(26 nodes) Apoptosis - multiple species network (Drosophila grimshawi)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DgriGH14701	GH14701. (233 aa)
	DgriGH17114	GH17114. (67 aa)
	DgriGH17120	GH17120. (419 aa)
	DgriGH16053	GH16053; Belongs to the peptidase C14A family. (470 aa)
	DgriGH15404	GH15404. (449 aa)
	DgriGH20962	GH20962. (502 aa)
	DgriGH21024	GH21024. (298 aa)
	DgriGH21025	GH21025. (302 aa)
	DgriGH21208	GH21208; Belongs to the peptidase C14A family. (318 aa)
	DgriGH11375	GH11375; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (103 aa)
	DgriGH11376	GH11376; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (108 aa)
	DgriGH19099	GH19099. (422 aa)
	DgriGH18453	GH18453. (4852 aa)
	DgriGH12331	GH12331. (370 aa)
	DgriGH24231	GH24231; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (440 aa)
	DgriGH24782	GH24782; Belongs to the peptidase C14A family. (500 aa)
	DgriGH13559	Mitogen-activated protein kinase. (369 aa)
	DgriGH13138	GH13138; Belongs to the peptidase C14A family. (292 aa)
	DgriGH20516	GH20516; Belongs to the peptidase C14A family. (309 aa)
	DgriGH19956	GH19956; Belongs to the peptidase C14A family. (351 aa)
	DgriGH19945	GH19945; Belongs to the peptidase C14A family. (294 aa)
	HtrA2	Serine protease HTRA2, mitochondrial; Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase- independent and serine protease activity-dependent mechanism. Can antagonize antiapoptotic activity of th by directly inducing the degradation of th (By similarity); Belongs to the peptidase S1C family. (426 aa)
	DgriGH13432	GH13432. (141 aa)
	DgriGH17516	GH17516; Belongs to the peptidase C14A family. (309 aa)
	DgriGH23155	GH23155. (1429 aa)
	DgriGH22247	GH22247. (156 aa)

Your Current Organism:

Drosophila grimshawi

NCBI taxonomy Id: 7222
Other names: D. grimshawi, Idiomyia grimshawi

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DgriGH11375	DgriGH11376	B4JEH5	B4JEH6	GH11375; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	GH11376; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.902
DgriGH11375	DgriGH13138	B4JEH5	B4JQQ6	GH11375; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	GH13138; Belongs to the peptidase C14A family.	0.451
DgriGH11375	DgriGH15404	B4JEH5	B4J320	GH11375; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	GH15404.	0.494
DgriGH11375	DgriGH16053	B4JEH5	B4J2U2	GH11375; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	GH16053; Belongs to the peptidase C14A family.	0.451
DgriGH11375	DgriGH17516	B4JEH5	B4JU12	GH11375; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	GH17516; Belongs to the peptidase C14A family.	0.451
DgriGH11375	DgriGH18453	B4JEH5	B4JIM6	GH11375; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	GH18453.	0.506
DgriGH11375	DgriGH19099	B4JEH5	B4JIH7	GH11375; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	GH19099.	0.491
DgriGH11375	DgriGH19945	B4JEH5	B4JRK0	GH11375; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	GH19945; Belongs to the peptidase C14A family.	0.451
DgriGH11375	DgriGH19956	B4JEH5	B4JRJ9	GH11375; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	GH19956; Belongs to the peptidase C14A family.	0.451
DgriGH11375	DgriGH20516	B4JEH5	B4JRE2	GH11375; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	GH20516; Belongs to the peptidase C14A family.	0.451
DgriGH11375	DgriGH20962	B4JEH5	B4J4Q5	GH11375; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	GH20962.	0.494
DgriGH11375	DgriGH21024	B4JEH5	B4J569	GH11375; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	GH21024.	0.666
DgriGH11375	DgriGH21025	B4JEH5	B4J570	GH11375; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	GH21025.	0.666
DgriGH11375	DgriGH21208	B4JEH5	B4J750	GH11375; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	GH21208; Belongs to the peptidase C14A family.	0.451
DgriGH11375	DgriGH23155	B4JEH5	B4JVN7	GH11375; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	GH23155.	0.972
DgriGH11375	DgriGH24782	B4JEH5	B4JNA9	GH11375; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	GH24782; Belongs to the peptidase C14A family.	0.474
DgriGH11375	HtrA2	B4JEH5	B4JTT7	GH11375; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Serine protease HTRA2, mitochondrial; Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase- independent and serine protease activity-dependent mechanism. Can antagonize antiapoptotic activity of th by directly inducing the degradation of th (By similarity); Belongs to the peptidase S1C family.	0.412
DgriGH11376	DgriGH11375	B4JEH6	B4JEH5	GH11376; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	GH11375; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.902
DgriGH11376	DgriGH13138	B4JEH6	B4JQQ6	GH11376; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	GH13138; Belongs to the peptidase C14A family.	0.513
DgriGH11376	DgriGH15404	B4JEH6	B4J320	GH11376; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	GH15404.	0.494