STRINGSTRING
mei-9 mei-9 Xpac Xpac Xpd Xpd Ubi-p63E Ubi-p63E RfC4 RfC4 CG8142 CG8142 mrn mrn hay hay FBgn0035644 FBgn0035644 Tfb4 Tfb4 Ssl1 Ssl1 RpS27A RpS27A RfC3 RfC3 RPA2 RPA2 pic pic FBgn0264326 FBgn0264326 PCNA PCNA Ercc1 Ercc1 Tfb1 Tfb1 Gnf1 Gnf1 Chrac-14 Chrac-14 Parp Parp Tfb5 Tfb5 Mes4 Mes4 Cul4 Cul4 Roc1a Roc1a RpL40 RpL40 RPA3 RPA3 RfC38 RfC38 Ubi-p5E Ubi-p5E
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
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textmining
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mei-9DNA repair endonuclease XPF; Implicated in recombination events during meiosis, mostly in meiotic exchange. May directly resolve Holliday junctions within recombination intermediates leading to DNA exchange. Also required for the repair of mismatches within meiotic heteroduplex DNA and for nucleotide excision repair. (961 aa)
XpacDNA repair protein complementing XP-A cells homolog; Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region (By similarity). Belongs to the XPA family. (296 aa)
XpdXeroderma pigmentosum D (Xpd) encodes a DNA helicase that is a subunit of the basal transcription and DNA repair factor TFIIH. (769 aa)
Ubi-p63EPolyubiquitin; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degradatio [...] (763 aa)
RfC4Replication factor C subunit 2; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. Subunit 2 binds ATP. (331 aa)
CG8142LD35209p; ATP binding; DNA clamp loader activity. It is involved in the biological process described with: DNA-dependent DNA replication; DNA repair. (353 aa)
mrnGeneral transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (499 aa)
hayGeneral transcription and DNA repair factor IIH helicase subunit XPB; ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of haywire/XPB/ERCC3, but not its helicase activity, is req [...] (798 aa)
FBgn0035644DNA polymerase epsilon subunit 2; Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). Has a role in the entrance and progression through S phase. Has a role in endoreplication. Essential for viability and tissue development. (525 aa)
Tfb4Transcription factor B4; RNA polymerase II CTD heptapeptide repeat kinase activity; DNA-dependent ATPase activity. (299 aa)
Ssl1General transcription factor IIH subunit; Zinc ion binding; nucleic acid binding. (438 aa)
RpS27AUbiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involve [...] (156 aa)
RfC3Replication factor C subunit 3; ATP binding; DNA clamp loader activity. It is involved in the biological process described with: leading strand elongation; DNA repair; sister chromatid cohesion; DNA-dependent DNA replication. (332 aa)
RPA2Replication protein A2, isoform A; Single-stranded DNA binding. It is involved in the biological process described with: double-strand break repair via homologous recombination; DNA repair; DNA replication; nucleotide-excision repair. (246 aa)
picPiccolo (pic) encodes the Ddb1 protein, which functions to recruit substrate receptors to Cul4-based E3 ubiquitin ligase complexes, which catalyze the ubiquitylation and subsequent destruction of proteins that function in cell growth and proliferation as well as transcription, replication and repair of the genome. (1140 aa)
FBgn0264326DNA polymerase epsilon catalytic subunit 1; Catalytic component of the DNA polymerase epsilon complex. Participates in chromosomal DNA replication. Required during synthesis of the leading DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork (By similarity). Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication. Has a role in the G1-S transition and/or S-phase progression of the mitotic cycle and endocycle progression. Involved in DNA synthesis during DNA repair (By similarity). [...] (2236 aa)
PCNAProliferating cell nuclear antigen; Likely to be an auxiliary protein of DNA polymerase delta complex and is probably involved in the control of DNA replication and repair by increasing the polymerase's processibility. Belongs to the PCNA family. (260 aa)
Ercc1Nucleotide excision repair protein ERCC1; Ercc1 (Ercc1) encodes the non-catalytic partner of the nuclease encoded by mei-9 that cuts structures formed during DNA repair. The mei-9-Ercc1 heterodimer interacts with the product of mus312 to make meiotic crossovers. The functions of the product of Ercc1 include repair of UV-induced DNA damage, repair of base adducts, a backup pathway for mismatch repair and meiotic recombination. (259 aa)
Tfb1General transcription factor IIH subunit 1; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFII [...] (585 aa)
Gnf1Replication factor C subunit 1; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit binds to the primer-template junction (By similarity). (1008 aa)
Chrac-14DNA polymerase epsilon subunit 3; Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). Histone-like protein which promotes nucleosome sliding of ATP-dependent nucleosome remodeling complexes. Part of the chromatin-accessibility complex (CHRAC) which uses energy/ATP to increase the general accessibility of DNA in chromatin. As an heterodimer with Chrac-16, binds DNA and facilitates nucleosome sliding by Acf. Has a role in DNA damage response by preventing cid mislocalization to chromatin [...] (128 aa)
ParpPoly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. Mainly mediates glutamate and aspartate ADP-ribosylation of target proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of glutamate and aspartate residues and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units. (994 aa)
Tfb5Transcription factor B5 (Tfb5) encodes a subunit of the basal transcription and DNA repair factor TFIIH, which operates in transcription and DNA repair. (73 aa)
Mes4DNA polymerase epsilon subunit 4; Mesoderm-expressed 4 (Mes4) encodes a protein related to the mammalian NF-Y transcription factor complex subunit C. It is one of the maternal target genes of the transcription factor encoded by dl and is regulated by the DRE/DREF pathway. (155 aa)
Cul4Cullin 4 (Cul4) encodes the molecular scaffold for the CRL4 E3 ubiquitin ligase complex, which catalyzes the ubiquitylation and subsequent destruction of proteins that function in cell growth and proliferation as well as transcription, replication and repair of the genome; Belongs to the cullin family. (821 aa)
Roc1aRING-box protein 1A; Core component of multiple SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Required for the specific SCF-dependent proteolysis of CI, but not that of ARM, suggesting that it also participates in the selection of substrates inside the SCF complex. During early metamorphosis, part of [...] (136 aa)
RpL40Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...] (128 aa)
RPA3Replication protein A3 (RPA3) encodes a protein involved in the maintenance of the neuronal stem cell population. (112 aa)
RfC38Replication factor C 38kD subunit, isoform A; DNA clamp loader activity. It is involved in the biological process described with: DNA-dependent DNA replication; sister chromatid cohesion; DNA repair; leading strand elongation. (356 aa)
Ubi-p5EUbiquitin-5E, isoform A; Protein tag; ubiquitin protein ligase binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; protein ubiquitination; modification-dependent protein catabolic process; cellular protein modification process. (534 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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