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CG8051 CG8051 ZnT77C ZnT77C ZnT35C ZnT35C Catsup Catsup Ctr1B Ctr1B ZnT86D ZnT86D CG14864 CG14864 Zip89B Zip89B MtnC MtnC Mco3 Mco3 Ctr1C Ctr1C ZnT41F ZnT41F Zip42C.1 Zip42C.1 ZnT49B ZnT49B Zip48C Zip48C Zip99C Zip99C Hsc20 Hsc20 MTF-1 MTF-1 Zip88E Zip88E Ccs Ccs ZnT33D ZnT33D Mco1 Mco1 CG30345 CG30345 Zip42C.2 Zip42C.2 MtnD MtnD Ctr1A Ctr1A Mvl Mvl ZnT63C ZnT63C Atox1 Atox1 Fer2LCH Fer2LCH Fer1HCH Fer1HCH ATP7 ATP7 MtnA MtnA dao dao Zip102B Zip102B MtnB MtnB MtnE MtnE Tsf1 Tsf1 Zip71B Zip71B
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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CG8051SD10554p; Monocarboxylic acid transmembrane transporter activity. It is involved in the biological process described with: transmembrane transport; monocarboxylic acid transport. (616 aa)
ZnT77CZinc transporter 77C (ZnT77C) encodes a protein involved in zinc detoxification and zinc transmembrane import. (513 aa)
ZnT35CZinc transporter 35C (ZnT35C) encodes a protein involved in cellular and organismal zinc efflux that plays a major role in the detoxification of zinc excess. ZnT35C is a target of the metal-responsive transcription factor encoded by MTF-1. (472 aa)
CatsupProtein catecholamines up; Negatively regulates tyrosine hydroxylase activity; Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily. (449 aa)
Ctr1BCopper transporter 1B (Ctr1B) encodes a protein that ensures copper uptake in the intestine. Ctr1B transcription is upregulated under conditions of copper depletion via the metal-responsive transcription factor encoded by MTF-1. (174 aa)
ZnT86DZinc transporter 86D (ZnT86D) encodes a transporter involved in zinc detoxification. (366 aa)
CG14864Uncharacterized protein, isoform A. (547 aa)
Zip89BZinc/iron regulated transporter-related protein 89B (Zip89B) encodes a protein involved in zinc detoxification and zinc transmembrane import. (495 aa)
MtnCMetallothionein-3; Metallothionein C (MtnC) encodes a member of the Metallothionein family whose transcription is strongly inducible by copper and cadmium ions. Its induction depends on the transcription factor encoded by MTF-1; Belongs to the metallothionein superfamily. Type 5 family. (43 aa)
Mco3Multicopper oxidase 3 (Mco3) encodes a multi-copper oxidase enzyme that is located in the cellular secretory pathway. It is developmentally regulated and has been proposed to affect iron and copper homeostasis. (677 aa)
Ctr1CCopper transporter 1C (Ctr1C) is expressed in the male gonad. The autosomal gene seems to have originated as a retrogene copy of the X-linked Ctr1A, thus maintaining copper delivery during male spermatogenesis when the X chromosome is inactive. (270 aa)
ZnT41FZinc ion transmembrane transporter activity. It is involved in the biological process described with: detoxification of zinc ion; regulation of sequestering of zinc ion; zinc ion transport; zinc ion transmembrane transport; response to zinc ion. (498 aa)
Zip42C.1Zinc/iron regulated transporter-related protein 42C.1 (Zip42C.1) encodes a plasma membrane resident zinc transporter belonging to the Zinc-Iron Permease family. It works together with the products of Zip42C.2 and Zip89B in dietary zinc absorption. (352 aa)
ZnT49BZinc transporter 49B, isoform B; Cation transmembrane transporter activity. It is involved in the biological process described with: transmembrane transport; cation transport. (660 aa)
Zip48CZinc/iron regulated transporter-related protein 48C; Zinc ion transmembrane transporter activity. It is involved in the biological process described with: zinc ion transmembrane transport. (341 aa)
Zip99CZinc/iron regulated transporter-related protein 99C (Zip99C) encodes an iron transporter located on the Golgi and endoplasmic reticulum that moves iron from the cytoplasm into the secretory compartments; Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily. (355 aa)
Hsc20Heat shock protein cognate 20 (Hsc20) encodes a mitochondrial chaperone that facilitates iron sulfur cluster assembly or transfer from the product of IscU to other scaffold proteins. Hsc20 is required for larval growth and cellular iron sensing. (240 aa)
MTF-1Metal response element-binding Transcription Factor-1 (MTF-1) encodes a zinc finger protein that primarily controls the homeostasis of physiological trace metals, such as zinc and copper, and the detoxification of non-essential, toxic heavy metals, such as cadmium, mercury, and silver. It activates a number of genes in response to heavy metal load but also induces transcription of the copper importer encoded by Ctr1B upon copper depletion. Variations in the DNA binding site can affect its response to a specific metal. (1006 aa)
Zip88EZinc/iron regulated transporter-related protein 88E; Zinc ion transmembrane transporter activity. It is involved in the biological process described with: zinc ion transmembrane transport. (366 aa)
CcsCopper chaperone for superoxide dismutase (Ccs) encodes a protein required for the proper superoxide dismutase function of the product of Sod1. It is involved in determination of lifespan, oxidative stress, and cytosolic aconitase activity. (264 aa)
ZnT33DZinc ion transmembrane transporter activity. (701 aa)
Mco1Multicopper oxidase 1 (Mco1) encodes a plasma membrane-bound multicopper oxidase that is positioned to oxidize substrates in the hemolymph, such as ascorbate, and its biological role is unknown. (959 aa)
CG30345IP12271p; Transporter activity. It is involved in the biological process described with: transmembrane transport. (496 aa)
Zip42C.2Zinc/iron regulated transporter-related protein 42C.2 (Zip42C.2) encodes a protein involved in zinc detoxification and zinc transmembrane import. (310 aa)
MtnDMetallothionein-4; Metallothionein D (MtnD) encodes a member of the Metallothionein family whose transcription is strongly inducible by copper and cadmium ions. Its induction depends on the transcription factor encoded by MTF-1; Belongs to the metallothionein superfamily. Type 5 family. (44 aa)
Ctr1ACopper transporter 1A (Ctr1A) encodes a plasma membrane protein that functions as a copper transporter. It is required to drive neuropeptide maturation during normal growth and development. (241 aa)
MvlMalvolio (Mvl) encodes a member of the SLC11 family of metal ion transporters that transports divalent metal cations, including Mn[2+] and Fe[2+]. Its function has been linked to feeding-related decisions, possibly via modulation of dopaminergic signaling. (639 aa)
ZnT63CZinc transporter 63C, isoform F; Zinc transporter 63C (ZnT63C) encodes a plasma membrane resident zinc transporter belonging to the zinc transporter family that is mainly responsible for zinc export from the cell or into organelles. It plays a key role in effluxing zinc from enterocytes into circulation during dietary zinc absorption. (545 aa)
Atox1Antioxidant 1 copper chaperone (Atox1) null mutants are unable to develop on low-copper food. Furthermore, the intestinal copper importer encoded by Ctr1B, which is regulated by copper demand, fails to be induced upon copper starvation in Atox1 mutant larvae, while intestinal metallothionein is upregulated. This suggests intestinal copper accumulation, combined with insufficient delivery to the rest of the body. (89 aa)
Fer2LCHFerritin 2 light chain homologue (Fer2LCH) encodes one of two subunits of the major iron storage complex, the ferritin molecule. In insects, ferritin is assembled from 12 Fer1HCH and 12 Fer2LCH subunits and can be found in the secretory pathway of cells and in hemolymph. The product of Fer2LCH provides iron nucleation sites in the internal cavity of the complex required for iron mineralization and is essential for embryogenesis. (236 aa)
Fer1HCHFerritin 1 heavy chain homologue (Fer1HCH) encodes one of two subunits of the major iron storage complex, the ferritin molecule. In insects, ferritin is assembled from 12 Fer1HCH and 12 Fer2LCH subunits and can be found in the secretory pathway of cells and in hemolymph. The product of Fer1HCH has ferroxidase activity required for iron loading into ferritin and is essential for embryogenesis. (245 aa)
ATP7ATP7, isoform B; ATP7 (ATP7) encodes a copper transmembrane transporter involved in cuticle pigmentation, copper homeostasis and larval development. (1254 aa)
MtnAMetallothionein-1; Metallothionein A (MtnA) encodes a member of the Metallothionein family whose transcript level is higher than that of the other four Drosophila metallothioneins. Transcription is strongly induced by copper and cadmium ions and this induction depends on the transcription factor encoded by MTF-1; Belongs to the metallothionein superfamily. Type 5 family. (40 aa)
daoDown and out, isoform A. (882 aa)
Zip102BZinc/iron regulated transporter-related protein 102B, isoform E; Metal ion transmembrane transporter activity. It is involved in the biological process described with: metal ion transport; transmembrane transport. (297 aa)
MtnBMetallothionein-2; Metallothionein B (MtnB) encodes one of the five metallothioneins. They are metal-binding polypeptides that coordinate both physiological and xenobiotic metal ions, either for homeostasis or detoxification purposes. The product of MtnB shows a preference towards divalent metal ion binding. (43 aa)
MtnEMetallothionein E (MtnE) encodes one of the five metallothioneins. They are metal-binding polypeptides that coordinate both physiological and xenobiotic metal ions, either for homeostasis or detoxification purposes. The product of MtnE shows the least specificity towards binding metal ions. (41 aa)
Tsf1Transferrin 1 (Tsf1) encodes an iron binding protein induced during the immune response. Iron sequestration is a classical host defense mechanism to combat bacterial infection. (641 aa)
Zip71BZinc/iron regulated transporter-related protein 71B (Zip71B) encodes a protein involved in zinc detoxification and zinc transmembrane import. (572 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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