Centrosomal protein 135kDa (Cep135) encodes a microtubule binding protein important for centriole elongation and stability. It promotes centrosome asymmetry and spindle orientation in neuroblasts and it is required for male fertility.

Centrosomal protein 97kDa, isoform B; Centrosomal protein 97kDa (Cep97) encodes a centriolar protein that localizes to the distal end of both mother and daughter centrioles. It interacts with the product of Cp110, which is also localized to the distal end of the centrioles. Together they seem to prevent the centriole microtubules from extending beyond the distal end of the centriole.

Centrosomal protein 135kDa (Cep135) encodes a microtubule binding protein important for centriole elongation and stability. It promotes centrosome asymmetry and spindle orientation in neuroblasts and it is required for male fertility.

Centriolar coiled coil protein 110kDa (Cp110) encodes a centriolar protein that localizes to the distal end of both mother and daughter centrioles. It seems to prevent the centriole microtubules from extending beyond the distal end of the centriole. It interacts with the product of Cep97, another protein localized to the distal end of the centrioles.

Centrosomal protein 135kDa (Cep135) encodes a microtubule binding protein important for centriole elongation and stability. It promotes centrosome asymmetry and spindle orientation in neuroblasts and it is required for male fertility.

Pericentrin-like protein, isoform F; Pericentrin-like protein (Plp) encodes a protein localized to centrioles and centrosomes that plays an important role together with the product of cnn in organizing the pericentriolar material of the centrosome during interphase. It is also required for proper cilium function.

Centrosomal protein 135kDa (Cep135) encodes a microtubule binding protein important for centriole elongation and stability. It promotes centrosome asymmetry and spindle orientation in neuroblasts and it is required for male fertility.

Serine/threonine-protein kinase PLK4; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the mother centriole cylinder, using mother centriole as a platform, leading to the recruitment of centriole biogenesis proteins such as Sas-6. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Centrosome amplification following overexpression can initiate tumorigenesis, highlighting [...]

Centrosomal protein 135kDa (Cep135) encodes a microtubule binding protein important for centriole elongation and stability. It promotes centrosome asymmetry and spindle orientation in neuroblasts and it is required for male fertility.

Spindle assembly abnormal 4 (Sas-4) encodes a centriole protein that is essential for centriole assembly. It is recruited to centrioles through an interaction with the centriole protein encoded by ana2, and it helps recruit microtubules to the centriole.

Centrosomal protein 135kDa (Cep135) encodes a microtubule binding protein important for centriole elongation and stability. It promotes centrosome asymmetry and spindle orientation in neuroblasts and it is required for male fertility.

Spindle assembly abnormal protein 6 homolog; Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication. In ciliated neurons, required for centriole assembly but not necessary for cilium basal body and cilia function. Required for sperm cilium basal body elongation together with Cep135 and Ana2.

Centrosomal protein 135kDa (Cep135) encodes a microtubule binding protein important for centriole elongation and stability. It promotes centrosome asymmetry and spindle orientation in neuroblasts and it is required for male fertility.

Anastral spindle 1 (ana1) encodes a cytoplasmic protein located in the centrioles, including the sperm giant centriole and proximal centriole-like structure, which assists in centrioles formation. Its roles include coordinated movement behavior, sperm motility, and fertility.

Centrosomal protein 135kDa (Cep135) encodes a microtubule binding protein important for centriole elongation and stability. It promotes centrosome asymmetry and spindle orientation in neuroblasts and it is required for male fertility.

Anastral spindle 2 (ana2) encodes a centriole protein that is essential for centriole assembly, promoting the assembly of the central "cartwheel" structure. It may also have an independent role in promoting asymmetric divisions in larval neuroblasts.

Centrosomal protein 135kDa (Cep135) encodes a microtubule binding protein important for centriole elongation and stability. It promotes centrosome asymmetry and spindle orientation in neuroblasts and it is required for male fertility.

Asterless (asl) encodes a component of the centriole that is required for centrosome function. It contributes to asymmetric cell division, sperm development and centriole replication and elongation.

Centrosomal protein 135kDa (Cep135) encodes a microtubule binding protein important for centriole elongation and stability. It promotes centrosome asymmetry and spindle orientation in neuroblasts and it is required for male fertility.

Centrosomin (cnn) encodes an essential mitotic centrosome component. During early embryogenesis it is required to organize the mitotic spindle, the actin cytoskeleton and centriole replication. It is also required for mitotic and meiotic divisions during spermatogenesis, as well as organization of the sperm axoneme. The product of cnn can interact with microtubules, actin and the kinase encoded by polo.

Centrosomal protein 135kDa (Cep135) encodes a microtubule binding protein important for centriole elongation and stability. It promotes centrosome asymmetry and spindle orientation in neuroblasts and it is required for male fertility.

Spindle defective 2 (spd-2) encodes a centriole and centrosome protein that is primarily involved in centrosome assembly. Together with the product of cnn, it helps to assemble a "scaffold" around the mother centriole that can recruit other centrosomal proteins to the centrosome during mitosis.

Centrosomal protein 97kDa, isoform B; Centrosomal protein 97kDa (Cep97) encodes a centriolar protein that localizes to the distal end of both mother and daughter centrioles. It interacts with the product of Cp110, which is also localized to the distal end of the centrioles. Together they seem to prevent the centriole microtubules from extending beyond the distal end of the centriole.

Centrosomal protein 135kDa (Cep135) encodes a microtubule binding protein important for centriole elongation and stability. It promotes centrosome asymmetry and spindle orientation in neuroblasts and it is required for male fertility.

Centrosomal protein 97kDa, isoform B; Centrosomal protein 97kDa (Cep97) encodes a centriolar protein that localizes to the distal end of both mother and daughter centrioles. It interacts with the product of Cp110, which is also localized to the distal end of the centrioles. Together they seem to prevent the centriole microtubules from extending beyond the distal end of the centriole.

Centriolar coiled coil protein 110kDa (Cp110) encodes a centriolar protein that localizes to the distal end of both mother and daughter centrioles. It seems to prevent the centriole microtubules from extending beyond the distal end of the centriole. It interacts with the product of Cep97, another protein localized to the distal end of the centrioles.

Centrosomal protein 97kDa, isoform B; Centrosomal protein 97kDa (Cep97) encodes a centriolar protein that localizes to the distal end of both mother and daughter centrioles. It interacts with the product of Cp110, which is also localized to the distal end of the centrioles. Together they seem to prevent the centriole microtubules from extending beyond the distal end of the centriole.

Pericentrin-like protein, isoform F; Pericentrin-like protein (Plp) encodes a protein localized to centrioles and centrosomes that plays an important role together with the product of cnn in organizing the pericentriolar material of the centrosome during interphase. It is also required for proper cilium function.

Centrosomal protein 97kDa, isoform B; Centrosomal protein 97kDa (Cep97) encodes a centriolar protein that localizes to the distal end of both mother and daughter centrioles. It interacts with the product of Cp110, which is also localized to the distal end of the centrioles. Together they seem to prevent the centriole microtubules from extending beyond the distal end of the centriole.

Serine/threonine-protein kinase PLK4; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the mother centriole cylinder, using mother centriole as a platform, leading to the recruitment of centriole biogenesis proteins such as Sas-6. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Centrosome amplification following overexpression can initiate tumorigenesis, highlighting [...]

Centrosomal protein 97kDa, isoform B; Centrosomal protein 97kDa (Cep97) encodes a centriolar protein that localizes to the distal end of both mother and daughter centrioles. It interacts with the product of Cp110, which is also localized to the distal end of the centrioles. Together they seem to prevent the centriole microtubules from extending beyond the distal end of the centriole.

Spindle assembly abnormal 4 (Sas-4) encodes a centriole protein that is essential for centriole assembly. It is recruited to centrioles through an interaction with the centriole protein encoded by ana2, and it helps recruit microtubules to the centriole.

Centrosomal protein 97kDa, isoform B; Centrosomal protein 97kDa (Cep97) encodes a centriolar protein that localizes to the distal end of both mother and daughter centrioles. It interacts with the product of Cp110, which is also localized to the distal end of the centrioles. Together they seem to prevent the centriole microtubules from extending beyond the distal end of the centriole.

Spindle assembly abnormal protein 6 homolog; Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication. In ciliated neurons, required for centriole assembly but not necessary for cilium basal body and cilia function. Required for sperm cilium basal body elongation together with Cep135 and Ana2.

Centrosomal protein 97kDa, isoform B; Centrosomal protein 97kDa (Cep97) encodes a centriolar protein that localizes to the distal end of both mother and daughter centrioles. It interacts with the product of Cp110, which is also localized to the distal end of the centrioles. Together they seem to prevent the centriole microtubules from extending beyond the distal end of the centriole.

Anastral spindle 1 (ana1) encodes a cytoplasmic protein located in the centrioles, including the sperm giant centriole and proximal centriole-like structure, which assists in centrioles formation. Its roles include coordinated movement behavior, sperm motility, and fertility.

Centrosomal protein 97kDa, isoform B; Centrosomal protein 97kDa (Cep97) encodes a centriolar protein that localizes to the distal end of both mother and daughter centrioles. It interacts with the product of Cp110, which is also localized to the distal end of the centrioles. Together they seem to prevent the centriole microtubules from extending beyond the distal end of the centriole.

Anastral spindle 2 (ana2) encodes a centriole protein that is essential for centriole assembly, promoting the assembly of the central "cartwheel" structure. It may also have an independent role in promoting asymmetric divisions in larval neuroblasts.

Centrosomal protein 97kDa, isoform B; Centrosomal protein 97kDa (Cep97) encodes a centriolar protein that localizes to the distal end of both mother and daughter centrioles. It interacts with the product of Cp110, which is also localized to the distal end of the centrioles. Together they seem to prevent the centriole microtubules from extending beyond the distal end of the centriole.

Asterless (asl) encodes a component of the centriole that is required for centrosome function. It contributes to asymmetric cell division, sperm development and centriole replication and elongation.