(5 nodes) Insulin-like superfamily network (Drosophila melanogaster)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Ilp6	Insulin-like peptide 6 (Ilp6) encodes a protein that promotes growth during starvation. (107 aa)
	Ilp7	Insulin-like peptide 7 (Ilp7) encodes a secreted insulin-like peptide that binds to the receptor encoded by InR to activate the insulin signaling pathway. It is expressed by small populations of neurons and plays roles in female egg-site selection, sleep duration, and nutrient-dependent food intake and tracheal growth. (159 aa)
	Ilp1	Probable insulin-like peptide 1 A chain; Insulin receptor binding; hormone activity. It is involved in the biological process described with: insulin receptor signaling pathway. (154 aa)
	Ilp2	Probable insulin-like peptide 2 A chain; Plays a role in regulating body size by increasing cell size and cell number of individual organs. Probably mediates its growth effects by acting as a ligand for the insulin receptor and transducing a signal via the Chico/PI3K/Akt(PKB) pathway. (137 aa)
	Ilp3	Insulin-like peptide 3 (Ilp3) encodes a peptide involved in the insulin signaling pathway, the sugar-mediated activation of TOR signaling, sleep and mating behavior in females. (120 aa)

Your Current Organism:

Drosophila melanogaster

NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ilp1	Ilp2	FBpp0076057	FBpp0076058	Probable insulin-like peptide 1 A chain; Insulin receptor binding; hormone activity. It is involved in the biological process described with: insulin receptor signaling pathway.	Probable insulin-like peptide 2 A chain; Plays a role in regulating body size by increasing cell size and cell number of individual organs. Probably mediates its growth effects by acting as a ligand for the insulin receptor and transducing a signal via the Chico/PI3K/Akt(PKB) pathway.	0.993
Ilp1	Ilp3	FBpp0076057	FBpp0076102	Probable insulin-like peptide 1 A chain; Insulin receptor binding; hormone activity. It is involved in the biological process described with: insulin receptor signaling pathway.	Insulin-like peptide 3 (Ilp3) encodes a peptide involved in the insulin signaling pathway, the sugar-mediated activation of TOR signaling, sleep and mating behavior in females.	0.990
Ilp1	Ilp6	FBpp0076057	FBpp0070390	Probable insulin-like peptide 1 A chain; Insulin receptor binding; hormone activity. It is involved in the biological process described with: insulin receptor signaling pathway.	Insulin-like peptide 6 (Ilp6) encodes a protein that promotes growth during starvation.	0.990
Ilp1	Ilp7	FBpp0076057	FBpp0070552	Probable insulin-like peptide 1 A chain; Insulin receptor binding; hormone activity. It is involved in the biological process described with: insulin receptor signaling pathway.	Insulin-like peptide 7 (Ilp7) encodes a secreted insulin-like peptide that binds to the receptor encoded by InR to activate the insulin signaling pathway. It is expressed by small populations of neurons and plays roles in female egg-site selection, sleep duration, and nutrient-dependent food intake and tracheal growth.	0.990
Ilp2	Ilp1	FBpp0076058	FBpp0076057	Probable insulin-like peptide 2 A chain; Plays a role in regulating body size by increasing cell size and cell number of individual organs. Probably mediates its growth effects by acting as a ligand for the insulin receptor and transducing a signal via the Chico/PI3K/Akt(PKB) pathway.	Probable insulin-like peptide 1 A chain; Insulin receptor binding; hormone activity. It is involved in the biological process described with: insulin receptor signaling pathway.	0.993
Ilp2	Ilp3	FBpp0076058	FBpp0076102	Probable insulin-like peptide 2 A chain; Plays a role in regulating body size by increasing cell size and cell number of individual organs. Probably mediates its growth effects by acting as a ligand for the insulin receptor and transducing a signal via the Chico/PI3K/Akt(PKB) pathway.	Insulin-like peptide 3 (Ilp3) encodes a peptide involved in the insulin signaling pathway, the sugar-mediated activation of TOR signaling, sleep and mating behavior in females.	0.994
Ilp2	Ilp6	FBpp0076058	FBpp0070390	Probable insulin-like peptide 2 A chain; Plays a role in regulating body size by increasing cell size and cell number of individual organs. Probably mediates its growth effects by acting as a ligand for the insulin receptor and transducing a signal via the Chico/PI3K/Akt(PKB) pathway.	Insulin-like peptide 6 (Ilp6) encodes a protein that promotes growth during starvation.	0.988
Ilp2	Ilp7	FBpp0076058	FBpp0070552	Probable insulin-like peptide 2 A chain; Plays a role in regulating body size by increasing cell size and cell number of individual organs. Probably mediates its growth effects by acting as a ligand for the insulin receptor and transducing a signal via the Chico/PI3K/Akt(PKB) pathway.	Insulin-like peptide 7 (Ilp7) encodes a secreted insulin-like peptide that binds to the receptor encoded by InR to activate the insulin signaling pathway. It is expressed by small populations of neurons and plays roles in female egg-site selection, sleep duration, and nutrient-dependent food intake and tracheal growth.	0.982
Ilp3	Ilp1	FBpp0076102	FBpp0076057	Insulin-like peptide 3 (Ilp3) encodes a peptide involved in the insulin signaling pathway, the sugar-mediated activation of TOR signaling, sleep and mating behavior in females.	Probable insulin-like peptide 1 A chain; Insulin receptor binding; hormone activity. It is involved in the biological process described with: insulin receptor signaling pathway.	0.990
Ilp3	Ilp2	FBpp0076102	FBpp0076058	Insulin-like peptide 3 (Ilp3) encodes a peptide involved in the insulin signaling pathway, the sugar-mediated activation of TOR signaling, sleep and mating behavior in females.	Probable insulin-like peptide 2 A chain; Plays a role in regulating body size by increasing cell size and cell number of individual organs. Probably mediates its growth effects by acting as a ligand for the insulin receptor and transducing a signal via the Chico/PI3K/Akt(PKB) pathway.	0.994
Ilp3	Ilp6	FBpp0076102	FBpp0070390	Insulin-like peptide 3 (Ilp3) encodes a peptide involved in the insulin signaling pathway, the sugar-mediated activation of TOR signaling, sleep and mating behavior in females.	Insulin-like peptide 6 (Ilp6) encodes a protein that promotes growth during starvation.	0.990
Ilp3	Ilp7	FBpp0076102	FBpp0070552	Insulin-like peptide 3 (Ilp3) encodes a peptide involved in the insulin signaling pathway, the sugar-mediated activation of TOR signaling, sleep and mating behavior in females.	Insulin-like peptide 7 (Ilp7) encodes a secreted insulin-like peptide that binds to the receptor encoded by InR to activate the insulin signaling pathway. It is expressed by small populations of neurons and plays roles in female egg-site selection, sleep duration, and nutrient-dependent food intake and tracheal growth.	0.988
Ilp6	Ilp1	FBpp0070390	FBpp0076057	Insulin-like peptide 6 (Ilp6) encodes a protein that promotes growth during starvation.	Probable insulin-like peptide 1 A chain; Insulin receptor binding; hormone activity. It is involved in the biological process described with: insulin receptor signaling pathway.	0.990
Ilp6	Ilp2	FBpp0070390	FBpp0076058	Insulin-like peptide 6 (Ilp6) encodes a protein that promotes growth during starvation.	Probable insulin-like peptide 2 A chain; Plays a role in regulating body size by increasing cell size and cell number of individual organs. Probably mediates its growth effects by acting as a ligand for the insulin receptor and transducing a signal via the Chico/PI3K/Akt(PKB) pathway.	0.988
Ilp6	Ilp3	FBpp0070390	FBpp0076102	Insulin-like peptide 6 (Ilp6) encodes a protein that promotes growth during starvation.	Insulin-like peptide 3 (Ilp3) encodes a peptide involved in the insulin signaling pathway, the sugar-mediated activation of TOR signaling, sleep and mating behavior in females.	0.990
Ilp6	Ilp7	FBpp0070390	FBpp0070552	Insulin-like peptide 6 (Ilp6) encodes a protein that promotes growth during starvation.	Insulin-like peptide 7 (Ilp7) encodes a secreted insulin-like peptide that binds to the receptor encoded by InR to activate the insulin signaling pathway. It is expressed by small populations of neurons and plays roles in female egg-site selection, sleep duration, and nutrient-dependent food intake and tracheal growth.	0.990
Ilp7	Ilp1	FBpp0070552	FBpp0076057	Insulin-like peptide 7 (Ilp7) encodes a secreted insulin-like peptide that binds to the receptor encoded by InR to activate the insulin signaling pathway. It is expressed by small populations of neurons and plays roles in female egg-site selection, sleep duration, and nutrient-dependent food intake and tracheal growth.	Probable insulin-like peptide 1 A chain; Insulin receptor binding; hormone activity. It is involved in the biological process described with: insulin receptor signaling pathway.	0.990
Ilp7	Ilp2	FBpp0070552	FBpp0076058	Insulin-like peptide 7 (Ilp7) encodes a secreted insulin-like peptide that binds to the receptor encoded by InR to activate the insulin signaling pathway. It is expressed by small populations of neurons and plays roles in female egg-site selection, sleep duration, and nutrient-dependent food intake and tracheal growth.	Probable insulin-like peptide 2 A chain; Plays a role in regulating body size by increasing cell size and cell number of individual organs. Probably mediates its growth effects by acting as a ligand for the insulin receptor and transducing a signal via the Chico/PI3K/Akt(PKB) pathway.	0.982
Ilp7	Ilp3	FBpp0070552	FBpp0076102	Insulin-like peptide 7 (Ilp7) encodes a secreted insulin-like peptide that binds to the receptor encoded by InR to activate the insulin signaling pathway. It is expressed by small populations of neurons and plays roles in female egg-site selection, sleep duration, and nutrient-dependent food intake and tracheal growth.	Insulin-like peptide 3 (Ilp3) encodes a peptide involved in the insulin signaling pathway, the sugar-mediated activation of TOR signaling, sleep and mating behavior in females.	0.988
Ilp7	Ilp6	FBpp0070552	FBpp0070390	Insulin-like peptide 7 (Ilp7) encodes a secreted insulin-like peptide that binds to the receptor encoded by InR to activate the insulin signaling pathway. It is expressed by small populations of neurons and plays roles in female egg-site selection, sleep duration, and nutrient-dependent food intake and tracheal growth.	Insulin-like peptide 6 (Ilp6) encodes a protein that promotes growth during starvation.	0.990