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Proc-R Proc-R Orcokinin Orcokinin ETH ETH Akh Akh Mip Mip Lk Lk Lkr Lkr CapaR CapaR Dh31 Dh31 AstC AstC rk rk Pburs Pburs sNPF sNPF Hug Hug PK2-R1 PK2-R1 PK2-R2 PK2-R2 Crz Crz Eh Eh Lgr1 Lgr1 Burs Burs CCAP CCAP AstA AstA Capa Capa Dh44-R1 Dh44-R1 AkhR AkhR TrissinR TrissinR Dh44-R2 Dh44-R2 CCHa1 CCHa1 Gpb5 Gpb5 Trissin Trissin natalisin natalisin SIFaR SIFaR CCHa2 CCHa2 CCAP-R CCAP-R SIFa SIFa NPFR NPFR RYa RYa CrzR CrzR MsR1 MsR1 MsR2 MsR2 Dh31-R Dh31-R NPF NPF sNPF-R sNPF-R ETHR ETHR AstCC AstCC Dh44 Dh44 RYa-R RYa-R Gpa2 Gpa2
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proteins of unknown 3D structure
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Proc-RG protein-coupled receptor activity; proctolin receptor activity; neuropeptide receptor activity. It is involved in the biological process described with: G protein-coupled receptor signaling pathway; neuropeptide signaling pathway. (545 aa)
OrcokininOrcokinin, isoform A. (133 aa)
ETHEcdysis triggering hormone (ETH) encodes two peptides (DrmETH1 and DrmETH2) involved in ecdysis. ETH depletion leads to respiratory and behavioral deficits, unsuccessful ecdysis and lethality. (203 aa)
AkhAdipokinetic hormone (Akh) encodes a peptide hormone secreted by the corpora cardiaca. It signals to the G-protein coupled receptor encoded by AkhR to regulate circulating hemolymph carbohydrates and stored lipid and glycogen in the fat body; Belongs to the AKH/HRTH/RPCH family. (79 aa)
MipAllatostatins MIP; Ligand for the sex peptide receptor (SPR). Stabilizes sleep and maintains sleep homeostasis to inhibit the activity of wake-promoting circuits, such as those that involve the pigment dispersing factor (pdf) neurons. Regulated by the circadian clock network and pathways associated with a sleep homeostat. May also have a regulatory role in gut motility. (211 aa)
LkLeucokinin (Lk) encodes a neuropeptide that regulates water balance and food intake. Three groups of leucokinergic neurons are identified in the brain and abdominal ganglion of larvae and adults. Serotonin and insulin peptides have receptors in the abdominal leucokinergic neurons. (160 aa)
LkrLeucokinin receptor (Lkr) encodes a 7-transmembrane domain G-protein-coupled receptor (GPCR) with the product of Lk as a ligand. It signals through intracellular calcium, and is implicated in ion regulation by the Malpighian tubules and in feeding control. (542 aa)
CapaRNeuropeptides capa receptor; Acts as a receptor for the neuropeptides CAP-1 and CAP-2, but not CAP-3. Probably a component of signal transduction pathway that leads to Malpighian tubule fluid secretion in response to these ligands. (477 aa)
Dh31Diuretic hormone class 2; Regulation of fluid secretion. Stimulates Malpighian tubules fluid secretion by activating the apical membrane V-ATPase via cyclic AMP of principal cells in the main secretory segment. (117 aa)
AstCAllatostatin C (AstC) encodes a myotropic factor involved in heart rate decrease. (122 aa)
rkRickets (rk) encodes a G-protein coupled receptor that signals intracellularly using the second messenger cAMP. It binds the heterodimeric hormone bursicon and is developmentally important for molting-related behaviors. It is also required after adult emergence for cuticle hardening and melanization. (1360 aa)
PbursPartner of Bursicon (Pburs) encodes a cystine knot protein that dimerizes with the product of Burs to form the bursicon neurohormone that acts on the receptor encoded by rk. Bursicon neurohormone is released after adult emergence and is required for tanning and hardening of the cuticle and expansion of the wings. (141 aa)
sNPFShort neuropeptide F precursor (sNPF) encodes a protein that binds to the product of sNPF-R and activates ERK-Dilps signaling or the PKA-CREB pathway. Its roles include the regulation of cell and organism growth, carbohydrate metabolism, lifespan, feeding behavior, locomotion, circadian rhythm, and sleep. (281 aa)
HugProtein hugin; Probably has a role in larval molting; Belongs to the pyrokinin family. (191 aa)
PK2-R1Pyrokinin 2 receptor 1 (PK2-R1) encodes a G protein-coupled receptor that binds the neuropeptide encoded by Hug with high affinity. After binding, a second messenger cascade is initiated in cells that are target for the product of Hug (mainly neurons of the central nervous system). (660 aa)
PK2-R2Pyrokinin 2 receptor 2 (PK2-R2) encodes a G protein-coupled receptor that binds the neuropeptide encoded by Hug with high affinity. After binding, a second messenger cascade is initiated in cells that are target for the product of Hug (mainly neurons of the central nervous system). (599 aa)
CrzCorazonin (Crz) encodes a neuropeptide expressed in specific groups of neurons. It functions as a neurohormone and neuromodulator, which involves a G-protein-coupled receptor. Its roles include ethanol and trehalose metabolism, and male reproductive activity. (154 aa)
EhEclosion hormone (Eh) encodes a neurohormone involved in the control of ecdysis. At each ecdysis, the neurohormone is released into the hemolymph where it serves to potentiate the release of the product of ETH through a positive endocrine feedback loop. The product of Eh is also released into the nervous system where it contributes to turning on ecdysis. (97 aa)
Lgr1Leucine-rich repeat-containing G protein-coupled receptor 1 (Lgr1) encodes a Leucine-rich repeat-containing G protein-coupled receptor (LGR type A) that shows highest similarity with vertebrate glycoprotein hormone (TSH and Thyrostimulin, FSH, LH ) receptors. (831 aa)
BursBursicon (Burs) encodes a cystine knot protein that dimerizes with the product of Pburs to form the bursicon neurohormone. Bursicon neurohormone is released after adult emergence and acts on the receptor encoded by rk for tanning and hardening of the cuticle and expansion of the wings. (173 aa)
CCAPCrustacean cardioactive peptide (CCAP) encodes a conserved 9 amino acid neuropeptide. It is produced by 1-2 neurons in each segment of the ventral nervous system and is released during the shedding of the old exoskeleton (ecdysis). It also has cardioactive functions. (155 aa)
AstAAllatostatin-A; May act as a neurotransmitter or neuromodulator. (151 aa)
CapaCardio acceleratory peptide 2b; Capability (Capa) encodes three neuropeptides: two of the periviscerokinin family (CAPA-1 and CAPA-2) and one pyrokinin (pyrokinin-1) that activate the class A GPCRs encoded by CapaR and PK1-R respectively. Capa is expressed in neurosecretory cells innervating corpora cardiaca and abdomen. CAPA-1 and -2 act as diuretic hormones on the Malpighian tubules. (151 aa)
Dh44-R1Diuretic hormone 44 receptor 1 (Dh44-R1) encodes a G-Protein Coupled Receptor of the Family B class of GPCRs (Secretin Receptor-like). It is involved in regulation of diuresis, sperm storage in females and circadian control of locomotion. (504 aa)
AkhRAdipokinetic hormone receptor (AkhR) encodes a G protein-coupled receptor for the hormone encoded by Akh. It modulates both lipid and carbohydrate homeostasis. (455 aa)
TrissinRTrissin receptor; G-protein coupled receptor which is activated by the Trissin peptide in vitro, leading to increased intracellular calcium ion levels. (669 aa)
Dh44-R2Diuretic hormone 44 receptor 2 (Dh44-R2) encodes a protein that exhibits diuretic hormone receptor activity. It is involved in G protein-coupled receptor signaling pathways, hormone-mediated signaling pathways, and response to salt stress. (476 aa)
CCHa1Neuropeptide CCHamide-1; Ligand for the CCHamide-1 receptor CCHa1-R. (182 aa)
Gpb5Glycoprotein hormone beta 5 (Gpb5) encodes a ligand of the G protein-coupled receptor encoded by Lgr1. It is involved in hormone-mediated signaling. (169 aa)
TrissinTrissin; Activates the G-protein coupled receptor TrissinR in vitro, leading to increased intracellular calcium ion levels. (108 aa)
natalisinNatalisin, isoform D; Natalisin (natalisin) encodes five signaling peptides with potent agonist activities toward the product of TkR86C. (553 aa)
SIFaRSIFamide receptor (SIFaR) encodes a G-protein coupled peptide receptor involved in both the neuropeptide and the G-protein coupled receptor signaling pathways. It is required for sensory perception of pain, determination of lifespan and sexual behavior. (758 aa)
CCHa2Neuropeptide CCHamide-2; Ligand for the CCHamide-2 receptor CCHa2-R. In one study, shown to be an orexigenic peptide which induces appetite and stimulates food intake, leading to the release of insulin-like peptides which stimulate growth. In another study, shown to be a nutrient-sensitive peptide derived from peripheral tissues which controls growth by directly regulating the production and release of insulin-like peptides. (136 aa)
CCAP-RCardioacceleratory peptide receptor; Binds to the cardioactive peptide (CCAP), which is a neuropeptide; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (494 aa)
SIFaNeuropeptide SIFamide; Ligand for the neuropeptide SIFamide receptor. Modulates sexual behavior by negatively regulating female receptivity to male courtship and by playing a role in male sex discrimination. Also involved in promoting sleep. Belongs to the FARP (FMRFamide related peptide) family. (72 aa)
NPFRNeuropeptide F receptor; Receptor for NPF. Integral part of the sensory system that mediates food signaling, providing the neural basis for the regulation of food response; coordinates larval foraging and social behavior changes during development. Required in dopaminergic (DA) neurons that innervate the mushroom body for satiety to suppress appetitive memory performance; a key factor in the internal state of hunger in the brain. NPF neurons coordinately modulate diverse sensory and motor neurons important for feeding, flight, and locomotion. NPF/NPFR pathway exerts its suppressive eff [...] (489 aa)
RYaRYamide neuropeptides; Neuropeptides RYamide-1 and RYamide-2 are ligands for the G- protein coupled receptor RYa-R. May suppress feeding behavior. (109 aa)
CrzRCorazonin receptor (CrzR) encodes a member of the Class A family of G-protein-coupled receptor that transduces the siganl of the neuropeptide encoded by Crz. It is involved in ethanol-induced behavior and ethanol metabolism. (644 aa)
MsR1Myosuppressin receptor 1 (MsR1) encodes a class A transmembrane G protein coupled receptor that binds the neuropeptide ligand encoded by Ms and acts through the adenylate cyclase-inhibiting GPCR signaling pathway. It inhibits visceral muscle contraction, and negatively regulates cardiac contractility and gut motility. (556 aa)
MsR2Myosuppressin receptor 2 (MsR2) encodes a G protein coupled receptor activated by the product of Ms (TDVDHVFLRFamide). It elevates neurotransmitter release in motor neurons and aids larval escape responses to light. (647 aa)
Dh31-RDiuretic hormone 31 Receptor (Dh31-R) encodes a protein that exhibits diuretic hormone receptor activity. It is involved in G protein-coupled receptor signaling pathwayS; Belongs to the G-protein coupled receptor 2 family. (604 aa)
NPFNeuropeptide F; Integral part of the sensory system that mediates food signaling, providing the neural basis for the regulation of food response; coordinates larval foraging and social behavior changes during development. Required in dopaminergic (DA) neurons that innervate the mushroom body for satiety to suppress appetitive memory performance; a key factor in the internal state of hunger in the brain. NPF neurons coordinately modulate diverse sensory and motor neurons important for feeding, flight, and locomotion. NPF/NPFR pathway exerts its suppressive effect on larval aversion to d [...] (102 aa)
sNPF-RShort neuropeptide F receptor (sNPF-R) encodes the G-protein-coupled receptor for the neuropeptide ligand encoded by sNPF, which utilizes the intracelluar ERK pathway or PKA-CREB pathway. It contributes to the regulation of growth, food intake, food-search behavior, appetitive memory, and sleep. (600 aa)
ETHRETHR (ETHR) encodes two distinct G protein-coupled receptors through alternative splicing. During development, the receptors are essential in initiating the molt-related behaviors of ecdysis, and in adults they function to promote juvenile hormone signaling and reproduction. (471 aa)
AstCCAllatostatin double C, isoform C; Hormone activity. (261 aa)
Dh44Diuretic hormone 44, isoform A; Hormone activity; G protein-coupled receptor binding; diuretic hormone activity; neuropeptide hormone activity. It is involved in the biological process described with: locomotor rhythm; G protein-coupled receptor signaling pathway; neuropeptide signaling pathway; body fluid secretion; hormone-mediated signaling pathway. (356 aa)
RYa-RRYamide receptor; Receptor for the neuropeptides RYamide-1 and RYamide-2. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. RYamide signaling may suppress feeding behavior. (518 aa)
Gpa2Glycoprotein hormone alpha 2 (Gpa2) encodes a protein that, when linked to the product of Gpb5, can activate the G protein-coupled receptor encoded by Lgr1. (129 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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