STRINGSTRING
sl sl Shc Shc Sos Sos Ras85D Ras85D drk drk Vav Vav bsk bsk Pak3 Pak3 Jra Jra Rac1 Rac1 Mkk4 Mkk4 CG15529 CG15529
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
sl1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Small wing (sl) encodes a phosphatidylinositol-specific phospholiase type C that is required as a general modulator for growth downstream of the insulin pathway, and interacts with the Ras-MAPK pathway. (1236 aa)
ShcSHC-adaptor protein (Shc) encodes a protein involved in receptor tyrosine kinase signalling. It regulates anti-parasitoid immune response and tracheal development. (409 aa)
SosProtein son of sevenless; Promotes the exchange of Ras-bound GDP by GTP. Functions in signaling pathways initiated by the sevenless and epidermal growth factor receptor tyrosine kinases; implies a role for the ras pathway in neuronal development. (1596 aa)
Ras85DRas-like protein 1; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays a role in eye development by regulating cell growth, survival of postmitotic ommatidial cells and differentiation of photoreceptor cells. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis. (189 aa)
drkProtein enhancer of sevenless 2B; Downstream of receptor kinase (drk) encodes an adaptor protein that recognizes phosphorylated tyrosine residues of membrane receptors and triggers the Ras/Raf/MAPK pathway. drk product contributes to the regulation of cytoskeletal organization and participates in developmental and cognitive processes (associative learning, anesthesia resistant memory). (211 aa)
VavVav guanine nucleotide exchange factor (Vav) encodes a protein that belongs to the Dbl GEF superfamily. It functions as a GDP/GTP exchange factor for the product of Rac1 and an adaptor protein. Both activities are activated by direct tyrosine phosphorylation. (1001 aa)
bskStress-activated protein kinase JNK; Responds to activation by environmental stress by phosphorylating a number of transcription factors, primarily components of AP-1 such as Jra and also the transcriptional repressor aop, and thus regulates transcriptional activity. Component of the immune response activated by bacterial infection, and is involved in wound healing and in dorsal closure, a morphogenetic movement during embryogenesis. Functions in the systematic response to wounding acting downstream of the Hayan-phenoloxidase PPO1 cascade. Exhibits cytoprotective activity in neuronal c [...] (372 aa)
Pak3Non-specific serine/threonine protein kinase; Pak3 (Pak3) encodes a Ser/Thr kinase implicated in myoblast fusion, synapse development, wound healing and border cell migration. It functions downstream of the small Rac GTPases to regulate actin cytoskeletal organization. (583 aa)
JraTranscription factor AP-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Plays a role in dorsal closure. Belongs to the bZIP family. Jun subfamily. (372 aa)
Rac1Ras-related protein Rac1; During various developmental processes, regulates changes in cell morphology in response to extracellular signals. During oogenesis, mediates signaling from the tyrosine kinase (RTK) chemoattractant receptors (Egfr and Pvr) to the guidance pathway that control the directional persistent collective migration of the border cell (BC) cluster through the nurse cells to the oocyte. Once activating by Pvr and Egfr, promotes the formation of forward-directed actin protrusions which stabilize the DE- cadherin (shg)-mediated adhesions. In turn, DE-mediated adhesion bet [...] (192 aa)
Mkk4MAP kinase kinase 4 (Mkk4) encodes a mitogen activated protein kinase kinase (MAPKK) involved in the Jun kinase (JNK) pathway. It is directly activated by the MAPKKK encoded by Tak1. Mkk4 product roles include activation of intracellular JNK signalling upon the TNF family ligand encoded by egr and regulation of axon stability. (424 aa)
CG15529RH14395p. (196 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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