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Pat1 Pat1 Klp59D Klp59D Klp59C Klp59C Klp61F Klp61F Klp10A Klp10A nod nod Klp68D Klp68D Klp64D Klp64D CG10845 CG10845 Kif3C Kif3C Kap3 Kap3 ncd ncd Klp67A Klp67A Klp54D Klp54D
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Pat1Protein interacting with APP tail-1 (Pat1) encodes a protein required for the product of Khc to transport cargo and to maximize its motility. In oocytes the products of Pat1 and Klc act in a redundant manner. (686 aa)
Klp59DKinesin-like protein at 59D (Klp59D) encodes a kinesin involved in the regulation spindle microtubule dynamics and sperm ciliogenesis; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (729 aa)
Klp59CKinesin-like protein Klp59C; Required during anaphase to drive sister chromatid separation to actively depolymerize kinetochore microtubules at their kinetochore- associated plus ends, thereby contributing to chromatid mobility through a 'Pac-man' mechanism. (626 aa)
Klp61FKinesin-like protein Klp61F; Important role in mitotic dividing cells. Microtubule motor required for spindle body separation. Slow plus-end directed microtubule motor capable of cross-linking and sliding apart antiparallel microtubules, thereby pushing apart the associated spindle poles during spindle assembly and function. Forms cross-links between microtubules within interpolar microtubule bundles. Contributes to the length of the metaphase spindle, maintains the prometaphase spindle by antagonizing Ncd, drives anaphase B, and also contributes to normal chromosome congression, kinet [...] (1066 aa)
Klp10AKinesin-like protein Klp10A; Required during anaphase to drive sister chromatid separation to promote flux by actively depolymerizing kinetochore microtubules at their pole-associated minus ends, thereby moving chromatids through a 'poleward flux'. Involved in asymmetric cell division of sensory organ precursor (SOP) cells by playing a role in the asymmetric localization of Sara- expressing endosomes to the pIIa daughter cell but not to the pIIb cell. Klp98A targets Sara-expressing endosomes to the central spindle which is symmetrically arranged in early cell division. During late cyto [...] (805 aa)
nodKinesin-like protein Nod; No distributive disjunction (nod) encodes a kinesin-like protein that is important for nonexchange chromosome biology. The nod product is necessary for chromosome segregation during meiosis and for proper chromosome alignment along the meiotic spindle. (666 aa)
Klp68DKinesin-like protein at 68D (Klp68D) encodes the kinesin-2beta motor subunit of the heterotrimeric kinesin-2. It associates with the products of Klp64D and Kap3. It plays an essential role in the sensory cilia assembly, microtubule organization in dendrites, and axonal transport. (784 aa)
Klp64DKinesin-like protein at 64D (Klp64D) encodes the kinesin-2alpha motor subunit of the heterotrimeric kinesin-2. It associates with the products of Klp68D and Kap3. It plays an essential role in sensory cilia assembly and axonal transport; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (677 aa)
CG10845FI06030p; Microtubule binding. (463 aa)
Kif3CKinesin-like protein; It is involved in the biological process described with: microtubule-based movement; cell projection organization; anterograde dendritic transport of neurotransmitter receptor complex; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (649 aa)
Kap3Kinesin associated protein 3 (Kap3) encodes the non-motor accessory subunit of the heterotrimeric kinesin-2. It associates to the coiled-coil stalk domain of the products of Klp68D andKlp64D. It plays an essential role in sensory cilia assembly and axonal transport. (1038 aa)
ncdProtein claret segregational; Non-claret disjunctional (ncd) encodes a minus-end-directed kinesin microtubule motor protein and the sole member of the kinesin-14 motor family. It is required for spindle assembly in oocytes and chromosome attachment to spindles in early embryos; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. NCD subfamily. (700 aa)
Klp67AKinesin-like protein at 67A (Klp67A) encodes a microtubule motor protein involved in chromosome congression and mitotic spindle morphogenesis; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (814 aa)
Klp54DKinesin-like protein; Microtubule binding; ATPase activity; ATP binding; microtubule motor activity. It is involved in the biological process described with: microtubule-based movement; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (760 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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