Bub1 kinase (Bub1) encodes a spindle checkpoint protein regulating chromosome congression. It also contributes to clathrin-dependent endocytosis of pathogens.

Bub3, isoform A; Bub3 (Bub3) encodes a protein that functions in the spindle assembly checkpoint (SAC) pathway. This mitotic checkpoint pathway inhibits the APC/C complex and hence the transition from metaphase to anaphase, as long as there are free kinetochores that are not yet attached to the mitotic spindle in the cell. The product of Bub3 is localized at the kinetochore during mitosis with maximal levels observed at free kinetochores. Together with other SAC proteins it forms mitotic checkpoint complexes that bind and inhibit the APC/C.

Bub1 kinase (Bub1) encodes a spindle checkpoint protein regulating chromosome congression. It also contributes to clathrin-dependent endocytosis of pathogens.

Bub1-related kinase (BubR1) encodes a motif-rich protein with a C-terminal serine-threonine kinase domain. During prometaphase and metaphase, it plays important roles in spindle assembly checkpoint signalling, stabilization of kinetochore-microtuble attachments and chromosome alignment. It is also essential to maintain sister-chromatid cohesion during meiotic progression and for normal maintenance of Synaptonemal Complex in females.

Bub1 kinase (Bub1) encodes a spindle checkpoint protein regulating chromosome congression. It also contributes to clathrin-dependent endocytosis of pathogens.

RT07324p; ATP-dependent microtubule motor activity, plus-end-directed; microtubule motor activity; ATP binding; microtubule binding. It is involved in the biological process described with: microtubule-based movement; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

Bub1 kinase (Bub1) encodes a spindle checkpoint protein regulating chromosome congression. It also contributes to clathrin-dependent endocytosis of pathogens.

Uncharacterized protein.

Bub1 kinase (Bub1) encodes a spindle checkpoint protein regulating chromosome congression. It also contributes to clathrin-dependent endocytosis of pathogens.

RE25723p; Protein serine/threonine kinase activity; ATP binding. It is involved in the biological process described with: protein phosphorylation; mitotic cell cycle.

Bub1 kinase (Bub1) encodes a spindle checkpoint protein regulating chromosome congression. It also contributes to clathrin-dependent endocytosis of pathogens.

GEO07887p1; Deterin (Det) encodes a component of the chromosomal passenger complex involved in regulation of apoptosis and cytokinesis.

Bub1 kinase (Bub1) encodes a spindle checkpoint protein regulating chromosome congression. It also contributes to clathrin-dependent endocytosis of pathogens.

Inner centromere protein (Incenp) encodes a component of the chromosomal passenger complex, acting as a subunit that targets and activates the product of aurB. It controls different processes during cell division, including regulation of chromosome structure, kinetochore-microtubule error correction, chromosome segregation and cytokinesis.

Bub1 kinase (Bub1) encodes a spindle checkpoint protein regulating chromosome congression. It also contributes to clathrin-dependent endocytosis of pathogens.

Kinesin-like protein at 3A (Klp3A) encodes a microtubule motor protein involved in chromosome segregation and mitotic spindle morphogenesis; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

Bub1 kinase (Bub1) encodes a spindle checkpoint protein regulating chromosome congression. It also contributes to clathrin-dependent endocytosis of pathogens.

Mitotic arrest-deficient 1 (Mad1) encodes a conserved, essential component of the spindle checkpoint. During mitosis, it is recruited to unattached kinetochores, where it binds the product of mad2 and promotes the assembly of the products of mad2 and fzy into the mitotic checkpoint complex. During interphase, Mad1 is intranuclear, bound to the product of mad2, and associated primarily with the nuclear pore complex.

Bub1 kinase (Bub1) encodes a spindle checkpoint protein regulating chromosome congression. It also contributes to clathrin-dependent endocytosis of pathogens.

Monopolar spindle 1, isoform B; Monopolar spindle 1 (Mps1) encodes a conserved protein kinase that is associated with kinetochores and is required for the mitotic and meiotic spindle assembly checkpoints.

Bub1 kinase (Bub1) encodes a spindle checkpoint protein regulating chromosome congression. It also contributes to clathrin-dependent endocytosis of pathogens.

GTPase-activating protein RacGAP84C; Involved in the morphogenesis of the adult appendages. GTPase-activating protein for p21-Rac. Promotes the exchange of Rac- bound GDP by GTP.

Bub1 kinase (Bub1) encodes a spindle checkpoint protein regulating chromosome congression. It also contributes to clathrin-dependent endocytosis of pathogens.

Rho GTPase activating protein at 18B (RhoGAP18B) encodes a protein that can act as a GTPase activating protein for several Rho GTPase and is involved in the regulation of actin dynamics.

Bub1 kinase (Bub1) encodes a spindle checkpoint protein regulating chromosome congression. It also contributes to clathrin-dependent endocytosis of pathogens.

Spindly (Spindly) encodes a key regulator of dynein recruitment to kinetochores and is involved in the spindle assembly checkpoint during the cell cycle. It also contributes to cell morphology and migration.

Bub1 kinase (Bub1) encodes a spindle checkpoint protein regulating chromosome congression. It also contributes to clathrin-dependent endocytosis of pathogens.

Centromere/kinetochore protein zw10; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin, Mad2 complexes and spindly/CG15415 onto kinetochores. During cytokinesis in male meiotic cells it is required for completion of cleavage furrow ingression, possibly in conjunction with Rint1. Required for maintenance of Golgi stack number and morphology, and acroblast assembly. Its function related to the spindle assembly machinery is proposed to depend on its association in the RZZ complex. Failure [...]

Bub1 kinase (Bub1) encodes a spindle checkpoint protein regulating chromosome congression. It also contributes to clathrin-dependent endocytosis of pathogens.

Protein zwilch; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin, Mad2 complexes and spindly/CG15415 onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the RZZ complex. Failure to assemble the complex due to the absence of any one of its components, results in the incorrect redistribution of the remaining components to diverse membrane compartments ; Belongs to the ZWILCH family.

Bub1 kinase (Bub1) encodes a spindle checkpoint protein regulating chromosome congression. It also contributes to clathrin-dependent endocytosis of pathogens.

Protein abnormal spindle; Required to maintain the structure of the centrosomal microtubule organizing center (MTOC) during mitosis. May have a preferential role in regulating neurogenesis. Required for germ cell mitosis and oocyte differentiation.

Bub1 kinase (Bub1) encodes a spindle checkpoint protein regulating chromosome congression. It also contributes to clathrin-dependent endocytosis of pathogens.

Aurora B (aurB) encodes a serine-threonine kinase and member of the chromosomal passenger complex. It plays multiple roles in mitosis including the correction of erroneous chromosome-spindle interactions, chromosome condensation, kinetochore assembly, spindle assembly checkpoint and cytokinesis.

Bub1 kinase (Bub1) encodes a spindle checkpoint protein regulating chromosome congression. It also contributes to clathrin-dependent endocytosis of pathogens.

Australin, isoform A; Australin (aust) is a male meiotic specific paralogue of borr, which encodes one of the three targeting subunits for the product of aurB in the chromosomal passenger complex (CPC). The CPC is critical in regulating multiple aspects of cell division, including chromosome condensation, kinetochore function and cytokinesis, through the kinase activity of the product of aurB.

Bub1 kinase (Bub1) encodes a spindle checkpoint protein regulating chromosome congression. It also contributes to clathrin-dependent endocytosis of pathogens.

Borealin-related (borr) encodes one of the three targeting subunits for the product of aurB in the chromosomal passenger complex. It helps to target the complex to the centromere region of chromosomes and the cleavage furrow during cytokinesis. At centromeres the complex is involved both in pausing mitotic progression when there are chromosome mis-attachments and in correcting those mis-attachments. At the cleavage furrow, the complex is involved in regulating the process of abscission (cell separation).

Bub1 kinase (Bub1) encodes a spindle checkpoint protein regulating chromosome congression. It also contributes to clathrin-dependent endocytosis of pathogens.

CENP-ana, isoform A; CENP-ana (cana) encodes a kinetochore kinesin that contributes to metaphase chromosome alignment; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.