(11 nodes) Sperm DNA condensation, and DNA binding, bending network (Drosophila melanogaster)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

textmining

co-expression

protein homology

Your Input:
	goddard	GEO12017p1; Goddard (goddard) is a newly evolved gene that encodes a predicted disordered protein with no homology to other protein families. It is implicated in male reproduction, as males with reduced goddard expression fail to produce sperm. (113 aa)
	Mst77F	Histone-like protein 18C; Not known. Encoded in the intron of cAMP-dependent protein kinase regulatory chain type I. (215 aa)
	CG33284	Uncharacterized protein. (115 aa)
	ProtB	Protamine B (ProtB) encodes a protamine protein involved in packaging the paternal genome in sperm. Protamines are small highly basic proteins with numerous cysteines. (144 aa)
	ProtA	Protamine A (ProtA) encodes a protamine protein involved in packaging the paternal genome in sperm. Protamines are small highly basic proteins with numerous cysteines. (146 aa)
	tHMG1	Testis-enriched HMG-box-containing protein 1 (tHMG1) encodes a chromosomal protein involved in spermatogenesis. (126 aa)
	Tpl94D	Transition protein-like 94D (Tpl94D) encodes a HMG-box domain protein that is expressed during chromatin reorganization in spermatids. (164 aa)
	tHMG2	Testis-enriched HMG-box-containing protein 2 (tHMG2) encodes a chromosomal protein involved in spermatogenesis. (134 aa)
	Prtl99C	Protamine-like 99C (Prtl99C) encodes a sperm chromatin-associated protein that is essential for male fertility. It acts additively together with the products of Mst77F, ProtA and ProtB to compact the paternal chromatin; Belongs to the UPF0771 family. (201 aa)
	CG43072	GEO02514p1. (82 aa)
	CG13541	IP06556p. (172 aa)

Your Current Organism:

Drosophila melanogaster

NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CG13541	CG33284	FBpp0309887	FBpp0077949	IP06556p.	Uncharacterized protein.	0.927
CG13541	CG43072	FBpp0309887	FBpp0293361	IP06556p.	GEO02514p1.	0.916
CG13541	Mst77F	FBpp0309887	FBpp0077928	IP06556p.	Histone-like protein 18C; Not known. Encoded in the intron of cAMP-dependent protein kinase regulatory chain type I.	0.416
CG13541	ProtA	FBpp0309887	FBpp0080244	IP06556p.	Protamine A (ProtA) encodes a protamine protein involved in packaging the paternal genome in sperm. Protamines are small highly basic proteins with numerous cysteines.	0.517
CG13541	Prtl99C	FBpp0309887	FBpp0290959	IP06556p.	Protamine-like 99C (Prtl99C) encodes a sperm chromatin-associated protein that is essential for male fertility. It acts additively together with the products of Mst77F, ProtA and ProtB to compact the paternal chromatin; Belongs to the UPF0771 family.	0.606
CG13541	Tpl94D	FBpp0309887	FBpp0083732	IP06556p.	Transition protein-like 94D (Tpl94D) encodes a HMG-box domain protein that is expressed during chromatin reorganization in spermatids.	0.446
CG13541	goddard	FBpp0309887	FBpp0075435	IP06556p.	GEO12017p1; Goddard (goddard) is a newly evolved gene that encodes a predicted disordered protein with no homology to other protein families. It is implicated in male reproduction, as males with reduced goddard expression fail to produce sperm.	0.936
CG13541	tHMG1	FBpp0309887	FBpp0083651	IP06556p.	Testis-enriched HMG-box-containing protein 1 (tHMG1) encodes a chromosomal protein involved in spermatogenesis.	0.583
CG13541	tHMG2	FBpp0309887	FBpp0290698	IP06556p.	Testis-enriched HMG-box-containing protein 2 (tHMG2) encodes a chromosomal protein involved in spermatogenesis.	0.590
CG33284	CG13541	FBpp0077949	FBpp0309887	Uncharacterized protein.	IP06556p.	0.927
CG33284	CG43072	FBpp0077949	FBpp0293361	Uncharacterized protein.	GEO02514p1.	0.919
CG33284	Mst77F	FBpp0077949	FBpp0077928	Uncharacterized protein.	Histone-like protein 18C; Not known. Encoded in the intron of cAMP-dependent protein kinase regulatory chain type I.	0.442
CG33284	ProtA	FBpp0077949	FBpp0080244	Uncharacterized protein.	Protamine A (ProtA) encodes a protamine protein involved in packaging the paternal genome in sperm. Protamines are small highly basic proteins with numerous cysteines.	0.510
CG33284	ProtB	FBpp0077949	FBpp0080243	Uncharacterized protein.	Protamine B (ProtB) encodes a protamine protein involved in packaging the paternal genome in sperm. Protamines are small highly basic proteins with numerous cysteines.	0.429
CG33284	Prtl99C	FBpp0077949	FBpp0290959	Uncharacterized protein.	Protamine-like 99C (Prtl99C) encodes a sperm chromatin-associated protein that is essential for male fertility. It acts additively together with the products of Mst77F, ProtA and ProtB to compact the paternal chromatin; Belongs to the UPF0771 family.	0.623
CG33284	Tpl94D	FBpp0077949	FBpp0083732	Uncharacterized protein.	Transition protein-like 94D (Tpl94D) encodes a HMG-box domain protein that is expressed during chromatin reorganization in spermatids.	0.465
CG33284	goddard	FBpp0077949	FBpp0075435	Uncharacterized protein.	GEO12017p1; Goddard (goddard) is a newly evolved gene that encodes a predicted disordered protein with no homology to other protein families. It is implicated in male reproduction, as males with reduced goddard expression fail to produce sperm.	0.831
CG33284	tHMG1	FBpp0077949	FBpp0083651	Uncharacterized protein.	Testis-enriched HMG-box-containing protein 1 (tHMG1) encodes a chromosomal protein involved in spermatogenesis.	0.582
CG33284	tHMG2	FBpp0077949	FBpp0290698	Uncharacterized protein.	Testis-enriched HMG-box-containing protein 2 (tHMG2) encodes a chromosomal protein involved in spermatogenesis.	0.611
CG43072	CG13541	FBpp0293361	FBpp0309887	GEO02514p1.	IP06556p.	0.916