(35 nodes) Apoptosis - fly network (Drosophila ananassae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DanaGF11452	Uncharacterized protein, isoform B. (327 aa)
	DanaGF23901	Uncharacterized protein, isoform B. (926 aa)
	DanaGF13942	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (375 aa)
	DanaGF19353	Uncharacterized protein, isoform B; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (811 aa)
	DanaGF17464	Uncharacterized protein, isoform G. (5044 aa)
	HtrA2	Serine protease HTRA2, mitochondrial; Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase- independent and serine protease activity-dependent mechanism. Can antagonize antiapoptotic activity of th by directly inducing the degradation of th (By similarity); Belongs to the peptidase S1C family. (426 aa)
	DanaGF18666	Uncharacterized protein; Belongs to the peptidase C14A family. (338 aa)
	DanaGF17624	Protein kinase domain-containing protein. (1357 aa)
	DanaGF16724	Uncharacterized protein. (491 aa)
	DanaGF17710	Uncharacterized protein, isoform A. (1169 aa)
	DanaGF18291	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (290 aa)
	DanaGF18313	Protein kinase domain-containing protein. (458 aa)
	DanaGF17969	Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family. (678 aa)
	DanaGF24261	Uncharacterized protein, isoform A. (244 aa)
	DanaGF12821	Receptor protein-tyrosine kinase. (1439 aa)
	DanaGF12018	BZIP domain-containing protein. (379 aa)
	DanaGF12924	Transcription factor BTF3; Belongs to the NAC-beta family. (171 aa)
	DanaGF13064	Uncharacterized protein; Belongs to the peptidase C14A family. (326 aa)
	DanaGF13179	Uncharacterized protein. (654 aa)
	DanaGF13242	Uncharacterized protein, isoform A. (840 aa)
	DanaGF11057	Uncharacterized protein. (309 aa)
	DanaGF13818	Uncharacterized protein, isoform A. (850 aa)
	DanaGF15022	Uncharacterized protein. (187 aa)
	DanaGF15147	Uncharacterized protein; Belongs to the intermediate filament family. (624 aa)
	DanaGF14126	Mitogen-activated protein kinase. (376 aa)
	DanaGF20507	Uncharacterized protein, isoform A. (455 aa)
	DanaGF20874	Protein kinase domain-containing protein. (1170 aa)
	DanaGF23311	Uncharacterized protein. (1087 aa)
	kay	Transcription factor kayak; Developmentally regulated transcription factor AP-1 binds and recognizes the enhancer DNA sequence: 5'-TGA[CG]TCA-3'. May play a role in the function or determination of a particular subset of cells in the developing embryo. Is able to carry out its function either independently of or in conjunction with Jra (By similarity). (529 aa)
	DanaGF20853	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (108 aa)
	DanaGF21986	Uncharacterized protein. (512 aa)
	DanaGF22213	Uncharacterized protein. (727 aa)
	DanaGF22232	Uncharacterized protein; Belongs to the peptidase C14A family. (502 aa)
	DanaGF15984	Protein kinase domain-containing protein. (732 aa)
	DanaGF20595	Uncharacterized protein, isoform A; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (724 aa)

Your Current Organism:

Drosophila ananassae

NCBI taxonomy Id: 7217
Other names: D. ananassae, Drosophila annanassae

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DanaGF11057	DanaGF11452	B3MJ45	A0A0N8P0C7	Uncharacterized protein.	Uncharacterized protein, isoform B.	0.971
DanaGF11057	DanaGF12821	B3MJ45	B3MC66	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.791
DanaGF11057	DanaGF13064	B3MJ45	B3MFH1	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.797
DanaGF11057	DanaGF17624	B3MJ45	B3LXS9	Uncharacterized protein.	Protein kinase domain-containing protein.	0.651
DanaGF11057	DanaGF18666	B3MJ45	B3LWX5	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.703
DanaGF11057	DanaGF19353	B3MJ45	A0A0P9AI21	Uncharacterized protein.	Uncharacterized protein, isoform B; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.666
DanaGF11057	DanaGF20595	B3MJ45	B3N1Y0	Uncharacterized protein.	Uncharacterized protein, isoform A; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.883
DanaGF11057	DanaGF20853	B3MJ45	B3MU97	Uncharacterized protein.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.954
DanaGF11057	DanaGF22232	B3MJ45	B3MYZ3	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.915
DanaGF11057	HtrA2	B3MJ45	B3LVG7	Uncharacterized protein.	Serine protease HTRA2, mitochondrial; Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase- independent and serine protease activity-dependent mechanism. Can antagonize antiapoptotic activity of th by directly inducing the degradation of th (By similarity); Belongs to the peptidase S1C family.	0.604
DanaGF11452	DanaGF11057	A0A0N8P0C7	B3MJ45	Uncharacterized protein, isoform B.	Uncharacterized protein.	0.971
DanaGF11452	DanaGF19353	A0A0N8P0C7	A0A0P9AI21	Uncharacterized protein, isoform B.	Uncharacterized protein, isoform B; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.589
DanaGF11452	DanaGF20595	A0A0N8P0C7	B3N1Y0	Uncharacterized protein, isoform B.	Uncharacterized protein, isoform A; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.927
DanaGF11452	DanaGF20853	A0A0N8P0C7	B3MU97	Uncharacterized protein, isoform B.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.667
DanaGF11452	DanaGF22232	A0A0N8P0C7	B3MYZ3	Uncharacterized protein, isoform B.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.427
DanaGF12018	DanaGF12821	B3MD12	B3MC66	BZIP domain-containing protein.	Receptor protein-tyrosine kinase.	0.427
DanaGF12018	DanaGF14126	B3MD12	B3MPN7	BZIP domain-containing protein.	Mitogen-activated protein kinase.	0.998
DanaGF12018	DanaGF16724	B3MD12	B3LZ87	BZIP domain-containing protein.	Uncharacterized protein.	0.616
DanaGF12018	DanaGF20507	B3MD12	B3MPW4	BZIP domain-containing protein.	Uncharacterized protein, isoform A.	0.471
DanaGF12018	DanaGF20874	B3MD12	B3MS41	BZIP domain-containing protein.	Protein kinase domain-containing protein.	0.610