STRINGSTRING
Kah Kah dmrt11E dmrt11E CG6163 CG6163 Ir67b Ir67b CG11149 CG11149 CG15480 CG15480 CG6689 CG6689 Hexim Hexim beat-IIb beat-IIb dmrt93B dmrt93B HHEX HHEX nau nau CG7786 CG7786 CG17716 CG17716 CG32006 CG32006 fd102C fd102C CG33557 CG33557 Sox102F Sox102F CG16815 CG16815 Doa Doa Larp7 Larp7 meso18E meso18E Sfp24Bd Sfp24Bd CG34427 CG34427 CG4374 CG4374 CG14117 CG14117 CG11617 CG11617 CG33978 CG33978 CG33203 CG33203 RunxA RunxA CG12605 CG12605 dsf dsf fuss fuss Drgx Drgx CG31999 CG31999 sens-2 sens-2 CG15824 CG15824 bin3 bin3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KahRH55216p; Kahuli (Kah) encodes a member of the Snail/Scratch family of transcription factors, which regulate transcription by binding the E-box motif ACAGGTG. (442 aa)
dmrt11Edoublesex-Mab related 11E (dmrt11E) encodes a transcription factor-like protein containing a highly conserved DNA-binding DM domain that plays a critical role in sex determination and spermatogenesis. (377 aa)
CG6163Uncharacterized protein, isoform A; It is involved in the biological process described with: regulation of transcription by RNA polymerase II. (428 aa)
Ir67bIonotropic receptor 67b; Ligand-gated ion channel activity. It is involved in the biological process described with: detection of chemical stimulus. (574 aa)
CG11149FI01434p; Glucuronosyltransferase activity. It is involved in the biological process described with: protein O-linked mannosylation. (493 aa)
CG15480Uncharacterized protein. (166 aa)
CG6689LD13921p; Zinc ion binding; DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding. It is involved in the biological process described with: regulation of transcription by RNA polymerase II. (613 aa)
HeximHexamethylene bisacetamide inducible (Hexim) encodes an RNA binding protein. When associated with snRNA:7SK, it recruits and inhibits the positive transcription elongation factor encoded by Cdk9. Regulated release and re-sequestration of the product of Cdk9 by the snRNA:7SK snRNP plays an essential role in RNA polymerase II elongation control. (360 aa)
beat-IIbBeaten path IIb, isoform A; It is involved in the biological process described with: motor neuron axon guidance; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. (407 aa)
dmrt93BDoublesex-Mab related 93B; DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II regulatory region sequence-specific DNA binding. It is involved in the biological process described with: regulation of transcription by RNA polymerase II. (325 aa)
HHEXHematopoietically expressed homeobox (HHEX) encodes a transcription factor involved in response to sucrose. (323 aa)
nauNautilus (nau) encodes a protein that belongs to the bHLH family of transcription factors. It is the unique Drosophila ortholog of the mammalian family of bHLH Myogenic Regulatory Factors. It is involved in somatic muscle myogenesis. (332 aa)
CG7786BZIP domain-containing protein; DNA-binding transcription factor activity; RNA polymerase II regulatory region sequence-specific DNA binding. It is involved in the biological process described with: developmental process; regulation of transcription by RNA polymerase II. (192 aa)
CG17716Uncharacterized protein, isoform A; CG17716 encodes a predicted secreted immunoglobulin domain protein expressed in the embryonic central nervous system. (822 aa)
CG32006RT11906p1; Sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific. It is involved in the biological process described with: anatomical structure morphogenesis; cell differentiation; regulation of transcription by RNA polymerase II. (443 aa)
fd102CForkhead domain 102C; DNA-binding transcription factor activity, RNA polymerase II-specific; sequence-specific DNA binding. It is involved in the biological process described with: cell differentiation; regulation of transcription by RNA polymerase II; anatomical structure morphogenesis. (599 aa)
CG33557BHLH domain-containing protein; RNA polymerase II regulatory region sequence-specific DNA binding; protein dimerization activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor activity. It is involved in the biological process described with: regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II. (150 aa)
Sox102FSox102F, isoform B; Sox102F (Sox102F) encodes a transcription factor in the Sox gene family that regulates the Wnt signaling pathway. Its roles include heart development and cardiac function, and wing vein development and patterning. (618 aa)
CG16815Uncharacterized protein. (192 aa)
DoaSerine/threonine-protein kinase Doa; Negative regulator of the copia retrotransposon element of the white (w) gene. In the eye, it is required for normal pigmentation, photoreceptor cell development and for organization of interommatidial bristles. Also essential for embryonic segmentation and differentiation of the nervous system. Functions in the control of alternative splicing by phosphorylating the arginine/serine-rich splicing factors, SR proteins; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily. (2045 aa)
Larp7La related protein 7 (Larp7) encodes an obligate component of the 7SK snRNP. The 7SK snRNP plays an essential role in RNA polymerase II elongation control by regulating the activity of the positive transcription elongation factor encoded by Cdk9. (595 aa)
meso18EMeso18E, isoform A; It is involved in the biological process described with: mesoderm development. (553 aa)
Sfp24BdSeminal fluid protein 24Bd; Serine-type endopeptidase inhibitor activity. (111 aa)
CG34427Chitin-binding type-2 domain-containing protein; Chitin binding. It is involved in the biological process described with: chitin metabolic process. (269 aa)
CG4374Uncharacterized protein, isoform B; DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding. It is involved in the biological process described with: regulation of gene expression; regulation of transcription by RNA polymerase II. (772 aa)
CG14117RE44251p. (165 aa)
CG11617RE08174p; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific. It is involved in the biological process described with: regulation of transcription by RNA polymerase II; muscle organ development; positive regulation of transcription by RNA polymerase II; cell development; negative regulation of transcription by RNA polymerase II. (294 aa)
CG33978Uncharacterized protein, isoform C; Calcium ion binding. (2289 aa)
CG33203Uncharacterized protein, isoform F; Signaling receptor activity. (500 aa)
RunxARunt related A, isoform D; DNA-binding transcription factor activity; ATP binding; DNA binding. It is involved in the biological process described with: regulation of transcription, DNA-templated; dendrite morphogenesis. (663 aa)
CG12605LP01683p; RNA polymerase II regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II. (619 aa)
dsfDissatisfaction, isoform A; Dissatisfaction (dsf) encodes a nuclear receptor that regulates hemocyte proliferation, courtship behavior and neural differentiation. (691 aa)
fussFussel, isoform B; Fussel (fuss) encodes a protein that belongs to the highly conserved Sno/Ski family of Smad binding proteins. fuss mutant phenotypes in the larval brain phenocopy babo and Smox mutants, suggesting a role in Activin signaling. fuss overexpression antagonizes both Dpp and Activin signaling. (770 aa)
DrgxDorsal root ganglia homeobox, isoform E; RNA polymerase II regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific. It is involved in the biological process described with: regulation of transcription, DNA-templated. (587 aa)
CG31999RE68558p; Calcium ion binding. It is involved in the biological process described with: extracellular matrix organization. (917 aa)
sens-2Senseless-2, isoform A; Nucleic acid binding. (746 aa)
CG15824Uncharacterized protein, isoform B. (1957 aa)
bin3Probable RNA methyltransferase bin3; S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA, leading to stabilize it (Probable). Required for dorso-ventral patterning in oogenesis and for anterior-posterior pattern formation during embryogenesis, possibly by binding and stabilizing 7SK RNA, thereby promoting formation of a repressive RNA-protein complex. (1367 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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