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Prosbeta2R1 Prosbeta2R1 Prosalpha3 Prosalpha3 Prosbeta5R1 Prosbeta5R1 Ubi-p63E Ubi-p63E Prosalpha4 Prosalpha4 Rpn1 Rpn1 Rpn12 Rpn12 Prosbeta2 Prosbeta2 Rpt6 Rpt6 Rpn10 Rpn10 Rpn5 Rpn5 Prosbeta7 Prosbeta7 Prosbeta2R2 Prosbeta2R2 Rpn11 Rpn11 CG13088 CG13088 RpS27A RpS27A Prosbeta3 Prosbeta3 aurA aurA Prosalpha2 Prosalpha2 CG9588 CG9588 Fbxl7 Fbxl7 Prosalpha4T1 Prosalpha4T1 Rpn7 Rpn7 Rpt5 Rpt5 Rpn9 Rpn9 Prosalpha5 Prosalpha5 Prosbeta1 Prosbeta1 Rpn6 Rpn6 PI31 PI31 Prosbeta5 Prosbeta5 Cul1 Cul1 CG30382 CG30382 Rpt1 Rpt1 Prosalpha7 Prosalpha7 SkpA SkpA Rpn3 Rpn3 Rpt4 Rpt4 Roc1a Roc1a REG REG Rpn8 Rpn8 Rpn2 Rpn2 RpL40 RpL40 Prosbeta4 Prosbeta4 Prosbeta5R2 Prosbeta5R2 CG12096 CG12096 Prosalpha4T2 Prosalpha4T2 Prosalpha6 Prosalpha6 Ubi-p5E Ubi-p5E Rpt2 Rpt2 Rpt3 Rpt3
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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Prosbeta2R1Proteasome subunit beta; Endopeptidase activity; threonine-type endopeptidase activity. It is involved in the biological process described with: proteasome-mediated ubiquitin-dependent protein catabolic process; proteasomal protein catabolic process; proteasomal ubiquitin-independent protein catabolic process. (307 aa)
Prosalpha3Proteasome subunit alpha type-4; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. (264 aa)
Prosbeta5R1Proteasome subunit beta; Threonine-type endopeptidase activity; endopeptidase activity. It is involved in the biological process described with: proteasomal protein catabolic process; proteasomal ubiquitin-independent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process. (315 aa)
Ubi-p63EPolyubiquitin; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degradatio [...] (763 aa)
Prosalpha4Proteasome subunit alpha type-7-1; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity; Belongs to the peptidase T1A family. (249 aa)
Rpn126S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (919 aa)
Rpn1226S proteasome regulatory complex subunit p30; It is involved in the biological process described with: proteasome-mediated ubiquitin-dependent protein catabolic process; ubiquitin-dependent protein catabolic process. (264 aa)
Prosbeta2Proteasome beta2 subunit (Prosbeta2) encodes a component of the 26S proteasome, which degrades polyubiquitinated proteins in the cytoplasm and nucleus. (272 aa)
Rpt626S proteasome regulatory subunit 8; Regulatory particle triple-A ATPase 6 (Rpt6) encodes a subunit of the proteasome, which is responsible for the ATP-dependent degradation of obsolete or damaged proteins. Rpt6 product belongs to the heterohexameric ring formed by triple-A ATPases that unfolds ubiquitinated target proteins before their degradation. (405 aa)
Rpn10Regulatory particle non-ATPase 10 (Rpn10) encodes one of the polyubiquitin receptor subunits of the 26S proteasome. It recognizes and binds the polyubiquitin moiety of proteins intended for proteasomal degradation or the ubiquitin-like domain of extraproteasomal ubiquitin receptors. (396 aa)
Rpn5Regulatory particle non-ATPase 5; It is involved in the biological process described with: proteasome-mediated ubiquitin-dependent protein catabolic process. (502 aa)
Prosbeta7Proteasome subunit beta type-4; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity); Belongs to the peptidase T1B family. (268 aa)
Prosbeta2R2Proteasome beta2 subunit-related 2; Endopeptidase activity; threonine-type endopeptidase activity. It is involved in the biological process described with: proteasomal ubiquitin-independent protein catabolic process; proteasomal protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process. (322 aa)
Rpn1126S proteasome non-ATPase regulatory subunit 14; Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of the 'Lys-63'-specific deubiquitination of the proteasome is unclear (By similarity). Belongs to the peptidase M67A family. PSMD14 subfamily. (308 aa)
CG13088AT02038p; It is involved in the biological process described with: G2/M transition of mitotic cell cycle; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; regulation of cell cycle. (401 aa)
RpS27AUbiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involve [...] (156 aa)
Prosbeta3Proteasome subunit beta type-3; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. (205 aa)
aurAAurora A (aurA) encodes a protein kinase required for proper neuroblast self-renewal by regulating assymmetric protein localization. It contributes to spindle orientation, centrosome separation and pole cell formation. (411 aa)
Prosalpha2Proteasome subunit alpha type-2; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. (234 aa)
CG958826S proteasome non-ATPase regulatory subunit 9; Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). (220 aa)
Fbxl7F-box and leucine-rich repeat protein 7 (Fbxl7) encodes a ubiquitin ligase that regulates Hippo signaling. (772 aa)
Prosalpha4T1Proteasome subunit alpha type-7-1A; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. (249 aa)
Rpn726S proteasome non-ATPase regulatory subunit 6; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (389 aa)
Rpt5Regulatory particle triple-A ATPase 5 (Rpt5) encodes a component of the 26S proteasome, which degrades polyubiquitinated proteins in the cytoplasm and nucleus. (428 aa)
Rpn926S proteasome regulatory complex subunit p39A; Structural molecule activity. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; proteasome assembly; proteasome-mediated ubiquitin-dependent protein catabolic process. (382 aa)
Prosalpha5Proteasome subunit alpha type-5; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity; Belongs to the peptidase T1A family. (244 aa)
Prosbeta1Proteasome subunit beta; Endopeptidase activity; threonine-type endopeptidase activity. It is involved in the biological process described with: proteasome-mediated ubiquitin-dependent protein catabolic process; proteasomal ubiquitin-independent protein catabolic process; proteasomal protein catabolic process. (224 aa)
Rpn626S proteasome non-ATPase regulatory subunit 11; Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, RPN6 is required for proteasome assembly (By similarity). May act as linker between 19S regulatory subunit and the 20S proteasome core. (439 aa)
PI31Proteasome inhibitor PI31 subunit; Plays an important role in the control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Enhances 26S proteasome function by promoting its assembly through the interaction with the assembly chaperones PSMD9 and PMSD5. Functions together with ntc to control non-apoptotic caspase activation during sperm individualization. In testis, is required for proper protein degradation and germline cell cycle progression. (270 aa)
Prosbeta5Proteasome beta5 subunit (Prosbeta5) encodes an endopeptidase subunit of the of the 26S proteasome; Belongs to the peptidase T1B family. (282 aa)
Cul1Cullin homolog 1; Core component of multiple SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. During early metamorphosis, part of the SCF-slmb complex that negatively regulates the InR/PI3K/TOR pathway to activate the pruning of unnecessary larv [...] (774 aa)
CG30382Proteasome subunit alpha type-6; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity); Belongs to the peptidase T1A family. (244 aa)
Rpt126S proteasome regulatory complex subunit p48B; Regulatory particle triple-A ATPase 1 (Rpt1) encodes an AAA-type ATPase protein that forms part of the heterohexameric ATPase ring of the regulatory complex of the 26S proteasome. (433 aa)
Prosalpha7Proteasome subunit alpha type-3; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity); Belongs to the peptidase T1A family. (253 aa)
SkpASKP1-related A (SkpA) encodes a subunit of Skp, Cullin, F-box (SCF)-containing ubiquitin ligase complexes. It regulates centrosome duplication, chromatin condensation, cell cycle progression, cell polarity, dendrite pruning and endoreduplication. (162 aa)
Rpn3Probable 26S proteasome non-ATPase regulatory subunit 3; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (494 aa)
Rpt4Regulatory particle triple-A ATPase 4 (Rpt4) encodes the 19S proteasomal ATPase, which is a component of the 26S proteosome complex. It localizes to the nucleolus and participates in regulating rRNA transcription. It physically interacts with the tumor suppressor encoded by BHD. (397 aa)
Roc1aRING-box protein 1A; Core component of multiple SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Required for the specific SCF-dependent proteolysis of CI, but not that of ARM, suggesting that it also participates in the selection of substrates inside the SCF complex. During early metamorphosis, part of [...] (136 aa)
REGProteasome regulator dREG; REG (REG) encodes an endopeptidase regulator involved in the regulation of the mitotic G1/S transition and proteasomal protein catabolism. (245 aa)
Rpn826S proteasome non-ATPase regulatory subunit 7; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Belongs to the peptidase M67A family. (358 aa)
Rpn226S proteasome non-ATPase regulatory subunit 1; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (1029 aa)
RpL40Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...] (128 aa)
Prosbeta4Proteasome beta4 subunit (Prosbeta4) encodes a protein involved in proteasomal degradation; Belongs to the peptidase T1B family. (201 aa)
Prosbeta5R2Proteasome subunit beta; Threonine-type endopeptidase activity; endopeptidase activity. It is involved in the biological process described with: proteasomal ubiquitin-independent protein catabolic process; proteasomal protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process. (279 aa)
CG1209626S proteasome non-ATPase regulatory subunit 5; Acts as a chaperone during the assembly of the 26S proteasome. (506 aa)
Prosalpha4T2Proteasome subunit alpha type-7-1B; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. (252 aa)
Prosalpha6Proteasome subunit alpha type-1; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity; Belongs to the peptidase T1A family. (279 aa)
Ubi-p5EUbiquitin-5E, isoform A; Protein tag; ubiquitin protein ligase binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; protein ubiquitination; modification-dependent protein catabolic process; cellular protein modification process. (534 aa)
Rpt226S proteasome regulatory subunit 4; Regulatory particle triple-A ATPase 2 (Rpt2) encodes one of six ATPases that form the base of the regulatory 19S cap of the proteasome. The Rpt2 product is involved in the recognition of specific substrates destined for degradation, such as those involved in Notch signalling pathway. (439 aa)
Rpt3Regulatory particle triple-A ATPase 3, isoform A; Proteasome-activating ATPase activity; ATPase activity; ATP binding. It is involved in the biological process described with: positive regulation of RNA polymerase II transcription preinitiation complex assembly; proteasome-mediated ubiquitin-dependent protein catabolic process; protein catabolic process; Belongs to the AAA ATPase family. (413 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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