(16 nodes) Autophagy - other network (Drosophila melanogaster)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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Your Input:
	Atg5	Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with Atg12, through a ubiquitin-like conjugating system involving Atg7 as an E1-like activating enzyme and Atg10 as an E2-like conjugating enzyme, is essential for its function. The Atg12-Atg5 conjugate acts as an E3- like enzyme which is required for lipidation of Atg8 and its association to the vesicle membranes (By similarity). (269 aa)
	Atg8a	Autophagy-related 8a (Atg8a) encodes a ubiquitin-like protein that is conjugated to phosphatidylethanolamine, and this lipid modification anchors it into the membrane of forming and completed autophagosomes. Atg8a product has roles in autophagosome formation, maintaining neuromuscular function and normal lifespan. (121 aa)
	Atg101	Autophagy-related 101 (Atg101) encodes a subunit of the evolutionarily conserved Atg1 kinase complex, which controls the initiation of autophagosome formation. (218 aa)
	Atg3	Autophagy-related 3 (Atg3) encodes a protein involved in multiple autophagy processes such as autophagosome assembly, cellular response to starvation, and glycophagy. (330 aa)
	Atg4a	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (411 aa)
	Atg13	Autophagy-related protein 13 homolog; Autophagy factor required for autophagosome formation. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of Atg13 and Atg1. The Atg1- Atg13 complex functions at multiple levels to mediate and adjust nutrient-dependent autophagic signaling. Involved in the autophagic degradation of dBruce which controls DNA fragmentation in nurse cells. (523 aa)
	Atg4b	Cysteine protease; Autophagy-related 4b (Atg4b) encodes a cysteine protease that cleaves the precursor product of Atg8a at the C-terminal region, thereby initiating autophagosome formation; Belongs to the peptidase C54 family. (668 aa)
	Atg6	Beclin-1-like protein; Autophagy-related 6 (Atg6) encodes a component of the Vps34 complex that is required for the formation of PI3P, and functions in vesicle trafficking including autophagy and endocytosis. (422 aa)
	Atg14	Autophagy-related 14 (Atg14) encodes a protein involved in autophagy. (503 aa)
	Atg7	Autophagy-related 7 (Atg7) encodes an E1-type ligase for the autophagic ubiquitin-like proteins encoded by Atg8a and Atg12. Its roles include autophagosome formation, maintaining neuromuscular function and normal lifespan. (684 aa)
	Atg12	Autophagy protein 12-like; Required for autophagy. (111 aa)
	Atg1	Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy. (855 aa)
	Atg17	Autophagy-related 17 (Atg17) encodes a subunit of the evolutionarily conserved Atg1 kinase complex, which controls the initiation of autophagosome formation. The product of Atg17 also has a role in maintaining neuromuscular function and normal lifespan. (1357 aa)
	Atg16	Autophagy-related 16 (Atg16) encodes a protein that forms an E3-like protein complex. This complex contributes to the the covalent binding of the lipid phosphatidylethanolamine to the product of Atg8a, a key autophagy protein involved in autophagosome biogenesis. The product of Atg16 is involved in autophagosome biogenesis, maintenance of proper neuromuscular function, lifespan, ethanol sedation, and enteroendocrine cell function in the intestine. (612 aa)
	Atg10	Autophagy-related 10, isoform B; Atg12 transferase activity; Atg12 conjugating enzyme activity. It is involved in the biological process described with: cellular protein modification process; macroautophagy. (172 aa)
	Atg8b	Autophagy-related 8b, isoform A; Microtubule binding; protein tag; ubiquitin protein ligase binding; GABA receptor binding. It is involved in the biological process described with: macroautophagy; autophagosome maturation; cellular response to nitrogen starvation; autophagy of mitochondrion; autophagosome assembly. (120 aa)

Your Current Organism:

Drosophila melanogaster

NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Atg1	Atg10	FBpp0289788	FBpp0309509	Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy.	Autophagy-related 10, isoform B; Atg12 transferase activity; Atg12 conjugating enzyme activity. It is involved in the biological process described with: cellular protein modification process; macroautophagy.	0.880
Atg1	Atg101	FBpp0289788	FBpp0074406	Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy.	Autophagy-related 101 (Atg101) encodes a subunit of the evolutionarily conserved Atg1 kinase complex, which controls the initiation of autophagosome formation.	0.999
Atg1	Atg12	FBpp0289788	FBpp0289288	Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy.	Autophagy protein 12-like; Required for autophagy.	0.998
Atg1	Atg13	FBpp0289788	FBpp0081333	Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy.	Autophagy-related protein 13 homolog; Autophagy factor required for autophagosome formation. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of Atg13 and Atg1. The Atg1- Atg13 complex functions at multiple levels to mediate and adjust nutrient-dependent autophagic signaling. Involved in the autophagic degradation of dBruce which controls DNA fragmentation in nurse cells.	0.999
Atg1	Atg14	FBpp0289788	FBpp0084739	Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy.	Autophagy-related 14 (Atg14) encodes a protein involved in autophagy.	0.999
Atg1	Atg16	FBpp0289788	FBpp0308289	Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy.	Autophagy-related 16 (Atg16) encodes a protein that forms an E3-like protein complex. This complex contributes to the the covalent binding of the lipid phosphatidylethanolamine to the product of Atg8a, a key autophagy protein involved in autophagosome biogenesis. The product of Atg16 is involved in autophagosome biogenesis, maintenance of proper neuromuscular function, lifespan, ethanol sedation, and enteroendocrine cell function in the intestine.	0.992
Atg1	Atg17	FBpp0289788	FBpp0306962	Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy.	Autophagy-related 17 (Atg17) encodes a subunit of the evolutionarily conserved Atg1 kinase complex, which controls the initiation of autophagosome formation. The product of Atg17 also has a role in maintaining neuromuscular function and normal lifespan.	0.999
Atg1	Atg3	FBpp0289788	FBpp0074822	Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy.	Autophagy-related 3 (Atg3) encodes a protein involved in multiple autophagy processes such as autophagosome assembly, cellular response to starvation, and glycophagy.	0.998
Atg1	Atg4a	FBpp0289788	FBpp0077618	Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy.	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family.	0.998
Atg1	Atg4b	FBpp0289788	FBpp0082569	Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy.	Cysteine protease; Autophagy-related 4b (Atg4b) encodes a cysteine protease that cleaves the precursor product of Atg8a at the C-terminal region, thereby initiating autophagosome formation; Belongs to the peptidase C54 family.	0.994
Atg1	Atg5	FBpp0289788	FBpp0071023	Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy.	Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with Atg12, through a ubiquitin-like conjugating system involving Atg7 as an E1-like activating enzyme and Atg10 as an E2-like conjugating enzyme, is essential for its function. The Atg12-Atg5 conjugate acts as an E3- like enzyme which is required for lipidation of Atg8 and its association to the vesicle membranes (By similarity).	0.998
Atg1	Atg6	FBpp0289788	FBpp0083975	Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy.	Beclin-1-like protein; Autophagy-related 6 (Atg6) encodes a component of the Vps34 complex that is required for the formation of PI3P, and functions in vesicle trafficking including autophagy and endocytosis.	0.999
Atg1	Atg7	FBpp0289788	FBpp0085891	Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy.	Autophagy-related 7 (Atg7) encodes an E1-type ligase for the autophagic ubiquitin-like proteins encoded by Atg8a and Atg12. Its roles include autophagosome formation, maintaining neuromuscular function and normal lifespan.	0.973
Atg1	Atg8a	FBpp0289788	FBpp0071427	Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy.	Autophagy-related 8a (Atg8a) encodes a ubiquitin-like protein that is conjugated to phosphatidylethanolamine, and this lipid modification anchors it into the membrane of forming and completed autophagosomes. Atg8a product has roles in autophagosome formation, maintaining neuromuscular function and normal lifespan.	0.998
Atg1	Atg8b	FBpp0289788	FBpp0312339	Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy.	Autophagy-related 8b, isoform A; Microtubule binding; protein tag; ubiquitin protein ligase binding; GABA receptor binding. It is involved in the biological process described with: macroautophagy; autophagosome maturation; cellular response to nitrogen starvation; autophagy of mitochondrion; autophagosome assembly.	0.994
Atg10	Atg1	FBpp0309509	FBpp0289788	Autophagy-related 10, isoform B; Atg12 transferase activity; Atg12 conjugating enzyme activity. It is involved in the biological process described with: cellular protein modification process; macroautophagy.	Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy.	0.880
Atg10	Atg101	FBpp0309509	FBpp0074406	Autophagy-related 10, isoform B; Atg12 transferase activity; Atg12 conjugating enzyme activity. It is involved in the biological process described with: cellular protein modification process; macroautophagy.	Autophagy-related 101 (Atg101) encodes a subunit of the evolutionarily conserved Atg1 kinase complex, which controls the initiation of autophagosome formation.	0.939
Atg10	Atg12	FBpp0309509	FBpp0289288	Autophagy-related 10, isoform B; Atg12 transferase activity; Atg12 conjugating enzyme activity. It is involved in the biological process described with: cellular protein modification process; macroautophagy.	Autophagy protein 12-like; Required for autophagy.	0.998
Atg10	Atg13	FBpp0309509	FBpp0081333	Autophagy-related 10, isoform B; Atg12 transferase activity; Atg12 conjugating enzyme activity. It is involved in the biological process described with: cellular protein modification process; macroautophagy.	Autophagy-related protein 13 homolog; Autophagy factor required for autophagosome formation. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of Atg13 and Atg1. The Atg1- Atg13 complex functions at multiple levels to mediate and adjust nutrient-dependent autophagic signaling. Involved in the autophagic degradation of dBruce which controls DNA fragmentation in nurse cells.	0.940
Atg10	Atg14	FBpp0309509	FBpp0084739	Autophagy-related 10, isoform B; Atg12 transferase activity; Atg12 conjugating enzyme activity. It is involved in the biological process described with: cellular protein modification process; macroautophagy.	Autophagy-related 14 (Atg14) encodes a protein involved in autophagy.	0.881