25 items (Drosophila grimshawi) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DgriGH21651	GH21651. (903 aa)
	DgriGH20706	Mevalonate kinase. (392 aa)
	DgriGH20637	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. (393 aa)
	DgriGH20474	GH20474; Belongs to the universal ribosomal protein uS9 family. (148 aa)
	DgriGH22060	GH22060. (296 aa)
	DgriGH10945	GH10945. (844 aa)
	DgriGH10637	GH10637. (249 aa)
	DgriGH10628	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1486 aa)
	DgriGH10440	GH10440; Belongs to the universal ribosomal protein uS5 family. (268 aa)
	DgriGH18412	GH18412. (794 aa)
	DgriGH19026	GH19026. (395 aa)
	DgriGH18468	GH18468. (235 aa)
	mEFG1	Elongation factor G, mitochondrial; Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Essential during development as it acts as a retrograde signal from mitochondria to the nuc [...] (747 aa)
	DgriGH21615	GH21615. (760 aa)
	mRRF2	Ribosome-releasing factor 2, mitochondrial; Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Not involved in the GTP-dependent ribosomal translocation step during translation elongation; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. (734 aa)
	DgriGH17436	GH17436. (976 aa)
	DgriGH22891	GH22891. (681 aa)
	DgriGH16203	GH16203. (712 aa)
	DgriGH16904	GH16904. (331 aa)
	DgriGH14641	GH14641. (415 aa)
	DgriGH14623	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family. (999 aa)
	DgriGH15895	GH15895. (1033 aa)
	DgriGH14960	GH14960. (490 aa)
	DgriGH20955	GH20955. (844 aa)
	DgriGH21079	GH21079. (662 aa)

Your Current Organism:

Drosophila grimshawi

NCBI taxonomy Id: 7222
Other names: D. grimshawi, Idiomyia grimshawi

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DgriGH10440	DgriGH10628	B4JE34	B4JCU9	GH10440; Belongs to the universal ribosomal protein uS5 family.	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	0.706
DgriGH10440	DgriGH10637	B4JE34	B4JCT4	GH10440; Belongs to the universal ribosomal protein uS5 family.	GH10637.	0.642
DgriGH10440	DgriGH10945	B4JE34	B4JB96	GH10440; Belongs to the universal ribosomal protein uS5 family.	GH10945.	0.988
DgriGH10440	DgriGH14623	B4JE34	B4IY26	GH10440; Belongs to the universal ribosomal protein uS5 family.	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family.	0.505
DgriGH10440	DgriGH14641	B4JE34	B4IXZ8	GH10440; Belongs to the universal ribosomal protein uS5 family.	GH14641.	0.646
DgriGH10440	DgriGH14960	B4JE34	B4J155	GH10440; Belongs to the universal ribosomal protein uS5 family.	GH14960.	0.572
DgriGH10440	DgriGH15895	B4JE34	B4J0V8	GH10440; Belongs to the universal ribosomal protein uS5 family.	GH15895.	0.950
DgriGH10440	DgriGH16904	B4JE34	B4IXN7	GH10440; Belongs to the universal ribosomal protein uS5 family.	GH16904.	0.544
DgriGH10440	DgriGH17436	B4JE34	B4JVB3	GH10440; Belongs to the universal ribosomal protein uS5 family.	GH17436.	0.950
DgriGH10440	DgriGH18468	B4JE34	B4JIK0	GH10440; Belongs to the universal ribosomal protein uS5 family.	GH18468.	0.645
DgriGH10440	DgriGH19026	B4JE34	B4JI36	GH10440; Belongs to the universal ribosomal protein uS5 family.	GH19026.	0.999
DgriGH10440	DgriGH20474	B4JE34	B4J9C2	GH10440; Belongs to the universal ribosomal protein uS5 family.	GH20474; Belongs to the universal ribosomal protein uS9 family.	0.999
DgriGH10440	DgriGH20955	B4JE34	B4J4A6	GH10440; Belongs to the universal ribosomal protein uS5 family.	GH20955.	0.988
DgriGH10440	DgriGH21615	B4JE34	B4JRX5	GH10440; Belongs to the universal ribosomal protein uS5 family.	GH21615.	0.654
DgriGH10440	DgriGH22060	B4JE34	B4J9X0	GH10440; Belongs to the universal ribosomal protein uS5 family.	GH22060.	0.659
DgriGH10440	mEFG1	B4JE34	B4JQM7	GH10440; Belongs to the universal ribosomal protein uS5 family.	Elongation factor G, mitochondrial; Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Essential during development as it acts as a retrograde signal from mitochondria to the nuc [...]	0.973
DgriGH10440	mRRF2	B4JE34	B4JSI3	GH10440; Belongs to the universal ribosomal protein uS5 family.	Ribosome-releasing factor 2, mitochondrial; Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Not involved in the GTP-dependent ribosomal translocation step during translation elongation; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.	0.546
DgriGH10628	DgriGH10440	B4JCU9	B4JE34	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	GH10440; Belongs to the universal ribosomal protein uS5 family.	0.706
DgriGH10628	DgriGH10945	B4JCU9	B4JB96	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	GH10945.	0.598
DgriGH10628	DgriGH14623	B4JCU9	B4IY26	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family.	0.578