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| | CG2652 | GH07966p; It is involved in the biological process described with: regulation of transcription, DNA-templated. (235 aa) |
| | Tip60 | Histone acetyltransferase Tip60; Tat interactive protein 60kDa (Tip60) encodes a lysine acetyltransferase that acetylates histone proteins to regulate chromatin packaging and epigenetic gene control. It also acetylates non-histone proteins, and plays a role in apoptosis, DNA repair and various neural processes. (541 aa) |
| | mof | Males-absent on the first protein; Histone acetyltransferase that plays a direct role in the specific histone acetylation associated with dosage compensation as part of the MSL complex. Dosage compensation insures that males with a single X chromosome have the same amount of most X-linked gene products as females with two X chromosomes. May be directly involved in the acetylation of histone 4 at 'Lys-16' on the X chromosome of males where it is recruited by the MSL complex. As part of the NSL complex may associate with promoters of X chromosomal as well as autosomal genes and positivel [...] (827 aa) |
| | NC2alpha | Negative Cofactor 2alpha (NC2alpha) encodes a protein that, together with the product of NC2beta forms the negative cofactor 2 complex (NC2), which represses transcription from TATA box-dependent core promoters and activates transcription from DPE-dependent core promoters. (341 aa) |
| | CG30184 | IP08069p. (223 aa) |
| | rno | Rhinoceros (rno) encodes a nuclear protein that functions in the Egfr signaling pathway, downstream of MAP kinase activation, and regulates transcription of Egfr targets. It is involved in cell differentiation and developmental patterning; Belongs to the JADE family. (3241 aa) |
| | Rcd5 | Reduction in Cnn dots 5 (Rcd5) encodes a protein that belongs to the family of forkhead-associated domain proteins. As part of the non-specific lethal complex, it regulates transcription of housekeeping genes by facilitating recruitment of RNA polymerase II to promoters. During mitosis it plays a key role in chromosomal-dependent microtubule assembly, centriole duplication and pericentriolar material maturation. (578 aa) |
| | e(y)2 | Enhancer of yellow 2 transcription factor; Involved in mRNA export coupled transcription activation by association with both the AMEX and the SAGA complexes. The SAGA complex is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Involved in t [...] (101 aa) |
| | Arp6 | Actin-related protein 6; Nucleosome binding; chromatin binding. It is involved in the biological process described with: histone exchange; heterochromatin organization; Belongs to the actin family. ARP6 subfamily. (398 aa) |
| | e(y)1 | Transcription initiation factor TFIID subunit 9; Enhancer of yellow 1 (e(y)1) encodes a TAF9 protein and a main component of the Transcription factor II D (TFIID) complex. TFIID is involved in recruiting the transcription machinery to core promoters and organizing specific enhancer-promoter interactions. (278 aa) |
| | Spt7 | LD38742p; Spt7 (Spt7) encodes a subunit of the SAGA chromatin modifying complex. (359 aa) |
| | Arp8 | Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize (By similarity); Belongs to the actin family. ARP8 subfamily. (607 aa) |
| | Ing3 | Inhibitor of growth protein; Histone acetyltransferase activity. It is involved in the biological process described with: histone acetylation; histone exchange. (686 aa) |
| | rept | RuvB-like helicase 2; Acts as a transcriptional coactivator in Wg signaling caused by altered arm signaling. Pont and rept interfere antagonistically with nuclear arm signaling function, and are required to enhance or reduce arm activity, respectively. Also an essential cofactor for the normal function of Myc; required for cellular proliferation and growth. (481 aa) |
| | CG32202 | GEO10739p1; DNA binding. It is involved in the biological process described with: positive regulation of apoptotic process; apoptotic signaling pathway. (141 aa) |
| | EAChm | Enhancer of Acetyltransferase Chameau (EAChm) encodes a protein that regulates gene transcription in embryos by enhancing the activity of the histone H3 acetyltransferase encoded by chm. (211 aa) |
| | CG12316 | GH22749p; Chromatin binding. It is involved in the biological process described with: histone H4-K16 acetylation. (1188 aa) |
| | Spt20 | Spt20, isoform A; Transcription coregulator activity. It is involved in the biological process described with: regulation of transcription by RNA polymerase II; histone acetylation. (1873 aa) |
| | Gcn5 | Gcn5 acetyltransferase (Gcn5) encodes a lysine acetyltransferase subunit of several chromatin modifying complexes. It contributes to oogenesis and metamorphosis. (813 aa) |
| | PCID2 | PCI domain-containing protein 2 homolog; Required for mRNA export together with Moe. Associates with translationally active polysomes. (395 aa) |
| | msl-3 | Protein male-specific lethal-3; Male-specific lethal 3 (msl-3) encodes a chromodomain protein, reported to interact with H3K36me3, H4K20me1 and DNA. It is a member of the Male-Specific-Lethal dosage compensation complex, which increases male X chromosome transcription approximately two-fold. Homozygous mutant males die as larvae, while females are viable. (512 aa) |
| | Eaf6 | Esa1-associated factor 6; Histone acetyltransferase activity (H3-K23 specific). (225 aa) |
| | msl-2 | E3 ubiquitin-protein ligase msl-2; The Msl proteins are essential for elevating transcription of the single X chromosome in the male (X chromosome dosage compensation). Msl-2 is required for translation and/or stability of msl-1 in males. In complex with msl-1, acts as an E3 ubiquitin ligase that promotes ubiquitination of histone H2B. Belongs to the MSL2 family. (773 aa) |
| | Taf10b | Transcription initiation factor TFIID subunit 10b; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. (146 aa) |
| | Saf6 | SAGA factor-like TAF6 (Saf6) encodes a component of the Spt-Ada-Gcn5 Acetyltransferase (SAGA) chromatin modifying complex. This complex is responsible for acetylation of histones and deubiquitination of the product of His2B at active promoters. The product of Saf6 replaces the product of mia within SAGA when the product of mia is restricted to the TFIID transcription complex. Notably, the product of Saf6 is essential for SAGA's co-activator function but does not impact either of its enzymatic activities. (717 aa) |
| | CG31917 | RE52596p2; Nucleosome binding; histone deacetylase binding. It is involved in the biological process described with: regulation of histone deacetylation; histone exchange. (151 aa) |
| | Atac1 | Ada2a-containing complex component 1 (Atac1) encodes a protein involved in chromatin remodeling and histone acetylation. (356 aa) |
| | Gas41 | LD16161p; Gas41 (Gas41) encodes a protein that contributes to histone acetylation and is involved in chromatin organization and RNA interference. (227 aa) |
| | D12 | D12 (D12) encodes a protein involved in chromatin remodeling and histone acetylation. (969 aa) |
| | CG6700 | Uncharacterized protein, isoform A. (874 aa) |
| | Ada1-2 | Transcriptional Adaptor 1-2 (Ada1-2) encodes a subunit of the SAGA chromatin modifying complex. (308 aa) |
| | Ada1-1 | Transcriptional Adaptor 1-1 (Ada1-1) encodes a subunit of the SAGA chromatin modifying complex. (308 aa) |
| | Ing5 | Inhibitor of growth family member 5 (Ing5) encodes a histone acetyltransferase that forms part of the Enok complex, which interacts with the product of elg1 to promote the G1/S transition via proliferating cell nuclear antigen (PCNA) unloading. (285 aa) |
| | NC2beta | Protein Dr1; Bifunctional basic transcription factor. Activates transcription of DPE (Downstream Promoter Element) containing promoters while repressing transcription of promoters which contain TATA elements. Together with Chrac-14, promotes nucleosome sliding of ATP-dependent nucelosome remodeling complexes. Belongs to the NC2 beta/DR1 family. (183 aa) |
| | Atac2 | Ada2a-containing complex component 2 (Atac2) encodes a protein involved in chromatin organization, intestinal stem cell homeostasis, and histone acetylation. (774 aa) |
| | msl-1 | Protein male-specific lethal-1; The Msl proteins are essential for elevating transcription of the single X chromosome in the male (X chromosome dosage compensation). Msl-1 is a pioneer protein. Mle, msl-1 and msl-3 are colocalized on the X chromosome. Each of the MSL proteins requires all the other MSLs for wild-type X-chromosome binding. In complex with msl-2, promotes ubiquitination of histone H2B. (1039 aa) |
| | pont | RuvB-like helicase 1; Acts as a transcriptional coactivator in Wg signaling caused by altered arm signaling. Pont and rept interfere antagonistically with nuclear arm signaling function, and are required to enhance or reduce arm activity, respectively. Also an essential cofactor for the normal function of Myc; required for cellular proliferation and growth. (456 aa) |
| | Spt3 | FI01013p; Spt3 (Spt3) encodes a encodes a subunit of the SAGA chromatin modifying complex. (384 aa) |
| | MBD-R2 | MBD-R2 (MBD-R2) encodes a Zinc finger C2H2 transcription factor. It is a component of nonspecific lethal (NSL) complex involved in transcriptional activation. (1169 aa) |
| | Arp5 | Actin-related protein 5; Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. (648 aa) |
| | Ino80 | Chromatin-remodeling ATPase INO80; INO80 complex subunit (Ino80) encodes a component of the INO80 chromatin remodelling complex that interacts with Polycomb and Trithorax group proteins. It is involved in the regulation of homeotic gene expression and regression of ecdysone dependent transcription; Belongs to the SNF2/RAD54 helicase family. (1638 aa) |
| | wda | Will decrease acetylation (wda) encodes a component of the highly conserved Spt-Ada-Gcn5 Acetyltransferase (SAGA) chromatin modifying complex. This complex is responsible for acetylation of histones and deubiquitination of the product of His2B at active promoters. The product of wda is a component of the histone-acetyltransferase (HAT) module, and is essential for full HAT activity of the the product of Gcn5. (743 aa) |
| | CG14551 | MIP11318p. (201 aa) |
| | CG1894 | Histone acetyltransferase activity; histone binding; H4 histone acetyltransferase activity. It is involved in the biological process described with: histone acetylation; positive regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; Belongs to the MYST (SAS/MOZ) family. (421 aa) |
| | Brd8 | Bromodomain containing 8; It is involved in the biological process described with: negative regulation of gene expression; histone exchange; histone acetylation. (872 aa) |
| | mle | Dosage compensation regulator; Required in males for dosage compensation of X chromosome linked genes. Mle, msl-1 and msl-3 are colocalized on X chromosome. Each of the msl proteins requires all the other msls for wild-type X- chromosome binding. Probably unwinds double-stranded DNA and RNA in a 3' to 5' direction; Belongs to the DEAD box helicase family. DEAH subfamily. (1293 aa) |
| | DMAP1 | DNA methyltransferase 1-associated protein 1; Involved in transcription repression and activation (By similarity). Required for larvae and pupal development, and for normal innate immune responses. Involved in modulating the activation of the immune deficiency pathway (Imd), acting either downstream of, or at the level of, the NF-kappa-B factor Rel. Possibly functions with akirin to regulate Rel, and its interaction with the Brahma complex protein Bap55 suggests that it may regulate the IMD pathway at the level of chromatin remodeling. (433 aa) |
| | Xpc | DNA repair protein complementing XP-C cells homolog; Involved in DNA excision repair. May play a part in DNA damage recognition and/or in altering chromatin structure to allow access by damage-processing enzymes (By similarity). (1294 aa) |
| | MrgBP | MRG/MORF4L binding protein; It is involved in the biological process described with: histone exchange; histone acetylation; regulation of transcription by RNA polymerase II. (201 aa) |
| | CG18004 | FI20187p1; It is involved in the biological process described with: chromatin remodeling. (297 aa) |
| | Ada2b | Transcriptional adapter 2B; Required for the function of some acidic activation domains, which activate transcription from a distant site. Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. (555 aa) |
| | Sgf11 | SAGA-associated factor 11 homolog; Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Binds independently on SAGA to promoters in an RNA- dependent manner. Bind [...] (196 aa) |
| | CG3437 | Uncharacterized protein; It is involved in the biological process described with: centrosome duplication; spindle assembly. (349 aa) |
| | Hel89B | Helicase 89B (Hel89B) encodes a protein that belongs to the SNF2 family of chromatin regulators. Hel89B product binds to large number of sites on polytene chromosomes and positively regulates the expression of antimicrobial peptide genes. (1923 aa) |
| | CG42750 | Dipeptidase; Beta-lactamase activity; dipeptidase activity; dipeptidyl-peptidase activity; metalloexopeptidase activity. It is involved in the biological process described with: proteolysis; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. (1068 aa) |
| | Nipped-A | Transcription-associated protein 1; Part of the Tip60 chromatin-remodeling complex which is involved in DNA repair. Upon induction of DNA double- strand breaks, this complex acetylates phosphorylated H2AV in nucleosomes and exchanges it with unmodified H2AV. During wing development, required for activity of Notch and its coactivator mam. Function in promoting mam function is likely to involve both the Tip60 and SAGA complexes. (3790 aa) |
| | CG17732 | Uncharacterized protein. (790 aa) |
| | CG43338 | Uncharacterized protein, isoform B. (853 aa) |
| | wds | Protein will die slowly; Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'. (361 aa) |
| | Atac3 | Ada2a-containing complex component 3 (Atac3) encodes a protein involved in chromatin remodeling and histone acetylation. (583 aa) |
| | nsl1 | Non-specific lethal 1, isoform M; Non-specific lethal 1 (nsl1) encodes a H4 histone acetyltransferase involved in muscle development, oogenesis and regulation of endocytosis. (1570 aa) |
| | Ada2a | Transcriptional adapter 2A; GCN5-independent Rpb4 complexes are highly enriched in decondensed chromosome puffs so may play a role in RNA polymerase II- dependent transcription. (562 aa) |
| | Rcd1 | Reduction in Cnn dots 1 (Rcd1) encodes a protein involved in centriole replication and transcription regulation. (1131 aa) |
| | dikar | Dikar, isoform F; Dikar (dikar) encodes a protein involved in long-term memory. (3261 aa) |
| | E(Pc) | Enhancer of Polycomb (E(Pc)) encodes a chromatin protein that functions as a suppressor of position-effect variegation. An unusual member of the Polycomb group; it does not exhibit homeotic transformations on its own, but rather enhances mutations in other Polycomb group genes. It forms part of the TIP60 histone acetyltransferase complex, which has been involved in many processes, including both transcriptional activation and repression. (2097 aa) |
| | Atxn7 | Ataxin 7 (Atxn7) encodes a component of the SAGA chromatin modifying complex, which is responsible for acetylation of histones and deubiquitination of the product of His2B at active promoters. The product of Atxn7 anchors the non-stop containing deubiquitinase module to the remainder of SAGA. Atxn7 is an essential gene for larval survival, neural development, and maintenance of neural tissues. (971 aa) |
| | chm | Chameau (chm) encodes a histone acetyl transferase involved in epigenetic mechanisms of transcriptional control and regulation of replication origin activity. Its functions include modulation of JNK activity and gene regulation by Polycomb group genes; Belongs to the MYST (SAS/MOZ) family. (811 aa) |
| | CG12659 | LD10749p; It is involved in the biological process described with: chromatin remodeling. (110 aa) |
| | CG17493 | Uncharacterized protein, isoform B; Calcium ion binding. It is involved in the biological process described with: mitotic cell cycle; centriole replication. (182 aa) |
| | JIL-1 | Chromosomal serine/threonine-protein kinase JIL-1; Phosphorylates 'Ser-10' of histone H3. May regulate gene expression by establishing or maintaining the structure of more open chromatin regions. Also required for normal polytene chromosome structure, for oogenesis and for viability throughout development. Regulates the structure of polytene chromosomes in salivary glands. May phosphorylate 'Ser-1' of histone H2A. (1207 aa) |
| | MRG15 | NuA4 complex subunit EAF3 homolog; Part of the Tip60 chromatin-remodeling complex which is involved in DNA repair. Upon induction of DNA double-strand breaks, this complex acetylates phosphorylated H2AV in nucleosomes and exchanges it with unmodified H2AV. (429 aa) |
| | His2Av | Histone H2A.v; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. Acts as a Polycomb group (PcG) protein required to maintain the transcriptionally repre [...] (141 aa) |
| | Ada3 | Transcriptional Adaptor 3 (Ada3) encodes subunit of some chromatin modifying complexes. (588 aa) |
| | dgt1 | Dim gamma-tubulin 1, isoform C; Histone acetyltransferase activity (H4-K16 specific); histone acetyltransferase activity (H4-K8 specific); histone acetyltransferase activity (H4-K5 specific). It is involved in the biological process described with: histone H4-K16 acetylation; histone H4-K8 acetylation; histone H4-K5 acetylation. (589 aa) |
| | YL-1 | Vacuolar protein sorting-associated protein 72 homolog; Part of the Tip60 chromatin-remodeling complex which is involved in DNA repair. Upon induction of DNA double-strand breaks, this complex acetylates phosphorylated H2AV in nucleosomes and exchanges it with unmodified H2AV. (351 aa) |
| | Sgf29 | SAGA-associated factor 29kDa (Sgf29) encodes a encodes subunit of some chromatin modifying complexes. (289 aa) |
| | dom | Helicase domino; Mediates the ATP-dependent exchange of unmodified histone H2AV for its phosphorylated and acetylated form H2AVK5acS138ph, leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in Notch signaling. Represses E2F target genes. Required for somatic stem cell self-renewal but not for germline stem cell self-renewal. Involved in oogenesis. Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. (3233 aa) |
| | enok | Histone acetyltransferase; Enoki mushroom (enok) encodes a MYST family histone acetyltransferase that acetylates lysine residues on histones, including H3K23, to regulate gene transcription. It contributes to stem cell self-renewal, oogenesis and neural development; Belongs to the MYST (SAS/MOZ) family. (2291 aa) |
| | l(3)L1231 | Lethal (3) L1231, isoform A; It is involved in the biological process described with: gravitaxis. (1200 aa) |
| | e(y)2b | Enhancer of yellow 2b transcription factor; Testis-specific paralog of the ubiquitously expressed transcription and mRNA export factor e(y)2. Cannot functionally replace e(y)2; Belongs to the ENY2 family. (95 aa) |
| | Br140 | Bromodomain-containing protein, 140kD (Br140) encodes a histone acetyltransferase that is a component of the Enok complex, which interacts with the product of elg1 via Br140 to promote the G1/S transition via proliferating cell nuclear antigen (PCNA) unloading. (1430 aa) |
| | CG11970 | BcDNA.LD23876; Protease binding. (1658 aa) |
| | not | Ubiquitin carboxyl-terminal hydrolase nonstop; Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of histone H2B, thereby acting as a coactivator in a large subset of genes. Required to counteract heterochromatin silencing. Controls the development of neuronal connectivity in visual system by being required for accurate axon targeting in the optic lobe. Required for expression of ecdysone-induced genes such as br/broad. Belongs to the peptidase C19 family. UBP8 subfamily. (496 aa) |
| | CG10395 | Uncharacterized protein, isoform D; It is involved in the biological process described with: ATP-dependent chromatin remodeling. (281 aa) |
| | xmas | Protein xmas-2; Xmas (xmas) encodes encodes a hydrophilic protein that is involved in spermatogenesis, oogenesis and embryogenesis. (2079 aa) |
