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RpL22 RpL22 RpL36 RpL36 sta sta RpL35 RpL35 RpL17 RpL17 RpS14a RpS14a RpS6 RpS6 RpL29 RpL29 RpL23 RpL23 RpS24 RpS24 RpL22-like RpL22-like RpL12 RpL12 RpL39 RpL39 RpL19 RpL19 RpL8 RpL8 RpL28 RpL28 RpS15Aa RpS15Aa RpL37a RpL37a RpS10b RpS10b RpS12 RpS12 RpL10Ab RpL10Ab RpS17 RpS17 RpL14 RpL14 RpL13A RpL13A RpL35A RpL35A RpS25 RpS25 RpS5b RpS5b RpS20 RpS20 RpS27 RpS27 RpL4 RpL4 RpL32 RpL32 RpL6 RpL6 RpS18 RpS18 RpL18A RpL18A RpLP2 RpLP2 RpS15 RpS15 RpS23 RpS23 RpS11 RpS11 RpL31 RpL31 RpS7 RpS7 RpS8 RpS8 RpL15 RpL15 RpS3A RpS3A eIF5B eIF5B RpL13 RpL13 RpS2 RpS2 RpL21 RpL21 RpL27 RpL27 RpLP1 RpLP1 RpL18 RpL18 RpL10 RpL10 RpLP0 RpLP0 RpS29 RpS29 RpL40 RpL40 RpL38 RpL38 RpS21 RpS21 RpL27A RpL27A RpL3 RpL3 RpS19a RpS19a RpL9 RpL9 RpL30 RpL30 RpL11 RpL11 RpS9 RpS9 RpL24 RpL24 RpS16 RpS16 RpL7A RpL7A RpS28b RpS28b RpL7 RpL7 RpL5 RpL5 RpL36A RpL36A Ubi-p5E Ubi-p5E RpS3 RpS3 RpS4 RpS4 RpS13 RpS13 RpS26 RpS26 RpL26 RpL26 RpL23A RpL23A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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RpL22Ribosomal protein L22 (RpL22) encodes a member of the eukaryotic ribosomal protein eL22 family. It is ubiquitously expressed, forms part of the large ribosomal subunit and is involved in protein synthesis. (299 aa)
RpL3660S ribosomal protein L36; Component of the large ribosomal subunit. (115 aa)
sta40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Required during oogenesis and imaginal development. Belongs to the universal ribosomal protein uS2 family. (270 aa)
RpL35Ribosomal protein L35, isoform A; mRNA binding; structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); translation. (123 aa)
RpL1760S ribosomal protein L17; Structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation; Belongs to the universal ribosomal protein uL22 family. (186 aa)
RpS14a40S ribosomal protein S14a; Small ribosomal subunit rRNA binding; structural constituent of ribosome; mRNA 5'-UTR binding. It is involved in the biological process described with: cytoplasmic translation; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); translation; ribosomal small subunit assembly; Belongs to the universal ribosomal protein uS11 family. (151 aa)
RpS640S ribosomal protein S6; May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA. (248 aa)
RpL2960S ribosomal protein L29; Chromatin binding; structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation; Belongs to the eukaryotic ribosomal protein eL29 family. (76 aa)
RpL2360S ribosomal protein L23; Large ribosomal subunit rRNA binding; structural constituent of ribosome; myosin binding. It is involved in the biological process described with: translation; cytoplasmic translation; Belongs to the universal ribosomal protein uL14 family. (140 aa)
RpS24Ribosomal protein S24 (RpS24) encodes an essential component of the small ribosomal subunit that functions in protein synthesis. It is classified as a 'Minute' gene as heterozygous mutants exhibit a slower developmental rate and small adult bristles; Belongs to the eukaryotic ribosomal protein eS24 family. (131 aa)
RpL22-likeRibosomal protein L22-like (RpL22-like) encodes a eukaryotic-specific component of the large ribosomal subunit involved in protein synthesis. (312 aa)
RpL12Ribosomal protein L12 (RpL12) encodes a protein of the large subunit of the ribosome. It regulates transcription of ribosomal proteins and ribosome biogenesis genes as well as interacting with the Enhancer of Trithorax and Polycomb protein encoded by corto. (165 aa)
RpL3960S ribosomal protein L39; Structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation; translation; Belongs to the eukaryotic ribosomal protein eL39 family. (51 aa)
RpL19Ribosomal protein L19 (RpL19) encodes a ribosomal structural constituent; Belongs to the eukaryotic ribosomal protein eL19 family. (203 aa)
RpL8Ribosomal protein L8 (RpL8) encodes a ribosomal structural constituent. (256 aa)
RpL2860S ribosomal protein L28; Structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation; translation; Belongs to the eukaryotic ribosomal protein eL28 family. (144 aa)
RpS15Aa40S ribosomal protein S15Aa; Structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation; translation; Belongs to the universal ribosomal protein uS8 family. (130 aa)
RpL37aProbable 60S ribosomal protein L37-A; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL37 family. (93 aa)
RpS10bRibosomal protein S10b (RpS10b) encodes a structural constituent of ribosomes; Belongs to the eukaryotic ribosomal protein eS10 family. (160 aa)
RpS12Ribosomal protein S12 (RpS12) is an essential gene encoding a protein component of the cytoplasmic small ribosomal subunit. (139 aa)
RpL10AbRibosomal protein L10Ab (RpL10Ab) is an essential gene during oogenesis that encodes a ribosomal protein of the large ribosome subunit; Belongs to the universal ribosomal protein uL1 family. (217 aa)
RpS17Ribosomal protein S17 (RpS17) encodes an essential component of the ribosomal 40S subunit. RpS17 mutants have dominant, haploinsufficient effects on cellular and organismal growth rate, and on bristle size; Belongs to the eukaryotic ribosomal protein eS17 family. (131 aa)
RpL14Ribosomal protein L14 (RpL14) encodes a component of the large subunit of cytoplasmic ribosomes, which translate mRNAs encoded by the nuclear genome. RpL14 is haploinsufficient - heterozygous mutants display the 'Minute' phenotype, characterized by a slower developmental rate and small adult bristles. (166 aa)
RpL13ARibosomal protein L13A (RpL13A) encodes a component of the large ribosomal subunit, and thus involved in mRNA translation. Mutations in genes encoding ribosomal proteins affect fertility, viability and other Drosophila phenotypes, described as Minute; Belongs to the universal ribosomal protein uL13 family. (205 aa)
RpL35ARibosomal protein L35A; Structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation; ribosomal large subunit biogenesis. (157 aa)
RpS2540S ribosomal protein S25; Structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation; Belongs to the eukaryotic ribosomal protein eS25 family. (117 aa)
RpS5b40S ribosomal protein S5b; rRNA binding; structural constituent of ribosome; mRNA binding. It is involved in the biological process described with: cytoplasmic translation; ribosomal small subunit assembly; translation; Belongs to the universal ribosomal protein uS7 family. (230 aa)
RpS2040S ribosomal protein S20; RNA binding; structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation; translation. (120 aa)
RpS2740S ribosomal protein S27; RNA binding; structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation; ribosomal small subunit assembly; translation. (84 aa)
RpL460S ribosomal protein L4; Structural constituent of ribosome; RNA binding. It is involved in the biological process described with: cytoplasmic translation; translation; Belongs to the universal ribosomal protein uL4 family. (401 aa)
RpL3260S ribosomal protein L32; Structural constituent of ribosome. It is involved in the biological process described with: translation; cytoplasmic translation. (147 aa)
RpL6Ribosomal protein L6, isoform B; RNA binding; structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation; ribosomal large subunit assembly. (262 aa)
RpS18Ribosomal protein S18 (RpS18) encodes a ribosomal protein located at the top of the head of the 40S subunit and contacts several helices of the 18S rRNA. (152 aa)
RpL18A60S ribosomal protein L18a; Structural constituent of ribosome. It is involved in the biological process described with: translation; cytoplasmic translation; Belongs to the eukaryotic ribosomal protein eL20 family. (177 aa)
RpLP260S acidic ribosomal protein P2; Plays an important role in the elongation step of protein synthesis; Belongs to the eukaryotic ribosomal protein P1/P2 family. (113 aa)
RpS15Ribosomal protein S15 (RpS15) encodes a protein that plays a role in assembly, structure and function of the ribosome and functions in protein synthesis. It is phosphorylated by the kinase encoded by Lrrk, causing protein synthesis upregulation; Belongs to the universal ribosomal protein uS19 family. (148 aa)
RpS2340S ribosomal protein S23; Structural constituent of ribosome. It is involved in the biological process described with: translation; cytoplasmic translation. (143 aa)
RpS1140S ribosomal protein S11; Structural constituent of ribosome. It is involved in the biological process described with: translation; cytoplasmic translation; Belongs to the universal ribosomal protein uS17 family. (155 aa)
RpL3160S ribosomal protein L31; Structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation; Belongs to the eukaryotic ribosomal protein eL31 family. (124 aa)
RpS740S ribosomal protein S7; Structural constituent of ribosome. It is involved in the biological process described with: translation; ribosomal small subunit biogenesis; cytoplasmic translation; rRNA processing; Belongs to the eukaryotic ribosomal protein eS7 family. (194 aa)
RpS8Ribosomal protein S8 (RpS8) encodes a structural constituent of ribosomes that is involved in larval lymph gland hemopoiesis; Belongs to the eukaryotic ribosomal protein eS8 family. (208 aa)
RpL1560S ribosomal protein L15; Structural constituent of ribosome; RNA binding. It is involved in the biological process described with: cytoplasmic translation; Belongs to the eukaryotic ribosomal protein eL15 family. (204 aa)
RpS3ARibosomal protein S3A (RpS3A) encodes an essential component of the small ribosomal subunit that functions in protein synthesis. It is classified as a 'Minute' gene as heterozygous mutants exhibit a slower developmental rate and small adult bristles; Belongs to the eukaryotic ribosomal protein eS1 family. (268 aa)
eIF5BProtein binding; translation initiation factor activity; GTPase activity; GTP binding; DEAD/H-box RNA helicase binding. It is involved in the biological process described with: translational initiation. (1144 aa)
RpL13Ribosomal protein L13 (RpL13) encodes a ribosomal structural constituent; Belongs to the eukaryotic ribosomal protein eL13 family. (218 aa)
RpS2Ribosomal protein S2 (RpS2) encodes a highly conserved component of the 40S ribolomal comlex. RpS2 product controls the assembly and nuclear export of the pre-ribosome and appears to have a specific function during oogenesis. (267 aa)
RpL21Ribosomal protein L21, isoform A; Structural constituent of ribosome. It is involved in the biological process described with: translation; cytoplasmic translation. (159 aa)
RpL2760S ribosomal protein L27; Structural constituent of ribosome. It is involved in the biological process described with: translation; cytoplasmic translation; Belongs to the eukaryotic ribosomal protein eL27 family. (135 aa)
RpLP1Ribosomal protein LP1 (RpLP1) encodes a member of the cytoplasmic large ribosomal protein family. (112 aa)
RpL1860S ribosomal protein L18; Structural constituent of ribosome; RNA binding. It is involved in the biological process described with: cytoplasmic translation; translation. (188 aa)
RpL1060S ribosomal protein L10; Structural constituent of ribosome. It is involved in the biological process described with: translation; ribosomal large subunit assembly; cytoplasmic translation. (218 aa)
RpLP060S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10; Belongs to the universal ribosomal protein uL10 family. (317 aa)
RpS2940S ribosomal protein S29; Zinc ion binding; structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation. (56 aa)
RpL40Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...] (128 aa)
RpL38Ribosomal protein L38 (RpL38) encodes a component of the large subunit of cytoplasmic ribosomes, which translate mRNAs encoded by the nuclear genome. RpL38 is haploinsufficient - heterozygous mutants display the 'Minute' phenotype, characterized by a slower developmental rate and small adult bristles. (70 aa)
RpS2140S ribosomal protein S21; May be an associated component of the ribosome rather than a core structural subunit. May act as a translation initiation factor. Has a role in regulation of cell proliferation in the hematopoietic organs and the imaginal disks of larva. (83 aa)
RpL27ARibosomal protein L27A (RpL27A) encodes a ribosomal structural constituent; Belongs to the universal ribosomal protein uL15 family. (149 aa)
RpL360S ribosomal protein L3; The L3 protein is a component of the large subunit of cytoplasmic ribosomes. (416 aa)
RpS19aRibosomal protein S19a (RpS19a) encodes a structural constituent of ribosomes; Belongs to the eukaryotic ribosomal protein eS19 family. (156 aa)
RpL9Ribosomal protein L9 (RpL9) encodes a ribosomal structural constituent; Belongs to the universal ribosomal protein uL6 family. (190 aa)
RpL30Ribosomal protein L30, isoform B; RNA binding; structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation; translation. (111 aa)
RpL1160S ribosomal protein L11; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] (184 aa)
RpS9Ribosomal protein S9 (RpS9) encodes a structural constituent of ribosomes. (195 aa)
RpL2460S ribosomal protein L24; Structural constituent of ribosome; RNA binding. It is involved in the biological process described with: cytoplasmic translation; assembly of large subunit precursor of preribosome; translation; ribosomal large subunit assembly; Belongs to the eukaryotic ribosomal protein eL24 family. (155 aa)
RpS1640S ribosomal protein S16; Structural constituent of ribosome; RNA binding. It is involved in the biological process described with: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); cytoplasmic translation; translation; Belongs to the universal ribosomal protein uS9 family. (148 aa)
RpL7ARibosomal protein L7A (RpL7A) encodes a ribosomal structural constituent; Belongs to the eukaryotic ribosomal protein eL8 family. (271 aa)
RpS28b40S ribosomal protein S28; Structural constituent of ribosome. It is involved in the biological process described with: ribosomal small subunit assembly; translation; maturation of SSU-rRNA; cytoplasmic translation; Belongs to the eukaryotic ribosomal protein eS28 family. (65 aa)
RpL760S ribosomal protein L7; Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (By similarity). (252 aa)
RpL560S ribosomal protein L5; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] (299 aa)
RpL36ARibosomal protein L36A, isoform A; Structural constituent of ribosome. It is involved in the biological process described with: translation; cytoplasmic translation; Belongs to the eukaryotic ribosomal protein eL42 family. (104 aa)
Ubi-p5EUbiquitin-5E, isoform A; Protein tag; ubiquitin protein ligase binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; protein ubiquitination; modification-dependent protein catabolic process; cellular protein modification process. (534 aa)
RpS3Ribosomal protein S3 (RpS3) encodes a component of the small subunit of cytoplasmic ribosomes, which translate mRNAs encoded by the nuclear genome. RpS3 is haploinsufficient - heterozygous mutants display the 'Minute' phenotype, characterized by a slower developmental rate and small adult bristles. The product of RpS3 also contains a DNA lyase activity and functions in DNA repair. (246 aa)
RpS4Ribosomal protein S4 (RpS4) encodes a structural constituent of ribosomes; Belongs to the eukaryotic ribosomal protein eS4 family. (261 aa)
RpS13Ribosomal protein S13 (RpS13) encodes a structural constituent of ribosomes; Belongs to the universal ribosomal protein uS15 family. (151 aa)
RpS2640S ribosomal protein S26; mRNA binding; structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation. (114 aa)
RpL26Ribosomal protein L26 (RpL26) encodes a protein component of large ribosomal subunits. (149 aa)
RpL23ARibosomal protein L23A (RpL23A) encodes an essential ribosomal RNA binding protein of the large ribosomal subunit involved in protein synthesis; Belongs to the universal ribosomal protein uL23 family. (277 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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