STRINGSTRING
PIG-K PIG-K GAA1 GAA1 CG3149 CG3149 PGAP1 PGAP1 xit xit PIG-T PIG-T PIG-M PIG-M Alg3 Alg3 Alg2 Alg2 PIG-B PIG-B fw fw hec hec Alg14 Alg14 PIG-F PIG-F IRSp53 IRSp53 Alg10 Alg10 PIG-Wa PIG-Wa PGAP2 PGAP2 PGAP5 PGAP5 wol wol PIG-U PIG-U gny gny Alg7 Alg7 Dpm1 Dpm1 Alg12 Alg12 Alg1 Alg1 Alg9 Alg9 PIG-P PIG-P Alg13 Alg13 PIG-O PIG-O CG8311 CG8311 GalT1 GalT1 CG30037 CG30037 CG30036 CG30036 PIG-N PIG-N PIG-G PIG-G Dpm3 Dpm3 Dpm2 Dpm2 Alg11 Alg11 PIG-Wb PIG-Wb PIG-H PIG-H PIG-V PIG-V PIG-S PIG-S sud1 sud1 PIG-X PIG-X PIG-A PIG-A PIG-Q PIG-Q PIG-L PIG-L PIG-Z PIG-Z PIG-C PIG-C
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIG-KPutative GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein (By similarity); Belongs to the peptidase C13 family. (355 aa)
GAA1Glycosylphosphatidylinositol anchor attachment 1 (GAA1) encodes a subunit of glycosylphosphatidylinositol (GPI) transamidase, which mediates GPI anchoring in the endoplasmic reticulum. GPI anchor attachment serves as a general mechanism for linking proteins to the cell surface membrane. (674 aa)
CG3149Protein RFT1 homolog; May be involved in N-linked oligosaccharide assembly. Belongs to the RFT1 family. (556 aa)
PGAP1GPI inositol-deacylase; Involved in inositol deacylation of GPI-anchored proteins. Belongs to the GPI inositol-deacylase family. (980 aa)
xitProbable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase; Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol (By similarity). Functions in developmental processes such as germband extension, the apical constriction of mesoderm precursor cells and ventral furrow formation in early embryogenesis prior to gastrulation. Involved in the glycosylation and intracellular distribution of shg ( [...] (511 aa)
PIG-TPhosphatidylinositol glycan anchor biosynthesis class T; GPI-anchor transamidase activity. It is involved in the biological process described with: attachment of GPI anchor to protein. (633 aa)
PIG-MGPI mannosyltransferase 1; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN- acyl-PI during GPI precursor assembly. (466 aa)
Alg3Lethal(2)neighbour of tid protein; dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity. It is involved in the biological process described with: protein glycosylation. (510 aa)
Alg2ALG2, alpha-1,3/1,6-mannosyltransferase; Alpha-1,3-mannosyltransferase activity; GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity. It is involved in the biological process described with: protein glycosylation in endoplasmic reticulum; oligosaccharide-lipid intermediate biosynthetic process. (424 aa)
PIG-BGPI mannosyltransferase 3; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2- GlcN-acyl-PI during GPI precursor assembly (By similarity). Belongs to the glycosyltransferase 22 family. PIGB subfamily. (561 aa)
fwFurrowed, isoform A; Furrowed (fw) encodes a selectin that mediates the interaction of planar cell polarity proteins by stabilizing the product of fz. (1174 aa)
hecHector, isoform A; Hector (hec) encodes a G-protein coupled receptor involved in male courtship behavior. (486 aa)
Alg14ALG14, UDP-N-acetylglucosaminyltransferase subunit; N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity. It is involved in the biological process described with: dolichol-linked oligosaccharide biosynthetic process. (191 aa)
PIG-FPhosphatidylinositol glycan anchor biosynthesis class F; Mannose-ethanolamine phosphotransferase activity. It is involved in the biological process described with: GPI anchor biosynthetic process. (236 aa)
IRSp53Insulin receptor substrate 53 kDa (IRSp53) encodes a protein required for filopodia formation during the adhesion and fusion of myoblasts. (1076 aa)
Alg10Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase; Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol (By similarity). Belongs to the ALG10 glucosyltransferase family. (449 aa)
PIG-WaPhosphatidylinositol-glycan biosynthesis class W protein; Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor. (459 aa)
PGAP2Post-GPI attachment to proteins factor 2; Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface (By similarity); Belongs to the PGAP2 family. (255 aa)
PGAP5Metallophosphoesterase 1 homolog; Post-GPI attachment to proteins 5 (PGAP5) encodes a protein that belongs to a dimetal-containing phosphoesterase family and catalyzes the remodeling of the glycan moiety on glycosylphosphatidylinositol (GPI)-anchored proteins. Its catalytic activity is a prerequisite for the efficient exit of GPI-anchor proteins from the ER; Belongs to the metallophosphoesterase superfamily. MPPE1 family. (370 aa)
wolDolichyl-phosphate beta-glucosyltransferase; Required for normal production of N-glycosylated proteins in the endoplasmic reticulum (ER). Required for embryonic segmentation, dorsal-ventral patterning and gastrulation. Required for chitin orientation and shaping of the apical and lateral plasma membranes of epidermal cells during cuticle differentiation. Also required for correctly shaping apical membrane topology of the epithelia of other organs such as the midgut and the hindgut. (326 aa)
PIG-UPhosphatidylinositol glycan anchor biosynthesis class U (PIG-U) encodes a subunit of glycosylphosphatidylinositol (GPI) transamidase, which mediates GPI anchoring in the endoplasmic reticulum. GPI anchor attachment serves as a general mechanism for linking proteins to the cell surface membrane. (426 aa)
gnyProbable dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase; Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol. Involved in cuticle differentiation. (475 aa)
Alg7GH19029p; phospho-N-acetylmuramoyl-pentapeptide-transferase activity; UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity. It is involved in the biological process described with: protein N-linked glycosylation; dolichyl diphosphate biosynthetic process. (409 aa)
Dpm1Probable dolichol-phosphate mannosyltransferase; Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; Belongs to the glycosyltransferase 2 family. (241 aa)
Alg12Probable Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase; Adds the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation; Belongs to the glycosyltransferase 22 family. (678 aa)
Alg1ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase; Mannosyltransferase activity. It is involved in the biological process described with: protein glycosylation. (446 aa)
Alg9Mannosyltransferase activity; alpha-1,2-mannosyltransferase activity. It is involved in the biological process described with: protein N-linked glycosylation. (623 aa)
PIG-PPhosphatidylinositol glycan anchor biosynthesis class P; Phosphatidylinositol N-acetylglucosaminyltransferase activity. It is involved in the biological process described with: GPI anchor biosynthetic process. (158 aa)
Alg13Glyco_tran_28_C domain-containing protein; N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity. It is involved in the biological process described with: dolichol-linked oligosaccharide biosynthetic process. (171 aa)
PIG-OPhosphatidylinositol glycan anchor biosynthesis class O; Mannose-ethanolamine phosphotransferase activity. It is involved in the biological process described with: GPI anchor biosynthetic process. (1077 aa)
CG8311Uncharacterized protein; Dolichol kinase activity. It is involved in the biological process described with: dolichyl monophosphate biosynthetic process. (503 aa)
GalT1Hexosyltransferase; Beta1,3-galactosyltransferase 1 (GalT1) encodes an enzyme involved in protein N-linked glycosylation. (466 aa)
CG30037Hexosyltransferase; Acetylgalactosaminyltransferase activity; acetylglucosaminyltransferase activity; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity; transferase activity, transferring hexosyl groups. It is involved in the biological process described with: protein N-linked glycosylation; protein glycosylation; protein O-linked glycosylation; oligosaccharide biosynthetic process. (420 aa)
CG30036Hexosyltransferase; Transferase activity, transferring hexosyl groups; acetylgalactosaminyltransferase activity; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity; acetylglucosaminyltransferase activity. It is involved in the biological process described with: protein N-linked glycosylation; oligosaccharide biosynthetic process; protein glycosylation; protein O-linked glycosylation. (388 aa)
PIG-NPhosphatidylinositol glycan anchor biosynthesis class N; Mannose-ethanolamine phosphotransferase activity. It is involved in the biological process described with: GPI anchor biosynthetic process. (894 aa)
PIG-GPhosphatidylinositol glycan anchor biosynthesis class G; CP2 mannose-ethanolamine phosphotransferase activity. It is involved in the biological process described with: GPI anchor biosynthetic process. (927 aa)
Dpm3Dolichol-phosphate mannosyltransferase subunit 3; Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER. Belongs to the DPM3 family. (94 aa)
Dpm2Dolichol phosphate-mannose biosynthesis regulatory protein; Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization. Belongs to the DPM2 family. (81 aa)
Alg11ALG11, alpha-1,2-mannosyltransferase, isoform A; GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity. It is involved in the biological process described with: protein N-linked glycosylation; oligosaccharide-lipid intermediate biosynthetic process. (475 aa)
PIG-WbPhosphatidylinositol-glycan biosynthesis class W protein; Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor. (504 aa)
PIG-HPhosphatidylinositol glycan anchor biosynthesis class H, isoform A; It is involved in the biological process described with: GPI anchor biosynthetic process. (221 aa)
PIG-VGPI mannosyltransferase 2; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly. Required for the GPI-mediated endoplasmic reticulum exit and proper targeting to the cell surface of chp. Required for GPI-mediated membrane attachment of chp, qsm and Cont. Essential for microvillar stability in the rhabdomere; Belongs to the PIGV family. (449 aa)
PIG-SPhosphatidylinositol glycan anchor biosynthesis class S (PIG-S) encodes a subunit of glycosylphosphatidylinositol (GPI) transamidase, which mediates GPI anchoring in the endoplasmic reticulum. GPI anchor attachment serves as a general mechanism for linking proteins to the cell surface membrane. (536 aa)
sud1Sudestada1 (sud1) encodes a prolyl hydroxylase that modifies a specific prolyl residue of the small ribosomal subunit protein encoded by RpS23. Lack of sud1 affects growth, triggers the unfolded protein response, as well as apoptosis and autophagy; Belongs to the TPA1 family. (536 aa)
PIG-XPhosphatidylinositol glycan anchor biosynthesis class X, isoform C; It is involved in the biological process described with: GPI anchor biosynthetic process. (243 aa)
PIG-APhosphatidylinositol glycan anchor biosynthesis class A, isoform A; Phosphatidylinositol N-acetylglucosaminyltransferase activity. It is involved in the biological process described with: GPI anchor biosynthetic process. (479 aa)
PIG-QPhosphatidylinositol glycan anchor biosynthesis class Q (PIG-Q) encodes a protein required for the biosynthesis of glycosylphosphatidylinositol, which is a component for anchoring eukaryotic proteins to membranes. (481 aa)
PIG-LPhosphatidylinositol glycan anchor biosynthesis class L, isoform B; N-acetylglucosaminylphosphatidylinositol deacetylase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides. It is involved in the biological process described with: GPI anchor biosynthetic process. (365 aa)
PIG-ZGPI mannosyltransferase 4; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. Transfers a fourth mannose to some trimannosyl- GPIs during GPI precursor assembly (By similarity). (696 aa)
PIG-CPhosphatidylinositol glycan anchor biosynthesis class C (PIG-C) encodes a subunit of GPI-GlcNAc transferase, which catalyzes the first reaction in the biosynthesis of the glycosylphosphatidylinositol (GPI)-anchor. (312 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.