(6 nodes) JUN kinase kinase activity, and Phosphatase 2C, C-terminal domain superfamily network (Drosophila melanogaster)

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	hep	Dual specificity mitogen-activated protein kinase kinase hemipterous; Required for the epithelial cell sheet movement called dorsal closure (DC), which allows establishment of the dorsal epidermis. Controls the expression in the dorsal epithelium edges of another dorsal closure gene, puckered (puc). Phosphorylates and activates the MAP kinase bsk; bsk signal transduction pathway mediates an immune response and morphogenesis; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. (1178 aa)
	Takl1	ATP binding; JUN kinase kinase kinase activity; protein kinase activity. It is involved in the biological process described with: activation of JUN kinase activity. (393 aa)
	CG6036	Protein serine/threonine phosphatase activity; magnesium-dependent protein serine/threonine phosphatase activity; magnesium ion binding; manganese ion binding. It is involved in the biological process described with: protein dephosphorylation; negative regulation of stress-activated MAPK cascade. (371 aa)
	alph	Alphabet, isoform E; Alphabet (alph) encodes a Ser/Thr phosphatase that regulates RAS/MAPK signaling. (374 aa)
	Takl2	Tak1-like 2 (Takl2) encodes a putative serine-threonine kinase with similarity to the kinase encoded by Tak1. It has a mild wound closure phenotype in larval wound healing assays. (281 aa)
	Mkk4	MAP kinase kinase 4 (Mkk4) encodes a mitogen activated protein kinase kinase (MAPKK) involved in the Jun kinase (JNK) pathway. It is directly activated by the MAPKKK encoded by Tak1. Mkk4 product roles include activation of intracellular JNK signalling upon the TNF family ligand encoded by egr and regulation of axon stability. (424 aa)

Your Current Organism:

Drosophila melanogaster

NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CG6036	Takl1	FBpp0084399	FBpp0083400	Protein serine/threonine phosphatase activity; magnesium-dependent protein serine/threonine phosphatase activity; magnesium ion binding; manganese ion binding. It is involved in the biological process described with: protein dephosphorylation; negative regulation of stress-activated MAPK cascade.	ATP binding; JUN kinase kinase kinase activity; protein kinase activity. It is involved in the biological process described with: activation of JUN kinase activity.	0.912
CG6036	Takl2	FBpp0084399	FBpp0291414	Protein serine/threonine phosphatase activity; magnesium-dependent protein serine/threonine phosphatase activity; magnesium ion binding; manganese ion binding. It is involved in the biological process described with: protein dephosphorylation; negative regulation of stress-activated MAPK cascade.	Tak1-like 2 (Takl2) encodes a putative serine-threonine kinase with similarity to the kinase encoded by Tak1. It has a mild wound closure phenotype in larval wound healing assays.	0.912
CG6036	alph	FBpp0084399	FBpp0084810	Protein serine/threonine phosphatase activity; magnesium-dependent protein serine/threonine phosphatase activity; magnesium ion binding; manganese ion binding. It is involved in the biological process described with: protein dephosphorylation; negative regulation of stress-activated MAPK cascade.	Alphabet, isoform E; Alphabet (alph) encodes a Ser/Thr phosphatase that regulates RAS/MAPK signaling.	0.904
Mkk4	Takl1	FBpp0306434	FBpp0083400	MAP kinase kinase 4 (Mkk4) encodes a mitogen activated protein kinase kinase (MAPKK) involved in the Jun kinase (JNK) pathway. It is directly activated by the MAPKKK encoded by Tak1. Mkk4 product roles include activation of intracellular JNK signalling upon the TNF family ligand encoded by egr and regulation of axon stability.	ATP binding; JUN kinase kinase kinase activity; protein kinase activity. It is involved in the biological process described with: activation of JUN kinase activity.	0.930
Mkk4	Takl2	FBpp0306434	FBpp0291414	MAP kinase kinase 4 (Mkk4) encodes a mitogen activated protein kinase kinase (MAPKK) involved in the Jun kinase (JNK) pathway. It is directly activated by the MAPKKK encoded by Tak1. Mkk4 product roles include activation of intracellular JNK signalling upon the TNF family ligand encoded by egr and regulation of axon stability.	Tak1-like 2 (Takl2) encodes a putative serine-threonine kinase with similarity to the kinase encoded by Tak1. It has a mild wound closure phenotype in larval wound healing assays.	0.979
Mkk4	hep	FBpp0306434	FBpp0073578	MAP kinase kinase 4 (Mkk4) encodes a mitogen activated protein kinase kinase (MAPKK) involved in the Jun kinase (JNK) pathway. It is directly activated by the MAPKKK encoded by Tak1. Mkk4 product roles include activation of intracellular JNK signalling upon the TNF family ligand encoded by egr and regulation of axon stability.	Dual specificity mitogen-activated protein kinase kinase hemipterous; Required for the epithelial cell sheet movement called dorsal closure (DC), which allows establishment of the dorsal epidermis. Controls the expression in the dorsal epithelium edges of another dorsal closure gene, puckered (puc). Phosphorylates and activates the MAP kinase bsk; bsk signal transduction pathway mediates an immune response and morphogenesis; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.	0.552
Takl1	CG6036	FBpp0083400	FBpp0084399	ATP binding; JUN kinase kinase kinase activity; protein kinase activity. It is involved in the biological process described with: activation of JUN kinase activity.	Protein serine/threonine phosphatase activity; magnesium-dependent protein serine/threonine phosphatase activity; magnesium ion binding; manganese ion binding. It is involved in the biological process described with: protein dephosphorylation; negative regulation of stress-activated MAPK cascade.	0.912
Takl1	Mkk4	FBpp0083400	FBpp0306434	ATP binding; JUN kinase kinase kinase activity; protein kinase activity. It is involved in the biological process described with: activation of JUN kinase activity.	MAP kinase kinase 4 (Mkk4) encodes a mitogen activated protein kinase kinase (MAPKK) involved in the Jun kinase (JNK) pathway. It is directly activated by the MAPKKK encoded by Tak1. Mkk4 product roles include activation of intracellular JNK signalling upon the TNF family ligand encoded by egr and regulation of axon stability.	0.930
Takl1	Takl2	FBpp0083400	FBpp0291414	ATP binding; JUN kinase kinase kinase activity; protein kinase activity. It is involved in the biological process described with: activation of JUN kinase activity.	Tak1-like 2 (Takl2) encodes a putative serine-threonine kinase with similarity to the kinase encoded by Tak1. It has a mild wound closure phenotype in larval wound healing assays.	0.911
Takl1	alph	FBpp0083400	FBpp0084810	ATP binding; JUN kinase kinase kinase activity; protein kinase activity. It is involved in the biological process described with: activation of JUN kinase activity.	Alphabet, isoform E; Alphabet (alph) encodes a Ser/Thr phosphatase that regulates RAS/MAPK signaling.	0.912
Takl1	hep	FBpp0083400	FBpp0073578	ATP binding; JUN kinase kinase kinase activity; protein kinase activity. It is involved in the biological process described with: activation of JUN kinase activity.	Dual specificity mitogen-activated protein kinase kinase hemipterous; Required for the epithelial cell sheet movement called dorsal closure (DC), which allows establishment of the dorsal epidermis. Controls the expression in the dorsal epithelium edges of another dorsal closure gene, puckered (puc). Phosphorylates and activates the MAP kinase bsk; bsk signal transduction pathway mediates an immune response and morphogenesis; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.	0.933
Takl2	CG6036	FBpp0291414	FBpp0084399	Tak1-like 2 (Takl2) encodes a putative serine-threonine kinase with similarity to the kinase encoded by Tak1. It has a mild wound closure phenotype in larval wound healing assays.	Protein serine/threonine phosphatase activity; magnesium-dependent protein serine/threonine phosphatase activity; magnesium ion binding; manganese ion binding. It is involved in the biological process described with: protein dephosphorylation; negative regulation of stress-activated MAPK cascade.	0.912
Takl2	Mkk4	FBpp0291414	FBpp0306434	Tak1-like 2 (Takl2) encodes a putative serine-threonine kinase with similarity to the kinase encoded by Tak1. It has a mild wound closure phenotype in larval wound healing assays.	MAP kinase kinase 4 (Mkk4) encodes a mitogen activated protein kinase kinase (MAPKK) involved in the Jun kinase (JNK) pathway. It is directly activated by the MAPKKK encoded by Tak1. Mkk4 product roles include activation of intracellular JNK signalling upon the TNF family ligand encoded by egr and regulation of axon stability.	0.979
Takl2	Takl1	FBpp0291414	FBpp0083400	Tak1-like 2 (Takl2) encodes a putative serine-threonine kinase with similarity to the kinase encoded by Tak1. It has a mild wound closure phenotype in larval wound healing assays.	ATP binding; JUN kinase kinase kinase activity; protein kinase activity. It is involved in the biological process described with: activation of JUN kinase activity.	0.911
Takl2	alph	FBpp0291414	FBpp0084810	Tak1-like 2 (Takl2) encodes a putative serine-threonine kinase with similarity to the kinase encoded by Tak1. It has a mild wound closure phenotype in larval wound healing assays.	Alphabet, isoform E; Alphabet (alph) encodes a Ser/Thr phosphatase that regulates RAS/MAPK signaling.	0.919
Takl2	hep	FBpp0291414	FBpp0073578	Tak1-like 2 (Takl2) encodes a putative serine-threonine kinase with similarity to the kinase encoded by Tak1. It has a mild wound closure phenotype in larval wound healing assays.	Dual specificity mitogen-activated protein kinase kinase hemipterous; Required for the epithelial cell sheet movement called dorsal closure (DC), which allows establishment of the dorsal epidermis. Controls the expression in the dorsal epithelium edges of another dorsal closure gene, puckered (puc). Phosphorylates and activates the MAP kinase bsk; bsk signal transduction pathway mediates an immune response and morphogenesis; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.	0.932
alph	CG6036	FBpp0084810	FBpp0084399	Alphabet, isoform E; Alphabet (alph) encodes a Ser/Thr phosphatase that regulates RAS/MAPK signaling.	Protein serine/threonine phosphatase activity; magnesium-dependent protein serine/threonine phosphatase activity; magnesium ion binding; manganese ion binding. It is involved in the biological process described with: protein dephosphorylation; negative regulation of stress-activated MAPK cascade.	0.904
alph	Takl1	FBpp0084810	FBpp0083400	Alphabet, isoform E; Alphabet (alph) encodes a Ser/Thr phosphatase that regulates RAS/MAPK signaling.	ATP binding; JUN kinase kinase kinase activity; protein kinase activity. It is involved in the biological process described with: activation of JUN kinase activity.	0.912
alph	Takl2	FBpp0084810	FBpp0291414	Alphabet, isoform E; Alphabet (alph) encodes a Ser/Thr phosphatase that regulates RAS/MAPK signaling.	Tak1-like 2 (Takl2) encodes a putative serine-threonine kinase with similarity to the kinase encoded by Tak1. It has a mild wound closure phenotype in larval wound healing assays.	0.919
hep	Mkk4	FBpp0073578	FBpp0306434	Dual specificity mitogen-activated protein kinase kinase hemipterous; Required for the epithelial cell sheet movement called dorsal closure (DC), which allows establishment of the dorsal epidermis. Controls the expression in the dorsal epithelium edges of another dorsal closure gene, puckered (puc). Phosphorylates and activates the MAP kinase bsk; bsk signal transduction pathway mediates an immune response and morphogenesis; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.	MAP kinase kinase 4 (Mkk4) encodes a mitogen activated protein kinase kinase (MAPKK) involved in the Jun kinase (JNK) pathway. It is directly activated by the MAPKKK encoded by Tak1. Mkk4 product roles include activation of intracellular JNK signalling upon the TNF family ligand encoded by egr and regulation of axon stability.	0.552