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e(y)1 e(y)1 Spt7 Spt7 Spt20 Spt20 Gcn5 Gcn5 Taf10b Taf10b Saf6 Saf6 Atac1 Atac1 D12 D12 Ada1-2 Ada1-2 Atac2 Atac2 Spt3 Spt3 wda wda Ada2b Ada2b Sgf11 Sgf11 Atac3 Atac3 Ada2a Ada2a Atxn7 Atxn7 Ada3 Ada3 Sgf29 Sgf29 not not
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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e(y)1Transcription initiation factor TFIID subunit 9; Enhancer of yellow 1 (e(y)1) encodes a TAF9 protein and a main component of the Transcription factor II D (TFIID) complex. TFIID is involved in recruiting the transcription machinery to core promoters and organizing specific enhancer-promoter interactions. (278 aa)
Spt7LD38742p; Spt7 (Spt7) encodes a subunit of the SAGA chromatin modifying complex. (359 aa)
Spt20Spt20, isoform A; Transcription coregulator activity. It is involved in the biological process described with: regulation of transcription by RNA polymerase II; histone acetylation. (1873 aa)
Gcn5Gcn5 acetyltransferase (Gcn5) encodes a lysine acetyltransferase subunit of several chromatin modifying complexes. It contributes to oogenesis and metamorphosis. (813 aa)
Taf10bTranscription initiation factor TFIID subunit 10b; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. (146 aa)
Saf6SAGA factor-like TAF6 (Saf6) encodes a component of the Spt-Ada-Gcn5 Acetyltransferase (SAGA) chromatin modifying complex. This complex is responsible for acetylation of histones and deubiquitination of the product of His2B at active promoters. The product of Saf6 replaces the product of mia within SAGA when the product of mia is restricted to the TFIID transcription complex. Notably, the product of Saf6 is essential for SAGA's co-activator function but does not impact either of its enzymatic activities. (717 aa)
Atac1Ada2a-containing complex component 1 (Atac1) encodes a protein involved in chromatin remodeling and histone acetylation. (356 aa)
D12D12 (D12) encodes a protein involved in chromatin remodeling and histone acetylation. (969 aa)
Ada1-2Transcriptional Adaptor 1-2 (Ada1-2) encodes a subunit of the SAGA chromatin modifying complex. (308 aa)
Atac2Ada2a-containing complex component 2 (Atac2) encodes a protein involved in chromatin organization, intestinal stem cell homeostasis, and histone acetylation. (774 aa)
Spt3FI01013p; Spt3 (Spt3) encodes a encodes a subunit of the SAGA chromatin modifying complex. (384 aa)
wdaWill decrease acetylation (wda) encodes a component of the highly conserved Spt-Ada-Gcn5 Acetyltransferase (SAGA) chromatin modifying complex. This complex is responsible for acetylation of histones and deubiquitination of the product of His2B at active promoters. The product of wda is a component of the histone-acetyltransferase (HAT) module, and is essential for full HAT activity of the the product of Gcn5. (743 aa)
Ada2bTranscriptional adapter 2B; Required for the function of some acidic activation domains, which activate transcription from a distant site. Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. (555 aa)
Sgf11SAGA-associated factor 11 homolog; Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Binds independently on SAGA to promoters in an RNA- dependent manner. Bind [...] (196 aa)
Atac3Ada2a-containing complex component 3 (Atac3) encodes a protein involved in chromatin remodeling and histone acetylation. (583 aa)
Ada2aTranscriptional adapter 2A; GCN5-independent Rpb4 complexes are highly enriched in decondensed chromosome puffs so may play a role in RNA polymerase II- dependent transcription. (562 aa)
Atxn7Ataxin 7 (Atxn7) encodes a component of the SAGA chromatin modifying complex, which is responsible for acetylation of histones and deubiquitination of the product of His2B at active promoters. The product of Atxn7 anchors the non-stop containing deubiquitinase module to the remainder of SAGA. Atxn7 is an essential gene for larval survival, neural development, and maintenance of neural tissues. (971 aa)
Ada3Transcriptional Adaptor 3 (Ada3) encodes subunit of some chromatin modifying complexes. (588 aa)
Sgf29SAGA-associated factor 29kDa (Sgf29) encodes a encodes subunit of some chromatin modifying complexes. (289 aa)
notUbiquitin carboxyl-terminal hydrolase nonstop; Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of histone H2B, thereby acting as a coactivator in a large subset of genes. Required to counteract heterochromatin silencing. Controls the development of neuronal connectivity in visual system by being required for accurate axon targeting in the optic lobe. Required for expression of ecdysone-induced genes such as br/broad. Belongs to the peptidase C19 family. UBP8 subfamily. (496 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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