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kdn kdn Fum1 Fum1 Fum2 Fum2 CG33791 CG33791 Scsalpha1 Scsalpha1 CG7430 CG7430 CG10749 CG10749 CG10748 CG10748 SdhAL SdhAL CG32026 CG32026 ScsbetaG ScsbetaG Fum4 Fum4 mAcon2 mAcon2 CG5214 CG5214 CG6629 CG6629 CG14740 CG14740 Men Men Mdh2 Mdh2 Scsalpha2 Scsalpha2 SdhD SdhD SdhB SdhB SdhA SdhA Pepck1 Pepck1 PCB PCB ATPCL ATPCL ScsbetaA ScsbetaA Menl-1 Menl-1 Fum3 Fum3 Idh Idh Nc73EF Nc73EF SdhC SdhC SdhBL SdhBL Mdh1 Mdh1 mAcon1 mAcon1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
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kdnProbable citrate synthase, mitochondrial; Plays a role in controlling neuronal activity and seizure susceptibility; Belongs to the citrate synthase family. (522 aa)
Fum1Fumarase 1, isoform A; Fumarate hydratase activity. It is involved in the biological process described with: fumarate metabolic process; tricarboxylic acid cycle. (495 aa)
Fum2Fumarase 2; Fumarate hydratase activity. It is involved in the biological process described with: tricarboxylic acid cycle; malate metabolic process; fumarate metabolic process. (503 aa)
CG33791GH27234p; Oxoglutarate dehydrogenase (succinyl-transferring) activity; thiamine pyrophosphate binding. It is involved in the biological process described with: tricarboxylic acid cycle. (1282 aa)
Scsalpha1Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. (328 aa)
CG7430Flavin adenine dinucleotide binding; dihydrolipoyl dehydrogenase activity; electron transfer activity. It is involved in the biological process described with: tricarboxylic acid cycle; lipoamide metabolic process; oxidation-reduction process; glycine catabolic process; cell redox homeostasis. (504 aa)
CG10749L-malate dehydrogenase activity. It is involved in the biological process described with: carbohydrate metabolic process; malate metabolic process; tricarboxylic acid cycle. (347 aa)
CG10748L-malate dehydrogenase activity. It is involved in the biological process described with: tricarboxylic acid cycle; malate metabolic process; carbohydrate metabolic process. (349 aa)
SdhALSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (651 aa)
CG32026GH12815p; Magnesium ion binding; NAD binding; isocitrate dehydrogenase (NAD+) activity. It is involved in the biological process described with: tricarboxylic acid cycle; isocitrate metabolic process. (719 aa)
ScsbetaGSuccinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (416 aa)
Fum4Fumarase 4; Fumarate hydratase activity. It is involved in the biological process described with: fumarate metabolic process; malate metabolic process; tricarboxylic acid cycle. (484 aa)
mAcon2Aconitate hydratase, mitochondrial; 4 iron, 4 sulfur cluster binding; aconitate hydratase activity. It is involved in the biological process described with: tricarboxylic acid cycle; multicellular organism reproduction; Belongs to the aconitase/IPM isomerase family. (783 aa)
CG5214GM01350p; Dihydrolipoyllysine-residue succinyltransferase activity. It is involved in the biological process described with: cellular respiration; tricarboxylic acid cycle. (468 aa)
CG6629AT18465p; Succinate dehydrogenase activity. It is involved in the biological process described with: tricarboxylic acid cycle; mitochondrial electron transport, succinate to ubiquinone. (261 aa)
CG14740Citrate (Si)-synthase activity. It is involved in the biological process described with: carbohydrate metabolic process; tricarboxylic acid cycle. (478 aa)
MenMalic enzyme (Men) encodes a dehydrogenase that catalyzes the oxidation of malate to pyruvate, with the concomitant reduction of NADP[+] to NADPH. It functions, along with the products of Idh, Zw, and Pgd, in a small network of NADP reducing enzymes. (763 aa)
Mdh2Malate dehydrogenase 2 (Mdh2) encodes one of the enzymes in the tricarboxylic acid cycle in mitochondria; Belongs to the LDH/MDH superfamily. (336 aa)
Scsalpha2Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. (342 aa)
SdhDSuccinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. (182 aa)
SdhBSuccinate dehydrogenase, subunit B (iron-sulfur) (SdhB) encodes the iron-sulfur cluster-containing subunit of the succinate dehydrogenase complex, which oxidizes succinate to fumarate and passes the electrons to quinones. The redox-active cofactors in this subunit are part of the electron transfer machinery in the complex; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (297 aa)
SdhASuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Maintaining electron transport chain function is required to prevent neurodegenerative changes seen in both early- and late-onset disorders. (661 aa)
Pepck1Phosphoenolpyruvate carboxykinase 1 (Pepck1) encodes an enzyme that converts oxaloacetate into phosphoenolpyruvate. It catalyzes the first committed step in gluconeogenesis and thus plays an essential role in glucose metabolism. (647 aa)
PCBPyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1197 aa)
ATPCLATP-citrate synthase; ATP citrate lyase (ATPCL) encodes a protein involved in glucose homeostasis; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family. (1112 aa)
ScsbetaASuccinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (503 aa)
Menl-1Malic enzyme; Malate dehydrogenase (decarboxylating) (NAD+) activity; malate dehydrogenase (decarboxylating) (NADP+) activity; NAD binding; malic enzyme activity. It is involved in the biological process described with: pyruvate metabolic process; oxidation-reduction process; malate metabolic process. (610 aa)
Fum3Fumarase 3, isoform A; Fumarate hydratase activity. It is involved in the biological process described with: fumarate metabolic process; malate metabolic process; tricarboxylic acid cycle. (470 aa)
IdhIsocitrate dehydrogenase (Idh) encodes a cytosolic enzyme that catalyzes the oxidative decarboxylation of isocitrate to 2-oxoglutarate, with the concomitant reduction of NADP[+] to NADPH. It functions, along with Men, Zw, and Pgd, in a small network of NADP reducing enzymes. (479 aa)
Nc73EFNeural conserved at 73EF, isoform I; Oxoglutarate dehydrogenase (succinyl-transferring) activity; thiamine pyrophosphate binding. It is involved in the biological process described with: tricarboxylic acid cycle. (1105 aa)
SdhCSuccinate dehydrogenase, subunit C (SdhC) encodes a protein involved in mitochondrial electron transport and oxidative stress response. (171 aa)
SdhBLSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (437 aa)
Mdh1Malate dehydrogenase 1 (Mdh1) encodes a L-malate dehydrogenase involved in the interconversion of malate and oxaloacetate. (337 aa)
mAcon1Aconitate hydratase, mitochondrial; Mitochondrial aconitase 1 (mAcon1) encodes an enzyme that harbors an iron-sulfur cluster and catalyses the first step of the Krebs Cycle in mitochondria, converting citrate into isocitrate; Belongs to the aconitase/IPM isomerase family. (787 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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