STRINGSTRING
Gr5a Gr5a Gr9a Gr9a Gr58a Gr58a Gr58b Gr58b Gr59a Gr59a Gr59b Gr59b Gr59c Gr59c Gr59f Gr59f Gr59e Gr59e Gr64a Gr64a Gr10b Gr10b Ir20a Ir20a Gr23a Gr23a Gr22e Gr22e Gr22a Gr22a Gr22c Gr22c Gr22f Gr22f Gr77a Gr77a Gr28a Gr28a Gr32a Gr32a Gr33a Gr33a Gr36a Gr36a Gr36b Gr36b Gr39a Gr39a Gr39b Gr39b Gr85a Gr85a Gr92a Gr92a Gr93a Gr93a Gr93c Gr93c Ir94a Ir94a Gr94a Gr94a Gr98a Gr98a Gr98d Gr98d Ir100a Ir100a Gr57a Gr57a Ir56b Ir56b Ir56d Ir56d Ir56a Ir56a Gr47b Gr47b Ir47a Ir47a Gr89a Gr89a Ir62a Ir62a Gr22b Gr22b Gr64e Gr64e Ir52a Ir52a Ir52b Ir52b Gr93b Gr93b Ir94f Ir94f Ir60b Ir60b Gr2a Gr2a Gr66a Gr66a Gr47a Gr47a Gr64c Gr64c Gr22d Gr22d Ir60e Ir60e Ir11a Ir11a Ir94c Ir94c Gr64d Gr64d Gr43a Gr43a Gr97a Gr97a Gr10a Gr10a
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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Gr5aGustatory receptor 5a for trehalose; Gustatory receptor required for response to the sugar trehalose in taste neurons. Gr5a neurons selectively respond to sugars, in contrast to Gr66a cells which respond to bitter compounds. Flies are attracted to sugars and avoid bitter substances, suggesting that Gr5a neuron activity is sufficient to mediate acceptance behavior. Sugar signal transduction occurs through coupling with G-proteins such as Galpha49B and G-salpha60A. (444 aa)
Gr9aPutative gustatory receptor 9a; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (341 aa)
Gr58aPutative gustatory receptor 58a; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (395 aa)
Gr58bPutative gustatory receptor 58b; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (408 aa)
Gr59aGustatory receptor; Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates; Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. (367 aa)
Gr59bGustatory receptor; Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates; Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. (366 aa)
Gr59cPutative gustatory receptor 59c; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (397 aa)
Gr59fPutative gustatory receptor 59f; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (406 aa)
Gr59ePutative gustatory receptor 59e; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (399 aa)
Gr64aGustatory receptor for sugar taste 64a; One of the few identified sugar gustatory receptors identified so far and which promotes the starvation-induced increase of feeding motivation. Required in combination with Gr64f to detect sucrose, maltose, and glucose. Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr5a subfamily. (456 aa)
Gr10bPutative gustatory receptor 10b; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates; Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr10a subfamily. (373 aa)
Ir20aIonotropic receptor 20a; Ligand-gated ion channel activity. It is involved in the biological process described with: detection of chemical stimulus. (563 aa)
Gr23aGustatory receptor 23a; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates; Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr2a subfamily. (374 aa)
Gr22eGustatory receptor for bitter taste 22e; Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. Seems to be involved in the sensing of bitter taste since it is expressed in neurons that mediate sensitivity to bitter compounds which are also avoidance-type taste neurons. (389 aa)
Gr22aPutative gustatory receptor 22a; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (394 aa)
Gr22cPutative gustatory receptor 22c; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (383 aa)
Gr22fPutative gustatory receptor 22f; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (378 aa)
Gr77aPutative gustatory receptor 77a; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (449 aa)
Gr28aPutative gustatory receptor 28a; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates (By similarity). Atypical expression suggests also nongustatory roles in the nervous system and tissues involved in proprioception, hygroreception, and other sensory modalities. It is also possible that it has chemosensory roles in the detection of internal ligands. (450 aa)
Gr32aGustatory and pheromone receptor 32a; Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. Required for the response to N,N-Diethyl-meta-toluamide (DEET), the most widely used insect repellent worldwide. Functions as a pheromone receptor for a male inhibitory pheromone and promotes male-male aggression and suppresses male-male courtship. Also promotes preferentially virgin females courting over mated females. Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr21a subfamily. (461 aa)
Gr33aGustatory and pheromone receptor 33a; Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. Required for sensing all nonvolatile repulsive chemicals, including tastants, pheromones, and especially N,N-Diethyl-meta-toluamide (DEET), the most widely used insect repellent worldwide. Functions also as a pheromone receptor for a male inhibitory pheromone leading to male-male courtship suppression. Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr66a subfamily. (475 aa)
Gr36aPutative gustatory receptor 36a; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates; Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr22e subfamily. (391 aa)
Gr36bPutative gustatory receptor 36b; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (391 aa)
Gr39aGustatory and pheromone receptor 39a, isoform C; Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. Plays a role in sustaining courtship behavior in males, possibly through the reception of a stimulating arrestant pheromone. (381 aa)
Gr39bPutative gustatory receptor 39b; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates (By similarity). Has also atypical sensory function in organ not limited to conventional taste sensing like abdominal ganglions. (369 aa)
Gr85aPutative gustatory receptor 85a; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates; Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr22e subfamily. (397 aa)
Gr92aPutative gustatory receptor 92a; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates; Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr93a subfamily. (386 aa)
Gr93aGustatory receptor for bitter taste 93a; Gustatory receptor required for response to the bitter in taste neurons. Gr93a cells respond to bitter compounds such as caffeine. Flies avoid bitter substances, suggesting that Gr93a neuron activity is sufficient to mediate avoidance behavior. Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr93a subfamily. (419 aa)
Gr93cPutative gustatory receptor 93c; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (397 aa)
Ir94aIonotropic receptor 94a; Ligand-gated ion channel activity. It is involved in the biological process described with: detection of chemical stimulus. (595 aa)
Gr94aPutative gustatory receptor 94a; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (404 aa)
Gr98aPutative gustatory receptor 98a; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates; Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr2a subfamily. (391 aa)
Gr98dPutative gustatory receptor 98d; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates; Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr2a subfamily. (412 aa)
Ir100aIonotropic receptor 100a; Ligand-gated ion channel activity. It is involved in the biological process described with: sensory perception of taste; detection of chemical stimulus. (603 aa)
Gr57aPutative gustatory receptor 57a; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (416 aa)
Ir56bIonotropic receptor 56b; Ligand-gated ion channel activity. It is involved in the biological process described with: detection of chemical stimulus. (408 aa)
Ir56dIonotropic receptor 56d; Ligand-gated ion channel activity. It is involved in the biological process described with: detection of chemical stimulus. (632 aa)
Ir56aIonotropic receptor 56a; Ligand-gated ion channel activity. It is involved in the biological process described with: detection of chemical stimulus. (603 aa)
Gr47bPutative gustatory receptor 47b; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (414 aa)
Ir47aIonotropic receptor 47a; Ligand-gated ion channel activity. It is involved in the biological process described with: detection of chemical stimulus. (593 aa)
Gr89aPutative gustatory receptor 89a; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates; Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr77a subfamily. (362 aa)
Ir62aIonotropic receptor 62a; Ligand-gated ion channel activity. It is involved in the biological process described with: detection of chemical stimulus. (606 aa)
Gr22bPutative gustatory receptor 22b; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates (By similarity). Seems to be involved in the sensing of bitter taste since it is expressed in neurons that mediate sensitivity to bitter compounds. (386 aa)
Gr64eGustatory receptor for sugar taste 64e; One of the few identified sugar gustatory receptors identified so far and which promotes the starvation-induced increase of feeding motivation. confers responsiveness to glycerol and is required for feeding preference for beer and other sources that have fermenting yeast. (460 aa)
Ir52aIonotropic receptor 52a; Ligand-gated ion channel activity. It is involved in the biological process described with: detection of chemical stimulus. (599 aa)
Ir52bIonotropic receptor 52b; Ligand-gated ion channel activity. It is involved in the biological process described with: detection of chemical stimulus. (596 aa)
Gr93bPutative gustatory receptor 93b; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (395 aa)
Ir94fIonotropic receptor 94f; Ligand-gated ion channel activity. It is involved in the biological process described with: detection of chemical stimulus. (558 aa)
Ir60bIonotropic receptor 60b; Ligand-gated ion channel activity. It is involved in the biological process described with: detection of chemical stimulus. (577 aa)
Gr2aPutative gustatory receptor 2a; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its not yet determined substrates. Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr2a subfamily. (428 aa)
Gr66aGustatory receptor for bitter taste 66a; Gustatory receptor required for response to the bitter in taste neurons. Gr66a cells respond to bitter compounds such as caffeine, theophylline, threonine or valine. Flies avoid bitter substances, suggesting that Gr66a neuron activity is sufficient to mediate avoidance behavior. Required for sensing and avoiding N,N- Diethyl-meta-toluamide (DEET), the most widely used insect repellent worldwide, as well as to L-canavanine, a plant-derived insecticide. Gr66a neurons are also involved in the sex-specific perception of molecules inducing male avoid [...] (527 aa)
Gr47aGustatory receptor; Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates; Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. (361 aa)
Gr64cGustatory receptor for sugar taste 64c; One of the few identified sugar gustatory receptors identified so far and which promotes the starvation-induced increase of feeding motivation. (419 aa)
Gr22dGustatory receptor 22d (Gr22d) encodes a transmembrane domain protein unrelated to GPCRs that is predicted to mediate response to non-volatile compounds. (387 aa)
Ir60eIonotropic receptor 60e; Ligand-gated ion channel activity. It is involved in the biological process described with: detection of chemical stimulus. (572 aa)
Ir11aIonotropic receptor 11a; Ligand-gated ion channel activity. It is involved in the biological process described with: sensory perception of taste; detection of chemical stimulus. (642 aa)
Ir94cIonotropic receptor 94c; Ligand-gated ion channel activity. It is involved in the biological process described with: detection of chemical stimulus. (604 aa)
Gr64dGustatory receptor for sugar taste 64d; One of the few identified sugar gustatory receptors identified so far and which promotes the starvation-induced increase of feeding motivation; Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr5a subfamily. (417 aa)
Gr43aGustatory receptor for sugar taste 43a; Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. Gr43a is the main sugar receptor in larvae. Functions as a narrowly tuned fructose receptor in taste neurons but also as a fructose receptor in the brain. Necessary and sufficient to sense hemolymph fructose and promote feeding in hungry flies but suppress feeding in satiated flies. (453 aa)
Gr97aPutative gustatory receptor 97a; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (425 aa)
Gr10aGustatory receptor 10a; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (408 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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