7 items (Drosophila melanogaster) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Uev1A	Ubiquitin-conjugating enzyme variant 1A (Uev1A) encodes a conserved protein that contributes to ubiquitin conjugating enzyme activity, but not catalytically, since it lacks the conserved cysteine residue essential for ubiquitin conjugation. It regulates genomic integrity, IMD pathway-mediated innate immunity, JNK-pathway mediated cell death and tumor invasion. (145 aa)
	Uba1	Ubiquitin activating enzyme 1 (Uba1) encodes an E1 enzyme involved in protein ubiquitylation. It contributes to multiple processes including regulation of Ras-ERK signaling, autophagy, apoptosis and tissue growth; Belongs to the ubiquitin-activating E1 family. (1191 aa)
	CG7656	FI11905p; Ubiquitin conjugating enzyme activity; ubiquitin-protein transferase activity. It is involved in the biological process described with: protein K48-linked ubiquitination; protein polyubiquitination; Belongs to the ubiquitin-conjugating enzyme family. (319 aa)
	ben	Bendless (ben) encodes an E2 ubiquitin-conjugating enzyme. It plays essential roles in multiple processes such as synaptic growth and maturation, axon guidance, innate immunity, genomic integrity, tumor growth, cell invasion, apoptosis, long-term memory and escape response. (151 aa)
	CG3473	GEO08666p1; Ubiquitin-protein transferase activity; ubiquitin conjugating enzyme activity. It is involved in the biological process described with: protein polyubiquitination; protein ubiquitination; protein K63-linked ubiquitination; postreplication repair; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
	Ubc4	Ubiquitin-conjugating enzyme E2-22 kDa; Catalyzes the covalent attachment of ubiquitin to other proteins. (199 aa)
	Ubi-p5E	Ubiquitin-5E, isoform A; Protein tag; ubiquitin protein ligase binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; protein ubiquitination; modification-dependent protein catabolic process; cellular protein modification process. (534 aa)

Your Current Organism:

Drosophila melanogaster

NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CG3473	Uba1	FBpp0310283	FBpp0087583	GEO08666p1; Ubiquitin-protein transferase activity; ubiquitin conjugating enzyme activity. It is involved in the biological process described with: protein polyubiquitination; protein ubiquitination; protein K63-linked ubiquitination; postreplication repair; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin activating enzyme 1 (Uba1) encodes an E1 enzyme involved in protein ubiquitylation. It contributes to multiple processes including regulation of Ras-ERK signaling, autophagy, apoptosis and tissue growth; Belongs to the ubiquitin-activating E1 family.	0.918
CG3473	Ubc4	FBpp0310283	FBpp0311673	GEO08666p1; Ubiquitin-protein transferase activity; ubiquitin conjugating enzyme activity. It is involved in the biological process described with: protein polyubiquitination; protein ubiquitination; protein K63-linked ubiquitination; postreplication repair; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin-conjugating enzyme E2-22 kDa; Catalyzes the covalent attachment of ubiquitin to other proteins.	0.542
CG3473	Ubi-p5E	FBpp0310283	FBpp0311816	GEO08666p1; Ubiquitin-protein transferase activity; ubiquitin conjugating enzyme activity. It is involved in the biological process described with: protein polyubiquitination; protein ubiquitination; protein K63-linked ubiquitination; postreplication repair; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin-5E, isoform A; Protein tag; ubiquitin protein ligase binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; protein ubiquitination; modification-dependent protein catabolic process; cellular protein modification process.	0.764
CG3473	Uev1A	FBpp0310283	FBpp0076859	GEO08666p1; Ubiquitin-protein transferase activity; ubiquitin conjugating enzyme activity. It is involved in the biological process described with: protein polyubiquitination; protein ubiquitination; protein K63-linked ubiquitination; postreplication repair; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin-conjugating enzyme variant 1A (Uev1A) encodes a conserved protein that contributes to ubiquitin conjugating enzyme activity, but not catalytically, since it lacks the conserved cysteine residue essential for ubiquitin conjugation. It regulates genomic integrity, IMD pathway-mediated innate immunity, JNK-pathway mediated cell death and tumor invasion.	0.999
CG3473	ben	FBpp0310283	FBpp0298297	GEO08666p1; Ubiquitin-protein transferase activity; ubiquitin conjugating enzyme activity. It is involved in the biological process described with: protein polyubiquitination; protein ubiquitination; protein K63-linked ubiquitination; postreplication repair; Belongs to the ubiquitin-conjugating enzyme family.	Bendless (ben) encodes an E2 ubiquitin-conjugating enzyme. It plays essential roles in multiple processes such as synaptic growth and maturation, axon guidance, innate immunity, genomic integrity, tumor growth, cell invasion, apoptosis, long-term memory and escape response.	0.901
CG7656	Uba1	FBpp0289558	FBpp0087583	FI11905p; Ubiquitin conjugating enzyme activity; ubiquitin-protein transferase activity. It is involved in the biological process described with: protein K48-linked ubiquitination; protein polyubiquitination; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin activating enzyme 1 (Uba1) encodes an E1 enzyme involved in protein ubiquitylation. It contributes to multiple processes including regulation of Ras-ERK signaling, autophagy, apoptosis and tissue growth; Belongs to the ubiquitin-activating E1 family.	0.985
CG7656	Ubc4	FBpp0289558	FBpp0311673	FI11905p; Ubiquitin conjugating enzyme activity; ubiquitin-protein transferase activity. It is involved in the biological process described with: protein K48-linked ubiquitination; protein polyubiquitination; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin-conjugating enzyme E2-22 kDa; Catalyzes the covalent attachment of ubiquitin to other proteins.	0.592
CG7656	Ubi-p5E	FBpp0289558	FBpp0311816	FI11905p; Ubiquitin conjugating enzyme activity; ubiquitin-protein transferase activity. It is involved in the biological process described with: protein K48-linked ubiquitination; protein polyubiquitination; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin-5E, isoform A; Protein tag; ubiquitin protein ligase binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; protein ubiquitination; modification-dependent protein catabolic process; cellular protein modification process.	0.896
CG7656	Uev1A	FBpp0289558	FBpp0076859	FI11905p; Ubiquitin conjugating enzyme activity; ubiquitin-protein transferase activity. It is involved in the biological process described with: protein K48-linked ubiquitination; protein polyubiquitination; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin-conjugating enzyme variant 1A (Uev1A) encodes a conserved protein that contributes to ubiquitin conjugating enzyme activity, but not catalytically, since it lacks the conserved cysteine residue essential for ubiquitin conjugation. It regulates genomic integrity, IMD pathway-mediated innate immunity, JNK-pathway mediated cell death and tumor invasion.	0.739
CG7656	ben	FBpp0289558	FBpp0298297	FI11905p; Ubiquitin conjugating enzyme activity; ubiquitin-protein transferase activity. It is involved in the biological process described with: protein K48-linked ubiquitination; protein polyubiquitination; Belongs to the ubiquitin-conjugating enzyme family.	Bendless (ben) encodes an E2 ubiquitin-conjugating enzyme. It plays essential roles in multiple processes such as synaptic growth and maturation, axon guidance, innate immunity, genomic integrity, tumor growth, cell invasion, apoptosis, long-term memory and escape response.	0.445
Uba1	CG3473	FBpp0087583	FBpp0310283	Ubiquitin activating enzyme 1 (Uba1) encodes an E1 enzyme involved in protein ubiquitylation. It contributes to multiple processes including regulation of Ras-ERK signaling, autophagy, apoptosis and tissue growth; Belongs to the ubiquitin-activating E1 family.	GEO08666p1; Ubiquitin-protein transferase activity; ubiquitin conjugating enzyme activity. It is involved in the biological process described with: protein polyubiquitination; protein ubiquitination; protein K63-linked ubiquitination; postreplication repair; Belongs to the ubiquitin-conjugating enzyme family.	0.918
Uba1	CG7656	FBpp0087583	FBpp0289558	Ubiquitin activating enzyme 1 (Uba1) encodes an E1 enzyme involved in protein ubiquitylation. It contributes to multiple processes including regulation of Ras-ERK signaling, autophagy, apoptosis and tissue growth; Belongs to the ubiquitin-activating E1 family.	FI11905p; Ubiquitin conjugating enzyme activity; ubiquitin-protein transferase activity. It is involved in the biological process described with: protein K48-linked ubiquitination; protein polyubiquitination; Belongs to the ubiquitin-conjugating enzyme family.	0.985
Uba1	Ubc4	FBpp0087583	FBpp0311673	Ubiquitin activating enzyme 1 (Uba1) encodes an E1 enzyme involved in protein ubiquitylation. It contributes to multiple processes including regulation of Ras-ERK signaling, autophagy, apoptosis and tissue growth; Belongs to the ubiquitin-activating E1 family.	Ubiquitin-conjugating enzyme E2-22 kDa; Catalyzes the covalent attachment of ubiquitin to other proteins.	0.991
Uba1	Ubi-p5E	FBpp0087583	FBpp0311816	Ubiquitin activating enzyme 1 (Uba1) encodes an E1 enzyme involved in protein ubiquitylation. It contributes to multiple processes including regulation of Ras-ERK signaling, autophagy, apoptosis and tissue growth; Belongs to the ubiquitin-activating E1 family.	Ubiquitin-5E, isoform A; Protein tag; ubiquitin protein ligase binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; protein ubiquitination; modification-dependent protein catabolic process; cellular protein modification process.	0.949
Uba1	Uev1A	FBpp0087583	FBpp0076859	Ubiquitin activating enzyme 1 (Uba1) encodes an E1 enzyme involved in protein ubiquitylation. It contributes to multiple processes including regulation of Ras-ERK signaling, autophagy, apoptosis and tissue growth; Belongs to the ubiquitin-activating E1 family.	Ubiquitin-conjugating enzyme variant 1A (Uev1A) encodes a conserved protein that contributes to ubiquitin conjugating enzyme activity, but not catalytically, since it lacks the conserved cysteine residue essential for ubiquitin conjugation. It regulates genomic integrity, IMD pathway-mediated innate immunity, JNK-pathway mediated cell death and tumor invasion.	0.764
Uba1	ben	FBpp0087583	FBpp0298297	Ubiquitin activating enzyme 1 (Uba1) encodes an E1 enzyme involved in protein ubiquitylation. It contributes to multiple processes including regulation of Ras-ERK signaling, autophagy, apoptosis and tissue growth; Belongs to the ubiquitin-activating E1 family.	Bendless (ben) encodes an E2 ubiquitin-conjugating enzyme. It plays essential roles in multiple processes such as synaptic growth and maturation, axon guidance, innate immunity, genomic integrity, tumor growth, cell invasion, apoptosis, long-term memory and escape response.	0.974
Ubc4	CG3473	FBpp0311673	FBpp0310283	Ubiquitin-conjugating enzyme E2-22 kDa; Catalyzes the covalent attachment of ubiquitin to other proteins.	GEO08666p1; Ubiquitin-protein transferase activity; ubiquitin conjugating enzyme activity. It is involved in the biological process described with: protein polyubiquitination; protein ubiquitination; protein K63-linked ubiquitination; postreplication repair; Belongs to the ubiquitin-conjugating enzyme family.	0.542
Ubc4	CG7656	FBpp0311673	FBpp0289558	Ubiquitin-conjugating enzyme E2-22 kDa; Catalyzes the covalent attachment of ubiquitin to other proteins.	FI11905p; Ubiquitin conjugating enzyme activity; ubiquitin-protein transferase activity. It is involved in the biological process described with: protein K48-linked ubiquitination; protein polyubiquitination; Belongs to the ubiquitin-conjugating enzyme family.	0.592
Ubc4	Uba1	FBpp0311673	FBpp0087583	Ubiquitin-conjugating enzyme E2-22 kDa; Catalyzes the covalent attachment of ubiquitin to other proteins.	Ubiquitin activating enzyme 1 (Uba1) encodes an E1 enzyme involved in protein ubiquitylation. It contributes to multiple processes including regulation of Ras-ERK signaling, autophagy, apoptosis and tissue growth; Belongs to the ubiquitin-activating E1 family.	0.991
Ubc4	Ubi-p5E	FBpp0311673	FBpp0311816	Ubiquitin-conjugating enzyme E2-22 kDa; Catalyzes the covalent attachment of ubiquitin to other proteins.	Ubiquitin-5E, isoform A; Protein tag; ubiquitin protein ligase binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; protein ubiquitination; modification-dependent protein catabolic process; cellular protein modification process.	0.920