| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Det | Incenp | FBpp0082849 | FBpp0088035 | GEO07887p1; Deterin (Det) encodes a component of the chromosomal passenger complex involved in regulation of apoptosis and cytokinesis. | Inner centromere protein (Incenp) encodes a component of the chromosomal passenger complex, acting as a subunit that targets and activates the product of aurB. It controls different processes during cell division, including regulation of chromosome structure, kinetochore-microtubule error correction, chromosome segregation and cytokinesis. | 0.999 |
| Det | Klp3A | FBpp0082849 | FBpp0070432 | GEO07887p1; Deterin (Det) encodes a component of the chromosomal passenger complex involved in regulation of apoptosis and cytokinesis. | Kinesin-like protein at 3A (Klp3A) encodes a microtubule motor protein involved in chromosome segregation and mitotic spindle morphogenesis; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.837 |
| Det | aurB | FBpp0082849 | FBpp0079769 | GEO07887p1; Deterin (Det) encodes a component of the chromosomal passenger complex involved in regulation of apoptosis and cytokinesis. | Aurora B (aurB) encodes a serine-threonine kinase and member of the chromosomal passenger complex. It plays multiple roles in mitosis including the correction of erroneous chromosome-spindle interactions, chromosome condensation, kinetochore assembly, spindle assembly checkpoint and cytokinesis. | 0.998 |
| Det | aust | FBpp0082849 | FBpp0310419 | GEO07887p1; Deterin (Det) encodes a component of the chromosomal passenger complex involved in regulation of apoptosis and cytokinesis. | Australin, isoform A; Australin (aust) is a male meiotic specific paralogue of borr, which encodes one of the three targeting subunits for the product of aurB in the chromosomal passenger complex (CPC). The CPC is critical in regulating multiple aspects of cell division, including chromosome condensation, kinetochore function and cytokinesis, through the kinase activity of the product of aurB. | 0.998 |
| Det | borr | FBpp0082849 | FBpp0079417 | GEO07887p1; Deterin (Det) encodes a component of the chromosomal passenger complex involved in regulation of apoptosis and cytokinesis. | Borealin-related (borr) encodes one of the three targeting subunits for the product of aurB in the chromosomal passenger complex. It helps to target the complex to the centromere region of chromosomes and the cleavage furrow during cytokinesis. At centromeres the complex is involved both in pausing mitotic progression when there are chromosome mis-attachments and in correcting those mis-attachments. At the cleavage furrow, the complex is involved in regulating the process of abscission (cell separation). | 0.999 |
| Det | feo | FBpp0082849 | FBpp0073266 | GEO07887p1; Deterin (Det) encodes a component of the chromosomal passenger complex involved in regulation of apoptosis and cytokinesis. | Fascetto (feo) encodes a protein that binds the central spindle microtubules and is required for proper midbody formation and cytokinesis. It also has roles in centrosome duplication and neurogenesis. | 0.887 |
| Det | pav | FBpp0082849 | FBpp0073083 | GEO07887p1; Deterin (Det) encodes a component of the chromosomal passenger complex involved in regulation of apoptosis and cytokinesis. | Kinesin-like protein; Pavarotti (pav) encodes a microtubule motor protein from the Kinesin superfamily. It plays important roles during the mitotic cycle including spindle formation, cortical cytoskeleton reorganization and cytokinesis. It also negatively regulates Wnt activity. | 0.823 |
| Det | pbl | FBpp0082849 | FBpp0076487 | GEO07887p1; Deterin (Det) encodes a component of the chromosomal passenger complex involved in regulation of apoptosis and cytokinesis. | Pebble, isoform B; Pebble (pbl) encodes a Rho guanine nucleotide exchange factor that contributes to multiple processes involving actin cytoskeleton reorganization, including cytokinesis, axogenesis and wound healing as well as cell shape regulation and cell migration during gastrulation. | 0.783 |
| Det | scra | FBpp0082849 | FBpp0087986 | GEO07887p1; Deterin (Det) encodes a component of the chromosomal passenger complex involved in regulation of apoptosis and cytokinesis. | Anillin; Required for cytokinesis. Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression and proper formation of the midbody. Required during cellularization of syncytial embryos for the proper formation and function of the furrow canals, the stable inward folds of the plasma membrane which separate the peripheral nuclei. Also required for the formation of the pole cells, the progenitors of the adult germline which are formed by cytokinesis of the cytoplasmic buds at the posterior pole of the syncytial embryo. Essential for embry [...] | 0.630 |
| Det | tum | FBpp0082849 | FBpp0086767 | GEO07887p1; Deterin (Det) encodes a component of the chromosomal passenger complex involved in regulation of apoptosis and cytokinesis. | Tumbleweed (tum) encodes a GTPase activating protein for Rho family GTPases involved in Wnt signalling regulation. | 0.770 |
| Incenp | Det | FBpp0088035 | FBpp0082849 | Inner centromere protein (Incenp) encodes a component of the chromosomal passenger complex, acting as a subunit that targets and activates the product of aurB. It controls different processes during cell division, including regulation of chromosome structure, kinetochore-microtubule error correction, chromosome segregation and cytokinesis. | GEO07887p1; Deterin (Det) encodes a component of the chromosomal passenger complex involved in regulation of apoptosis and cytokinesis. | 0.999 |
| Incenp | Klp3A | FBpp0088035 | FBpp0070432 | Inner centromere protein (Incenp) encodes a component of the chromosomal passenger complex, acting as a subunit that targets and activates the product of aurB. It controls different processes during cell division, including regulation of chromosome structure, kinetochore-microtubule error correction, chromosome segregation and cytokinesis. | Kinesin-like protein at 3A (Klp3A) encodes a microtubule motor protein involved in chromosome segregation and mitotic spindle morphogenesis; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.864 |
| Incenp | aurB | FBpp0088035 | FBpp0079769 | Inner centromere protein (Incenp) encodes a component of the chromosomal passenger complex, acting as a subunit that targets and activates the product of aurB. It controls different processes during cell division, including regulation of chromosome structure, kinetochore-microtubule error correction, chromosome segregation and cytokinesis. | Aurora B (aurB) encodes a serine-threonine kinase and member of the chromosomal passenger complex. It plays multiple roles in mitosis including the correction of erroneous chromosome-spindle interactions, chromosome condensation, kinetochore assembly, spindle assembly checkpoint and cytokinesis. | 0.999 |
| Incenp | aust | FBpp0088035 | FBpp0310419 | Inner centromere protein (Incenp) encodes a component of the chromosomal passenger complex, acting as a subunit that targets and activates the product of aurB. It controls different processes during cell division, including regulation of chromosome structure, kinetochore-microtubule error correction, chromosome segregation and cytokinesis. | Australin, isoform A; Australin (aust) is a male meiotic specific paralogue of borr, which encodes one of the three targeting subunits for the product of aurB in the chromosomal passenger complex (CPC). The CPC is critical in regulating multiple aspects of cell division, including chromosome condensation, kinetochore function and cytokinesis, through the kinase activity of the product of aurB. | 0.996 |
| Incenp | borr | FBpp0088035 | FBpp0079417 | Inner centromere protein (Incenp) encodes a component of the chromosomal passenger complex, acting as a subunit that targets and activates the product of aurB. It controls different processes during cell division, including regulation of chromosome structure, kinetochore-microtubule error correction, chromosome segregation and cytokinesis. | Borealin-related (borr) encodes one of the three targeting subunits for the product of aurB in the chromosomal passenger complex. It helps to target the complex to the centromere region of chromosomes and the cleavage furrow during cytokinesis. At centromeres the complex is involved both in pausing mitotic progression when there are chromosome mis-attachments and in correcting those mis-attachments. At the cleavage furrow, the complex is involved in regulating the process of abscission (cell separation). | 0.999 |
| Incenp | feo | FBpp0088035 | FBpp0073266 | Inner centromere protein (Incenp) encodes a component of the chromosomal passenger complex, acting as a subunit that targets and activates the product of aurB. It controls different processes during cell division, including regulation of chromosome structure, kinetochore-microtubule error correction, chromosome segregation and cytokinesis. | Fascetto (feo) encodes a protein that binds the central spindle microtubules and is required for proper midbody formation and cytokinesis. It also has roles in centrosome duplication and neurogenesis. | 0.950 |
| Incenp | pav | FBpp0088035 | FBpp0073083 | Inner centromere protein (Incenp) encodes a component of the chromosomal passenger complex, acting as a subunit that targets and activates the product of aurB. It controls different processes during cell division, including regulation of chromosome structure, kinetochore-microtubule error correction, chromosome segregation and cytokinesis. | Kinesin-like protein; Pavarotti (pav) encodes a microtubule motor protein from the Kinesin superfamily. It plays important roles during the mitotic cycle including spindle formation, cortical cytoskeleton reorganization and cytokinesis. It also negatively regulates Wnt activity. | 0.995 |
| Incenp | pbl | FBpp0088035 | FBpp0076487 | Inner centromere protein (Incenp) encodes a component of the chromosomal passenger complex, acting as a subunit that targets and activates the product of aurB. It controls different processes during cell division, including regulation of chromosome structure, kinetochore-microtubule error correction, chromosome segregation and cytokinesis. | Pebble, isoform B; Pebble (pbl) encodes a Rho guanine nucleotide exchange factor that contributes to multiple processes involving actin cytoskeleton reorganization, including cytokinesis, axogenesis and wound healing as well as cell shape regulation and cell migration during gastrulation. | 0.693 |
| Incenp | scra | FBpp0088035 | FBpp0087986 | Inner centromere protein (Incenp) encodes a component of the chromosomal passenger complex, acting as a subunit that targets and activates the product of aurB. It controls different processes during cell division, including regulation of chromosome structure, kinetochore-microtubule error correction, chromosome segregation and cytokinesis. | Anillin; Required for cytokinesis. Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression and proper formation of the midbody. Required during cellularization of syncytial embryos for the proper formation and function of the furrow canals, the stable inward folds of the plasma membrane which separate the peripheral nuclei. Also required for the formation of the pole cells, the progenitors of the adult germline which are formed by cytokinesis of the cytoplasmic buds at the posterior pole of the syncytial embryo. Essential for embry [...] | 0.935 |
| Incenp | tum | FBpp0088035 | FBpp0086767 | Inner centromere protein (Incenp) encodes a component of the chromosomal passenger complex, acting as a subunit that targets and activates the product of aurB. It controls different processes during cell division, including regulation of chromosome structure, kinetochore-microtubule error correction, chromosome segregation and cytokinesis. | Tumbleweed (tum) encodes a GTPase activating protein for Rho family GTPases involved in Wnt signalling regulation. | 0.951 |