGF21892	Uncharacterized protein, isoform B; Belongs to the protein kinase superfamily. (353 aa)
	DanaGF22644	IlGF domain-containing protein. (160 aa)
	DanaGF11377	Uncharacterized protein; Belongs to the heat shock protein 70 family. (650 aa)
	Atg5	Autophagy protein 5; Involved in autophagic vesicle formation. (269 aa)

Your Current Organism:

Drosophila ananassae

NCBI taxonomy Id: 7217
Other names: D. ananassae, Drosophila annanassae

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Atg5	DanaGF10442	Q3MQ20	B3M3L7	Autophagy protein 5; Involved in autophagic vesicle formation.	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	0.618
Atg5	DanaGF14216	Q3MQ20	B3MNH4	Autophagy protein 5; Involved in autophagic vesicle formation.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.538
Atg5	DanaGF16155	Q3MQ20	B3LZY7	Autophagy protein 5; Involved in autophagic vesicle formation.	Uncharacterized protein.	0.810
Atg5	DanaGF18327	Q3MQ20	B3M0A8	Autophagy protein 5; Involved in autophagic vesicle formation.	Uncharacterized protein, isoform A; Belongs to the PI3/PI4-kinase family.	0.489
Atg5	DanaGF26483	Q3MQ20	A0A0P8Y4C2	Autophagy protein 5; Involved in autophagic vesicle formation.	Raptor_N domain-containing protein.	0.594
Atg5	Sod1	Q3MQ20	B3M3W6	Autophagy protein 5; Involved in autophagic vesicle formation.	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family.	0.410
Atg5	foxo	Q3MQ20	B3LYS5	Autophagy protein 5; Involved in autophagic vesicle formation.	Forkhead box protein O; Transcription factor involved in the regulation of the insulin signaling pathway. Consistently activates both the downstream target Thord4EBP and the feedback control target InR. Involved in negative regulation of the cell cycle, modulating cell growth and proliferation. In response to cellular stresses, such as nutrient deprivation or increased levels of reactive oxygen species, foxo is activated and inhibits growth through the action of target genes such as Thor. Foxo activated in the adult fat body can regulate lifespan in adults; an insulin peptide itself m [...]	0.611
DanaGF10187	DanaGF16155	B3M6U0	B3LZY7	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein.	0.909
DanaGF10187	DanaGF22254	B3M6U0	A0A0P8XH72	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein, isoform B; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.458
DanaGF10442	Atg5	B3M3L7	Q3MQ20	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.618
DanaGF10442	DanaGF14216	B3M3L7	B3MNH4	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.998
DanaGF10442	DanaGF15239	B3M3L7	B3MP27	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	Uncharacterized protein.	0.902
DanaGF10442	DanaGF16155	B3M3L7	B3LZY7	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	Uncharacterized protein.	0.833
DanaGF10442	DanaGF16437	B3M3L7	B3LV84	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	Fork-head domain-containing protein.	0.908
DanaGF10442	DanaGF18327	B3M3L7	B3M0A8	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	Uncharacterized protein, isoform A; Belongs to the PI3/PI4-kinase family.	0.609
DanaGF10442	DanaGF26483	B3M3L7	A0A0P8Y4C2	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	Raptor_N domain-containing protein.	0.998
DanaGF10442	foxo	B3M3L7	B3LYS5	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	Forkhead box protein O; Transcription factor involved in the regulation of the insulin signaling pathway. Consistently activates both the downstream target Thord4EBP and the feedback control target InR. Involved in negative regulation of the cell cycle, modulating cell growth and proliferation. In response to cellular stresses, such as nutrient deprivation or increased levels of reactive oxygen species, foxo is activated and inhibits growth through the action of target genes such as Thor. Foxo activated in the adult fat body can regulate lifespan in adults; an insulin peptide itself m [...]	0.835
DanaGF11377	DanaGF11829	B3MX94	B3MFI6	Uncharacterized protein; Belongs to the heat shock protein 70 family.	Uncharacterized protein, isoform A; Belongs to the small heat shock protein (HSP20) family.	0.583
DanaGF11829	DanaGF11377	B3MFI6	B3MX94	Uncharacterized protein, isoform A; Belongs to the small heat shock protein (HSP20) family.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.583
DanaGF11829	DanaGF17965	B3MFI6	B3M2S4	Uncharacterized protein, isoform A; Belongs to the small heat shock protein (HSP20) family.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.676