STRINGSTRING
CG18128 CG18128 Ak2 Ak2 cN-IIIB cN-IIIB nmdyn-D6 nmdyn-D6 CG6951 CG6951 Ak1 Ak1 CG11811 CG11811 CG17224 CG17224 CG10581 CG10581 CG8891 CG8891 CG8349 CG8349 Apf Apf RnrL RnrL dUTPase dUTPase CG31793 CG31793 nmdyn-D7 nmdyn-D7 CG5276 CG5276 Adk1 Adk1 AdSL AdSL AdSS AdSS Cmpk Cmpk CG6330 CG6330 Mesh1 Mesh1 CG15547 CG15547 l(2)k01209 l(2)k01209 NT5E-2 NT5E-2 CG30103 CG30103 Ak6 Ak6 RnrS RnrS CG3788 CG3788 kri kri CG5757 CG5757 CG42249 CG42249 CG8360 CG8360 CG8353 CG8353 NTPase NTPase Pde1c Pde1c Ak3 Ak3 CG11883 CG11883 veil veil CG32549 CG32549 AMPdeam AMPdeam Pde11 Pde11 bur bur Pde8 Pde8 CTPsyn CTPsyn awd awd Aprt Aprt Adk2 Adk2 ras ras
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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CG18128FI08065p; Purine-nucleoside phosphorylase activity. It is involved in the biological process described with: nucleoside metabolic process. (339 aa)
Ak2Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways; Belongs to the adenylate kinase family. AK2 subfamily. (240 aa)
cN-IIIB7-methylguanosine phosphate-specific 5'-nucleotidase; Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate. Also able to mediate hydrolysis of diphosphate (m(7)GDP) to 7-methylguanosine and 2 inorganic phosphate with lower activity. The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids. Also has weak activity for CMP. UMP and purine nucleotides are poor substrates. Belongs to the pyrimidine 5'-nucleotidase family. (319 aa)
nmdyn-D6Nucleoside diphosphate kinase activity. It is involved in the biological process described with: GTP biosynthetic process; nucleoside triphosphate biosynthetic process; CTP biosynthetic process; UTP biosynthetic process; nucleoside diphosphate phosphorylation. (151 aa)
CG6951Probable deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase. (203 aa)
Ak1ATP binding; adenylate kinase activity; uridylate kinase activity; Belongs to the adenylate kinase family. (229 aa)
CG11811GH06691p; Guanylate kinase activity. It is involved in the biological process described with: purine nucleotide metabolic process. (233 aa)
CG17224FI09636p; Uridine phosphorylase activity. It is involved in the biological process described with: nucleotide catabolic process; nucleoside metabolic process. (300 aa)
CG10581IP06402p; Nucleotide phosphatase activity, acting on free nucleotides. (189 aa)
CG8891Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (191 aa)
CG8349CMP/dCMP-type deaminase domain-containing protein; Cytidine deaminase activity; zinc ion binding. It is involved in the biological process described with: cytidine deamination. (264 aa)
ApfDiadenosine tetraphosphate hydrolase; Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity. (142 aa)
RnrLRibonucleoside-diphosphate reductase large subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (812 aa)
dUTPaseDeoxyuridine triphosphatase, isoform A; dUTP diphosphatase activity; magnesium ion binding. It is involved in the biological process described with: dUMP biosynthetic process; dUTP metabolic process; dUTP catabolic process. (188 aa)
CG31793LD28489p; ATPase activity; ATPase-coupled transmembrane transporter activity; ATP binding. It is involved in the biological process described with: transmembrane transport. (1307 aa)
nmdyn-D7FI21821p1; ATP binding; nucleoside diphosphate kinase activity. It is involved in the biological process described with: nucleoside diphosphate phosphorylation; UTP biosynthetic process; CTP biosynthetic process; GTP biosynthetic process; nucleoside triphosphate biosynthetic process; Belongs to the NDK family. (387 aa)
CG5276CG5276 protein; Nucleoside-diphosphatase activity; guanosine-diphosphatase activity; calcium ion binding; nucleoside-triphosphatase activity; uridine-diphosphatase activity. It is involved in the biological process described with: proteoglycan biosynthetic process. (419 aa)
Adk1AT16233p; Adenosine kinase activity. It is involved in the biological process described with: purine ribonucleoside salvage; AMP biosynthetic process. (396 aa)
AdSLAdenylosuccinate Lyase (AdSL) encodes a protein that might be a lyase involved in purine nucleotide metabolic process based on orthology; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (481 aa)
AdSSAdenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). Plays a role in the regulation of adult life span. (447 aa)
CmpkUMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (253 aa)
CG6330GH09623p; Uridine phosphorylase activity. It is involved in the biological process described with: nucleoside metabolic process; gravitaxis; nucleotide catabolic process. (368 aa)
Mesh1Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1; Metazoan SpoT homolog-1 (Mesh1) encodes a structural and functional ortholog of bacterial protein SpoT. It hydrolyzes ppGpp to GDP. Its mutants show retarded growth in amino acid-starved media, suggesting the conserved role in stringent responses. (179 aa)
CG15547NDK domain-containing protein; It is involved in the biological process described with: negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway. (390 aa)
l(2)k01209ATP binding; kinase activity; uridine kinase activity. It is involved in the biological process described with: nucleoside metabolic process; pyrimidine-containing compound salvage. (626 aa)
NT5E-2Ecto-5'-nucleotidase 2 (NT5E-2) encodes a glycosyl phosphatidylinositol (GPI)-linked membrane-bound glycoprotein with 5'-nucleotidase activity that converts extracellular AMP to adenosine; Belongs to the 5'-nucleotidase family. (585 aa)
CG30103Uncharacterized protein; It is involved in the biological process described with: AMP catabolic process; Belongs to the 5'-nucleotidase family. (584 aa)
Ak6Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. AMP is the best phosphate acceptor, and CMP is also a good substrate. All nucleoside triphosphates ATP, TTP, CTP, GTP, and UTP are accepted as phosphate donors. ATP is the best phosphate donor. May have a role in nuclear energy homeostasis; Belongs to the adenylate kinase family. AK6 subfamily. (175 aa)
RnrSRibonucleoside-diphosphate reductase subunit M2; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (393 aa)
CG3788Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (378 aa)
kriKrishah, isoform A; Krishah (kri) encodes a uracil phosphoribosyltransferase. (261 aa)
CG5757CG5757-PA; Thymidylate kinase activity; ATP binding; nucleoside diphosphate kinase activity; uridylate kinase activity. It is involved in the biological process described with: dUDP biosynthetic process; dTTP biosynthetic process; dTDP biosynthetic process. (211 aa)
CG42249Uncharacterized protein, isoform C; Nucleotide binding; nucleoside-diphosphatase activity; nucleoside-triphosphatase activity; metal ion binding. It is involved in the biological process described with: AMP catabolic process; Belongs to the 5'-nucleotidase family. (558 aa)
CG8360Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. (158 aa)
CG8353Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (170 aa)
NTPaseNTPase, isoform F; Uridine-diphosphatase activity; guanosine-diphosphatase activity; Belongs to the GDA1/CD39 NTPase family. (524 aa)
Pde1cCalcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1; Cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Required for male fertility and male mating behavior. (1173 aa)
Ak3GTP:AMP phosphotransferase, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (216 aa)
CG11883Uncharacterized protein, isoform C; Hydrolase activity. It is involved in the biological process described with: nucleotide catabolic process. (792 aa)
veilVeil, isoform A; Veil (veil) encodes a GPI-linked protein that functions as a 5'-nucleotidase; Belongs to the 5'-nucleotidase family. (599 aa)
CG32549Uncharacterized protein, isoform G; 5'-nucleotidase activity. (709 aa)
AMPdeamAMP deaminase activity. It is involved in the biological process described with: IMP biosynthetic process; IMP salvage; AMP metabolic process; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (798 aa)
Pde11Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively. (1451 aa)
burBurgundy, isoform B; Burgundy (bur) encodes a GMP synthetase required for axon guidance. It regulates the activity of the ubiquitin protease encoded by Usp7. (683 aa)
Pde8High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (By similarity). Involved in the positive regulation of MAP kinase signaling and in inhibiting oxidative stress-induced cell death. (1050 aa)
CTPsynCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides (By similarity). Isoform 1 is required for cytoophidium assembly in female germline cells. (627 aa)
awdNucleoside diphosphate kinase; Abnormal wing discs (awd) encodes a nucleotide diphosphate kinase that regulates with the product of shi the endocytosis of different surface proteins (e.g. those encoded by N, btl, Pvr, and shg). During development, it regulates morphogenesis of trachea, follicular epithelium, and imaginal discs and contributes to neurotransmission and border cell migration; Belongs to the NDK family. (168 aa)
AprtAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (182 aa)
Adk2Adenosine kinase activity. It is involved in the biological process described with: purine ribonucleoside salvage; AMP biosynthetic process. (345 aa)
rasInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (590 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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