STRINGSTRING
AstA-R1 AstA-R1 mAChR-C mAChR-C Gbeta5 Gbeta5 Galphas Galphas mAChR-A mAChR-A Gbeta76C Gbeta76C Galphai Galphai Oct-TyrR Oct-TyrR CG13995 CG13995 mAChR-B mAChR-B Ggamma1 Ggamma1 AstC-R1 AstC-R1 Gbeta13F Gbeta13F Galphao Galphao CG17760 CG17760 Dhit Dhit CG30054 CG30054 CG43324 CG43324 RSG7 RSG7 CG42450 CG42450 Octalpha2R Octalpha2R Tre1 Tre1 ric8a ric8a Ggamma30A Ggamma30A AstC-R2 AstC-R2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
AstA-R1Allatostatin A receptor 1 (AstA-R1) encodes a G-protein coupled receptor for the neuropeptide encoded by AstA. (394 aa)
mAChR-CMuscarinic Acetylcholine Receptor, C-type (mAChR-C) encodes a G protein-coupled receptor activated by acetylcholine; Belongs to the G-protein coupled receptor 1 family. (371 aa)
Gbeta5RH17413p; GTPase activator activity; G-protein gamma-subunit binding. It is involved in the biological process described with: G protein-coupled receptor signaling pathway; dopamine receptor signaling pathway; positive regulation of GTPase activity. (358 aa)
GalphasG protein alpha s subunit (Galphas) encodes an alpha subunit of the class of heterotrimeric G proteins, found on the cytosolic face of the plasma membrane. An inactive GDP-bound form forms a heterotrimer with beta and gamma subunits. On activation by a 7-TM receptor, the product of Galphas exchanges GDP for GTP, dissociates from the trimer, and activates adenylyl cyclase, thus initiating cAMP signaling. Galphas roles include neurophysiology, and behaviors including learning; Belongs to the G-alpha family. G(s) subfamily. (385 aa)
mAChR-AMuscarinic acetylcholine receptor DM1; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. May have a role in the processing of olfactory and mechanosensory signals; regulation of neurosecretion. (805 aa)
Gbeta76CGuanine nucleotide-binding protein subunit beta-2; G protein beta-subunit 76C (Gbeta76C) encodes a protein that forms a Gbeta-gamma complex that is anchored to the plasma membrane via lipid modification of the gamma-subunit. The Gbeta-gamma complex plays an essential role in phototransduction by presenting the Gqalpha-subunit to rhodopsin GPCRs for efficient activation, and preventing spontaneous GDP-GTP exchange on the Gqalpha-subunit. (346 aa)
GalphaiG protein alpha i subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Plays a role in glial cell differentiation during embryogenesis; loco, Galphao and the G-protein coupled receptor, moody, are required in the surface glia to achieve effective insulation of the nerve cord; Belongs to the G-alpha family. G(i/o/t/z) subfamily. (355 aa)
Oct-TyrRTyramine/octopamine receptor; Receptor for both octopamine and tyramine, invertebrate neurotransmitters, and neuromodulators. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The rank order of potency for agonists is tyramine > octopamine > dopamine > epinephrine > norepinephrine > serotonin > histamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > cyproheptadine > dihydroergotamine > clonidine > synephrine. Tyramine has a functional role in the olfactory system as a neurotransmitter or a neuromodulator. (601 aa)
CG13995Neuropeptide receptor activity; G protein-coupled receptor activity. It is involved in the biological process described with: G protein-coupled receptor signaling pathway; neuropeptide signaling pathway. (545 aa)
mAChR-BMuscarinic Acetylcholine Receptor, B-type (mAChR-B) encodes a G protein-coupled receptor activated by acetylcholine; Belongs to the G-protein coupled receptor 1 family. (1019 aa)
Ggamma1Guanine nucleotide-binding protein subunit gamma-1; G protein gamma 1 (Ggamma1) encodes a protein involved in the G-protein coupled receptor signaling pathway. Ggamma1-product regulates actomyosin dynamics and contributes to heart morphogenesis, asymmetric neuroblast division and convergent extension movements during gastrulation. (70 aa)
AstC-R1Allatostatin C receptor 1 (AstC-R1) encodes G-protein coupled receptor for the neuropeptide encoded by AstC. (483 aa)
Gbeta13FGuanine nucleotide-binding protein subunit beta-1; G protein beta-subunit 13F (Gbeta13F) encodes an ubiquitous, maternal product required for gastrulation movements of early embryo and regulating medial (mesoderm and ectoderm) and junctional Myosin II (ectoderm) via RhoI pathway. The product of Gbeta13F is detected apically and at adherens junctions. (340 aa)
GalphaoG protein alpha o subunit (Galphao) encodes the most abundant G protein in the nervous tissue and is involved in signaling by a variety of GPCRs. It contributes to heart development, axonogenesis, neuro-muscular junction formation, asymmetric cell division, planar cell polarity, blood-brain barrier establishment, Wnt signaling, and gustatory and olfactory sensory perception; Belongs to the G-alpha family. G(i/o/t/z) subfamily. (354 aa)
CG17760SD21019p; GTPase activity; G protein-coupled receptor binding; guanyl nucleotide binding; G-protein beta/gamma-subunit complex binding. It is involved in the biological process described with: adenylate cyclase-modulating G protein-coupled receptor signaling pathway; phospholipase C-activating dopamine receptor signaling pathway. (353 aa)
DhitDouble hit (Dhit) encodes a protein that negatively regulates Galpha signaling and is involved in several GPCR-mediated signaling and developmental programs, such as asymmetric cell division in the sensory organ lineage. (274 aa)
CG30054Uncharacterized protein, isoform E; Guanyl nucleotide binding; G-protein beta/gamma-subunit complex binding; GTPase activity; G protein-coupled receptor binding. It is involved in the biological process described with: adenylate cyclase-modulating G protein-coupled receptor signaling pathway; phospholipase C-activating dopamine receptor signaling pathway. (353 aa)
CG43324Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (66 aa)
RSG7Regulator of G-protein signaling 7, isoform A; It is involved in the biological process described with: regulation of G protein-coupled receptor signaling pathway; intracellular signal transduction. (647 aa)
CG42450Uncharacterized protein, isoform B; It is involved in the biological process described with: intracellular signal transduction; G protein-coupled receptor signaling pathway. (1280 aa)
Octalpha2RAlpha2-adrenergic-like octopamine receptor, isoform B; Heterotrimeric G-protein binding; octopamine receptor activity; G protein-coupled receptor activity; G protein-coupled amine receptor activity. It is involved in the biological process described with: cell-cell signaling; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; adenylate cyclase-activating adrenergic receptor signaling pathway; G protein-coupled receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway. (740 aa)
Tre1Trapped in endoderm 1 (Tre1) encodes a G protein-coupled receptor of the rhodopsin class. Its functions include primordial germ cell/pole cell migration and programmed cell death, central nervous system stem cell division orientation, and mating/courtship behavior. (399 aa)
ric8aSynembryn; Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins independently of G-protein coupled receptors. Acts by exchanging bound GDP for free GTP. Plays a key role in asymmetric spindle positioning, a step for asymmetric cell division that generates cell diversity during development by activating G(i) alpha protein independently of G-protein coupled receptors. In addition to its GEF activity, it plays an essential role in cortical subcellular localization of heterotrimeric G proteins, suggesting it acts as a facilitator of G-alpha funct [...] (573 aa)
Ggamma30AGuanine nucleotide-binding protein subunit gamma-e; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. This subunit functions in visual transduction in the compound eye. (238 aa)
AstC-R2Allatostatin C receptor 2 (AstC-R2) encodes G-protein coupled receptor for the neuropeptide encoded by AstC. (593 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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