node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CG33156 | CG8080 | FBpp0086803 | FBpp0087714 | Uncharacterized protein, isoform E; NAD+ kinase activity. It is involved in the biological process described with: NAD metabolic process; NADP biosynthetic process. | NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. | 0.985 |
CG33156 | Nadsyn | FBpp0086803 | FBpp0073675 | Uncharacterized protein, isoform E; NAD+ kinase activity. It is involved in the biological process described with: NAD metabolic process; NADP biosynthetic process. | Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source (By similarity). Because of its role in energy metabolism, involved in the modulation of aged- related cardiac function, mobility, and lifespan. | 0.954 |
CG33156 | Naprt | FBpp0086803 | FBpp0077172 | Uncharacterized protein, isoform E; NAD+ kinase activity. It is involved in the biological process described with: NAD metabolic process; NADP biosynthetic process. | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis; Belongs to the NAPRTase family. | 0.564 |
CG33156 | Nmnat | FBpp0086803 | FBpp0084124 | Uncharacterized protein, isoform E; NAD+ kinase activity. It is involved in the biological process described with: NAD metabolic process; NADP biosynthetic process. | Nicotinamide mononucleotide adenylyltransferase (Nmnat) encodes an essential enzyme in the NAD salvage pathway, catalyzing the last step of NAD synthesis. It is also a neuronal maintenance factor that protects neurons from excitotoxicity, environmental stress and protein misfolding induced degeneration. | 0.956 |
CG33156 | Sirt1 | FBpp0086803 | FBpp0080015 | Uncharacterized protein, isoform E; NAD+ kinase activity. It is involved in the biological process described with: NAD metabolic process; NADP biosynthetic process. | NAD-dependent histone deacetylase sirtuin-1; NAD-dependent histone deacetylase involved in heterochromatic silencing. Mildly suppresses the heterochromatin-mediated silencing phenomenon known as position-effect variegation (PEV). Required for epigenetic silencing of the polycomb group proteins. Has histone H4 deacetylase activity in vitro. Required maternally for establishing proper segmentation of the embryo. Involved in sex determination. May be involved in the regulation of life span. | 0.922 |
CG33156 | Sirt2 | FBpp0086803 | FBpp0310647 | Uncharacterized protein, isoform E; NAD+ kinase activity. It is involved in the biological process described with: NAD metabolic process; NADP biosynthetic process. | NAD-dependent protein deacetylase Sirt2; NAD-dependent protein deacetylase (By similarity). May be involved in the regulation of life span; Belongs to the sirtuin family. Class I subfamily. | 0.922 |
CG33156 | Sirt4 | FBpp0086803 | FBpp0070817 | Uncharacterized protein, isoform E; NAD+ kinase activity. It is involved in the biological process described with: NAD metabolic process; NADP biosynthetic process. | NAD-dependent protein deacylase Sirt4; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues. | 0.918 |
CG33156 | Sirt6 | FBpp0086803 | FBpp0293897 | Uncharacterized protein, isoform E; NAD+ kinase activity. It is involved in the biological process described with: NAD metabolic process; NADP biosynthetic process. | Sirtuin 6 (Sirt6) encodes an NAD-dependent histone deacetylase in the class IV of the Sirtuin family. It is involved in chromatin silencing and determination of adult lifespan. | 0.918 |
CG33156 | Sirt7 | FBpp0086803 | FBpp0084733 | Uncharacterized protein, isoform E; NAD+ kinase activity. It is involved in the biological process described with: NAD metabolic process; NADP biosynthetic process. | NAD-dependent protein deacetylase Sirt7; NAD-dependent protein deacetylase. | 0.918 |
CG8080 | CG33156 | FBpp0087714 | FBpp0086803 | NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. | Uncharacterized protein, isoform E; NAD+ kinase activity. It is involved in the biological process described with: NAD metabolic process; NADP biosynthetic process. | 0.985 |
CG8080 | Nadsyn | FBpp0087714 | FBpp0073675 | NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. | Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source (By similarity). Because of its role in energy metabolism, involved in the modulation of aged- related cardiac function, mobility, and lifespan. | 0.948 |
CG8080 | Nmnat | FBpp0087714 | FBpp0084124 | NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. | Nicotinamide mononucleotide adenylyltransferase (Nmnat) encodes an essential enzyme in the NAD salvage pathway, catalyzing the last step of NAD synthesis. It is also a neuronal maintenance factor that protects neurons from excitotoxicity, environmental stress and protein misfolding induced degeneration. | 0.948 |
CG8080 | Sirt1 | FBpp0087714 | FBpp0080015 | NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. | NAD-dependent histone deacetylase sirtuin-1; NAD-dependent histone deacetylase involved in heterochromatic silencing. Mildly suppresses the heterochromatin-mediated silencing phenomenon known as position-effect variegation (PEV). Required for epigenetic silencing of the polycomb group proteins. Has histone H4 deacetylase activity in vitro. Required maternally for establishing proper segmentation of the embryo. Involved in sex determination. May be involved in the regulation of life span. | 0.900 |
CG8080 | Sirt2 | FBpp0087714 | FBpp0310647 | NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. | NAD-dependent protein deacetylase Sirt2; NAD-dependent protein deacetylase (By similarity). May be involved in the regulation of life span; Belongs to the sirtuin family. Class I subfamily. | 0.900 |
CG8080 | Sirt4 | FBpp0087714 | FBpp0070817 | NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. | NAD-dependent protein deacylase Sirt4; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues. | 0.900 |
CG8080 | Sirt6 | FBpp0087714 | FBpp0293897 | NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. | Sirtuin 6 (Sirt6) encodes an NAD-dependent histone deacetylase in the class IV of the Sirtuin family. It is involved in chromatin silencing and determination of adult lifespan. | 0.900 |
CG8080 | Sirt7 | FBpp0087714 | FBpp0084733 | NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. | NAD-dependent protein deacetylase Sirt7; NAD-dependent protein deacetylase. | 0.900 |
Nadsyn | CG33156 | FBpp0073675 | FBpp0086803 | Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source (By similarity). Because of its role in energy metabolism, involved in the modulation of aged- related cardiac function, mobility, and lifespan. | Uncharacterized protein, isoform E; NAD+ kinase activity. It is involved in the biological process described with: NAD metabolic process; NADP biosynthetic process. | 0.954 |
Nadsyn | CG8080 | FBpp0073675 | FBpp0087714 | Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source (By similarity). Because of its role in energy metabolism, involved in the modulation of aged- related cardiac function, mobility, and lifespan. | NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. | 0.948 |
Nadsyn | Naprt | FBpp0073675 | FBpp0077172 | Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source (By similarity). Because of its role in energy metabolism, involved in the modulation of aged- related cardiac function, mobility, and lifespan. | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis; Belongs to the NAPRTase family. | 0.984 |