| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AstC | CCHa1 | FBpp0079821 | FBpp0112144 | Allatostatin C (AstC) encodes a myotropic factor involved in heart rate decrease. | Neuropeptide CCHamide-1; Ligand for the CCHamide-1 receptor CCHa1-R. | 0.850 |
| AstC | CCHa2 | FBpp0079821 | FBpp0292355 | Allatostatin C (AstC) encodes a myotropic factor involved in heart rate decrease. | Neuropeptide CCHamide-2; Ligand for the CCHamide-2 receptor CCHa2-R. In one study, shown to be an orexigenic peptide which induces appetite and stimulates food intake, leading to the release of insulin-like peptides which stimulate growth. In another study, shown to be a nutrient-sensitive peptide derived from peripheral tissues which controls growth by directly regulating the production and release of insulin-like peptides. | 0.676 |
| AstC | NPF | FBpp0079821 | FBpp0304075 | Allatostatin C (AstC) encodes a myotropic factor involved in heart rate decrease. | Neuropeptide F; Integral part of the sensory system that mediates food signaling, providing the neural basis for the regulation of food response; coordinates larval foraging and social behavior changes during development. Required in dopaminergic (DA) neurons that innervate the mushroom body for satiety to suppress appetitive memory performance; a key factor in the internal state of hunger in the brain. NPF neurons coordinately modulate diverse sensory and motor neurons important for feeding, flight, and locomotion. NPF/NPFR pathway exerts its suppressive effect on larval aversion to d [...] | 0.841 |
| AstC | NPFR | FBpp0079821 | FBpp0300637 | Allatostatin C (AstC) encodes a myotropic factor involved in heart rate decrease. | Neuropeptide F receptor; Receptor for NPF. Integral part of the sensory system that mediates food signaling, providing the neural basis for the regulation of food response; coordinates larval foraging and social behavior changes during development. Required in dopaminergic (DA) neurons that innervate the mushroom body for satiety to suppress appetitive memory performance; a key factor in the internal state of hunger in the brain. NPF neurons coordinately modulate diverse sensory and motor neurons important for feeding, flight, and locomotion. NPF/NPFR pathway exerts its suppressive eff [...] | 0.506 |
| AstC | Orcokinin | FBpp0079821 | FBpp0072118 | Allatostatin C (AstC) encodes a myotropic factor involved in heart rate decrease. | Orcokinin, isoform A. | 0.842 |
| AstC | sNPF | FBpp0079821 | FBpp0080859 | Allatostatin C (AstC) encodes a myotropic factor involved in heart rate decrease. | Short neuropeptide F precursor (sNPF) encodes a protein that binds to the product of sNPF-R and activates ERK-Dilps signaling or the PKA-CREB pathway. Its roles include the regulation of cell and organism growth, carbohydrate metabolism, lifespan, feeding behavior, locomotion, circadian rhythm, and sleep. | 0.857 |
| AstC | sNPF-R | FBpp0079821 | FBpp0304913 | Allatostatin C (AstC) encodes a myotropic factor involved in heart rate decrease. | Short neuropeptide F receptor (sNPF-R) encodes the G-protein-coupled receptor for the neuropeptide ligand encoded by sNPF, which utilizes the intracelluar ERK pathway or PKA-CREB pathway. It contributes to the regulation of growth, food intake, food-search behavior, appetitive memory, and sleep. | 0.605 |
| CCHa1 | AstC | FBpp0112144 | FBpp0079821 | Neuropeptide CCHamide-1; Ligand for the CCHamide-1 receptor CCHa1-R. | Allatostatin C (AstC) encodes a myotropic factor involved in heart rate decrease. | 0.850 |
| CCHa1 | CCHa2 | FBpp0112144 | FBpp0292355 | Neuropeptide CCHamide-1; Ligand for the CCHamide-1 receptor CCHa1-R. | Neuropeptide CCHamide-2; Ligand for the CCHamide-2 receptor CCHa2-R. In one study, shown to be an orexigenic peptide which induces appetite and stimulates food intake, leading to the release of insulin-like peptides which stimulate growth. In another study, shown to be a nutrient-sensitive peptide derived from peripheral tissues which controls growth by directly regulating the production and release of insulin-like peptides. | 0.838 |
| CCHa1 | NPF | FBpp0112144 | FBpp0304075 | Neuropeptide CCHamide-1; Ligand for the CCHamide-1 receptor CCHa1-R. | Neuropeptide F; Integral part of the sensory system that mediates food signaling, providing the neural basis for the regulation of food response; coordinates larval foraging and social behavior changes during development. Required in dopaminergic (DA) neurons that innervate the mushroom body for satiety to suppress appetitive memory performance; a key factor in the internal state of hunger in the brain. NPF neurons coordinately modulate diverse sensory and motor neurons important for feeding, flight, and locomotion. NPF/NPFR pathway exerts its suppressive effect on larval aversion to d [...] | 0.745 |
| CCHa1 | NPFR | FBpp0112144 | FBpp0300637 | Neuropeptide CCHamide-1; Ligand for the CCHamide-1 receptor CCHa1-R. | Neuropeptide F receptor; Receptor for NPF. Integral part of the sensory system that mediates food signaling, providing the neural basis for the regulation of food response; coordinates larval foraging and social behavior changes during development. Required in dopaminergic (DA) neurons that innervate the mushroom body for satiety to suppress appetitive memory performance; a key factor in the internal state of hunger in the brain. NPF neurons coordinately modulate diverse sensory and motor neurons important for feeding, flight, and locomotion. NPF/NPFR pathway exerts its suppressive eff [...] | 0.431 |
| CCHa1 | Orcokinin | FBpp0112144 | FBpp0072118 | Neuropeptide CCHamide-1; Ligand for the CCHamide-1 receptor CCHa1-R. | Orcokinin, isoform A. | 0.561 |
| CCHa1 | sNPF | FBpp0112144 | FBpp0080859 | Neuropeptide CCHamide-1; Ligand for the CCHamide-1 receptor CCHa1-R. | Short neuropeptide F precursor (sNPF) encodes a protein that binds to the product of sNPF-R and activates ERK-Dilps signaling or the PKA-CREB pathway. Its roles include the regulation of cell and organism growth, carbohydrate metabolism, lifespan, feeding behavior, locomotion, circadian rhythm, and sleep. | 0.712 |
| CCHa1 | sNPF-R | FBpp0112144 | FBpp0304913 | Neuropeptide CCHamide-1; Ligand for the CCHamide-1 receptor CCHa1-R. | Short neuropeptide F receptor (sNPF-R) encodes the G-protein-coupled receptor for the neuropeptide ligand encoded by sNPF, which utilizes the intracelluar ERK pathway or PKA-CREB pathway. It contributes to the regulation of growth, food intake, food-search behavior, appetitive memory, and sleep. | 0.524 |
| CCHa2 | AstC | FBpp0292355 | FBpp0079821 | Neuropeptide CCHamide-2; Ligand for the CCHamide-2 receptor CCHa2-R. In one study, shown to be an orexigenic peptide which induces appetite and stimulates food intake, leading to the release of insulin-like peptides which stimulate growth. In another study, shown to be a nutrient-sensitive peptide derived from peripheral tissues which controls growth by directly regulating the production and release of insulin-like peptides. | Allatostatin C (AstC) encodes a myotropic factor involved in heart rate decrease. | 0.676 |
| CCHa2 | CCHa1 | FBpp0292355 | FBpp0112144 | Neuropeptide CCHamide-2; Ligand for the CCHamide-2 receptor CCHa2-R. In one study, shown to be an orexigenic peptide which induces appetite and stimulates food intake, leading to the release of insulin-like peptides which stimulate growth. In another study, shown to be a nutrient-sensitive peptide derived from peripheral tissues which controls growth by directly regulating the production and release of insulin-like peptides. | Neuropeptide CCHamide-1; Ligand for the CCHamide-1 receptor CCHa1-R. | 0.838 |
| CCHa2 | NPF | FBpp0292355 | FBpp0304075 | Neuropeptide CCHamide-2; Ligand for the CCHamide-2 receptor CCHa2-R. In one study, shown to be an orexigenic peptide which induces appetite and stimulates food intake, leading to the release of insulin-like peptides which stimulate growth. In another study, shown to be a nutrient-sensitive peptide derived from peripheral tissues which controls growth by directly regulating the production and release of insulin-like peptides. | Neuropeptide F; Integral part of the sensory system that mediates food signaling, providing the neural basis for the regulation of food response; coordinates larval foraging and social behavior changes during development. Required in dopaminergic (DA) neurons that innervate the mushroom body for satiety to suppress appetitive memory performance; a key factor in the internal state of hunger in the brain. NPF neurons coordinately modulate diverse sensory and motor neurons important for feeding, flight, and locomotion. NPF/NPFR pathway exerts its suppressive effect on larval aversion to d [...] | 0.668 |
| CCHa2 | Orcokinin | FBpp0292355 | FBpp0072118 | Neuropeptide CCHamide-2; Ligand for the CCHamide-2 receptor CCHa2-R. In one study, shown to be an orexigenic peptide which induces appetite and stimulates food intake, leading to the release of insulin-like peptides which stimulate growth. In another study, shown to be a nutrient-sensitive peptide derived from peripheral tissues which controls growth by directly regulating the production and release of insulin-like peptides. | Orcokinin, isoform A. | 0.498 |
| CCHa2 | sNPF | FBpp0292355 | FBpp0080859 | Neuropeptide CCHamide-2; Ligand for the CCHamide-2 receptor CCHa2-R. In one study, shown to be an orexigenic peptide which induces appetite and stimulates food intake, leading to the release of insulin-like peptides which stimulate growth. In another study, shown to be a nutrient-sensitive peptide derived from peripheral tissues which controls growth by directly regulating the production and release of insulin-like peptides. | Short neuropeptide F precursor (sNPF) encodes a protein that binds to the product of sNPF-R and activates ERK-Dilps signaling or the PKA-CREB pathway. Its roles include the regulation of cell and organism growth, carbohydrate metabolism, lifespan, feeding behavior, locomotion, circadian rhythm, and sleep. | 0.660 |
| CCHa2 | sNPF-R | FBpp0292355 | FBpp0304913 | Neuropeptide CCHamide-2; Ligand for the CCHamide-2 receptor CCHa2-R. In one study, shown to be an orexigenic peptide which induces appetite and stimulates food intake, leading to the release of insulin-like peptides which stimulate growth. In another study, shown to be a nutrient-sensitive peptide derived from peripheral tissues which controls growth by directly regulating the production and release of insulin-like peptides. | Short neuropeptide F receptor (sNPF-R) encodes the G-protein-coupled receptor for the neuropeptide ligand encoded by sNPF, which utilizes the intracelluar ERK pathway or PKA-CREB pathway. It contributes to the regulation of growth, food intake, food-search behavior, appetitive memory, and sleep. | 0.461 |