(6 nodes) Mixed, incl. Water homeostasis, and TWIK related potassium channel (TREK) network (Drosophila melanogaster)

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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protein homology

Your Input:
	CG9876	FI01017p; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II regulatory region sequence-specific DNA binding. It is involved in the biological process described with: regulation of transcription, DNA-templated. (275 aa)
	CG8945	Peptidase_M14 domain-containing protein; Zinc ion binding; metallocarboxypeptidase activity. It is involved in the biological process described with: proteolysis. (1430 aa)
	CG10864	Uncharacterized protein; Potassium ion leak channel activity; potassium channel activity. It is involved in the biological process described with: potassium ion transmembrane transport; stabilization of membrane potential; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (389 aa)
	CG13634	Uncharacterized protein. (462 aa)
	CG10280	Metalloendopeptidase activity; zinc ion binding. It is involved in the biological process described with: proteolysis. (362 aa)
	Nach	Sodium channel protein Nach; Nach (Nach) encodes a predicted member of the Degenerin/Epithelial Sodium Channel family of proteins. It is mainly expressed in the tracheal system and functions in liquid clearance during tracheal development; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (553 aa)

Your Current Organism:

Drosophila melanogaster

NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CG10280	CG10864	FBpp0301222	FBpp0083069	Metalloendopeptidase activity; zinc ion binding. It is involved in the biological process described with: proteolysis.	Uncharacterized protein; Potassium ion leak channel activity; potassium channel activity. It is involved in the biological process described with: potassium ion transmembrane transport; stabilization of membrane potential; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.	0.684
CG10280	CG13634	FBpp0301222	FBpp0084117	Metalloendopeptidase activity; zinc ion binding. It is involved in the biological process described with: proteolysis.	Uncharacterized protein.	0.684
CG10280	CG8945	FBpp0301222	FBpp0074185	Metalloendopeptidase activity; zinc ion binding. It is involved in the biological process described with: proteolysis.	Peptidase_M14 domain-containing protein; Zinc ion binding; metallocarboxypeptidase activity. It is involved in the biological process described with: proteolysis.	0.601
CG10280	CG9876	FBpp0301222	FBpp0071889	Metalloendopeptidase activity; zinc ion binding. It is involved in the biological process described with: proteolysis.	FI01017p; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II regulatory region sequence-specific DNA binding. It is involved in the biological process described with: regulation of transcription, DNA-templated.	0.839
CG10280	Nach	FBpp0301222	FBpp0401613	Metalloendopeptidase activity; zinc ion binding. It is involved in the biological process described with: proteolysis.	Sodium channel protein Nach; Nach (Nach) encodes a predicted member of the Degenerin/Epithelial Sodium Channel family of proteins. It is mainly expressed in the tracheal system and functions in liquid clearance during tracheal development; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.	0.803
CG10864	CG10280	FBpp0083069	FBpp0301222	Uncharacterized protein; Potassium ion leak channel activity; potassium channel activity. It is involved in the biological process described with: potassium ion transmembrane transport; stabilization of membrane potential; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.	Metalloendopeptidase activity; zinc ion binding. It is involved in the biological process described with: proteolysis.	0.684
CG10864	CG13634	FBpp0083069	FBpp0084117	Uncharacterized protein; Potassium ion leak channel activity; potassium channel activity. It is involved in the biological process described with: potassium ion transmembrane transport; stabilization of membrane potential; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.	Uncharacterized protein.	0.811
CG10864	CG8945	FBpp0083069	FBpp0074185	Uncharacterized protein; Potassium ion leak channel activity; potassium channel activity. It is involved in the biological process described with: potassium ion transmembrane transport; stabilization of membrane potential; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.	Peptidase_M14 domain-containing protein; Zinc ion binding; metallocarboxypeptidase activity. It is involved in the biological process described with: proteolysis.	0.666
CG10864	CG9876	FBpp0083069	FBpp0071889	Uncharacterized protein; Potassium ion leak channel activity; potassium channel activity. It is involved in the biological process described with: potassium ion transmembrane transport; stabilization of membrane potential; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.	FI01017p; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II regulatory region sequence-specific DNA binding. It is involved in the biological process described with: regulation of transcription, DNA-templated.	0.744
CG10864	Nach	FBpp0083069	FBpp0401613	Uncharacterized protein; Potassium ion leak channel activity; potassium channel activity. It is involved in the biological process described with: potassium ion transmembrane transport; stabilization of membrane potential; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.	Sodium channel protein Nach; Nach (Nach) encodes a predicted member of the Degenerin/Epithelial Sodium Channel family of proteins. It is mainly expressed in the tracheal system and functions in liquid clearance during tracheal development; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.	0.801
CG13634	CG10280	FBpp0084117	FBpp0301222	Uncharacterized protein.	Metalloendopeptidase activity; zinc ion binding. It is involved in the biological process described with: proteolysis.	0.684
CG13634	CG10864	FBpp0084117	FBpp0083069	Uncharacterized protein.	Uncharacterized protein; Potassium ion leak channel activity; potassium channel activity. It is involved in the biological process described with: potassium ion transmembrane transport; stabilization of membrane potential; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.	0.811
CG13634	CG8945	FBpp0084117	FBpp0074185	Uncharacterized protein.	Peptidase_M14 domain-containing protein; Zinc ion binding; metallocarboxypeptidase activity. It is involved in the biological process described with: proteolysis.	0.570
CG13634	CG9876	FBpp0084117	FBpp0071889	Uncharacterized protein.	FI01017p; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II regulatory region sequence-specific DNA binding. It is involved in the biological process described with: regulation of transcription, DNA-templated.	0.750
CG13634	Nach	FBpp0084117	FBpp0401613	Uncharacterized protein.	Sodium channel protein Nach; Nach (Nach) encodes a predicted member of the Degenerin/Epithelial Sodium Channel family of proteins. It is mainly expressed in the tracheal system and functions in liquid clearance during tracheal development; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.	0.672
CG8945	CG10280	FBpp0074185	FBpp0301222	Peptidase_M14 domain-containing protein; Zinc ion binding; metallocarboxypeptidase activity. It is involved in the biological process described with: proteolysis.	Metalloendopeptidase activity; zinc ion binding. It is involved in the biological process described with: proteolysis.	0.601
CG8945	CG10864	FBpp0074185	FBpp0083069	Peptidase_M14 domain-containing protein; Zinc ion binding; metallocarboxypeptidase activity. It is involved in the biological process described with: proteolysis.	Uncharacterized protein; Potassium ion leak channel activity; potassium channel activity. It is involved in the biological process described with: potassium ion transmembrane transport; stabilization of membrane potential; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.	0.666
CG8945	CG13634	FBpp0074185	FBpp0084117	Peptidase_M14 domain-containing protein; Zinc ion binding; metallocarboxypeptidase activity. It is involved in the biological process described with: proteolysis.	Uncharacterized protein.	0.570
CG8945	CG9876	FBpp0074185	FBpp0071889	Peptidase_M14 domain-containing protein; Zinc ion binding; metallocarboxypeptidase activity. It is involved in the biological process described with: proteolysis.	FI01017p; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II regulatory region sequence-specific DNA binding. It is involved in the biological process described with: regulation of transcription, DNA-templated.	0.687
CG8945	Nach	FBpp0074185	FBpp0401613	Peptidase_M14 domain-containing protein; Zinc ion binding; metallocarboxypeptidase activity. It is involved in the biological process described with: proteolysis.	Sodium channel protein Nach; Nach (Nach) encodes a predicted member of the Degenerin/Epithelial Sodium Channel family of proteins. It is mainly expressed in the tracheal system and functions in liquid clearance during tracheal development; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.	0.837