STRINGSTRING
iav iav CG13526 CG13526 SERCA SERCA Eip63F-1 Eip63F-1 ntc ntc Stim Stim Mec2 Mec2 Trpml Trpml brv1 brv1 CG31960 CG31960 Itpr Itpr Pkd2 Pkd2 yuri yuri Rsbp15 Rsbp15 CG17770 CG17770 Fkbp12 Fkbp12 Pkc53E Pkc53E PI31 PI31 azot azot CG30378 CG30378 CaMKI CaMKI Gr28b Gr28b Lasp Lasp Frq1 Frq1 NFAT NFAT jar jar Acam Acam RyR RyR Cam Cam Cortactin Cortactin sqa sqa nan nan gish gish TrpA1 TrpA1 Trpgamma Trpgamma Orai Orai Trpm Trpm nompC nompC Piezo Piezo
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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iavInactive (iav) encodes a protein involved in the response to different stimuli such as startle, heat or sound; Belongs to the transient receptor (TC 1.A.4) family. (1123 aa)
CG13526Uncharacterized protein; Calcium ion binding. It is involved in the biological process described with: calcium-mediated signaling. (154 aa)
SERCACalcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type; Sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) encodes an endoplasmic reticulum (ER) calcium pump with roles in ER calcium homeostasis and lipid storage. (1020 aa)
Eip63F-1Calcium-binding protein E63-1; Ecdysone-induced protein 63F 1 (Eip63F-1) encodes a member of the EF-hand family of Ca[2+]-binding proteins, induced directly by 20-hydroxyecdysone in late third instar larvae. It is responsible for formation of the 63F early puff in the polytene chromosomes. (193 aa)
ntcProtein nutcracker; Functions together with PI31 to control non-apoptotic caspase activation during sperm individualization. Positively regulates PI31 stability. (314 aa)
StimStromal interaction molecule (Stim) encodes an endomasplic reticulum-membrane protein that is an essential component of the store-operated calcium entry mechanism, which in neurons regulates flight. (570 aa)
Mec2SD05291p; Protein binding. It is involved in the biological process described with: nephrocyte filtration. (350 aa)
TrpmlTransient receptor potential cation channel, mucolipin (Trpml) encodes a ion channel involved in autophagy, lateral inhibition and TOR signalling regulation. (652 aa)
brv1Brivido-1; Calcium channel activity; calcium ion binding. It is involved in the biological process described with: detection of temperature stimulus involved in thermoception; detection of mechanical stimulus; cellular response to cold; calcium ion transport. (728 aa)
CG31960GEO02651p1; Enzyme regulator activity; calcium ion binding. It is involved in the biological process described with: calcium-mediated signaling; microtubule cytoskeleton organization; Belongs to the calmodulin family. (148 aa)
ItprInositol 1,4,5,-trisphosphate receptor (Itpr) encodes an intracellular ligand gated calcium channel. It functions downstream of G-protein coupled receptors that activate Gq/PLCbeta signaling and generate inositol tris-phosphate. Itpr depletion affects ecdysone release, response to nutritional stress, lipid metabolism and flight; Belongs to the InsP3 receptor family. (2837 aa)
Pkd2Polycystic kidney disease 2 (Pkd2) encodes a calcium permeable cation channel of the transient receptor potential (TRP) family. Its roles include sperm motility, smooth muscle contraction, larval feeding behavior, detection of mechanical stimuli and cold nociception. (924 aa)
yuriYuri gagarin, isoform B; Yuri gagarin (yuri) encodes a protein involved in gravitaxis, ciliary basal body organization and sperm individualization. (890 aa)
Rsbp15AT09290p. (421 aa)
CG17770MIP05401p; Enzyme regulator activity; calcium ion binding. It is involved in the biological process described with: calcium-mediated signaling; microtubule cytoskeleton organization. (164 aa)
Fkbp1212 kDa FK506-binding protein; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Binds to ligand-free TGF beta type I receptor, from which it is released upon a ligand-induced, type II receptor mediated phosphorylation of the type I receptor. Binding is inhibitory to the signaling pathways of the TGF beta family ligands. (108 aa)
Pkc53EProtein kinase C, brain isozyme; PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins (By similarity). PKC also serves as the receptor for phorbol esters, a class of tumor promoters (By similarity). Acts in a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection ; Belongs to the prote [...] (679 aa)
PI31Proteasome inhibitor PI31 subunit; Plays an important role in the control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Enhances 26S proteasome function by promoting its assembly through the interaction with the assembly chaperones PSMD9 and PMSD5. Functions together with ntc to control non-apoptotic caspase activation during sperm individualization. In testis, is required for proper protein degradation and germline cell cycle progression. (270 aa)
azotGEO08584p1; Ahuizotl (azot) encodes a calcium dependent protein that ensures the elimination of less fit cells. Fitness-based cell culling is used to maintain tissue health, delay aging, and extend lifespan. During development it also prevents malformations; Belongs to the calmodulin family. (148 aa)
CG30378Uncharacterized protein; Calcium ion binding. (148 aa)
CaMKICalmodulin binding; ATP binding; calmodulin-dependent protein kinase activity. It is involved in the biological process described with: protein phosphorylation. (405 aa)
Gr28bPutative gustatory receptor 28b; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates (By similarity). Atypical expression suggests also nongustatory roles in the nervous system and tissues involved in proprioception, hygroreception, and other sensory modalities. It is also possible that it has chemosensory roles in the detection of internal ligands; Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr66a subfamily. (470 aa)
LaspLIM and SH3 domain protein Lasp; Lasp (Lasp) encodes a member of the nebulin family. It plays subtle roles in modulating the actin cytoskeleton in ovaries, testes, and muscles, by serving as a scaffold protein binding multiple partners, especially actin and myosin. In indirect flight muscles, it contributes to I-band and A-band architecture. (657 aa)
Frq1Frequenin-1; Ca(2+)-dependent modulation of synaptic efficacy. (187 aa)
NFATNFAT nuclear factor, isoform B; DNA-binding transcription factor activity; chromatin binding; transcription factor binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding. It is involved in the biological process described with: positive regulation of transcription by RNA polymerase II; negative regulation of synaptic vesicle exocytosis; response to salt stress. (1457 aa)
jarMyosin heavy chain 95F; Myosin is a protein that binds to actin and has ATPase activity that is activated by actin. Together CLIP-190 and jar may coordinate the interaction between the actin and microtubule cytoskeleton. May link endocytic vesicles to microtubules and may be involved in transport in the early embryo and in the dynamic process of dorsal closure. It is believed that its function changes during the life cycle. (1268 aa)
AcamCalmodulin-related protein 97A; May be involved in calcium-mediated signal transduction. (148 aa)
RyRRyanodine receptor (RyR) encodes an intracellular calcium channel localized in the sarcoplasmic reticulum of muscles and the endoplasmic reticulum of neurons and other cell types. It regulates the release of intracellular calcium stores and has a key role in muscle contraction. (5134 aa)
CamCalmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+) (By similarity). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). In photoreceptor cells, light-induced Ca(2+) influx activates calmodulin, which in turn is likely to promote Crag activity in trafficking of newly synthesized ninaE (Rh1) from the trans-Golgi network to rhabdomere membranes. Together with Akap200, regulates PKA activity and ethanol-induced sensitivity and tolerance. (149 aa)
CortactinCortactin, isoform A; Proline-rich region binding; actin filament binding. (559 aa)
sqaSpaghetti-squash activator (sqa) encodes a myosin light chain kinase-like protein. It is a substrate of the kinase encoded by Atg1 and is required for starvation-induced autophagy. (888 aa)
nanNanchung, isoform B; Nanchung (nan) encodes a member of the transient Receptor Potential (TRP) channel family. It is involved in the response to different stimuli such as startle, humidity or sound. (834 aa)
gishGilgamesh, isoform L; Gilgamesh (gish) encodes a plasma membrane-associated kinase that regulates Hedgehog and Wingless signaling activity. It is involved in planar cell polarity via regulation of Rab11-mediated vesicle trafficking. (537 aa)
TrpA1Transient receptor potential cation channel A1 (TrpA1) encodes a cation channel activated by warming and by reactive chemicals. Its roles include the control of thermotaxis at innocuous temperatures, as well as thermal and chemical nociception in response to noxious heat and chemical exposure. (1232 aa)
TrpgammaTransient receptor potential-gamma protein; A light-sensitive calcium channel that is required for inositide-mediated Ca(2+) entry in the retina during phospholipase C (PLC)-mediated phototransduction (By similarity). Forms a regulated cation channel when heteromultimerized with trpl; Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. (1188 aa)
OraiCalcium release-activated calcium channel protein 1; Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores. Regulates transcription factor NFAT nuclear import. (507 aa)
TrpmTransient receptor potential cation channel trpm; Calcium channel mediating constitutive calcium ion entry. Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. (2023 aa)
nompCNo mechanoreceptor potential C (nompC) encodes a pore-forming subunit for a mechanosensitive non-selective cation channel. It belongs to the TRP channel family and is expressed in peripheral sensory neurons. It senses gentle touch and regulates locomotion in larval body wall neurons. In the adult, the product of nompC is involved in hearing transduction in the Johnston's organ. (1761 aa)
PiezoPiezo-type mechanosensitive ion channel component; Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents. Plays a major role in nociception (response to strong or painful touch) ; Belongs to the PIEZO (TC 1.A.75) family. (2973 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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