(6 nodes) Mixed, incl. Ectoderm and mesoderm interaction, and Mitotic cohesin loading network (Drosophila melanogaster)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	vnd	Homeobox protein vnd; Ventral nervous system defective (vnd) encodes a Nk2-class homeodomain transcription factor that acts in a context-dependent manner as an activator or repressor. It has roles in neuroectoderm patterning, formation and specification of ventral neuroblasts and proper development of their cell lineages. (723 aa)
	brk	Putative transcription factor; Brinker (brk) encodes a transcriptional repressor that plays important roles in the development of many tissues, including most imaginal discs, where its expression is negatively regulated by Dpp signaling. (704 aa)
	sna	Snail (sna) encodes a transcription factor that contributes to embryonic mesoderm development, epithelial to mesenchymal transition and asymmetric cell division. (390 aa)
	zen	Protein zerknuellt 1; Required for the differentiation of the dorsal-ventral pattern, and does not appear to be involved in the process of segmentation. (353 aa)
	shn	Schnurri, isoform F; Schnurri (shn) encodes a zinc finger C2H2 transcription factor involved in Dpp signaling. It contributes to multiple processes including ectoderm and midgut development, wing disc patterning and morphogenesis of Malpighian tubules and dendrites. (2587 aa)
	twi	Twist (twi) encodes a transcription factor required for mesoderm cell fate. The product of twi is essential for gastrulation, the development of mesodermal derivatives, including somatic and visceral muscle, fat body and maintenance of muscle stem cells. (490 aa)

Your Current Organism:

Drosophila melanogaster

NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
brk	shn	FBpp0071007	FBpp0303470	Putative transcription factor; Brinker (brk) encodes a transcriptional repressor that plays important roles in the development of many tissues, including most imaginal discs, where its expression is negatively regulated by Dpp signaling.	Schnurri, isoform F; Schnurri (shn) encodes a zinc finger C2H2 transcription factor involved in Dpp signaling. It contributes to multiple processes including ectoderm and midgut development, wing disc patterning and morphogenesis of Malpighian tubules and dendrites.	0.932
brk	sna	FBpp0071007	FBpp0080298	Putative transcription factor; Brinker (brk) encodes a transcriptional repressor that plays important roles in the development of many tissues, including most imaginal discs, where its expression is negatively regulated by Dpp signaling.	Snail (sna) encodes a transcription factor that contributes to embryonic mesoderm development, epithelial to mesenchymal transition and asymmetric cell division.	0.688
brk	twi	FBpp0071007	FBpp0311714	Putative transcription factor; Brinker (brk) encodes a transcriptional repressor that plays important roles in the development of many tissues, including most imaginal discs, where its expression is negatively regulated by Dpp signaling.	Twist (twi) encodes a transcription factor required for mesoderm cell fate. The product of twi is essential for gastrulation, the development of mesodermal derivatives, including somatic and visceral muscle, fat body and maintenance of muscle stem cells.	0.691
brk	vnd	FBpp0071007	FBpp0070105	Putative transcription factor; Brinker (brk) encodes a transcriptional repressor that plays important roles in the development of many tissues, including most imaginal discs, where its expression is negatively regulated by Dpp signaling.	Homeobox protein vnd; Ventral nervous system defective (vnd) encodes a Nk2-class homeodomain transcription factor that acts in a context-dependent manner as an activator or repressor. It has roles in neuroectoderm patterning, formation and specification of ventral neuroblasts and proper development of their cell lineages.	0.797
brk	zen	FBpp0071007	FBpp0081170	Putative transcription factor; Brinker (brk) encodes a transcriptional repressor that plays important roles in the development of many tissues, including most imaginal discs, where its expression is negatively regulated by Dpp signaling.	Protein zerknuellt 1; Required for the differentiation of the dorsal-ventral pattern, and does not appear to be involved in the process of segmentation.	0.677
shn	brk	FBpp0303470	FBpp0071007	Schnurri, isoform F; Schnurri (shn) encodes a zinc finger C2H2 transcription factor involved in Dpp signaling. It contributes to multiple processes including ectoderm and midgut development, wing disc patterning and morphogenesis of Malpighian tubules and dendrites.	Putative transcription factor; Brinker (brk) encodes a transcriptional repressor that plays important roles in the development of many tissues, including most imaginal discs, where its expression is negatively regulated by Dpp signaling.	0.932
shn	sna	FBpp0303470	FBpp0080298	Schnurri, isoform F; Schnurri (shn) encodes a zinc finger C2H2 transcription factor involved in Dpp signaling. It contributes to multiple processes including ectoderm and midgut development, wing disc patterning and morphogenesis of Malpighian tubules and dendrites.	Snail (sna) encodes a transcription factor that contributes to embryonic mesoderm development, epithelial to mesenchymal transition and asymmetric cell division.	0.472
shn	twi	FBpp0303470	FBpp0311714	Schnurri, isoform F; Schnurri (shn) encodes a zinc finger C2H2 transcription factor involved in Dpp signaling. It contributes to multiple processes including ectoderm and midgut development, wing disc patterning and morphogenesis of Malpighian tubules and dendrites.	Twist (twi) encodes a transcription factor required for mesoderm cell fate. The product of twi is essential for gastrulation, the development of mesodermal derivatives, including somatic and visceral muscle, fat body and maintenance of muscle stem cells.	0.481
shn	vnd	FBpp0303470	FBpp0070105	Schnurri, isoform F; Schnurri (shn) encodes a zinc finger C2H2 transcription factor involved in Dpp signaling. It contributes to multiple processes including ectoderm and midgut development, wing disc patterning and morphogenesis of Malpighian tubules and dendrites.	Homeobox protein vnd; Ventral nervous system defective (vnd) encodes a Nk2-class homeodomain transcription factor that acts in a context-dependent manner as an activator or repressor. It has roles in neuroectoderm patterning, formation and specification of ventral neuroblasts and proper development of their cell lineages.	0.538
shn	zen	FBpp0303470	FBpp0081170	Schnurri, isoform F; Schnurri (shn) encodes a zinc finger C2H2 transcription factor involved in Dpp signaling. It contributes to multiple processes including ectoderm and midgut development, wing disc patterning and morphogenesis of Malpighian tubules and dendrites.	Protein zerknuellt 1; Required for the differentiation of the dorsal-ventral pattern, and does not appear to be involved in the process of segmentation.	0.493
sna	brk	FBpp0080298	FBpp0071007	Snail (sna) encodes a transcription factor that contributes to embryonic mesoderm development, epithelial to mesenchymal transition and asymmetric cell division.	Putative transcription factor; Brinker (brk) encodes a transcriptional repressor that plays important roles in the development of many tissues, including most imaginal discs, where its expression is negatively regulated by Dpp signaling.	0.688
sna	shn	FBpp0080298	FBpp0303470	Snail (sna) encodes a transcription factor that contributes to embryonic mesoderm development, epithelial to mesenchymal transition and asymmetric cell division.	Schnurri, isoform F; Schnurri (shn) encodes a zinc finger C2H2 transcription factor involved in Dpp signaling. It contributes to multiple processes including ectoderm and midgut development, wing disc patterning and morphogenesis of Malpighian tubules and dendrites.	0.472
sna	twi	FBpp0080298	FBpp0311714	Snail (sna) encodes a transcription factor that contributes to embryonic mesoderm development, epithelial to mesenchymal transition and asymmetric cell division.	Twist (twi) encodes a transcription factor required for mesoderm cell fate. The product of twi is essential for gastrulation, the development of mesodermal derivatives, including somatic and visceral muscle, fat body and maintenance of muscle stem cells.	0.888
sna	vnd	FBpp0080298	FBpp0070105	Snail (sna) encodes a transcription factor that contributes to embryonic mesoderm development, epithelial to mesenchymal transition and asymmetric cell division.	Homeobox protein vnd; Ventral nervous system defective (vnd) encodes a Nk2-class homeodomain transcription factor that acts in a context-dependent manner as an activator or repressor. It has roles in neuroectoderm patterning, formation and specification of ventral neuroblasts and proper development of their cell lineages.	0.670
sna	zen	FBpp0080298	FBpp0081170	Snail (sna) encodes a transcription factor that contributes to embryonic mesoderm development, epithelial to mesenchymal transition and asymmetric cell division.	Protein zerknuellt 1; Required for the differentiation of the dorsal-ventral pattern, and does not appear to be involved in the process of segmentation.	0.687
twi	brk	FBpp0311714	FBpp0071007	Twist (twi) encodes a transcription factor required for mesoderm cell fate. The product of twi is essential for gastrulation, the development of mesodermal derivatives, including somatic and visceral muscle, fat body and maintenance of muscle stem cells.	Putative transcription factor; Brinker (brk) encodes a transcriptional repressor that plays important roles in the development of many tissues, including most imaginal discs, where its expression is negatively regulated by Dpp signaling.	0.691
twi	shn	FBpp0311714	FBpp0303470	Twist (twi) encodes a transcription factor required for mesoderm cell fate. The product of twi is essential for gastrulation, the development of mesodermal derivatives, including somatic and visceral muscle, fat body and maintenance of muscle stem cells.	Schnurri, isoform F; Schnurri (shn) encodes a zinc finger C2H2 transcription factor involved in Dpp signaling. It contributes to multiple processes including ectoderm and midgut development, wing disc patterning and morphogenesis of Malpighian tubules and dendrites.	0.481
twi	sna	FBpp0311714	FBpp0080298	Twist (twi) encodes a transcription factor required for mesoderm cell fate. The product of twi is essential for gastrulation, the development of mesodermal derivatives, including somatic and visceral muscle, fat body and maintenance of muscle stem cells.	Snail (sna) encodes a transcription factor that contributes to embryonic mesoderm development, epithelial to mesenchymal transition and asymmetric cell division.	0.888
twi	vnd	FBpp0311714	FBpp0070105	Twist (twi) encodes a transcription factor required for mesoderm cell fate. The product of twi is essential for gastrulation, the development of mesodermal derivatives, including somatic and visceral muscle, fat body and maintenance of muscle stem cells.	Homeobox protein vnd; Ventral nervous system defective (vnd) encodes a Nk2-class homeodomain transcription factor that acts in a context-dependent manner as an activator or repressor. It has roles in neuroectoderm patterning, formation and specification of ventral neuroblasts and proper development of their cell lineages.	0.710
twi	zen	FBpp0311714	FBpp0081170	Twist (twi) encodes a transcription factor required for mesoderm cell fate. The product of twi is essential for gastrulation, the development of mesodermal derivatives, including somatic and visceral muscle, fat body and maintenance of muscle stem cells.	Protein zerknuellt 1; Required for the differentiation of the dorsal-ventral pattern, and does not appear to be involved in the process of segmentation.	0.815