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CG9577 CG9577 Pex5 Pex5 Spat Spat CG4586 CG4586 Acox57D-p Acox57D-p Acox57D-d Acox57D-d Fatp3 Fatp3 CG3589 CG3589 Dci Dci Pex10 Pex10 Ubi-p63E Ubi-p63E Mfe2 Mfe2 Cat Cat Pex7 Pex7 CG10672 CG10672 Pex14 Pex14 CG11236 CG11236 RpS27A RpS27A Nos Nos ScpX ScpX CG10194 CG10194 CRAT CRAT eff eff faf faf Hacl Hacl Pex13 Pex13 CG11077 CG11077 CG5009 CG5009 CG18003 CG18003 CG9527 CG9527 Ide Ide ADPS ADPS Dhap-at Dhap-at Pex12 Pex12 Idh Idh CG8032 CG8032 RpL40 RpL40 Amacr Amacr Fatp2 Fatp2 Hmgcl Hmgcl CG12338 CG12338 Ubi-p5E Ubi-p5E Fatp1 Fatp1 CROT CROT
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CG9577RE22677p; delta3,5-delta2,4-dienoyl-CoA isomerase activity. It is involved in the biological process described with: fatty acid beta-oxidation. (312 aa)
Pex5Peroxin 5, isoform A; Peroxisome matrix targeting signal-1 binding. It is involved in the biological process described with: protein import into peroxisome matrix, docking; response to anesthetic; peroxisome organization. (614 aa)
SpatSerine pyruvate aminotransferase (Spat) encodes an alanine-glyoxylate transaminase involved in glyoxylate catabolism. (394 aa)
CG4586Acyl-coenzyme A oxidase; Flavin adenine dinucleotide binding; FAD binding; fatty acid binding; acyl-CoA oxidase activity. It is involved in the biological process described with: fatty acid beta-oxidation; lipid homeostasis; fatty acid beta-oxidation using acyl-CoA oxidase. (677 aa)
Acox57D-pAcyl-coenzyme A oxidase; Flavin adenine dinucleotide binding; acyl-CoA oxidase activity; FAD binding; fatty acid binding. It is involved in the biological process described with: fatty acid beta-oxidation; lipid homeostasis; fatty acid beta-oxidation using acyl-CoA oxidase. (677 aa)
Acox57D-dAcyl-coenzyme A oxidase; FAD binding; fatty acid binding; acyl-CoA oxidase activity; flavin adenine dinucleotide binding. It is involved in the biological process described with: fatty acid beta-oxidation; lipid homeostasis; fatty acid beta-oxidation using acyl-CoA oxidase. (677 aa)
Fatp3Fatty acid transport protein 3, isoform A; Long-chain fatty acid-CoA ligase activity; very long-chain fatty acid-CoA ligase activity; long-chain fatty acid transporter activity. It is involved in the biological process described with: fatty acid biosynthetic process; triglyceride homeostasis. (687 aa)
CG3589LD11031p; Serine-type endopeptidase activity. It is involved in the biological process described with: proteolysis; protein processing; regulation of fatty acid beta-oxidation. (509 aa)
DciDodecenoyl-CoA delta-isomerase (Dci) encodes a protein that, when overexpressed, extends lifespan, enhances stress tolerance to oxidative and starvation stress and activates the product of foxo. (262 aa)
Pex10Peroxin 10 (Pex10) encodes a peroxisome protein important for sperm development. (299 aa)
Ubi-p63EPolyubiquitin; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degradatio [...] (763 aa)
Mfe2Peroxisomal Multifunctional enzyme type 2 (Mfe2) encodes a multifunctional protein harboring two separate enzyme activities: 2-enoyl-CoA hydratase 2 and 3-hydroxyacyl-CoA dehydrogenase. They function in the peroxisomal fatty acid breakdown spiral of beta-oxidation utilizing the (R)-isomer of the CoA-containing substrate; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (598 aa)
CatCatalase (Cat) encodes an enzyme that catalyzes the decomposition of hydrogen peroxide. It reduces the amount of oxidative damage to biomolecules and protects cells from the toxic effects of reactive oxygen species. (506 aa)
Pex7Peroxin 7, isoform A; Peroxisome matrix targeting signal-2 binding. It is involved in the biological process described with: peroxisome organization; protein import into peroxisome matrix. (339 aa)
CG10672SD02021p; Carbonyl reductase (NADPH) activity; 3-keto sterol reductase activity; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor. (317 aa)
Pex14Peroxin 14; Signaling receptor binding. It is involved in the biological process described with: protein targeting to peroxisome; peroxisome organization; protein import into peroxisome matrix, docking. (280 aa)
CG11236GH12548p; FAD binding; D-amino-acid oxidase activity. It is involved in the biological process described with: D-amino acid metabolic process; oxidation-reduction process. (341 aa)
RpS27AUbiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involve [...] (156 aa)
NosNitric oxide synthase; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. Truncated isoforms (isoform 3- isoform 6) are able to form intracellular complexes with the full- length protein and serve as dominant negative inhibitors of the enzyme activity; Belongs to the NOS family. (1349 aa)
ScpXSterol carrier protein X-related thiolase; Transferase activity, transferring acyl groups other than amino-acyl groups; phospholipid transporter activity. It is involved in the biological process described with: positive regulation of intracellular cholesterol transport; phospholipid transport; Belongs to the thiolase-like superfamily. Thiolase family. (544 aa)
CG10194GH04973p; Hydrolase activity. (351 aa)
CRATCarnitine O-acetyltransferase activity. It is involved in the biological process described with: fatty acid beta-oxidation; carnitine metabolic process, CoA-linked; Belongs to the carnitine/choline acetyltransferase family. (662 aa)
effUbiquitin-conjugating enzyme E2-17 kDa; Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Required for proper telomere behavior during cell divisions and possibly for ubiquitination of proteins involved in postmeiotic stages of spermatogenesis. Deletion mutations are lethal in homozygotes. (147 aa)
fafProbable ubiquitin carboxyl-terminal hydrolase FAF; Ubiquitin C-terminal hydrolase involved in development and the imd/NF-kappa-B (IMD) signaling cascade. Required for eye and embryo development, and plays a role in compound eye assembly and oogenesis respectively. In the larval eye disks, cells outside the assembling facets require this protein for short-range cell interactions that prevent the mystery cells from becoming photoreceptors. Also required for nuclear migration and cellularization in early embryogenesis and could play a role in pole cell determination, development or funct [...] (2778 aa)
HaclMagnesium ion binding; carbon-carbon lyase activity; thiamine pyrophosphate binding. It is involved in the biological process described with: fatty acid alpha-oxidation; Belongs to the TPP enzyme family. (568 aa)
Pex13Peroxin 13 (Pex13) encodes a peroxisome protein important for sperm development. (440 aa)
CG11077Mpv17-like protein; Involved in mitochondria homeostasis; Belongs to the peroxisomal membrane protein PXMP2/4 family. (168 aa)
CG5009Probable peroxisomal acyl-coenzyme A oxidase 1; Flavin adenine dinucleotide binding; fatty acid binding; FAD binding; acyl-CoA oxidase activity; Belongs to the acyl-CoA oxidase family. (669 aa)
CG18003L-lactate dehydrogenase activity; FMN binding; (S)-2-hydroxy-acid oxidase activity. It is involved in the biological process described with: lactate oxidation. (366 aa)
CG9527Acyl-coenzyme A oxidase; Fatty acid binding; FAD binding; acyl-CoA oxidase activity; pristanoyl-CoA oxidase activity; flavin adenine dinucleotide binding. It is involved in the biological process described with: lipid homeostasis; fatty acid beta-oxidation using acyl-CoA oxidase; fatty acid beta-oxidation. (724 aa)
IdeInsulin-degrading enzyme; Insulin degrading metalloproteinase (Ide) encodes a metalloprotease that controls growth in a cell-autonomous manner by regulating the level of the insulin-like peptide encoded by Ilp2. (990 aa)
ADPSAlkyldihydroxyacetonephosphate synthase; Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids; Belongs to the FAD-binding oxidoreductase/transferase type 4 family. (631 aa)
Dhap-atDihydroxyacetone phosphate acyltransferase, isoform C; Glycerone-phosphate O-acyltransferase activity. It is involved in the biological process described with: fatty acid metabolic process; ether lipid biosynthetic process; phospholipid biosynthetic process; Belongs to the GPAT/DAPAT family. (807 aa)
Pex12Peroxin 12 (Pex12) encodes a peroxisome protein important for sperm development; Belongs to the pex2/pex10/pex12 family. (297 aa)
IdhIsocitrate dehydrogenase (Idh) encodes a cytosolic enzyme that catalyzes the oxidative decarboxylation of isocitrate to 2-oxoglutarate, with the concomitant reduction of NADP[+] to NADPH. It functions, along with Men, Zw, and Pgd, in a small network of NADP reducing enzymes. (479 aa)
CG8032LD37279p; Oxidoreductase activity; polyamine oxidase activity. It is involved in the biological process described with: oxidation-reduction process. (583 aa)
RpL40Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...] (128 aa)
Amacralpha-methylacyl-CoA racemase activity. It is involved in the biological process described with: fatty acid alpha-oxidation. (373 aa)
Fatp2Long-chain fatty acid-CoA ligase activity; fatty acid transmembrane transporter activity; long-chain fatty acid transporter activity; very long-chain fatty acid-CoA ligase activity. It is involved in the biological process described with: fatty acid biosynthetic process; fatty acid transport; triglyceride homeostasis. (714 aa)
Hmgcl3-Hydroxymethyl-3-methylglutaryl-CoA lyase, isoform A; hydroxymethylglutaryl-CoA lyase activity. It is involved in the biological process described with: leucine metabolic process; leucine catabolic process; lipid metabolic process; ketone body biosynthetic process. (323 aa)
CG12338RE49860p; D-amino-acid oxidase activity; FAD binding. It is involved in the biological process described with: oxidation-reduction process; D-amino acid metabolic process. (335 aa)
Ubi-p5EUbiquitin-5E, isoform A; Protein tag; ubiquitin protein ligase binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; protein ubiquitination; modification-dependent protein catabolic process; cellular protein modification process. (534 aa)
Fatp1Fatty acid transport protein 1 (Fatp1) encodes a transmembrane protein with acyl-CoA synthetase activity required for photoreceptor survival. It is involved in the cellular uptake of long-chain fatty acids with a role in the catabolism of fatty acids as well as synthesis of triglycerides. (746 aa)
CROTCarnitine O-octanoyltransferase activity. It is involved in the biological process described with: fatty acid beta-oxidation. (618 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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