(25 nodes) Mixed, incl. Nicotinate and nicotinamide metabolism, and Pyridine nucleotide biosynthetic process network (Drosophila melanogaster)

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second shell of interactors

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proteins of unknown 3D structure

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	Sik2	Salt-inducible kinase 2 (Sik2) encodes a serine/threonine kinase that is activated by the product of Lkb1. It regulates lipid storage and energy homeostasis by controlling the activity of cAMP-response element-binding protein (CREB)-regulated transcription coactivator (CRTC). (1398 aa)
	Sirt4	NAD-dependent protein deacylase Sirt4; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues. (312 aa)
	CG12016	SD05789p2; Kinase activity; ribosylnicotinamide kinase activity. It is involved in the biological process described with: nicotinamide riboside metabolic process; nicotinamide nucleotide biosynthetic process. (323 aa)
	Nadsyn	Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source (By similarity). Because of its role in energy metabolism, involved in the modulation of aged- related cardiac function, mobility, and lifespan. (787 aa)
	Naprt	Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis; Belongs to the NAPRTase family. (667 aa)
	srl	Spargel, isoform B; Transcription coregulator activity; mRNA binding; nuclear receptor transcription coactivator activity; transcription factor binding; nucleic acid binding. (1067 aa)
	Sirt1	NAD-dependent histone deacetylase sirtuin-1; NAD-dependent histone deacetylase involved in heterochromatic silencing. Mildly suppresses the heterochromatin-mediated silencing phenomenon known as position-effect variegation (PEV). Required for epigenetic silencing of the polycomb group proteins. Has histone H4 deacetylase activity in vitro. Required maternally for establishing proper segmentation of the embryo. Involved in sex determination. May be involved in the regulation of life span. (823 aa)
	CG8420	LD42037p; It is involved in the biological process described with: multicellular organism reproduction. (531 aa)
	Naam	Nicotinamide amidase (Naam) encodes a nicotinamidase involved in lifespan determination, neuron apoptosis regulation and response to oxidative stress. (357 aa)
	Nmnat	Nicotinamide mononucleotide adenylyltransferase (Nmnat) encodes an essential enzyme in the NAD salvage pathway, catalyzing the last step of NAD synthesis. It is also a neuronal maintenance factor that protects neurons from excitotoxicity, environmental stress and protein misfolding induced degeneration. (389 aa)
	Sirt7	NAD-dependent protein deacetylase Sirt7; NAD-dependent protein deacetylase. (771 aa)
	CG11333	AT02774p; Catalytic activity. (204 aa)
	CG15071	Uncharacterized protein. (206 aa)
	CG33156	Uncharacterized protein, isoform E; NAD+ kinase activity. It is involved in the biological process described with: NAD metabolic process; NADP biosynthetic process. (490 aa)
	CG6145	RH58004p; NAD+ kinase activity. It is involved in the biological process described with: NADP biosynthetic process. (548 aa)
	CG8080	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. (413 aa)
	CG42855	Uncharacterized protein. (76 aa)
	Sik3	ATP binding; protein serine/threonine kinase activity. (1471 aa)
	foxo	Forkhead box protein O; Transcription factor involved in the regulation of the insulin signaling pathway. Consistently activates both the downstream target Thord4EBP and the feedback control target InR. Involved in negative regulation of the cell cycle, modulating cell growth and proliferation. In response to cellular stresses, such as nutrient deprivation or increased levels of reactive oxygen species, foxo is activated and inhibits growth through the action of target genes such as Thor. Foxo activated in the adult fat body can regulate lifespan in adults; an insulin peptide itself m [...] (622 aa)
	Sirt6	Sirtuin 6 (Sirt6) encodes an NAD-dependent histone deacetylase in the class IV of the Sirtuin family. It is involved in chromatin silencing and determination of adult lifespan. (325 aa)
	GramD1B	GRAM domain containing 1B, isoform E. (1249 aa)
	Crtc	CREB-regulated transcription coactivator (Crtc) encodes a highly conserved transcriptional coactivator of cAMP-response element-binding protein (CREB). Its nuclear localization is regulated by several factors including intracellular cAMP or calcium levels, or calcineurin. Sik family kinases also phosphorylate to inhibit the product of Crtc and, consequently, control energy homeostais and lipid metabolism. (889 aa)
	HDAC4	Histone deacetylase 4, isoform G; Histone deacetylase 4 (HDAC4) encodes a Class IIa histone deacetylase that modulates gene expression by associating with transcriptional factors. It is regulated by nucleocytoplasmic shuttling and contributes to embryogenesis, muscle development, circadian function, energy balance and memory. (1269 aa)
	Sirt2	NAD-dependent protein deacetylase Sirt2; NAD-dependent protein deacetylase (By similarity). May be involved in the regulation of life span; Belongs to the sirtuin family. Class I subfamily. (355 aa)
	CG3106	GH10201p; Transferase activity, transferring acyl groups other than amino-acyl groups. (742 aa)

Your Current Organism:

Drosophila melanogaster

NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CG11333	Nadsyn	FBpp0085150	FBpp0073675	AT02774p; Catalytic activity.	Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source (By similarity). Because of its role in energy metabolism, involved in the modulation of aged- related cardiac function, mobility, and lifespan.	0.469
CG11333	Naprt	FBpp0085150	FBpp0077172	AT02774p; Catalytic activity.	Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis; Belongs to the NAPRTase family.	0.473
CG11333	Nmnat	FBpp0085150	FBpp0084124	AT02774p; Catalytic activity.	Nicotinamide mononucleotide adenylyltransferase (Nmnat) encodes an essential enzyme in the NAD salvage pathway, catalyzing the last step of NAD synthesis. It is also a neuronal maintenance factor that protects neurons from excitotoxicity, environmental stress and protein misfolding induced degeneration.	0.438
CG12016	Naam	FBpp0072927	FBpp0083200	SD05789p2; Kinase activity; ribosylnicotinamide kinase activity. It is involved in the biological process described with: nicotinamide riboside metabolic process; nicotinamide nucleotide biosynthetic process.	Nicotinamide amidase (Naam) encodes a nicotinamidase involved in lifespan determination, neuron apoptosis regulation and response to oxidative stress.	0.532
CG12016	Nadsyn	FBpp0072927	FBpp0073675	SD05789p2; Kinase activity; ribosylnicotinamide kinase activity. It is involved in the biological process described with: nicotinamide riboside metabolic process; nicotinamide nucleotide biosynthetic process.	Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source (By similarity). Because of its role in energy metabolism, involved in the modulation of aged- related cardiac function, mobility, and lifespan.	0.650
CG12016	Naprt	FBpp0072927	FBpp0077172	SD05789p2; Kinase activity; ribosylnicotinamide kinase activity. It is involved in the biological process described with: nicotinamide riboside metabolic process; nicotinamide nucleotide biosynthetic process.	Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis; Belongs to the NAPRTase family.	0.666
CG12016	Nmnat	FBpp0072927	FBpp0084124	SD05789p2; Kinase activity; ribosylnicotinamide kinase activity. It is involved in the biological process described with: nicotinamide riboside metabolic process; nicotinamide nucleotide biosynthetic process.	Nicotinamide mononucleotide adenylyltransferase (Nmnat) encodes an essential enzyme in the NAD salvage pathway, catalyzing the last step of NAD synthesis. It is also a neuronal maintenance factor that protects neurons from excitotoxicity, environmental stress and protein misfolding induced degeneration.	0.658
CG15071	CG42855	FBpp0085788	FBpp0292992	Uncharacterized protein.	Uncharacterized protein.	0.912
CG15071	Sik3	FBpp0085788	FBpp0292995	Uncharacterized protein.	ATP binding; protein serine/threonine kinase activity.	0.673
CG3106	CG33156	FBpp0311996	FBpp0086803	GH10201p; Transferase activity, transferring acyl groups other than amino-acyl groups.	Uncharacterized protein, isoform E; NAD+ kinase activity. It is involved in the biological process described with: NAD metabolic process; NADP biosynthetic process.	0.670
CG3106	CG6145	FBpp0311996	FBpp0086806	GH10201p; Transferase activity, transferring acyl groups other than amino-acyl groups.	RH58004p; NAD+ kinase activity. It is involved in the biological process described with: NADP biosynthetic process.	0.533
CG3106	CG8080	FBpp0311996	FBpp0087714	GH10201p; Transferase activity, transferring acyl groups other than amino-acyl groups.	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.	0.431
CG3106	CG8420	FBpp0311996	FBpp0081453	GH10201p; Transferase activity, transferring acyl groups other than amino-acyl groups.	LD42037p; It is involved in the biological process described with: multicellular organism reproduction.	0.835
CG3106	GramD1B	FBpp0311996	FBpp0297429	GH10201p; Transferase activity, transferring acyl groups other than amino-acyl groups.	GRAM domain containing 1B, isoform E.	0.663
CG33156	CG3106	FBpp0086803	FBpp0311996	Uncharacterized protein, isoform E; NAD+ kinase activity. It is involved in the biological process described with: NAD metabolic process; NADP biosynthetic process.	GH10201p; Transferase activity, transferring acyl groups other than amino-acyl groups.	0.670
CG33156	CG6145	FBpp0086803	FBpp0086806	Uncharacterized protein, isoform E; NAD+ kinase activity. It is involved in the biological process described with: NAD metabolic process; NADP biosynthetic process.	RH58004p; NAD+ kinase activity. It is involved in the biological process described with: NADP biosynthetic process.	0.621
CG33156	CG8080	FBpp0086803	FBpp0087714	Uncharacterized protein, isoform E; NAD+ kinase activity. It is involved in the biological process described with: NAD metabolic process; NADP biosynthetic process.	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.	0.985
CG33156	CG8420	FBpp0086803	FBpp0081453	Uncharacterized protein, isoform E; NAD+ kinase activity. It is involved in the biological process described with: NAD metabolic process; NADP biosynthetic process.	LD42037p; It is involved in the biological process described with: multicellular organism reproduction.	0.834
CG33156	GramD1B	FBpp0086803	FBpp0297429	Uncharacterized protein, isoform E; NAD+ kinase activity. It is involved in the biological process described with: NAD metabolic process; NADP biosynthetic process.	GRAM domain containing 1B, isoform E.	0.656
CG33156	Nadsyn	FBpp0086803	FBpp0073675	Uncharacterized protein, isoform E; NAD+ kinase activity. It is involved in the biological process described with: NAD metabolic process; NADP biosynthetic process.	Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source (By similarity). Because of its role in energy metabolism, involved in the modulation of aged- related cardiac function, mobility, and lifespan.	0.954