(105 nodes) Protein processing network (Drosophila grimshawi)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DgriGH14708	GH14708. (365 aa)
	DgriGH16237	GH16237; Belongs to the peptidase S54 family. (321 aa)
	DgriGH16240	GH16240; Belongs to the peptidase S54 family. (436 aa)
	DgriGH15206	GH15206; Belongs to the peptidase S54 family. (476 aa)
	DgriGH15194	GH15194. (302 aa)
	DgriGH16271	GH16271. (2634 aa)
	DgriGH14645	GH14645; Belongs to the peptidase C1 family. (549 aa)
	DgriGH14546	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (536 aa)
	DgriGH15066	GH15066. (813 aa)
	DgriGH14386	GH14386. (1031 aa)
	DgriGH16049	GH16049; Belongs to the peptidase C2 family. (936 aa)
	DgriGH16053	GH16053; Belongs to the peptidase C14A family. (470 aa)
	DgriGH15393	GH15393; Belongs to the membrane-bound acyltransferase family. (492 aa)
	DgriGH20399	GH20399. (345 aa)
	DgriGH20358	GH20358. (505 aa)
	DgriGH20228	GH20228. (701 aa)
	DgriGH21656	GH21656. (101 aa)
	DgriGH20201	GH20201. (199 aa)
	DgriGH20200	GH20200; Belongs to the peptidase C2 family. (564 aa)
	DgriGH20154	GH20154. (1021 aa)
	DgriGH20152	GH20152. (1011 aa)
	DgriGH21752	GH21752. (803 aa)
	DgriGH20092	GH20092. (754 aa)
	DgriGH20583	GH20583; Belongs to the peptidase M16 family. (555 aa)
	DgriGH21315	GH21315. (613 aa)
	DgriGH19977	GH19977. (1465 aa)
	DgriGH21978	Angiotensin-converting enzyme. (633 aa)
	DgriGH21989	GH21989. (169 aa)
	DgriGH22057	GH22057. (143 aa)
	DgriGH10747	GH10747. (713 aa)
	DgriGH10990	GH10990. (647 aa)
	DgriGH11623	Mitochondrial inner membrane protease ATP23; Belongs to the peptidase M76 family. (275 aa)
	DgriGH11667	GH11667. (675 aa)
	DgriGH11125	Angiotensin-converting enzyme. (615 aa)
	DgriGH11126	Angiotensin-converting enzyme. (613 aa)
	DgriGH11182	GH11182. (229 aa)
	DgriGH10510	GH10510. (390 aa)
	DgriGH18446	Metalloendopeptidase. (1065 aa)
	DgriGH18445	Metalloendopeptidase. (1421 aa)
	DgriGH19130	Methionine aminopeptidase; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). (374 aa)
	DgriGH18413	GH18413. (716 aa)
	DgriGH19195	GH19195; Belongs to the peptidase S1 family. (422 aa)
	DgriGH18338	GH18338; Belongs to the peptidase M16 family. (470 aa)
	DgriGH19349	GH19349; Belongs to the peptidase S8 family. (1090 aa)
	DgriGH18873	GH18873; Belongs to the peptidase S8 family. (667 aa)
	DgriGH18698	GH18698. (99 aa)
	DgriGH18124	Signal peptidase complex catalytic subunit SEC11. (185 aa)
	DgriGH18118	GH18118. (769 aa)
	DgriGH18104	GH18104. (444 aa)
	DgriGH18918	Signal peptidase complex subunit 3. (178 aa)
	DgriGH18955	GH18955. (864 aa)
	DgriGH18046	GH18046. (571 aa)
	DgriGH19598	GH19598. (702 aa)
	DgriGH11823	GH11823. (537 aa)
	DgriGH12395	GH12395. (510 aa)
	DgriGH12372	GH12372. (194 aa)
	DgriGH12281	GH12281; Belongs to the peptidase C2 family. (666 aa)
	DgriGH12676	GH12676. (825 aa)
	DgriGH12695	GH12695; Belongs to the peptidase S8 family. (1658 aa)
	DgriGH11948	GH11948. (111 aa)
	DgriGH12802	GH12802. (886 aa)
	DgriGH24402	GH24402. (711 aa)
	DgriGH24626	GH24626. (787 aa)
	DgriGH24779	GH24779. (182 aa)
	DgriGH24780	GH24780. (1441 aa)
	DgriGH24851	GH24851. (875 aa)
	DgriGH24104	GH24104; Belongs to the peptidase S54 family. (420 aa)
	DgriGH13639	GH13639. (635 aa)
	DgriGH13261	GH13261. (678 aa)
	DgriGH13204	GH13204. (633 aa)
	DgriGH13737	GH13737. (239 aa)
	DgriGH13105	GH13105. (650 aa)
	DgriGH20297	GH20297. (603 aa)
	DgriGH20472	GH20472. (124 aa)
	DgriGH19956	GH19956; Belongs to the peptidase C14A family. (351 aa)
	DgriGH19945	GH19945; Belongs to the peptidase C14A family. (294 aa)
	DgriGH21824	GH21824. (590 aa)
	DgriGH18334	GH18334. (743 aa)
	DgriGH18323	GH18323. (697 aa)
	DgriGH18312	GH18312. (682 aa)
	hh	Protein hedgehog C-product; Intercellular signal essential for a variety of patterning events during development. Establishes the anterior-posterior axis of the embryonic segments and patterns the larval imaginal disks. Binds to the patched (ptc) receptor, which functions in association with smoothened (smo), to activate the transcription of target genes wingless (wg), decapentaplegic (dpp) and ptc. In the absence of hh, ptc represses the constitutive signaling activity of smo through fused (fu) (By similarity). The hedgehog protein C-product, which mediates the autocatalytic activity, [...] (479 aa)
	DgriGH13212	GH13212. (692 aa)
	DgriGH13201	GH13201. (693 aa)
	DgriGH13190	GH13190. (684 aa)
	DgriGH17094	GH17094. (1205 aa)
	DgriGH17137	GH17137. (661 aa)
	DgriGH16092	GH16092. (1033 aa)
	DgriGH22883	GH22883. (519 aa)
	DgriGH22855	GH22855. (764 aa)
	DgriGH22830	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (454 aa)
	DgriGH22829	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (451 aa)
	DgriGH22828	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (455 aa)
	DgriGH22819	GH22819. (1291 aa)
	DgriGH22772	GH22772. (691 aa)
	DgriGH17636	Mitochondrial inner membrane protease subunit. (167 aa)
	DgriGH14060	GH14060. (1046 aa)
	DgriGH14290	GH14290. (478 aa)
	DgriGH22306	GH22306. (424 aa)
	DgriGH25144	Methionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). (458 aa)
	DgriGH25251	GH25251. (658 aa)
	DgriGH24962	GH24962. (205 aa)
	DgriGH10916	Angiotensin-converting enzyme. (575 aa)
	DgriGH10905	GH10905. (114 aa)
	DgriGH13882	GH13882. (119 aa)
	DgriGH22226	GH22226. (92 aa)

Your Current Organism:

Drosophila grimshawi

NCBI taxonomy Id: 7222
Other names: D. grimshawi, Idiomyia grimshawi

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DgriGH11623	DgriGH20092	B4JC87	B4J768	Mitochondrial inner membrane protease ATP23; Belongs to the peptidase M76 family.	GH20092.	0.531
DgriGH11623	DgriGH20228	B4JC87	B4J5Q8	Mitochondrial inner membrane protease ATP23; Belongs to the peptidase M76 family.	GH20228.	0.552
DgriGH11623	DgriGH20583	B4JC87	B4J861	Mitochondrial inner membrane protease ATP23; Belongs to the peptidase M76 family.	GH20583; Belongs to the peptidase M16 family.	0.463
DgriGH11623	DgriGH21989	B4JC87	B4J956	Mitochondrial inner membrane protease ATP23; Belongs to the peptidase M76 family.	GH21989.	0.589
DgriGH11623	DgriGH24962	B4JC87	B4K2S9	Mitochondrial inner membrane protease ATP23; Belongs to the peptidase M76 family.	GH24962.	0.552
DgriGH11948	DgriGH15393	B4JL14	B4J348	GH11948.	GH15393; Belongs to the membrane-bound acyltransferase family.	0.558
DgriGH11948	DgriGH17094	B4JL14	B4JU93	GH11948.	GH17094.	0.957
DgriGH12372	DgriGH17636	B4JIX9	B4JX49	GH12372.	Mitochondrial inner membrane protease subunit.	0.856
DgriGH12372	DgriGH18104	B4JIX9	B4JH02	GH12372.	GH18104.	0.970
DgriGH12372	DgriGH18124	B4JIX9	B4JGV9	GH12372.	Signal peptidase complex catalytic subunit SEC11.	0.985
DgriGH12372	DgriGH18698	B4JIX9	B4JGT0	GH12372.	GH18698.	0.996
DgriGH12372	DgriGH18918	B4JIX9	B4JH35	GH12372.	Signal peptidase complex subunit 3.	0.993
DgriGH12372	DgriGH19349	B4JIX9	B4JFM7	GH12372.	GH19349; Belongs to the peptidase S8 family.	0.406
DgriGH12372	DgriGH21989	B4JIX9	B4J956	GH12372.	GH21989.	0.856
DgriGH12395	DgriGH18873	B4JIV8	B4JGF8	GH12395.	GH18873; Belongs to the peptidase S8 family.	0.463
DgriGH12676	DgriGH14290	B4JKJ7	B4JYH3	GH12676.	GH14290.	0.434
DgriGH12676	DgriGH15066	B4JKJ7	B4IZE0	GH12676.	GH15066.	0.902
DgriGH12676	DgriGH18338	B4JKJ7	B4JF35	GH12676.	GH18338; Belongs to the peptidase M16 family.	0.741
DgriGH12676	DgriGH20092	B4JKJ7	B4J768	GH12676.	GH20092.	0.456
DgriGH12676	DgriGH20399	B4JKJ7	B4J3U7	GH12676.	GH20399.	0.624