STRINGSTRING
PAN2 PAN2 DgriGH23665 DgriGH23665 DgriGH22207 DgriGH22207 DgriGH25306 DgriGH25306 DgriGH23512 DgriGH23512 DgriGH23438 DgriGH23438 DgriGH23931 DgriGH23931 DgriGH25139 DgriGH25139 DgriGH25200 DgriGH25200 DgriGH17959 DgriGH17959 DgriGH17623 DgriGH17623 DgriGH17651 DgriGH17651 DgriGH17871 DgriGH17871 DgriGH22729 DgriGH22729 DgriGH22955 DgriGH22955 DgriGH15246 DgriGH15246 DgriGH15268 DgriGH15268 DgriGH15257 DgriGH15257 DgriGH11203 DgriGH11203 DgriGH23342 DgriGH23342 DgriGH17541 DgriGH17541 DgriGH17988 DgriGH17988 DgriGH21615 DgriGH21615 DgriGH13753 DgriGH13753 DgriGH13624 DgriGH13624 DgriGH13613 DgriGH13613 DgriGH13374 DgriGH13374 DgriGH24090 DgriGH24090 DgriGH11902 DgriGH11902 DgriGH12756 DgriGH12756 DgriGH11976 DgriGH11976 DgriGH12029 DgriGH12029 DgriGH12645 DgriGH12645 DgriGH12467 DgriGH12467 DgriGH12466 DgriGH12466 DgriGH18468 DgriGH18468 DgriGH19060 DgriGH19060 DgriGH18033 DgriGH18033 DgriGH19557 DgriGH19557 DgriGH18702 DgriGH18702 DgriGH19441 DgriGH19441 DgriGH18755 DgriGH18755 DgriGH19240 DgriGH19240 GH11308 GH11308 DgriGH10610 DgriGH10610 DgriGH10637 DgriGH10637 DgriGH10206 DgriGH10206 DgriGH11439 DgriGH11439 DgriGH22060 DgriGH22060 DgriGH21477 DgriGH21477 DgriGH19913 DgriGH19913 DgriGH21959 DgriGH21959 DgriGH21958 DgriGH21958 DgriGH20601 DgriGH20601 DgriGH20636 DgriGH20636 DgriGH20673 DgriGH20673 DgriGH21171 DgriGH21171 DgriGH21707 DgriGH21707 DgriGH21691 DgriGH21691 DgriGH21690 DgriGH21690 DgriGH15334 DgriGH15334 DgriGH15355 DgriGH15355 DgriGH16116 DgriGH16116 DgriGH16115 DgriGH16115 DgriGH14962 DgriGH14962 DgriGH15595 DgriGH15595 DgriGH15630 DgriGH15630 DgriGH14473 DgriGH14473 DgriGH15817 DgriGH15817 DgriGH15748 DgriGH15748 DgriGH14641 DgriGH14641 DgriGH16922 DgriGH16922 DgriGH16904 DgriGH16904
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PAN2PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1242 aa)
DgriGH23665GH23665. (523 aa)
DgriGH22207GH22207. (413 aa)
DgriGH25306GH25306. (924 aa)
DgriGH23512GH23512. (103 aa)
DgriGH23438GH23438. (262 aa)
DgriGH23931GH23931. (1432 aa)
DgriGH25139Protein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (394 aa)
DgriGH25200GH25200. (232 aa)
DgriGH17959GH17959; Belongs to the PI3/PI4-kinase family. (3284 aa)
DgriGH17623GH17623. (511 aa)
DgriGH17651GH17651. (1148 aa)
DgriGH17871GH17871. (1754 aa)
DgriGH22729GH22729. (168 aa)
DgriGH22955GH22955; Belongs to the argonaute family. (990 aa)
DgriGH15246GH15246. (712 aa)
DgriGH15268GH15268. (69 aa)
DgriGH15257GH15257. (805 aa)
DgriGH11203GH11203. (1194 aa)
DgriGH23342GH23342. (1085 aa)
DgriGH17541GH17541. (571 aa)
DgriGH17988GH17988. (959 aa)
DgriGH21615GH21615. (760 aa)
DgriGH13753GH13753. (409 aa)
DgriGH13624GH13624. (918 aa)
DgriGH13613U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (155 aa)
DgriGH13374GH13374; Belongs to the DEAD box helicase family. (459 aa)
DgriGH24090GH24090. (1353 aa)
DgriGH11902GH11902. (610 aa)
DgriGH12756GH12756. (265 aa)
DgriGH11976GH11976. (1276 aa)
DgriGH12029GH12029. (370 aa)
DgriGH12645GH12645. (968 aa)
DgriGH12467GH12467. (135 aa)
DgriGH12466GH12466. (555 aa)
DgriGH18468GH18468. (235 aa)
DgriGH19060GH19060. (349 aa)
DgriGH180335'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II. (873 aa)
DgriGH19557GH19557. (968 aa)
DgriGH18702GH18702. (635 aa)
DgriGH19441GH19441. (380 aa)
DgriGH18755GH18755. (173 aa)
DgriGH19240GH19240. (911 aa)
GH11308Protein SMG8; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Probable component of kinase complex containing nonC and recruited to stalled ribosomes (By similarity). (945 aa)
DgriGH10610GH10610. (1203 aa)
DgriGH10637GH10637. (249 aa)
DgriGH10206GH10206. (113 aa)
DgriGH11439GH11439. (1398 aa)
DgriGH22060GH22060. (296 aa)
DgriGH21477GH21477. (274 aa)
DgriGH19913GH19913. (1545 aa)
DgriGH21959GH21959. (2201 aa)
DgriGH21958GH21958. (284 aa)
DgriGH20601GH20601. (1227 aa)
DgriGH20636Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (247 aa)
DgriGH20673GH20673. (300 aa)
DgriGH21171U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs. (137 aa)
DgriGH21707GH21707. (228 aa)
DgriGH21691GH21691. (374 aa)
DgriGH21690GH21690. (516 aa)
DgriGH15334GH15334. (516 aa)
DgriGH15355GH15355. (683 aa)
DgriGH16116GH16116. (1166 aa)
DgriGH16115GH16115. (90 aa)
DgriGH14962GH14962. (611 aa)
DgriGH15595GH15595. (916 aa)
DgriGH15630GH15630; Belongs to the RNR ribonuclease family. (1109 aa)
DgriGH14473GH14473. (926 aa)
DgriGH15817PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] (854 aa)
DgriGH15748Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. (930 aa)
DgriGH14641GH14641. (415 aa)
DgriGH16922GH16922. (324 aa)
DgriGH16904GH16904. (331 aa)
Your Current Organism:
Drosophila grimshawi
NCBI taxonomy Id: 7222
Other names: D. grimshawi, Idiomyia grimshawi
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