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Orcokinin Orcokinin ETH ETH Akh Akh Lk Lk Dh31 Dh31 AstC AstC rk rk Pburs Pburs sNPF sNPF Crz Crz Eh Eh Lgr1 Lgr1 Burs Burs CCAP CCAP AstA AstA AkhR AkhR CCHa1 CCHa1 Gpb5 Gpb5 CCHa2 CCHa2 NPFR NPFR CrzR CrzR NPF NPF sNPF-R sNPF-R ETHR ETHR AstCC AstCC Gpa2 Gpa2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
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OrcokininOrcokinin, isoform A. (133 aa)
ETHEcdysis triggering hormone (ETH) encodes two peptides (DrmETH1 and DrmETH2) involved in ecdysis. ETH depletion leads to respiratory and behavioral deficits, unsuccessful ecdysis and lethality. (203 aa)
AkhAdipokinetic hormone (Akh) encodes a peptide hormone secreted by the corpora cardiaca. It signals to the G-protein coupled receptor encoded by AkhR to regulate circulating hemolymph carbohydrates and stored lipid and glycogen in the fat body; Belongs to the AKH/HRTH/RPCH family. (79 aa)
LkLeucokinin (Lk) encodes a neuropeptide that regulates water balance and food intake. Three groups of leucokinergic neurons are identified in the brain and abdominal ganglion of larvae and adults. Serotonin and insulin peptides have receptors in the abdominal leucokinergic neurons. (160 aa)
Dh31Diuretic hormone class 2; Regulation of fluid secretion. Stimulates Malpighian tubules fluid secretion by activating the apical membrane V-ATPase via cyclic AMP of principal cells in the main secretory segment. (117 aa)
AstCAllatostatin C (AstC) encodes a myotropic factor involved in heart rate decrease. (122 aa)
rkRickets (rk) encodes a G-protein coupled receptor that signals intracellularly using the second messenger cAMP. It binds the heterodimeric hormone bursicon and is developmentally important for molting-related behaviors. It is also required after adult emergence for cuticle hardening and melanization. (1360 aa)
PbursPartner of Bursicon (Pburs) encodes a cystine knot protein that dimerizes with the product of Burs to form the bursicon neurohormone that acts on the receptor encoded by rk. Bursicon neurohormone is released after adult emergence and is required for tanning and hardening of the cuticle and expansion of the wings. (141 aa)
sNPFShort neuropeptide F precursor (sNPF) encodes a protein that binds to the product of sNPF-R and activates ERK-Dilps signaling or the PKA-CREB pathway. Its roles include the regulation of cell and organism growth, carbohydrate metabolism, lifespan, feeding behavior, locomotion, circadian rhythm, and sleep. (281 aa)
CrzCorazonin (Crz) encodes a neuropeptide expressed in specific groups of neurons. It functions as a neurohormone and neuromodulator, which involves a G-protein-coupled receptor. Its roles include ethanol and trehalose metabolism, and male reproductive activity. (154 aa)
EhEclosion hormone (Eh) encodes a neurohormone involved in the control of ecdysis. At each ecdysis, the neurohormone is released into the hemolymph where it serves to potentiate the release of the product of ETH through a positive endocrine feedback loop. The product of Eh is also released into the nervous system where it contributes to turning on ecdysis. (97 aa)
Lgr1Leucine-rich repeat-containing G protein-coupled receptor 1 (Lgr1) encodes a Leucine-rich repeat-containing G protein-coupled receptor (LGR type A) that shows highest similarity with vertebrate glycoprotein hormone (TSH and Thyrostimulin, FSH, LH ) receptors. (831 aa)
BursBursicon (Burs) encodes a cystine knot protein that dimerizes with the product of Pburs to form the bursicon neurohormone. Bursicon neurohormone is released after adult emergence and acts on the receptor encoded by rk for tanning and hardening of the cuticle and expansion of the wings. (173 aa)
CCAPCrustacean cardioactive peptide (CCAP) encodes a conserved 9 amino acid neuropeptide. It is produced by 1-2 neurons in each segment of the ventral nervous system and is released during the shedding of the old exoskeleton (ecdysis). It also has cardioactive functions. (155 aa)
AstAAllatostatin-A; May act as a neurotransmitter or neuromodulator. (151 aa)
AkhRAdipokinetic hormone receptor (AkhR) encodes a G protein-coupled receptor for the hormone encoded by Akh. It modulates both lipid and carbohydrate homeostasis. (455 aa)
CCHa1Neuropeptide CCHamide-1; Ligand for the CCHamide-1 receptor CCHa1-R. (182 aa)
Gpb5Glycoprotein hormone beta 5 (Gpb5) encodes a ligand of the G protein-coupled receptor encoded by Lgr1. It is involved in hormone-mediated signaling. (169 aa)
CCHa2Neuropeptide CCHamide-2; Ligand for the CCHamide-2 receptor CCHa2-R. In one study, shown to be an orexigenic peptide which induces appetite and stimulates food intake, leading to the release of insulin-like peptides which stimulate growth. In another study, shown to be a nutrient-sensitive peptide derived from peripheral tissues which controls growth by directly regulating the production and release of insulin-like peptides. (136 aa)
NPFRNeuropeptide F receptor; Receptor for NPF. Integral part of the sensory system that mediates food signaling, providing the neural basis for the regulation of food response; coordinates larval foraging and social behavior changes during development. Required in dopaminergic (DA) neurons that innervate the mushroom body for satiety to suppress appetitive memory performance; a key factor in the internal state of hunger in the brain. NPF neurons coordinately modulate diverse sensory and motor neurons important for feeding, flight, and locomotion. NPF/NPFR pathway exerts its suppressive eff [...] (489 aa)
CrzRCorazonin receptor (CrzR) encodes a member of the Class A family of G-protein-coupled receptor that transduces the siganl of the neuropeptide encoded by Crz. It is involved in ethanol-induced behavior and ethanol metabolism. (644 aa)
NPFNeuropeptide F; Integral part of the sensory system that mediates food signaling, providing the neural basis for the regulation of food response; coordinates larval foraging and social behavior changes during development. Required in dopaminergic (DA) neurons that innervate the mushroom body for satiety to suppress appetitive memory performance; a key factor in the internal state of hunger in the brain. NPF neurons coordinately modulate diverse sensory and motor neurons important for feeding, flight, and locomotion. NPF/NPFR pathway exerts its suppressive effect on larval aversion to d [...] (102 aa)
sNPF-RShort neuropeptide F receptor (sNPF-R) encodes the G-protein-coupled receptor for the neuropeptide ligand encoded by sNPF, which utilizes the intracelluar ERK pathway or PKA-CREB pathway. It contributes to the regulation of growth, food intake, food-search behavior, appetitive memory, and sleep. (600 aa)
ETHRETHR (ETHR) encodes two distinct G protein-coupled receptors through alternative splicing. During development, the receptors are essential in initiating the molt-related behaviors of ecdysis, and in adults they function to promote juvenile hormone signaling and reproduction. (471 aa)
AstCCAllatostatin double C, isoform C; Hormone activity. (261 aa)
Gpa2Glycoprotein hormone alpha 2 (Gpa2) encodes a protein that, when linked to the product of Gpb5, can activate the G protein-coupled receptor encoded by Lgr1. (129 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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