STRINGSTRING
Atg5 Atg5 Atg8a Atg8a Pi3K59F Pi3K59F Atg101 Atg101 Atg3 Atg3 CG10969 CG10969 CG33128 CG33128 CG31661 CG31661 Atg4a Atg4a BNIP3 BNIP3 CG12163 CG12163 CG5367 CG5367 CG6508 CG6508 CG17134 CG17134 Uvrag Uvrag pigeon pigeon Atg13 Atg13 Vps15 Vps15 Aduk Aduk Atg4b Atg4b CG17283 CG17283 CG5860 CG5860 CG5863 CG5863 Atg6 Atg6 Atg14 Atg14 Debcl Debcl Atg7 Atg7 CG10104 CG10104 Cp1 Cp1 Gat Gat ref(2)P ref(2)P squ squ Epg5 Epg5 Atg12 Atg12 Atg1 Atg1 Atg18a Atg18a Atg9 Atg9 Atg18b Atg18b Rubicon Rubicon Cln7 Cln7 Atg2 Atg2 Cln3 Cln3 Tango5 Tango5 CG31928 CG31928 Atg17 Atg17 Atg16 Atg16 CG5445 CG5445 Atg10 Atg10 CG3777 CG3777 Bace Bace CG11459 CG11459 Ppt1 Ppt1 CtsB1 CtsB1 Atg8b Atg8b cathD cathD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Atg5Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with Atg12, through a ubiquitin-like conjugating system involving Atg7 as an E1-like activating enzyme and Atg10 as an E2-like conjugating enzyme, is essential for its function. The Atg12-Atg5 conjugate acts as an E3- like enzyme which is required for lipidation of Atg8 and its association to the vesicle membranes (By similarity). (269 aa)
Atg8aAutophagy-related 8a (Atg8a) encodes a ubiquitin-like protein that is conjugated to phosphatidylethanolamine, and this lipid modification anchors it into the membrane of forming and completed autophagosomes. Atg8a product has roles in autophagosome formation, maintaining neuromuscular function and normal lifespan. (121 aa)
Pi3K59FPhosphatidylinositol 3-kinase catalytic subunit type 3; Phosphotidylinositol 3 kinase 59F (Pi3K59F) encodes a lipid kinase that is required for formation of Phosphatidylinositol 3-phosphate. It functions in a core protein complex that includes the products of Atg6 and Vps15. It is involved in the control of vesicle trafficking, including autophagy, endocytosis and phagocytosis. (949 aa)
Atg101Autophagy-related 101 (Atg101) encodes a subunit of the evolutionarily conserved Atg1 kinase complex, which controls the initiation of autophagosome formation. (218 aa)
Atg3Autophagy-related 3 (Atg3) encodes a protein involved in multiple autophagy processes such as autophagosome assembly, cellular response to starvation, and glycophagy. (330 aa)
CG10969Uncharacterized protein. (697 aa)
CG33128LP12231p; Aspartic-type endopeptidase activity. It is involved in the biological process described with: proteolysis; protein catabolic process; Belongs to the peptidase A1 family. (405 aa)
CG31661MIP16848p; Aspartic-type endopeptidase activity. It is involved in the biological process described with: eggshell chorion assembly; cell death; protein catabolic process; proteolysis; Belongs to the peptidase A1 family. (393 aa)
Atg4aCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (411 aa)
BNIP3RE48077p; It is involved in the biological process described with: mitochondrial outer membrane permeabilization; regulation of programmed cell death; positive regulation of apoptotic process. (201 aa)
CG12163Putative cysteine proteinase CG12163; May have a role in autophagic cell death. Belongs to the peptidase C1 family. (614 aa)
CG5367Uncharacterized protein; Cysteine-type endopeptidase activity. It is involved in the biological process described with: proteolysis involved in cellular protein catabolic process; immune response; Belongs to the peptidase C1 family. (338 aa)
CG6508Peptidase A1 domain-containing protein; Aspartic-type endopeptidase activity. It is involved in the biological process described with: protein catabolic process; proteolysis; Belongs to the peptidase A1 family. (423 aa)
CG17134RE02351p; Aspartic-type endopeptidase activity. It is involved in the biological process described with: proteolysis; protein catabolic process; Belongs to the peptidase A1 family. (391 aa)
UvragUV-resistance associated gene (Uvrag) encodes a protein that regulates autophagy and vesicle trafficking with the product of Atg6 and class C vacuolar protein sorting complexes. With the products of Atg6 and Pi3K59F, It forms a PI3K(III) complex and plays roles in receptor downregulation and the establishment of proper cell polarity. It is also critical for proper organ rotation during development by controlling receptor endocytosis and subsequent degradation. (696 aa)
pigeonPigeon (pigeon) encodes a member of the Gamma-secretase-activating protein family; Belongs to the GSAP family. (915 aa)
Atg13Autophagy-related protein 13 homolog; Autophagy factor required for autophagosome formation. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of Atg13 and Atg1. The Atg1- Atg13 complex functions at multiple levels to mediate and adjust nutrient-dependent autophagic signaling. Involved in the autophagic degradation of dBruce which controls DNA fragmentation in nurse cells. (523 aa)
Vps15Vacuolar protein sorting 15 (Vps15) encodes a serine/threonine protein kinase that is a core component of the Vps34/class III PI3-Kinase complex. It is required for the production of PI3P and influences multiple vesicle trafficking pathways, including autophagy and endocytosis. (1342 aa)
AdukAnother drosophila Unc-51-like kinase, isoform A; ATP binding; protein serine/threonine kinase activity. It is involved in the biological process described with: protein phosphorylation; positive regulation of autophagosome assembly; autophagy. (520 aa)
Atg4bCysteine protease; Autophagy-related 4b (Atg4b) encodes a cysteine protease that cleaves the precursor product of Atg8a at the C-terminal region, thereby initiating autophagosome formation; Belongs to the peptidase C54 family. (668 aa)
CG17283Peptidase A1 domain-containing protein; Aspartic-type endopeptidase activity. It is involved in the biological process described with: protein catabolic process; proteolysis; Belongs to the peptidase A1 family. (465 aa)
CG5860Peptidase A1 domain-containing protein; Aspartic-type endopeptidase activity. It is involved in the biological process described with: proteolysis; cell death; protein catabolic process; Belongs to the peptidase A1 family. (370 aa)
CG5863Peptidase A1 domain-containing protein; Aspartic-type endopeptidase activity. It is involved in the biological process described with: proteolysis; protein catabolic process; Belongs to the peptidase A1 family. (395 aa)
Atg6Beclin-1-like protein; Autophagy-related 6 (Atg6) encodes a component of the Vps34 complex that is required for the formation of PI3P, and functions in vesicle trafficking including autophagy and endocytosis. (422 aa)
Atg14Autophagy-related 14 (Atg14) encodes a protein involved in autophagy. (503 aa)
DebclDeath executioner Bcl-2 (Debcl) encodes a pro-apoptotic member of the Bcl-2 family involved in programmed cell death. (300 aa)
Atg7Autophagy-related 7 (Atg7) encodes an E1-type ligase for the autophagic ubiquitin-like proteins encoded by Atg8a and Atg12. Its roles include autophagosome formation, maintaining neuromuscular function and normal lifespan. (684 aa)
CG10104Peptidase A1 domain-containing protein; Aspartic-type endopeptidase activity. It is involved in the biological process described with: proteolysis; protein catabolic process; cell death; Belongs to the peptidase A1 family. (404 aa)
Cp1Cathepsin L heavy chain; Important for the overall degradation of proteins in lysosomes. Essential for adult male and female fertility. May play a role in digestion; Belongs to the peptidase C1 family. (371 aa)
GatGABA transporter (Gat) encodes a protein belonging to the SLC family that is expressed primarily in astrocytes, where it is thought to be required for uptake of GABA and other small molecules. It likely plays an important role in setting the excitatory/inhibitory balance of the CNS; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (636 aa)
ref(2)PProtein ref(2)P; Required for selective autophagy activation by ubiquitinated proteins. Implicated in sigma rhabdovirus multiplication and necessary for male fertility. Involved in activating transcription of Drs. (599 aa)
squSquash, isoform A; Squash (squ) encodes a protein acting in the piRNA pathway that responds to transposase activity in the germline. (241 aa)
Epg5Ectopic P granules protein 5 homolog; Involved in autophagy. Plays a role in late steps of autophagy; Belongs to the EPG5 family. (2455 aa)
Atg12Autophagy protein 12-like; Required for autophagy. (111 aa)
Atg1Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy. (855 aa)
Atg18aAutophagy-related 18a (Atg18a) encodes a protein that regulates autophagy by participating in isolation membrane elongation around cytoplasmic cargoes. (447 aa)
Atg9Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (852 aa)
Atg18bAutophagy-related 18b, isoform A; Phosphatidylinositol-3-phosphate binding; phosphatidylinositol-3,5-bisphosphate binding. (471 aa)
RubiconUncharacterized protein, isoform A; Phosphatidylinositol phosphate binding. It is involved in the biological process described with: negative regulation of autophagy. (827 aa)
Cln7Cln7, isoform A; It is involved in the biological process described with: transmembrane transport. (546 aa)
Atg2Autophagy-related 2 (Atg2) encodes a protein known to be required for autophagy. (1906 aa)
Cln3Battenin. (422 aa)
Tango5Transport and golgi organization 5, isoform A; It is involved in the biological process described with: autophagy; Golgi organization; protein secretion. (530 aa)
CG31928IP19042p; Aspartic-type endopeptidase activity. It is involved in the biological process described with: proteolysis; protein catabolic process; cell death; Belongs to the peptidase A1 family. (418 aa)
Atg17Autophagy-related 17 (Atg17) encodes a subunit of the evolutionarily conserved Atg1 kinase complex, which controls the initiation of autophagosome formation. The product of Atg17 also has a role in maintaining neuromuscular function and normal lifespan. (1357 aa)
Atg16Autophagy-related 16 (Atg16) encodes a protein that forms an E3-like protein complex. This complex contributes to the the covalent binding of the lipid phosphatidylethanolamine to the product of Atg8a, a key autophagy protein involved in autophagosome biogenesis. The product of Atg16 is involved in autophagosome biogenesis, maintenance of proper neuromuscular function, lifespan, ethanol sedation, and enteroendocrine cell function in the intestine. (612 aa)
CG5445MIP08896p; Ubiquitin binding. It is involved in the biological process described with: macroautophagy. (303 aa)
Atg10Autophagy-related 10, isoform B; Atg12 transferase activity; Atg12 conjugating enzyme activity. It is involved in the biological process described with: cellular protein modification process; macroautophagy. (172 aa)
CG3777SD17974p. (879 aa)
BaceBeta-site APP-cleaving enzyme (Bace) encodes an aspartic protease that cleaves amyloid precursor proteins. It contributes to glial cell survival and enhances neuronal degeneration caused by expression of Appl. In humans, Bace, together with the gamma-secretase complex, generates the toxic Abeta peptide that accumulates in Alzheimer's disease; Belongs to the peptidase A1 family. (372 aa)
CG11459GH15170p; Cysteine-type endopeptidase activity. It is involved in the biological process described with: proteolysis involved in cellular protein catabolic process; Belongs to the peptidase C1 family. (336 aa)
Ppt1Palmitoyl-protein thioesterase 1 (Ppt1) encodes a lysosomal enzyme that removes palmitoyl groups from particular target proteins during protein degradation within the lysosomal compartment. Palmitoylation is critical for the cellular localization and modulation of many signaling proteins. (314 aa)
CtsB1Cathepsin B1 (CtsB1) encodes a papain-like cysteine proteinase involved in lysosomal protein degradation; Belongs to the peptidase C1 family. (340 aa)
Atg8bAutophagy-related 8b, isoform A; Microtubule binding; protein tag; ubiquitin protein ligase binding; GABA receptor binding. It is involved in the biological process described with: macroautophagy; autophagosome maturation; cellular response to nitrogen starvation; autophagy of mitochondrion; autophagosome assembly. (120 aa)
cathDCathD, isoform A; cathD (cathD) encodes a protein involved in apoptosis and the defense response to Gram-negative bacteria; Belongs to the peptidase A1 family. (392 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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