(21 nodes) Hedgehog signaling pathway - fly network (Drosophila ananassae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DanaGF20585	Uncharacterized protein, isoform B. (629 aa)
	DanaGF23314	Uncharacterized protein, isoform B; Belongs to the protein kinase superfamily. (379 aa)
	DanaGF14531	Uncharacterized protein, isoform D; Belongs to the cullin family. (966 aa)
	hh	Protein hedgehog C-product; Intercellular signal essential for a variety of patterning events during development. Establishes the anterior-posterior axis of the embryonic segments and patterns the larval imaginal disks. Binds to the patched (ptc) receptor, which functions in association with smoothened (smo), to activate the transcription of target genes wingless (wg), decapentaplegic (dpp) and ptc. In the absence of hh, ptc represses the constitutive signaling activity of smo through fused (fu) (By similarity). The hedgehog protein C-product, which mediates the autocatalytic activity, [...] (472 aa)
	DanaGF17402	RING-type domain-containing protein. (141 aa)
	DanaGF18796	Uncharacterized protein, isoform A. (822 aa)
	DanaGF17785	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (722 aa)
	DanaGF17874	Suppressor of fused homolog. (476 aa)
	DanaGF18514	Uncharacterized protein. (614 aa)
	DanaGF25176	CULLIN_2 domain-containing protein; Belongs to the cullin family. (582 aa)
	DanaGF12393	Homeobox protein engrailed-like. (562 aa)
	DanaGF12372	SSD domain-containing protein. (1290 aa)
	DanaGF13641	CULLIN_2 domain-containing protein; Belongs to the cullin family. (775 aa)
	DanaGF12644	Uncharacterized protein, isoform A; Belongs to the SKP1 family. (161 aa)
	DanaGF11136	Uncharacterized protein, isoform A; Belongs to the SKP1 family. (161 aa)
	DanaGF11657	Uncharacterized protein. (1047 aa)
	DanaGF21176	Uncharacterized protein, isoform B; Belongs to the SKP1 family. (163 aa)
	DanaGF21383	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (337 aa)
	DanaGF23293	Uncharacterized protein, isoform B; Belongs to the protein kinase superfamily. (441 aa)
	DanaGF20630	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (1030 aa)
	DanaGF21892	Uncharacterized protein, isoform B; Belongs to the protein kinase superfamily. (353 aa)

Your Current Organism:

Drosophila ananassae

NCBI taxonomy Id: 7217
Other names: D. ananassae, Drosophila annanassae

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DanaGF11136	DanaGF12644	B3MHI5	B3MH30	Uncharacterized protein, isoform A; Belongs to the SKP1 family.	Uncharacterized protein, isoform A; Belongs to the SKP1 family.	0.900
DanaGF11136	DanaGF13641	B3MHI5	B3MGA3	Uncharacterized protein, isoform A; Belongs to the SKP1 family.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.994
DanaGF11136	DanaGF14531	B3MHI5	A0A0P8ZFA9	Uncharacterized protein, isoform A; Belongs to the SKP1 family.	Uncharacterized protein, isoform D; Belongs to the cullin family.	0.684
DanaGF11136	DanaGF17402	B3MHI5	B3LX43	Uncharacterized protein, isoform A; Belongs to the SKP1 family.	RING-type domain-containing protein.	0.906
DanaGF11136	DanaGF18514	B3MHI5	B3M2V7	Uncharacterized protein, isoform A; Belongs to the SKP1 family.	Uncharacterized protein.	0.992
DanaGF11136	DanaGF21176	B3MHI5	B3MQX8	Uncharacterized protein, isoform A; Belongs to the SKP1 family.	Uncharacterized protein, isoform B; Belongs to the SKP1 family.	0.913
DanaGF11136	DanaGF25176	B3MHI5	B3MAU5	Uncharacterized protein, isoform A; Belongs to the SKP1 family.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.993
DanaGF11657	DanaGF12372	B3MIF7	B3MFV3	Uncharacterized protein.	SSD domain-containing protein.	0.996
DanaGF11657	DanaGF13641	B3MIF7	B3MGA3	Uncharacterized protein.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.448
DanaGF11657	DanaGF14531	B3MIF7	A0A0P8ZFA9	Uncharacterized protein.	Uncharacterized protein, isoform D; Belongs to the cullin family.	0.456
DanaGF11657	DanaGF17874	B3MIF7	B3M1W5	Uncharacterized protein.	Suppressor of fused homolog.	0.459
DanaGF11657	DanaGF18514	B3MIF7	B3M2V7	Uncharacterized protein.	Uncharacterized protein.	0.666
DanaGF11657	DanaGF20585	B3MIF7	A0A0P8XDR4	Uncharacterized protein.	Uncharacterized protein, isoform B.	0.722
DanaGF11657	DanaGF20630	B3MIF7	B3MUK2	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.530
DanaGF11657	DanaGF21176	B3MIF7	B3MQX8	Uncharacterized protein.	Uncharacterized protein, isoform B; Belongs to the SKP1 family.	0.418
DanaGF11657	hh	B3MIF7	B3LV44	Uncharacterized protein.	Protein hedgehog C-product; Intercellular signal essential for a variety of patterning events during development. Establishes the anterior-posterior axis of the embryonic segments and patterns the larval imaginal disks. Binds to the patched (ptc) receptor, which functions in association with smoothened (smo), to activate the transcription of target genes wingless (wg), decapentaplegic (dpp) and ptc. In the absence of hh, ptc represses the constitutive signaling activity of smo through fused (fu) (By similarity). The hedgehog protein C-product, which mediates the autocatalytic activity, [...]	0.422
DanaGF12372	DanaGF11657	B3MFV3	B3MIF7	SSD domain-containing protein.	Uncharacterized protein.	0.996
DanaGF12372	DanaGF17785	B3MFV3	B3M096	SSD domain-containing protein.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.646
DanaGF12372	DanaGF17874	B3MFV3	B3M1W5	SSD domain-containing protein.	Suppressor of fused homolog.	0.932
DanaGF12372	DanaGF18514	B3MFV3	B3M2V7	SSD domain-containing protein.	Uncharacterized protein.	0.593