STRINGSTRING
csw csw Egfr Egfr dos dos Tie Tie sev sev CG9701 CG9701 btl btl Shc Shc Cbl Cbl Sos Sos htl htl bnl bnl Cad96Ca Cad96Ca boss boss drk drk ths ths tor tor Crk Crk pyr pyr Vav Vav CG3277 CG3277 C3G C3G CG13398 CG13398 stumps stumps Lnk Lnk
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cswTyrosine-protein phosphatase corkscrew; Required in all receptor tyrosine kinase signaling pathways. Functions downstream of the receptor tyrosine kinase torso, acting in concert with D-Raf via tailless. Also functions downstream of Egfr (epidermal growth factor receptor) and btl (fibroblast growth factor receptor). The SH2 domain suggests that csw effects its role by mediating heteromeric protein interactions. Maternally required for normal determination of cell fates at the termini of the embryo. Required for cell fate specification of the ventral ectoderm, in the developing embryoni [...] (945 aa)
EgfrEpidermal growth factor receptor; Binds to four ligands: Spitz, Gurken, Vein and Argos, which is an antagonist. Transduces the signal through the ras-raf-MAPK pathway. Involved in a myriad of developmental decisions. Critical for the proliferation of imaginal tissues, and for the determination of both the antero-posterior and dorso-ventral polarities of the oocyte. In the embryo, plays a role in the establishment of ventral cell fates, maintenance of amnioserosa and ventral neuroectodermal cells, germ band retraction, cell fate specification in the central nervous system and production [...] (1426 aa)
dosProtein daughter of sevenless; Essential component for signaling from various receptor tyrosine kinases such as Sevenless, TORSO and DER. Required for photoreceptor cell and wing development. (878 aa)
TieTie-like receptor tyrosine kinase (Tie) encodes a predicted transmembrane tyrosine kinase receptor. Its potential ligands for include Pvf protein family members. It may be involved in cell survival and cell migration. (1233 aa)
sevProtein sevenless; Receptor for an extracellular signal required to instruct a cell to differentiate into an R7 photoreceptor. The ligand for sev is the boss (bride of sevenless) protein on the surface of the neighboring R8 cell. (2554 aa)
CG9701LP05116p; Beta-glucosidase activity. It is involved in the biological process described with: carbohydrate metabolic process; Belongs to the glycosyl hydrolase 1 family. (541 aa)
btlFibroblast growth factor receptor homolog 2; May be required for patterning of muscle precursor cells: generation of mesodermal and endodermal layers, invaginations of various types of cells, and CNS formation. Essential for the ability of the migrating tracheal and midline cells to recognize external guiding cues. (1052 aa)
ShcSHC-adaptor protein (Shc) encodes a protein involved in receptor tyrosine kinase signalling. It regulates anti-parasitoid immune response and tracheal development. (409 aa)
CblCbl proto-oncogene (Cbl) encodes an E3 protein-ubiquitin ligase for protein post-translational modification in RTK signaling (EGFR, VEGFR, FGF, and RET families) and non-RTK signaling (Src family). After the ubiquitination mediated by the product of Cbl, the substrates will be targeted to protein degradation for controlling cell growth, survival, migration and inflammation. (878 aa)
SosProtein son of sevenless; Promotes the exchange of Ras-bound GDP by GTP. Functions in signaling pathways initiated by the sevenless and epidermal growth factor receptor tyrosine kinases; implies a role for the ras pathway in neuronal development. (1596 aa)
htlFibroblast growth factor receptor homolog 1; Heartless (htl) encodes a transmembrane tyrosine kinase receptor for secreted FGF ligands that utilizes the intracellular Ras-MAP kinase pathway. It contributes to embryonic mesoderm migration and the specification of several mature mesodermal cell derivatives; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily. (729 aa)
bnlBranchless (bnl) encodes a Fibroblast Growth Factor (FGF) receptor for secreted FGF ligands that utilizes the intracellular Ras-MAP kinase pathway. It contributes to embryonic tracheal migration; Belongs to the heparin-binding growth factors family. (770 aa)
Cad96CaCadherin 96Ca (Cad96Ca) encodes a receptor tyrosine kinase (RTK) that is a direct target of the transcription factor encoded by grh and is required for epidermal wound healing. It cooperates with the product of InR during wing growth. (773 aa)
bossProtein bride of sevenless; Acts as a ligand for sevenless tyrosine-kinase receptor during eye development. (896 aa)
drkProtein enhancer of sevenless 2B; Downstream of receptor kinase (drk) encodes an adaptor protein that recognizes phosphorylated tyrosine residues of membrane receptors and triggers the Ras/Raf/MAPK pathway. drk product contributes to the regulation of cytoskeletal organization and participates in developmental and cognitive processes (associative learning, anesthesia resistant memory). (211 aa)
thsThisbe, isoform A; Thisbe (ths) encodes is a Fibroblast growth factor (FGF) and ligand for the FGF receptor encoded by htl. It regulates the development of somatic and visceral muscle in the mesoderm, cardioblasts and glial cells. Its roles include acting as a chemoattractant in directional cell migration, and regulating adhesion, differentiation, and cell survival. (748 aa)
torTyrosine-protein kinase receptor torso; Probable receptor tyrosine kinase which is required for determination of anterior and posterior terminal structures in the embryo. During postembryonic development, involved in the initiation of metamorphosis probably by inducing the production of ecdysone in response to prothoracicotropic hormone Ptth. Binding to Ptth stimulates activation of canonical MAPK signaling leading to ERK phosphorylation (By similarity). (923 aa)
CrkAdapter molecule Crk; Adapter protein which interacts with C-terminal portion of mbc, homolog of human DOCK180. May play a role in cellular processes throughout development; Belongs to the CRK family. (271 aa)
pyrPyramus (pyr) encodes a Fibroblast growth factor (FGF) and ligand for the FGF receptor encoded by htl. It regulates the development of somatic and visceral muscle in the mesoderm, cardioblasts and glial cells. Its roles include acting as a chemoattractant in directional cell migration, and regulating adhesion, differentiation, and cell survival. (766 aa)
VavVav guanine nucleotide exchange factor (Vav) encodes a protein that belongs to the Dbl GEF superfamily. It functions as a GDP/GTP exchange factor for the product of Rac1 and an adaptor protein. Both activities are activated by direct tyrosine phosphorylation. (1001 aa)
CG3277Transmembrane receptor protein tyrosine kinase activity; ATP binding. It is involved in the biological process described with: transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of kinase activity; protein phosphorylation; multicellular organism development. (789 aa)
C3GGuanine nucleotide-releasing factor 2; C3G guanyl-nucleotide exchange factor (C3G) is expressed in the developing embryonic muscles and its product plays a role in body wall muscle development during larval stages. (1571 aa)
CG13398FI23523p1. (442 aa)
stumpsStumps, isoform E; Stumps (stumps) encodes a fibroblast growth factor (FGF) scaffolding protein. Upon FGF receptor activation, it mediates the recruitment of the phosphatase encoded by csw, which is essential for the activation of the MAPK pathway. (1220 aa)
LnkLnk, isoform D; Lnk (Lnk) encodes a member of the SH2B family of adaptor proteins. It functions within the insulin signalling pathway as an intracellular adaptor for the insulin receptor. It stabilises the interaction between the activated insulin receptor and the insulin receptor substrate, which are encoded by InR and chico respectively. (728 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.