(6 nodes) PAM complex, Tim23 associated import motor, and Pam16 network (Drosophila melanogaster)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CG11779	Mitochondrial import inner membrane translocase subunit TIM44; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the Tim44 family. (459 aa)
	Hsc70-5	Heat shock 70 kDa protein cognate 5. (686 aa)
	Roe1	GrpE protein homolog, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity). (213 aa)
	Tim23	Translocase of inner mitochondrial membrane 23; Protein transmembrane transporter activity. It is involved in the biological process described with: protein import into mitochondrial matrix. (206 aa)
	CG7394	Mitochondrial import inner membrane translocase subunit TIM14; Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity). (128 aa)
	blp	Mitochondrial import inner membrane translocase subunit Tim16; Black pearl (blp) encodes a conserved mitochondrial inner membrane protein. Its loss decreases cytochrome c oxidase activity and causes ROS production, leading to melanotic lesions ("black pearls") in blp-deficient flies; Belongs to the TIM16/PAM16 family. (141 aa)

Your Current Organism:

Drosophila melanogaster

NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CG11779	CG7394	FBpp0083163	FBpp0288463	Mitochondrial import inner membrane translocase subunit TIM44; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the Tim44 family.	Mitochondrial import inner membrane translocase subunit TIM14; Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity).	0.873
CG11779	Hsc70-5	FBpp0083163	FBpp0086694	Mitochondrial import inner membrane translocase subunit TIM44; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the Tim44 family.	Heat shock 70 kDa protein cognate 5.	0.989
CG11779	Roe1	FBpp0083163	FBpp0086795	Mitochondrial import inner membrane translocase subunit TIM44; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the Tim44 family.	GrpE protein homolog, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity).	0.983
CG11779	Tim23	FBpp0083163	FBpp0112504	Mitochondrial import inner membrane translocase subunit TIM44; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the Tim44 family.	Translocase of inner mitochondrial membrane 23; Protein transmembrane transporter activity. It is involved in the biological process described with: protein import into mitochondrial matrix.	0.990
CG11779	blp	FBpp0083163	FBpp0311409	Mitochondrial import inner membrane translocase subunit TIM44; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the Tim44 family.	Mitochondrial import inner membrane translocase subunit Tim16; Black pearl (blp) encodes a conserved mitochondrial inner membrane protein. Its loss decreases cytochrome c oxidase activity and causes ROS production, leading to melanotic lesions ("black pearls") in blp-deficient flies; Belongs to the TIM16/PAM16 family.	0.941
CG7394	CG11779	FBpp0288463	FBpp0083163	Mitochondrial import inner membrane translocase subunit TIM14; Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity).	Mitochondrial import inner membrane translocase subunit TIM44; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the Tim44 family.	0.873
CG7394	Hsc70-5	FBpp0288463	FBpp0086694	Mitochondrial import inner membrane translocase subunit TIM14; Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity).	Heat shock 70 kDa protein cognate 5.	0.956
CG7394	Roe1	FBpp0288463	FBpp0086795	Mitochondrial import inner membrane translocase subunit TIM14; Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity).	GrpE protein homolog, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity).	0.797
CG7394	Tim23	FBpp0288463	FBpp0112504	Mitochondrial import inner membrane translocase subunit TIM14; Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity).	Translocase of inner mitochondrial membrane 23; Protein transmembrane transporter activity. It is involved in the biological process described with: protein import into mitochondrial matrix.	0.910
CG7394	blp	FBpp0288463	FBpp0311409	Mitochondrial import inner membrane translocase subunit TIM14; Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity).	Mitochondrial import inner membrane translocase subunit Tim16; Black pearl (blp) encodes a conserved mitochondrial inner membrane protein. Its loss decreases cytochrome c oxidase activity and causes ROS production, leading to melanotic lesions ("black pearls") in blp-deficient flies; Belongs to the TIM16/PAM16 family.	0.939
Hsc70-5	CG11779	FBpp0086694	FBpp0083163	Heat shock 70 kDa protein cognate 5.	Mitochondrial import inner membrane translocase subunit TIM44; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the Tim44 family.	0.989
Hsc70-5	CG7394	FBpp0086694	FBpp0288463	Heat shock 70 kDa protein cognate 5.	Mitochondrial import inner membrane translocase subunit TIM14; Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity).	0.956
Hsc70-5	Roe1	FBpp0086694	FBpp0086795	Heat shock 70 kDa protein cognate 5.	GrpE protein homolog, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity).	0.995
Hsc70-5	Tim23	FBpp0086694	FBpp0112504	Heat shock 70 kDa protein cognate 5.	Translocase of inner mitochondrial membrane 23; Protein transmembrane transporter activity. It is involved in the biological process described with: protein import into mitochondrial matrix.	0.974
Hsc70-5	blp	FBpp0086694	FBpp0311409	Heat shock 70 kDa protein cognate 5.	Mitochondrial import inner membrane translocase subunit Tim16; Black pearl (blp) encodes a conserved mitochondrial inner membrane protein. Its loss decreases cytochrome c oxidase activity and causes ROS production, leading to melanotic lesions ("black pearls") in blp-deficient flies; Belongs to the TIM16/PAM16 family.	0.736
Roe1	CG11779	FBpp0086795	FBpp0083163	GrpE protein homolog, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity).	Mitochondrial import inner membrane translocase subunit TIM44; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the Tim44 family.	0.983
Roe1	CG7394	FBpp0086795	FBpp0288463	GrpE protein homolog, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity).	Mitochondrial import inner membrane translocase subunit TIM14; Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity).	0.797
Roe1	Hsc70-5	FBpp0086795	FBpp0086694	GrpE protein homolog, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity).	Heat shock 70 kDa protein cognate 5.	0.995
Roe1	Tim23	FBpp0086795	FBpp0112504	GrpE protein homolog, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity).	Translocase of inner mitochondrial membrane 23; Protein transmembrane transporter activity. It is involved in the biological process described with: protein import into mitochondrial matrix.	0.807
Roe1	blp	FBpp0086795	FBpp0311409	GrpE protein homolog, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity).	Mitochondrial import inner membrane translocase subunit Tim16; Black pearl (blp) encodes a conserved mitochondrial inner membrane protein. Its loss decreases cytochrome c oxidase activity and causes ROS production, leading to melanotic lesions ("black pearls") in blp-deficient flies; Belongs to the TIM16/PAM16 family.	0.809