LD44032p; Ubiquitin binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway.

Charged multivesicular body protein 2b (CHMP2B) encodes an ESCRT-III component. It plays an important role in the generation of multivesicular bodies in the endosomal lysosomal pathway. It is also considered to play an important role in autophagosome maturation.

LD44032p; Ubiquitin binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway.

Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.

LD44032p; Ubiquitin binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway.

Multivesicular body subunit 12, isoform A; Ubiquitin binding. It is involved in the biological process described with: virus maturation; viral budding; receptor catabolic process; endosome to lysosome transport via multivesicular body sorting pathway; regulation of epidermal growth factor receptor signaling pathway.

LD44032p; Ubiquitin binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway.

Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...]

LD44032p; Ubiquitin binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway.

Ubiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involve [...]

LD44032p; Ubiquitin binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway.

Signal transducing adaptor molecule (Stam) encodes a component of the ESCRT-0 complex, which mediates multivesicular body formation. It is involved in RTK signaling regulation, tracheal cell migration and endosomal trafficking.

LD44032p; Ubiquitin binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway.

Tumor susceptibility gene 101 (TSG101) encodes an ESCRT-I complex component that acts as an adapter for membrane rearrangements operated by ESCRT-III. Its roles include endosomal sorting of ubiquitinated cargoes, which is important for signaling regulation, cytokinesis, and budding of viruses and exovesicles.

LD44032p; Ubiquitin binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway.

Ubiquitin-5E, isoform A; Protein tag; ubiquitin protein ligase binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; protein ubiquitination; modification-dependent protein catabolic process; cellular protein modification process.

LD44032p; Ubiquitin binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway.

Polyubiquitin; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degradatio [...]

LD44032p; Ubiquitin binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway.

Vacuolar protein sorting 2 (Vps2) encodes an ion channel involved in the transmembrane transport of potassium.

LD44032p; Ubiquitin binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway.

Vacuolar protein sorting 20 (Vps20) encodes a member of the ESCRT-III complex, which sorts certain endocytosed receptors for degradation via the multivesicular body. As part of this complex, the product of Vps20 is also involved in abscission following cytokinesis.

LD44032p; Ubiquitin binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway.

Vacuolar protein sorting 24 (Vps24) encodes an essential subunit of ESCRT-III, one of the endosomal sorting complexes required for transport (ESCRT). It is involved in membrane remodeling in diverse cellular processes, such as multi-vesicular body biogenesis, cytokinesis and virus budding.

LD44032p; Ubiquitin binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway.

Vacuolar protein-sorting-associated protein 25; Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex (By similarity). Seems to function as a tumor suppressor by regulating Notch trafficking, hence preventing non-autonomous overproliferation. May be invo [...]

LD44032p; Ubiquitin binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway.

Vacuolar protein sorting 28 (Vps28) encodes a member of the ESCRT-I complex, which sorts certain endocytosed receptors for degradation via the multivesicular body.

LD44032p; Ubiquitin binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway.

Vacuolar protein-sorting-associated protein 36; Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex (By similarity). ESCRT-II interacts, through the Vps36 subunit, with bicoid mRNA. This interaction is required for the anterior localization of bicoid m [...]

LD44032p; Ubiquitin binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway.

Vacuolar protein sorting 37B, isoform A; It is involved in the biological process described with: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; protein targeting to vacuole; protein targeting to membrane; endosome transport via multivesicular body sorting pathway.

LD44032p; Ubiquitin binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway.

Vacuolar protein sorting 37A, isoform A; It is involved in the biological process described with: endosome transport via multivesicular body sorting pathway; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; protein targeting to vacuole; protein targeting to membrane.

LD44032p; Ubiquitin binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway.

Vacuolar-sorting protein SNF8; Larsen (lsn), also known as Vacuolar protein sorting 22, encodes a member of the ESCRT-II complex, which sorts certain endocytosed receptors for degradation via the multivesicular body. As part of this complex, it also has a role in bcd RNA localization.

LD44032p; Ubiquitin binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway.

GH13992p; Shrub (shrb) encodes Shrub encodes Vps32/Snf7, a filament-forming subunit of the ESCRT-III complex involved in inward membrane budding. It regulates multiple cellular processes involving ESCRTs activity including multivesicular body biogenesis, cytokinesis, membrane repair and regulation of membrane associated signaling.

Charged multivesicular body protein 2b (CHMP2B) encodes an ESCRT-III component. It plays an important role in the generation of multivesicular bodies in the endosomal lysosomal pathway. It is also considered to play an important role in autophagosome maturation.

LD44032p; Ubiquitin binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway.