node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Amph | CG8176 | FBpp0086941 | FBpp0112119 | Amphiphysin, isoform A; Amphiphysin (Amph) encodes a BAR and SH3 domain containing protein that regulates muscle transverse tubule formation. It exhibits post-synaptic localization at the neuromuscular junction and its mutants show locomotion defects. | AT02057p; Phospholipid binding; cytoskeletal protein binding; AP-2 adaptor complex binding. It is involved in the biological process described with: clathrin-dependent endocytosis; clathrin coat assembly. | 0.939 |
Amph | Chc | FBpp0086941 | FBpp0089398 | Amphiphysin, isoform A; Amphiphysin (Amph) encodes a BAR and SH3 domain containing protein that regulates muscle transverse tubule formation. It exhibits post-synaptic localization at the neuromuscular junction and its mutants show locomotion defects. | Clathrin heavy chain (Chc) encodes a protein that forms part of the clathrin complex, which is the major component of coated vesicles. | 0.982 |
Amph | Clc | FBpp0086941 | FBpp0290348 | Amphiphysin, isoform A; Amphiphysin (Amph) encodes a BAR and SH3 domain containing protein that regulates muscle transverse tubule formation. It exhibits post-synaptic localization at the neuromuscular junction and its mutants show locomotion defects. | Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. | 0.784 |
Amph | Dap160 | FBpp0086941 | FBpp0297159 | Amphiphysin, isoform A; Amphiphysin (Amph) encodes a BAR and SH3 domain containing protein that regulates muscle transverse tubule formation. It exhibits post-synaptic localization at the neuromuscular junction and its mutants show locomotion defects. | Dynamin associated protein 160 (Dap160) encodes an adaptor protein that contributes to endocytosis. It regulates the Notch pathway and mediates the asymmetric accumulation of a number or proteins, including the product of aPKC during neuroblast division. | 0.901 |
Amph | EndoA | FBpp0086941 | FBpp0306589 | Amphiphysin, isoform A; Amphiphysin (Amph) encodes a BAR and SH3 domain containing protein that regulates muscle transverse tubule formation. It exhibits post-synaptic localization at the neuromuscular junction and its mutants show locomotion defects. | Endophilin-A; Endophilin A (EndoA) encodes an essential protein for synaptic vesicle endocytosis. It recruits or stabilizes the product of Synj (required for vesicle uncoating) to endocytic membranes. | 0.777 |
Amph | Eps-15 | FBpp0086941 | FBpp0072340 | Amphiphysin, isoform A; Amphiphysin (Amph) encodes a BAR and SH3 domain containing protein that regulates muscle transverse tubule formation. It exhibits post-synaptic localization at the neuromuscular junction and its mutants show locomotion defects. | Epidermal growth factor receptor pathway substrate clone 15 (Eps-15) encodes a multi-domain adaptor protein involved in endocytosis. It interacts with several other endocytic factors such as those encoded by shi, stnB, Dap160 and AP-2alpha. It is enriched at sites of endocytosis and is required for normal synaptic bouton development and vesicle endocytosis during high frequency stimulation. | 0.863 |
Amph | Hip1 | FBpp0086941 | FBpp0075680 | Amphiphysin, isoform A; Amphiphysin (Amph) encodes a BAR and SH3 domain containing protein that regulates muscle transverse tubule formation. It exhibits post-synaptic localization at the neuromuscular junction and its mutants show locomotion defects. | Huntingtin interacting protein 1, isoform A; It is involved in the biological process described with: positive regulation of receptor-mediated endocytosis; clathrin coat assembly; actin filament organization. | 0.668 |
Amph | Synj | FBpp0086941 | FBpp0300559 | Amphiphysin, isoform A; Amphiphysin (Amph) encodes a BAR and SH3 domain containing protein that regulates muscle transverse tubule formation. It exhibits post-synaptic localization at the neuromuscular junction and its mutants show locomotion defects. | Synaptojanin, isoform A; Synaptojanin (Synj) encodes a synaptic Phosphoinositide phosphate (PtdInsP) phosphatase that catalyzes the hydrolysis of phosphate groups from phosphorylated inositols. It is recruited or stabilized by the product of EndoA to endocytic membranes, and it catalyzes dephosphorylation reactions implicated in the uncoating of nascent endocytic vesicles. When the product of Synj dephosphorylates phosphoinositides on nascent vesicles, endocytic adaptors with affinity for these lipids will leave the membrane to uncoat the vesicle. | 0.967 |
Amph | aux | FBpp0086941 | FBpp0078604 | Amphiphysin, isoform A; Amphiphysin (Amph) encodes a BAR and SH3 domain containing protein that regulates muscle transverse tubule formation. It exhibits post-synaptic localization at the neuromuscular junction and its mutants show locomotion defects. | Auxilin, isoform A; Auxilin (aux) encodes a co-factor for the ATPase Hsc70 that regulates Clathrin dynamics. It regulates Notch signaling, eye morphogenesis, sperm individualization and neuron death. | 0.734 |
Amph | lap | FBpp0086941 | FBpp0291394 | Amphiphysin, isoform A; Amphiphysin (Amph) encodes a BAR and SH3 domain containing protein that regulates muscle transverse tubule formation. It exhibits post-synaptic localization at the neuromuscular junction and its mutants show locomotion defects. | Phosphatidylinositol-binding clathrin assembly protein LAP; Assembly protein recruiting clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. Involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction; Belongs to the PICALM/SNAP91 family. | 0.669 |
Amph | lqf | FBpp0086941 | FBpp0089151 | Amphiphysin, isoform A; Amphiphysin (Amph) encodes a BAR and SH3 domain containing protein that regulates muscle transverse tubule formation. It exhibits post-synaptic localization at the neuromuscular junction and its mutants show locomotion defects. | Liquid facets (lqf) encodes an epsin, which is an endocytic adaptor that contributes to endocytic network stability/regulation and membrane bending. It contributes to endocytosis and regulates the BMP and Notch signaling pathways. | 0.674 |
Amph | shi | FBpp0086941 | FBpp0305866 | Amphiphysin, isoform A; Amphiphysin (Amph) encodes a BAR and SH3 domain containing protein that regulates muscle transverse tubule formation. It exhibits post-synaptic localization at the neuromuscular junction and its mutants show locomotion defects. | Dynamin; Microtubule-associated force-producing protein which is involved in the production of microtubule bundles and which is able to bind and hydrolyze GTP. Implicated in endocytic protein sorting; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | 0.998 |
CG8176 | Amph | FBpp0112119 | FBpp0086941 | AT02057p; Phospholipid binding; cytoskeletal protein binding; AP-2 adaptor complex binding. It is involved in the biological process described with: clathrin-dependent endocytosis; clathrin coat assembly. | Amphiphysin, isoform A; Amphiphysin (Amph) encodes a BAR and SH3 domain containing protein that regulates muscle transverse tubule formation. It exhibits post-synaptic localization at the neuromuscular junction and its mutants show locomotion defects. | 0.939 |
CG8176 | Chc | FBpp0112119 | FBpp0089398 | AT02057p; Phospholipid binding; cytoskeletal protein binding; AP-2 adaptor complex binding. It is involved in the biological process described with: clathrin-dependent endocytosis; clathrin coat assembly. | Clathrin heavy chain (Chc) encodes a protein that forms part of the clathrin complex, which is the major component of coated vesicles. | 0.889 |
CG8176 | Clc | FBpp0112119 | FBpp0290348 | AT02057p; Phospholipid binding; cytoskeletal protein binding; AP-2 adaptor complex binding. It is involved in the biological process described with: clathrin-dependent endocytosis; clathrin coat assembly. | Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. | 0.830 |
CG8176 | Dap160 | FBpp0112119 | FBpp0297159 | AT02057p; Phospholipid binding; cytoskeletal protein binding; AP-2 adaptor complex binding. It is involved in the biological process described with: clathrin-dependent endocytosis; clathrin coat assembly. | Dynamin associated protein 160 (Dap160) encodes an adaptor protein that contributes to endocytosis. It regulates the Notch pathway and mediates the asymmetric accumulation of a number or proteins, including the product of aPKC during neuroblast division. | 0.986 |
CG8176 | Eps-15 | FBpp0112119 | FBpp0072340 | AT02057p; Phospholipid binding; cytoskeletal protein binding; AP-2 adaptor complex binding. It is involved in the biological process described with: clathrin-dependent endocytosis; clathrin coat assembly. | Epidermal growth factor receptor pathway substrate clone 15 (Eps-15) encodes a multi-domain adaptor protein involved in endocytosis. It interacts with several other endocytic factors such as those encoded by shi, stnB, Dap160 and AP-2alpha. It is enriched at sites of endocytosis and is required for normal synaptic bouton development and vesicle endocytosis during high frequency stimulation. | 0.992 |
CG8176 | Hip1 | FBpp0112119 | FBpp0075680 | AT02057p; Phospholipid binding; cytoskeletal protein binding; AP-2 adaptor complex binding. It is involved in the biological process described with: clathrin-dependent endocytosis; clathrin coat assembly. | Huntingtin interacting protein 1, isoform A; It is involved in the biological process described with: positive regulation of receptor-mediated endocytosis; clathrin coat assembly; actin filament organization. | 0.670 |
CG8176 | Synj | FBpp0112119 | FBpp0300559 | AT02057p; Phospholipid binding; cytoskeletal protein binding; AP-2 adaptor complex binding. It is involved in the biological process described with: clathrin-dependent endocytosis; clathrin coat assembly. | Synaptojanin, isoform A; Synaptojanin (Synj) encodes a synaptic Phosphoinositide phosphate (PtdInsP) phosphatase that catalyzes the hydrolysis of phosphate groups from phosphorylated inositols. It is recruited or stabilized by the product of EndoA to endocytic membranes, and it catalyzes dephosphorylation reactions implicated in the uncoating of nascent endocytic vesicles. When the product of Synj dephosphorylates phosphoinositides on nascent vesicles, endocytic adaptors with affinity for these lipids will leave the membrane to uncoat the vesicle. | 0.595 |
CG8176 | aux | FBpp0112119 | FBpp0078604 | AT02057p; Phospholipid binding; cytoskeletal protein binding; AP-2 adaptor complex binding. It is involved in the biological process described with: clathrin-dependent endocytosis; clathrin coat assembly. | Auxilin, isoform A; Auxilin (aux) encodes a co-factor for the ATPase Hsc70 that regulates Clathrin dynamics. It regulates Notch signaling, eye morphogenesis, sperm individualization and neuron death. | 0.754 |